[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"deep-sedation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:deep-sedation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100638571","hfno-flow-rates-and-cerebral-oxygenation-during-deep-sedation-for-cystoscopy-100638571",false,"NCT07630038","HFNO Flow Rates and Cerebral Oxygenation During Deep Sedation for Cystoscopy","Effect of Different Flow Rates of High-Flow Nasal Oxygen on Peripheral and Cerebral Oxygenation and Ventilation During Procedural Sedation for Cystoscopy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥18 years\n* Scheduled to undergo elective cystoscopy under procedural sedation in an operating room setting\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Known neurological disorders\n* History of ischemic or hemorrhagic stroke\n* Peripheral artery disease\n* Vasculitis\n* Severe heart failure\n* Uncontrolled hypertension\n* Uncontrolled diabetes mellitus\n* Advanced-stage chronic obstructive pulmonary disease\n* Severe anemia (hemoglobin \\\u003C8 g\u002FdL)\n* Skin lesions that could interfere with near-infrared spectroscopy (NIRS) measurements\n* History of head trauma\n* History of cranial surgery\n* Nasal deformity or nasal obstruction",true,"ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","For Patients and Families\n\nThis study aims to investigate how high-flow oxygen therapy affects oxygen levels, especially brain oxygenation, during cystoscopy procedures performed under sedation. The goal is to improve patient safety and comfort by ensuring better oxygen delivery during the procedure. Different oxygen flow rates will be compared, while patients' breathing, oxygen levels, and vital signs are continuously monitored throughout the procedure. All methods used in the study are consistent with routine anesthesia practices, and patient safety remains the highest priority.\n\nFor Healthcare Professionals\n\nThis prospective randomized controlled study evaluates the effects of different high-flow nasal oxygen (HFNO) flow rates on cerebral oxygenation, peripheral oxygenation, and ventilation parameters in patients undergoing cystoscopy under procedural sedation. The primary aim is to determine the contribution of HFNO to sedation safety and to provide clinical evidence regarding the optimal flow rate. In addition, hypoxemia incidence, airway intervention requirements, hemodynamic variables, and sedation depth are being analyzed.",[27,28,29,30],"Deep Sedation","High Flow Nasal Canula","Cerebral Oxygenation","PSI",[28,27,32,30],"rSO2","NOT_YET_RECRUITING","2026-06-01",{"date":36,"type":37},"2026-06-05","ACTUAL",{"date":34,"type":21},{"date":40,"type":21},"2026-10-01",{"name":42,"class":43},"Firat University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100636694","bis-guided-sedation-versus-standard-clinical-sedation-during-elective-electrical-cardioversion-for-atrial-fibrillation-100636694","NCT07569016","BIS-Guided Sedation Versus Standard Clinical Sedation During Elective Electrical Cardioversion for Atrial Fibrillation","Bispectral Index-Guided Sedation Versus Standard Clinical Assessment-Guided Sedation During Elective Electrical Cardioversion for Atrial Fibrillation: A Prospective, Single-Center, Randomized Controlled, Assessor-Blinded Trial","BIS-ECV-RCT","Inclusion Criteria:\n\n* Age ≥18 years\n* Documented atrial fibrillation with indication for elective electrical cardioversion\n* American Society of Anesthesiologists (ASA) physical status class I, II, or III\n* Left ventricular ejection fraction ≥30% on echocardiography\n* Adequate anticoagulation: INR ≥2.0, OR ≥3 weeks of therapeutic anticoagulation, OR absence of left atrial thrombus confirmed by transesophageal echocardiography\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy or contraindication to propofol or fentanyl, or their excipients (soy, egg)\n* Hemodynamic instability (systolic blood pressure \\\u003C90 mmHg or symptomatic hypotension)\n* Decompensated heart failure (NYHA functional class IV)\n* Severe obstructive sleep apnea requiring CPAP or BiPAP therapy\n* Anticipated difficult airway (modified Mallampati classification class III or IV)\n* Baseline oxygen saturation \\\u003C94% or active chronic obstructive pulmonary disease\n* Severe hepatic impairment (transaminases \\>3× upper limit of normal) or severe renal impairment (eGFR \\\u003C30 mL\u002Fmin\u002F1.73m²)\n* Active psychiatric illness or cognitive impairment precluding questionnaire completion\n* Pregnancy or breastfeeding\n* Alcohol or substance use within the preceding 24 hours\n* Prior participation in this trial",{"count":54,"type":21},60,[24],"Electrical cardioversion (ECV) is a standard procedure used to restore normal heart rhythm in patients with atrial fibrillation (AF) by delivering a brief electrical shock to the heart. Because the procedure is painful and distressing, patients receive sedation - a controlled state of reduced consciousness - using short-acting intravenous medications. However, the optimal depth of sedation for ECV has not been well defined: too deep may cause breathing problems and low blood pressure, while too light may result in pain, awareness, or patient movement during the shock.\n\nBispectral index (BIS) monitoring is a non-invasive technology that continuously measures brain activity using an EEG sensor placed on the forehead, generating a numerical score from 0 (no brain activity) to 100 (fully awake). BIS scores between 61 and 80 correspond to moderate sedation, which preliminary observations suggest may be sufficient for ECV without the risks associated with deeper sedation.