[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"defibrillators-implantable\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:defibrillators-implantable":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,77,112,138],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100618534","conduction-system-pacing-and-av-junction-ablation-in-heart-failure-with-atrial-fibrillation-sync-af-htx-100618534",false,"NCT07332871","Conduction System Pacing and AV Junction Ablation in Heart Failure With Atrial Fibrillation (SYNC AF-HTx)","Safety and efficacY of conductioN System paCing and Atrioventricular Junctional Ablation Combined With ICD Implantation in Patients With End-stage Heart Failure and Atrial Fibrillation Eligible for Heart Transplantation (SYNC AF-HTx) : Multicenter Prospective Randomized Controlled Trial","Inclusion Criteria:\n\nCandidates for ICD implantation (primary or secondary prevention). Permanent AF (\\>6 months) unsuitable for or failed catheter ablation. End-stage heart failure considering heart transplant or LVAD. LVEF ≤ 35 within 6 weeks before enrollment. NYHA functional class ≥ II. On GDMT for at least 3 months. Age ≥ 19 years.\n\nExclusion Criteria:\n\nExisting LVAD or prior heart transplantation. Indications for cardiac resynchronization therapy (CRT). History of mechanical tricuspid valve replacement. Expected survival≤ 12 months. Inability to comply with the study protocol.","ALL","19 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to evaluate the safety and efficacy of conduction system pacing (CSP) using left bundle branch pacing (LBBP) and atrioventricular junction (AVJ) ablation in patients with end-stage heart failure and permanent atrial fibrillation (AF). Participants who are candidates for heart transplantation or left ventricular assist device (LVAD) implantation will be randomized to either the SYNC group (ICD implantation combined with LBBP and AVJ ablation) or the control group (ICD implantation only). The investigators will compare clinical outcomes, including mortality and heart failure hospitalization, between the two strategies over a 1-year follow-up period.",[26,27,28],"Heart Failure","Atrial Fibrillation","Defibrillators, Implantable",[30,31,32,33,34,35],"Left Bundle Branch Pacing (LBBP)","Conduction System Pacing (CSP)","Atrioventricular Junction Ablation (AVJ ablation)","End-stage Heart Failure","Heart Transplantation","ICD","NOT_YET_RECRUITING","2025-12-30",{"date":39,"type":40},"2026-01-12","ACTUAL",{"date":42,"type":20},"2026-01",{"date":44,"type":20},"2028-05",{"name":46,"class":47},"Yonsei University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":48},"100541500","correct-mobilization-time-after-implantation-of-an-intracardiac-electronic-device-implantation-100541500","NCT06330675","Correct Mobilization Time After Implantation of an Intracardiac Electronic Device Implantation","Safety and Benefits of Mobilization at 4 Hours Compared to 24 Hours After Implantation of an Intracardiac Electronic Device: a Randomized Clinical Trial of Non-inferiority, Open and Controlled in Parallel Groups","Inclusion Criteria:\n\n* ≥ 18 years old\n* Signed informed consent form\n* New permanent pacemaker implantation (PM) or implantable cardioverter-defibrillator (ICD)\n\nExclusion Criteria:\n\n* CIED implants after recent cardiac surgery\n* Upgrade or revision of implanted device\n* CRT implantation\n* Intraoperative complications","18 Years",{"count":58,"type":20},558,[23],"Bedrest is usually prescribed for patients management after cardiac electronic device implantation (CIED) in order to prevent complication. Due to the lack of guidelines available on the timing of postoperative mobilization management, the aim of the study is to evaluate the safety of early mobilization, comparing mobilization at 4-h against day-after procedure.",[62,28],"Pacemaker",[62,64,65,66],"Implantable cardioverter-defibrillator","Early mobilization","Bed-rest","RECRUITING","2025-08-08",{"date":70,"type":40},"2025-08-13",{"date":72,"type":40},"2023-02-01",{"date":74,"type":20},"2027-06-01",{"name":76,"class":47},"Caporali Elena",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":85,"enrollmentInfo":86,"targetDuration":88,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":48},"100580871","slew-rate-as-a-predictor-for-optimal-lead-fixation-100580871","NCT06842940","Slew Rate As a Predictor for Optimal Lead Fixation","Evaluating Slew Rate As a Predictor for Optimal Lead Fixation in Transvenous Cardiac Implantable Devices: a Prospective Multicenter Study","SLEW REGISTRY","Inclusion Criteria:\n\n* Implantation of a transvenous pacemaker with active lead fixation.\n* Implantation of a transvenous implantable cardioverter-defibrillator (ICD) with active lead fixation.\n\nExclusion Criteria:\n\n* Pregnancy.\n* Age under 18 years.\n* Implantation of a subcutaneous ICD (S-ICD).\n* Implantation of a leadless pacemaker.