[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"degenerative-cervical-myelopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:degenerative-cervical-myelopathy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,95,122,154],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100642527","vagus-nerve-stimulation-for-myelopathy-100642527",false,"NCT07660250","Vagus Nerve Stimulation for Myelopathy","Vagus Nerve Stimulation to Improve Post-operative Outcomes of Degenerative Cervical Myelopathy","Inclusion Criteria:\n\n* 18 years of age or older\n* Moderate or severe degenerative cervical myelopathy according to the mJOA\n* Decompression surgery planned\n\nExclusion Criteria:\n\n* • Pregnancy\n\n  * Electrically active implants (e.g. pacemaker)\n  * Known diagnosis of amyotrophic lateral sclerosis, multiple sclerosis, rheumatoid arthritis, concomitant thoracic and\u002For lumbar stenosis, spine tumor, HIV-related myelopathy\n  * Ongoing cancer therapy\n  * Ongoing use of immunomodulating or suppressive medication\n  * Sustained bradycardia with a heartrate \\\u003C50 beats per minute for \\> 5 minutes following admission.\n  * Prior cervical spine surgery",true,"ALL","18 Years",{"count":20,"type":21},36,"ESTIMATED","INTERVENTIONAL",[24],"NA","The objective of this study is to generate preliminary data to establish the feasibility and effectiveness of transauricular vagus nerve stimulation (taVNS) to improve post-operative outcomes of moderate to severe degenerative cervical myelopathy (DCM)",[27],"Degenerative Cervical Myelopathy",[29,30,31,32,33,34,35],"degenerative cervical myelopathy","myelopathy","cervical myelopathy","degenerative myelopathy","vagus nerve","vagus nerve stimulation","ear stimulation","RECRUITING","2026-06-15",{"date":39,"type":40},"2026-06-22","ACTUAL",{"date":42,"type":40},"2026-04-14",{"date":44,"type":21},"2028-05",{"name":46,"class":47},"Washington University School of Medicine","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":59,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":48},"100643232","a-multicenter-registry-based-study-across-the-spectrum-of-degenerative-cervical-myelopathy-100643232","NCT07641699","A Multicenter Registry-Based Study Across the Spectrum of Degenerative Cervical Myelopathy","A Multicenter Registry-Based Study of Degenerative Cervical Myelopathy Across the Full Disease Spectrum Based on a Disease-Specific Registry Platform and Linked Biobank","DCM-RB","Inclusion Criteria:\n\n* Age 18 years or older.\n* Cervical MRI confirms cervical spinal cord compression caused by degenerative pathology, including but not limited to disc protrusion or bulging, osteophyte formation, ligamentum flavum hypertrophy or ossification, ossification of the posterior longitudinal ligament, degenerative cervical canal stenosis, or other degenerative compressive factors.\n* At least one cervical level meets one or more of the following imaging criteria: partial or complete disappearance of the cerebrospinal fluid space around the spinal cord, direct contact between the spinal cord and degenerative compressive structures, focal spinal cord indentation, flattening or deformation, or other recognized imaging manifestations of degenerative cervical cord compression.\n* Meets one of the following clinical phenotypes: non-myelopathic degenerative cervical cord compression, with or without clinical radiculopathy; or clinically and radiologically confirmed mild, moderate, or severe degenerative cervical myelopathy.\n* Able to complete baseline core assessments and willing to participate in longitudinal follow-up.\n* Provides written informed consent. Additional consent may be obtained for specific biospecimen types or nested substudies.\n\nExclusion Criteria:\n\n* Cervical spinal cord compression or myelopathy mainly caused by non-degenerative etiologies, such as acute trauma, tumor, infection, inflammatory or demyelinating disease, vascular lesion, obvious congenital malformation, or other non-degenerative spinal cord disease.\n* Presence of a dominant other neurological disease or severe psychiatric or cognitive disorder that, in the investigator's judgment, would clearly interfere with DCM-related neurological functional assessment or make reliable follow-up impossible.\n* Objective inability to complete the core imaging assessment or core follow-up and judged by the investigator to be unsuitable for inclusion in the main registry cohort.\n* Refusal to sign informed consent or explicit refusal of core data collection and follow-up.",{"count":58,"type":21},200,"36 Months","OBSERVATIONAL","This is a multicenter, prospective, longitudinal, observational registry-based study of degenerative cervical myelopathy (DCM) across the full disease spectrum, linked to a disease-specific biobank. The study will enroll adults with non-myelopathic degenerative cervical cord compression, including asymptomatic degenerative cervical cord compression with or without radiculopathy, as well as patients with mild, moderate, or severe DCM. The study does not assign treatment or interfere with real-world clinical decision-making. All participants will undergo standardized baseline assessment, scheduled follow-up, and event-driven supplemental data collection. Core data include demographic information, comorbidities, disease characteristics, neurological examination, objective functional tests, patient-reported outcomes, cervical