[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"defecation-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:defecation-disorder":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,76,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100630055","electromyographic-biofeedback-therapy-in-patients-with-dyssynergic-defecation-100630055",false,"NCT07482696","Electromyographic Biofeedback Therapy in Patients With Dyssynergic Defecation","Effects of Game-Based Electromyographic Biofeedback Therapy on Quality of Life and Sleep Quality in Patients With Dyssynergic Defecation","Inclusion Criteria:\n\n1. Diagnosis of dyssynergic defecation was confirmed by anorectal manometry, which demonstrated paradoxical pelvic floor muscle contraction and\u002For inadequate relaxation during defecation.\n2. Eligibility for a pelvic floor rehabilitation program was based on a comprehensive evaluation conducted at the Physical Medicine and Rehabilitation Clinic.\n3. Age between 18 and 70 years.\n4. A history of chronic constipation lasting at least six months, in accordance with the Rome IV diagnostic criteria.\n5. Stool consistency was classified as type 1 or type 2 according to the Bristol Stool Scale, indicating a hard stool pattern.\n\nExclusion Criteria:\n\n1. Presence of communication barriers that may interfere with participation in the study.\n2. Cognitive impairment affects the ability to comply with rehabilitation programs or assessments.\n3. Pregnancy.\n4. Presence of severe depression and\u002For anxiety disorder.\n5. Untreated metabolic or endocrine disorders, including but not limited to diabetes mellitus, hypothyroidism, hypokalemia, and hypercalcemia.\n6. Use of medications known to cause or exacerbate constipation.\n7. History of spinal, rectal, or pelvic surgery, excluding cholecystectomy, hysterectomy, and appendectomy.\n8. Presence of colorectal malignancy or inflammatory bowel disease.\n9. Anorectal malformations or congenital pelvic floor anomalies.\n10. Spina bifida, spinal cord injury, or neurological disorders, including multiple sclerosis, Parkinson's disease, dementia, or epilepsy.\n11. Presence of severe cardiac or renal disease.\n12. Advanced-stage hemorrhoids, anal fissures, or anal fistulas.","ALL","18 Years","70 Years",{"count":20,"type":21},36,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aimed to investigate the effects of game-based electromyographic (EMG) biofeedback therapy on the quality of life and sleep quality of individuals diagnosed with dyssynergic defecation.",[27],"Defecation Disorder",[29,30,31,32],"Dyssynergic Defecation","Electromyographic Biofeedback","Pelvic Floor Rehabilitation","Constipation","NOT_YET_RECRUITING","2026-03-31",{"date":36,"type":37},"2026-04-06","ACTUAL",{"date":34,"type":21},{"date":40,"type":21},"2026-12-31",{"name":42,"class":43},"Kocaeli University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":32,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100440546","neuropathological-changes-of-the-intestinal-wall-in-patients-with-bowel-evacuation-disorders-100440546","NCT05016700","Neuropathological Changes of the Intestinal Wall in Patients With Bowel Evacuation Disorders","Correlation of Clinical Symptoms With Neuromorphological Changes of the Colorectal Wall in Patients With a Bowel Evacuation Disorder","Inclusion Criteria:\n\n* obstructive defecation disorder scheduled for surgery\n* must be able to undergo surgery\n* \\> 18 years of age\n* informed consent\n\nExclusion Criteria:\n\n* no defecation disorder\n* no surgery needed\n* unable to undergo surgery\n* ≤ 18 years\n* no consent",{"count":53,"type":21},500,"OBSERVATIONAL","Constipation and defecation disorders affect about 15% of the European population and of those up to 30% of the patients over 65 years of age. For those affected, this is associated with major restrictions in quality of life and high health care costs .\n\nThe underlying causes of constipation and defecation are complex and only partially understood.\n\nIntestinal (full wall) resections taken in clinical practice from these patients when conservative therapy has been exhausted show rarefaction of ganglion cell nests in the myenteric plexus and submucosal plexus as well as changes in cholinergic innervation.\n\nInitial histopathological investigations suggest an inflammatory genesis of this rarefaction of ganglion cell nests, which will be further characterised\u002Finvestigated in the context of this study on the basis of further histopathological and serological investigations. This may lead to novel therapeutic approaches that can causally treat the symptoms of those affected.",[27,57,58],"Neuropathology","Autoimmune Diseases",[57,60,61,62,63,64,65],"Defecation disorder","Autoimmune disease","Hypoganglionosis","Autoimmune ganglionitis","Neurological bowel disorder","Colon surgery","RECRUITING","2025-03-07",{"date":69,"type":37},"2025-03-10",{"date":71,"type":37},"2019-03-20",{"date":73,"type":21},"2033-12-31",{"name":75,"class":43},"Evangelisches Klinikum Köln Weyertal gGmbH",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":44},"100564578","the-effect-of-abdominal-massage-on-gastrointestinal-functions-in-mechanically-ventilated-patients-receiving-enteral-nutrition-in-intensive-care-100564578","NCT06631001","\"The Effect of Abdominal Massage on Gastrointestinal Functions in Mechanically Ventilated Patients Receiving Enteral Nutrition in Intensive Care\"","The Effect of Abdominal Massage on Gastrointestinal Functions in Mechanically Ventilated Patients Receiving Enteral Nutrition in Intensive Care","AMGF-ICU","Inclusion Criteria:\n\n* Patients over 18 years of age.\n* Patients who have been intubated and are on enteral feeding for at least 5 days.\n* Patients without wounds on the extremities or abdominal area.