\n\nThis randomized controlled trial will compare two approaches to sedation monitoring during elective ECV for AF:\n\n* Group 1 (BIS Group): Sedation is guided by BIS monitoring, targeting a score of 61-80.\n* Group 2 (Control Group): Sedation is guided by standard clinical assessment (loss of response to verbal commands and eyelash reflex), with BIS recorded but not visible to the treating team.\n\nBoth groups will receive the same medications (propofol and fentanyl). The primary outcome is how quickly patients recover after the procedure, measured by the Modified Aldrete Score - a standard clinical recovery assessment tool. Secondary outcomes include patient and physician satisfaction, procedural pain, risk of awareness during the procedure, cardioversion success rate, hemodynamic stability, and complication rates.\n\nThe trial will enroll 60 adult patients at Istanbul University-Cerrahpasa Cardiology Institute. Findings are expected to provide evidence-based guidance for standardizing sedation protocols during ECV.",[58,59,27],"Atrial Fibrillation","Electric Countershock",[61,59,62,63,64,65],"atrial fibrillation","sedation","bispectral index","propofol","anesthesia recovery","RECRUITING","2026-05-12",{"date":69,"type":37},"2026-05-15",{"date":71,"type":37},"2026-04-13",{"date":73,"type":21},"2026-07-15",{"name":75,"class":43},"Istanbul University - Cerrahpasa",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100549638","comparison-of-nasal-continuous-positive-airway-pressure-cpap-mask-and-nasal-airway-in-molar-tooth-extraction-under-deep-sedation-100549638","NCT06436638","Comparison of Nasal Continuous Positive Airway Pressure (CPAP) Mask and Nasal Airway in Molar Tooth Extraction Under Deep Sedation","Comparison of Nasal Continuous Positive Airway Pressure (CPAP) Mask and Nasal Airway in Terms of Intraoperative Anesthesia Quality and Postoperative Associated Complications in Impacted Molar Tooth Extraction Patients Under Deep Sedation; A Multi-Center Study","Inclusion Criteria:\n\n* Volunteer adult patients aged 18-60 years\n* Patients scheduled for impacted tooth extraction\n* Cases with surgical time ≥20 minutes and ≤60 minutes\n* American Society of Anaesthesiologists (ASA) physical status I and II patients\n* Patients with BMI≤30\n\nExclusion Criteria:\n\n* Patients under 18 years old-over 60 years old\n* Surgeries with a procedure time over 1 hour or less than 20 minutes\n* American Society of Anaesthesiologists (ASA) physical status III and higher patients\n* Presence of conditions such as mental retardation that impair the patient's ability to make decisions about himself\u002Fherself\n* Patients with respiratory system diseases such as asthma, chronic obstructive pulmonary disease (COPD) or airway hyperreactivity\n* Patients with a condition that severely narrows the nasal passage opening (e.g. adenoid hypertrophy, etc.)\n* Patients with BMI\\>30\n* Patients who refused to participate in the study","60 Years",{"count":54,"type":21},"OBSERVATIONAL","In patients with high levels of fear and anxiety, it is recommended to perform dental procedures under sedation or general anesthesia depending on the nature of the procedure. In dental treatment under anesthesia, it is important that the procedure is comfortable and well tolerated by the patient. In addition, patient comfort is important in all dental procedures to prevent the development of avoidance behavior.\n\nDuring dental procedures performed under anesthesia, the oral cavity is completely within the scope of the surgical or procedure field. In this respect, sedation and general anesthesia in dental procedures and operations have specific risks and challenges.Since there is a risk of respiratory depression, hypoxia and hypercarbia during deep sedation, non-invasive ventilation support provided to patients with airway devices would be beneficial. In the research clinics where the study will be conducted, deep sedation with non-invasive mechanical ventilation support using a nasal CPAP (Continuous Positive Airway Pressure) mask or nasal airway is applied during the extraction of impacted molars. Thus, many dental procedures are routinely performed under deep sedation without the need for general anesthesia. There are very limited data in the literature on the use of a nasal CPAP mask during sedation for different procedures in patients with obstructive sleep apnea or obesity. However, no study comparing ventilation support during deep sedation with nasal CPAP mask and nasal airway has been found in the literature.\n\nThe aim of this study is to compare the non-invasive ventilation support provided with 2 different airway devices during the procedure in terms of intraoperative and postoperative related complications, ventilation parameters, patient and surgeon satisfaction.\n\nThe hypothesis of the study is that two different ventilation support methods during deep sedation may be superior to each other in terms of anesthesia quality, postoperative complications related to airway devices, patient and surgeon satisfaction.\n\nIn the study, a total of 60 patients (Group airway, n;30, Group Mask, n;30) from 2 centers are planned to be included in the study by performing power analysis with a statistical power of the trial \\>0.8.\n\nThe permutation method will be applied within the scope of the restricted randomization method to determine the group of patients to be included.",[27,88,89,90,91],"Non-invasive Ventilation Support","Nasal Airway","Nasal CPAP Mask","Impacted Molar","2026-03-19",{"date":94,"type":37},"2026-03-20",{"date":96,"type":37},"2024-07-02",{"date":98,"type":21},"2026-06",{"name":100,"class":43},"Gözde Nur Erkan",2]