MRI findings, treatment pathway, treatment changes, adverse events, and long-term clinical outcomes. In participating centers, standardized biospecimen collection will be performed to support nested biomarker, immune, imaging, electrophysiological, and traditional Chinese medicine syndrome substudies. The main objective is to establish a standardized multicenter registry platform covering non-myelopathic degenerative cervical cord compression and mild, moderate, and severe DCM; to describe clinical trajectories, imaging evolution, treatment pathways, and long-term outcomes; and to identify factors associated with disease deterioration and functional prognosis.",[27,63,64,65],"Non-myelopathic Degenerative Cervical Cord Compression","Asymptomatic Degenerative Cervical Cord Compression","Cervical Spinal Cord Compression",[67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84],"Degenerative cervical myelopathy","DCM","Non-myelopathic degenerative cervical cord compression","NMDCCC","Asymptomatic degenerative cervical cord compression","ADCC","Cervical spinal cord compression","Cervical spondylotic myelopathy","Patient registry","Biobank","Natural history","Disease progression","mJOA","Cervical MRI","Diffusion tensor imaging","T2 mapping","Blood biomarker","Traditional Chinese medicine syndrome","NOT_YET_RECRUITING","2026-06-07",{"date":88,"type":40},"2026-06-11",{"date":90,"type":21},"2026-06-01",{"date":92,"type":21},"2031-12-31",{"name":94,"class":47},"Wangjing Hospital, China Academy of Chinese Medical Sciences",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":105,"briefSummary":106,"conditions":107,"keywords":108,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":4},"100620488","conservative-care-versus-decompression-trial-for-degenerative-cervical-myelopathy-pilot-100620488","NCT07358273","Conservative Care Versus Decompression Trial for Degenerative Cervical Myelopathy Pilot","Conservative Care Versus Decompression Trial for Degenerative Cervical Myelopathy Pilot: A Multicenter Randomized Controlled Feasibility Trial","CADET-DCM","Inclusion Criteria:\n\n* 18 years of age or older\n* Show evidence of spinal cord compression between C2 and T1 on MRI or CT myelography conducted within 2 years of enrollment\n* Present with mild DCM defined as a score of 15-17 on the modified Japanese Orthopaedic Association (mJOA) score\n\nExclusion Criteria:\n\n* Clinical suspicion that myelopathic symptoms are exacerbated or caused by another neurologic condition (i.e. amyotrophic lateral sclerosis, multiple sclerosis, syringomyelia, peripheral neuropathy)\n* Demonstrate ossification of the posterior longitudinal ligament (OPLL)\n* Previous cervical spine surgery\n* Report known or suspected tandem symptomatic thoracic or lumbar spinal stenosis\n* Present with an acute traumatic spinal cord injury (i.e., central cord syndrome)\n* Have a prior history of an acute spinal cord injury\n* Have spinal cord compression due to an infectious or oncologic process\n* Inflammatory arthritis\n* Significant active health-related comorbidity (ASA Class IV or higher)\n* English language ability insufficient to complete outcome questionnaires",{"count":104,"type":21},56,[24],"This study is a pilot randomized clinical trial designed to test whether it is feasible to conduct a larger study comparing two standard treatments for mild degenerative cervical myelopathy (DCM).\n\nThe main questions it aims to answer are:\n\n* Can enough participants be recruited and successfully complete follow-up assessments?\n* Will participants adhere to their assigned treatment?\n\nResearchers will compare two groups:\n\n* Surgical group: Participants receive decompressive spine surgery (with or without fusion).\n* Conservative care group: Participants follow a structured program that includes education, fall prevention strategies, and tailored exercises.\n\nParticipants will:\n\n* Complete baseline and follow-up assessments at 6 weeks, 6 months, and 12 months.\n* In the surgical group: undergo surgery within 12 weeks of randomization and receive standard post-operative care.\n* In the conservative care group: follow a 6-week progressive exercise program and continue self-management strategies.\n* Complete a monthly online symptom monitoring questionnaire",[27],[30,109,110,111,112],"spinal cord diseases","surgery","conservative care","spine","2026-01-13",{"date":115,"type":40},"2026-01-22",{"date":117,"type":21},"2026-02",{"date":119,"type":21},"2027-06",{"name":121,"class":47},"McMaster University",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":130,"maxAge":131,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":134,"briefSummary":137,"conditions":138,"keywords":139,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":48},"100615888","phase-1-stimulation-based-therapy-to-improve-balance-in-dcm-100615888","NCT07298460","Stimulation-based Therapy to Improve Balance in DCM","Transcutaneous Spinal Cord Stimulation to Improve Postural Stability After Surgery for Degenerative Cervical Myelopathy","STIM-DCM","Inclusion Criteria:\n\n* DCM participants who have undergone surgery for DCM more than 12 months prior and report persistent impaired imbalance\n\nExclusion Criteria:\n\n* uncontrolled cardiopulmonary disease, legal blindness, unstable medical condition that can interfere with the study, breakdown in skin area that will come into contact with electrodes, active implanted medical device, pregnancy, and seizures\n* concurrent occupational or physical therapy during study participation for any condition\n* history of inability to tolerate MEP\u002FSSEP for any reason, or complete paralysis of the legs (lower limb mJOA=0)\n* cognitive impairment and unable to give consent","50 Years","90 Years",{"count":133,"type":21},45,[135,136],"PHASE1","PHASE2","The goal of this clinical trial is to determine if a treatment called transcutaneous spinal cord stimulation (tSCS), when combined with balance training, can help improve balance in adults who have had surgery for degenerative cervical myelopathy (DCM). DCM is a condition that affects the spinal cord in the neck and often causes problems with walking and balance, even after surgery.