\n* Patients without a history of surgical intervention or radiotherapy in the abdominal area.\n* Patients without current gastrointestinal symptoms (constipation, diarrhea, vomiting, abdominal distension, or increased gastric residual volume).\n* Patients without intestinal obstruction.\n* Patients who have given consent through a first-degree relative.\n* Patients with no contraindications for abdominal massage.\n* Glasgow Coma Scale GCS \\> 3.\n* Acute Physiology and Chronic Health Evaluation (APACHE II) score \\> 16\n\nExclusion Criteria:\n\n* Patients receiving intermittent enteral nutrition\n* Patients not on mechanical ventilation\n* Patients with contraindications for abdominal massage\n* Patients fed via Percutaneous Endoscopic Gastrostomy\n* Patients who were intubated later\n* Patients hospitalized due to postoperative reasons",{"count":85,"type":21},70,[24],"This study aims to evaluate the effects of abdominal massage on gastrointestinal functions in mechanically ventilated patients receiving enteral nutrition in intensive care units.",[27,89,90],"Gastrointestinal Motility Disorder","Gastrointestinal Motility and Defecation Conditions",[92,90,93,94,95],"Abdominal massage","Gastrointestinal Motility","Intensive care","enteral nutrition","2025-02-15",{"date":98,"type":37},"2025-02-19",{"date":100,"type":37},"2025-01-06",{"date":102,"type":21},"2025-08-29",{"name":104,"class":43},"Mersin University",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":44},"100523772","the-revo-study-low-volume-vs-high-volume-rectal-irrigation-100523772","NCT06100055","The ReVo Study: Low-volume vs High-volume Rectal Irrigation","The ReVo Study (REctal Irrigation VOlume Study - 'Low Versus High Volume Irrigation - Optimising Rectal Irrigation Volume in Evacuatory Dysfunction'; A Randomised Controlled Trial)","ReVo","Inclusion Criteria:\n\n* All adult patients over 18 years who have self-reported problematic constipation secondary to evacuation disorders\n* With symptom onset of more than 6 months\n* Symptoms must meet American College of Gastroenterology definition of constipation which is symptoms including unsatisfactory defecation with either infrequent stools, difficulty in passing stool or both for at least previous 3 months (25)\n* All should have tried and failed conservative management (laxatives, life-style modification and bio-feedback)\n* Patients should also have ability and willingness to give informed consent.\n* Patients or carer should be able to use rectal irrigation\n\nExclusion Criteria:\n\nPatients with\n\n* Major colorectal resection surgery, pelvic floor surgery to address defaecatory problems such as posterior vaginal repair, STARR, rectopexy and sacral nerve stimulation within last three months\n* Pregnancy\n* Active rectal bleeding\n* Colorectal cancer\n* Complicated diverticular disease or acute diverticulitis\n* Anal or colorectal stenosis\n* Inflammatory bowel disease\n* Undergoing chemotherapy\n* Ischemic colitis\n* Used rectal irrigation in the past one year",{"count":114,"type":21},166,[24],"Rectal irrigation, which is the introduction of warm tap water through the anal canal into the rectum to initiate defaecation, is recommended to be considered in patients with chronic constipation, which is refractory to conservative measures such as lifestyle modification, laxatives, nurse-led bowel retraining programmes which focuses on bio-feedback as well as psychosocial support.\n\nTwo systems of rectal irrigation are available based on volume delivered, low and high volume. It is unknown if one type of irrigation is superior to the other and whether one type has better outcomes in patients with a particular pathology.\n\nTherefore, a comparison is required between the two types of irrigation to assess their acceptability as a therapy and response rates in patients with chronic constipation secondary to difficulty emptying rectum.\n\nThis trial\u002Fresearch aims to compare low-volume rectal irrigation with high-volume rectal irrigation in patients with chronic constipation secondary to disorders of difficulty emptying rectum.\n\nThe main questions it aims to answer are:\n\n* if one type of rectal irrigation is superior to the other\n* whether one type of rectal irrigation has better outcomes in patients with a particular pathology on pelvic floor ultrasound\n* assess the acceptability and response rates to rectal irrigation.\n\nParticipants upon recruitment will be allocated to either low-volume rectal irrigation or high volume rectal irrigation groups. This will purely be by chance where the possibility of being in either of the groups will be 50%. They will then undergo a baseline assessment with four quality-of-life questionnaires and clinical examination. Following this a pelvic floor ultrasound will be performed to assess the cause of their symptoms. Lastly they will be provided training on using rectal irrigation (the type they have been assigned to). They will then be asked to commence irrigation at home from the next day.\n\nParticipants will continue to use irrigation for three months and then have a three-monthly follow-up where the quality of life questionnaires will be filled again. This data will then be used to assess any improvement in symptoms after using rectal irrigation. After three months of using rectal irrigation, participation in the trial will come to and end.",[118,32,119,27],"Constipation - Functional","Constipation by Outlet Obstruction",[121,122,123,124,125],"chronic constipation","rectal irrigation","evacuation disorders","low-volume rectal irrigation","high-volume rectal irrigation","2024-07-26",{"date":128,"type":37},"2024-07-29",{"date":130,"type":37},"2024-05-10",{"date":132,"type":21},"2025-07",{"name":134,"class":43},"Guy's and St Thomas' NHS Foundation Trust"]