\n* Patients requiring a new lead position with a previously implanted pacemaker or ICD","100 Years",{"count":87,"type":20},516,"12 Months","OBSERVATIONAL","The goal of this observational study is to identify the most reliable electrical parameter measured at the time of implantation that can predict optimal lead fixation and long-term lead performance in patients undergoing transvenous pacemaker or implantable cardioverter-defibrillator (ICD) implant.\n\nThe main questions it aims to answer are:\n\n* Is there a correlation between the slew rate measured at the time of lead implantation and the sensing measured at the 12-month follow-up?\n* Is there a correlation between all electrical parameters recorded at implantation (including slew rate, current of injury, acute sensing, acute impedance, and acute pacing threshold) and the electrical parameters assessed at 12 months post-implantation (specifically chronic sensing, chronic impedance, and chronic pacing threshold)? Participants will undergo regular follow-up evaluations, with device interrogation visits scheduled at 1 and 12 months post-implantation as part of routine clinical care.",[28,92,93,94],"Electrodes, Implanted","Pacemaker, Artificial","Predictive Value of Tests",[96,97,98,99,100,101,102],"pacemaker","implantable cardiac defibrillator","lead","slew rate","sensing","active fixation","electrical performance","2025-02-20",{"date":105,"type":40},"2025-02-24",{"date":107,"type":40},"2023-02-18",{"date":109,"type":20},"2027-02-28",{"name":111,"class":47},"Paolo Pastori, MD",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":119,"targetDuration":121,"studyType":89,"phases":4,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":48},"100572897","french-cohorte-extra-vascular-implantable-cardioverter-defibrillator-100572897","NCT06739239","French COhoRte Extra-Vascular Implantable CardiovErter DefibrillatoR","FOREVER","Inclusion Criteria:\n\n* All patients undergoing EV-ICD implantation\n\nExclusion Criteria:\n\n* Refusal of consent",{"count":120,"type":20},1000,"5 Years","Implantable cardioverter-defibrillators (ICDs) are widely recognized for their efficacy in reducing the risk of sudden cardiac death in high-risk patients. Nonetheless, there remains significant scope for improving outcomes through advancements in device technology and design. The extravascular cardioverter-defibrillator (EV-ICD) represents such an innovation, offering key advantages over other ICD systems. It incorporates a lead positioned in the substernal space, enabling the delivery of pause-prevention security pacing, antitachycardia pacing, and defibrillation energy similar to that provided by conventional transvenous ICDs.\n\nPrevious studies have demonstrated that EV-ICDs can be implanted safely and are capable of terminating majority of induced ventricular arrhythmias during implantation; however, follow-up data are limited to highly experienced selected centers and over a relatively small follow-up period (6-month follow-up). The FOREVER cohort study, initiated by the French Institute of Health and Medical Research, aims to evaluate the EV-ICD use in France.\n\nThis nationwide evaluation will provide an exhaustive collection of all EV-ICD implantations in France, offering valuable real-world evidence on the long-term safety and efficacy of the device.",[28,124],"Sudden Cardiac Death Due to Cardiac Arrhythmia",[126,127,128],"Implantable cardioverter defibrillator","sudden cardiac death","Extravascular Implantable Cardioverter-Defibrillator","2024-12-17",{"date":131,"type":40},"2024-12-20",{"date":133,"type":40},"2024-02-01",{"date":135,"type":20},"2030-12-31",{"name":137,"class":47},"Paris Sudden Death Expertise Center",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":146,"targetDuration":148,"studyType":89,"phases":4,"briefSummary":149,"conditions":150,"keywords":152,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":48},"100562008","prospective-kln-bonn-registry-for-the-extraction-of-pacmaker-and-icd-leads-100562008","NCT06597578","Prospective Köln Bonn Registry for the Extraction of Pacmaker and ICD Leads","Prospektives KÖln Bonner Register Zur Extraktion Von Schrittmacher- Und ICD-Sonden (KÖBES)","KOBES","Inclusion Criteria:\n\n* All patients with a standard indication for lead extraction according to the HRS \u002F EHRA guidelines\n\nExclusion Criteria:\n\n* None",{"count":147,"type":20},200,"1 Year","The KOBES registry is an all-comers prospective clinical registry of the cooperative Köln Bonn lead extraction center. All patients undergoing complex lead extraction procedures (i.e. indwelling leads \\> 6months) in the hybrid operating room with cardiothoracic standby will be included in the registry. Preoperative, intraoperative\u002Fprocedural and postoperative parameters will be recorded. All patients will be asked to provide written informed consent. Data will be pseudonomyzed and entered into a data sheet. Data will be monitored by a board and evaluated independently.",[151,93,28],"Infections",[153,154,155,156,96,157,158],"lead extraction","cardiac device","infection","complication","implantable cardioverter-defibrillator","extraction tools","2024-09-13",{"date":161,"type":40},"2024-09-19",{"date":163,"type":40},"2023-06-04",{"date":165,"type":20},"2027-12-31",{"name":167,"class":47},"Evangelic Hospital Kalk Cologne"]