\n\nThis study will also look at how tSCS affects the nervous system and whether it is safe and practical to use in this group of patients. The results will help researchers plan a larger study in the future.\n\nMain Questions:\n\n* Does tSCS combined with balance training improve balance more than balance training alone?\n* Does stimulation at both the neck and mid-back work better than stimulation at the mid-back only?\n* What changes in nerve and muscle activity occur with tSCS?\n\nWhat will happen in this study:\n\n* Participants will be randomly assigned to one of three groups:\n\n  1. tSCS applied to the mid-back (thoracic area) plus balance training\n  2. tSCS applied to both the neck and mid-back (combined stimulation) plus balance training\n  3. Sham stimulation (electrodes placed but no stimulation) plus balance training\n* All participants will complete 12 sessions over 4 weeks (3 sessions per week).\n* Each session will include 30 minutes of balance training and 30 minutes of walking exercises.\n* Participants will receive stimulation or sham treatment during these sessions.\n* Balance and walking tests will be done before and after the program.\n* Nerve and muscle activity will also be measured at the same time points.\n\nThis pilot study will help determine if tSCS is effective and safe, and will provide information needed to design a larger trial.",[27],[29,140,141,142,143,144],"spinal cord stimulation","balance","therapy","rehabilitation","postural instability","2025-12-19",{"date":147,"type":40},"2025-12-23",{"date":149,"type":21},"2026-07-01",{"date":151,"type":21},"2028-07-01",{"name":153,"class":47},"Medical College of Wisconsin",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":176,"leadSponsor":178,"locationsCount":48},"100576158","rehab-in-mild-stable-dcm-feasibility-rct-comparing-structured-rehabilitation-to-clinical-surveillance-100576158","NCT06781658","Rehab in Mild Stable DCM: Feasibility RCT Comparing Structured Rehabilitation to Clinical Surveillance","Rehab in Mild DCM: Study Protocol for a Feasibility Randomised Controlled Trial to Compare the Effectiveness of a Structured Rehabilitation Intervention to Clinical Surveillance in People With Mild Stable Degenerative Cervical Myelopathy.","RehabmildDCM","Inclusion Criteria:\n\n* • Diagnosis of DCM (Clinical symptom of DCM +\u002F- Upper motor neuron sign + imaging evidence of cervical cord compression). Diagnosis will be confirmed by a consultant neurosurgeon (19).\n\n  * Modified Japanese Orthopaedic assessment (mJOA) score of 15-17, indicating mild DCM. The mJOA is a clinician administered validated measure of DCM severity (20)\n  * Adequate comprehension of English to understand the purpose of the study and give written informed consent\n\nExclusion Criteria:\n\n* Patient or surgeon preference for urgent surgical decompression for progressive DCM, motor radiculopathy or severe unrelenting radicular arm pain or significant risk factors for progression including co-existing cervical radiculopathy and circumferential cord compression.\n\n  * Diagnosis of other neurological condition that could confound assessment.\n  * Involvement in another clinical study or trial\n  * Pregnancy\n  * If the participant is unable to commit to a 12-week programme of up to 10 sessions of supervised rehabilitation and participating in a regular home exercise programme for the duration of the study.",{"count":163,"type":21},24,[24],"The goal of this feasibility RCT is to establish the feasibility of undertaking a RCT investigating the effectiveness of a multi component structured rehabilitation intervention aiming at reducing physical disability in people with mild stable Degenerative Cervical Myelopathy. The main question it will answer are what is the incidence of mild stable DCM in the neurosurgical OPD clinics, what is the eligibility rate and participate rate of those eligible. It will also investigate the acceptability of the intervention to both participants and clinicians and participant retention.\n\nResearchers will compare a structured rehabilitation intervention to clinical surveillance. The structured rehabilitation intervention will include education, a physical activity behavioural change intervention, cervical range of motion exercises, neck, upper limb and scapular strengthening exercises and task specific hand function training.",[27],[67,168,169,170,171],"Mild DCM","Rehabilitation","clinical Surveillance","Feasibility RCT","2025-01-13",{"date":174,"type":40},"2025-01-17",{"date":172,"type":21},{"date":177,"type":21},"2026-06-30",{"name":179,"class":47},"Royal College of Surgeons, Ireland"]