[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"degenerative-cervical-spinal-stenosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:degenerative-cervical-spinal-stenosis":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":24,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100556716","a-novel-surgical-criteria-for-degenerative-cervical-myelopathy-in-chinese-ethnicity-100556716",false,"NCT06528730","A Novel Surgical Criteria for Degenerative Cervical Myelopathy in Chinese Ethnicity","Inclusion Criteria:\n\n* MRI confirmed Chinese DCM surgical candidates\n* All gender\n* Older than 45 years old\n* Independent walkers\n* No previous cervical spinal surgery\n* Cognitively capable of following instructions.\n\nExclusion Criteria:\n\n* Active diagnosis of tuberculosis spine\n* Lumbar spinal diseases\n* Extra-pyramidal\n* Cerebral or cerebellar disorders\n* Peripheral neuropathies\n* Previous spinal operations\n* Unable to walk independently with or without aids\n* Non-communicable subjects and cognitively incapable of expressing their symptoms clearly","ALL","45 Years",{"count":18,"type":19},100,"ESTIMATED","OBSERVATIONAL","Degenerative Cervical Myelopathy (DCM) is an age-related irreversible degenerative disease predominantly affecting the elderly aged 50 and over. DCM is usually triggered by ossification of the posterior longitudinal ligament or ossification of ligamentum flavum or prolapsed intervertebral disc over the cervical spine. Specific clinical signs characterized the presence of cervical spinal cord compression; including Hoffmann's sign, Finger Escape Sign, Scapulohumeral Reflex, and Reverse Supinator Reflex. Hand numbness, clumsiness, and gait disturbance. These are featured clinical manifestations and well-known indicators for detailed clinical and radiographic investigation, such as Magnetic Resonance Imaging (MRI) for diagnosis and surgical planning.\n\nSurgical intervention is considered to be the most effective treatment for DCM worldwide. It is the only evidence-based treatment to halt disease progression and allow modest improvement in function and quality of life. DCM progression is not specific to predict the timing for surgery, though it is still debated. Length of symptoms, pre-operative Modified Japanese Orthopaedic Association Scoring System for Cervical Myelopathy (mJOA) and physical performance are suggested as recovery predictors in DCM.\n\nIn current practice, the offer of surgical treatment is entirely based on the combination of the evidence of cord compression in Magnetic Resonance Imaging (MRI) and mJOA. DCM who are at risk of critical neurological deficits have a reduced anteroposterior diameter of the spinal canal less than 9 mm or cross-sectional area of the spinal cord less than 40 sq. mm; mJOA less than 13 with evidence of functional deterioration will be offered with surgical intervention. MRI and mJOA are used as the golden standard for the indication of surgical intervention in the aspect of radiological deformities and self- perceived functional deficits. The concern on the clinical predictor, the physical performance, was overlooked and lacked a compromised criterion in the physical performance tests for surgical decisions. Therefore, this study aims to develop DCM-specific criteria from physical performance tests in predicting the surgical indication for DCM in the Chinese population.",[23],"Degenerative Cervical Spinal Stenosis",[25,26,27,28,29],"Degenerative cervical myelopathy","diagnosis","physical performance tests","surgeical criteria","functional deficits","RECRUITING","2026-05-16",{"date":33,"type":34},"2026-05-20","ACTUAL",{"date":36,"type":34},"2023-10-01",{"date":38,"type":19},"2050-07-30",{"name":40,"class":41},"The University of Hong Kong","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":15,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":42},"100491654","functional-and-structural-changes-in-the-central-nervous-system-following-spinal-cord-injury-100491654","NCT05681936","Functional and Structural Changes in the Central Nervous System Following Spinal Cord Injury","Inclusion Criteria:\n\n* Age \\> 18 years\n* Informed consent\n* Willing to take part and follow requirements of the protocol\n\nPatients additionally need to fulfil the following study-specific inclusion criteria:\n\nCross-sectional study:\n\n* Chronic traumatic SCI (\\> 12 months after injury) or\n* Diagnosed degenerative spondylotic myelopathy (DCM)\n\nLongitudinal study:\n\n* Acute traumatic SCI (\\\u003C 2 months after injury) or\n* Patients with neurogenic lower urinary tract dysfunction (NLUTD) who undergo routine tibial nerve stimulation (TNS) treatment as part of their rehabilitation (but independently of this study) at Balgrist University Hospital\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Contraindications for MRI (presence of pacemaker or other type of stimulator in the body, presence of metallic foreign body in or on the body, etc.); we will comply with the imaging center's (SCMI) guidelines and in case of doubt we will exclude the participant from the study\n* No informed consent\n* History of psychiatric or neurological disease, apart from those induced by SCI (e.g.epilepsy)\n* History of skull opening or head trauma\n* Known or suspected non-adherence, drug or alcohol abuse\n* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.\n* Women who are pregnant (when uncertain, participants will undergo urine testing) or breastfeeding\n* Intention to become pregnant during the course of the study\n* Body mass index (BMI) \\> 35\n* Individuals especially in need of protection (according to Research with Human Subjects published by the Swiss Academy of Medical Sciences)",true,"18 Years",{"count":52,"type":19},225,"Building on recent improvements, state-of-the-art functional MRI will be applied as an advanced diagnostic tool for the lumbosacral cord in spinal cord injury (SCI) patients to characterize the remaining neuronal activity of the motor and sensory neurons. Alterations in the activity pattern will reveal the effect upon task-related spinal cord activity of the lower motor neurons and sensory neurons undergoing trauma-induced neurodegeneration, at a spatial specificity that has not been possible so far. Results of this study will be of crucial importance because SCI patients can only profit from regeneration-inducing therapies if spinal neuronal function is preserved below the level of lesion.",[55,56,23],"Spinal Cord Injuries","Neurogenic Bladder Dysfunction","2025-12-08",{"date":59,"type":34},"2025-12-15",{"date":61,"type":34},"2023-01-01",{"date":63,"type":19},"2027-08-31",{"name":65,"class":41},"University of Zurich",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":15,"minAge":73,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":4},"100606599","laminoplasty-versus-laminectomy-with-lateral-mass-fixation-in-management-of-degenerative-cervical-canal-stenosis-100606599","NCT07177651","Laminoplasty Versus Laminectomy With Lateral Mass Fixation in Management of Degenerative Cervical Canal Stenosis","Comparative Study Between Laminoplasty Versus Laminectomy With Lateral Mass Fixation in Management of Degenerative Cervical Canal Stenosis","Inclusion Criteria:\n\n* Patients aged 40 ≥ years with clinically significant cervical canal stenosis (based on imaging and neurological symptoms).\n* Surgical indication for cervical decompression.\n* Adequate follow up data (minimum 1 year).\n* Patients fit for surgery.\n\nExclusion Criteria:\n\n* Patients unfit for surgery or contraindication to general anaesthesia.\n* Congenital deformities or significant spinal deformities unrelated to stenosis.\n* Patients with cervical kyphosis, active infection or known allergy to titanium.\n* Previous cervical spine surgery.","40 Years",{"count":75,"type":19},2,"INTERVENTIONAL",[78],"NA","Cervical canal stenosis (CCS) is a condition characterized by the narrowing of the spinal canal in the cervical spine, leading to compression of the spinal cord and nerve roots. This can result in a variety of neurological deficits, including myelopathy, radiculopathy, and motor dysfunction. The primary goal of treatment is to relieve neural compression and improve or preserve neurological function. Surgical decompression, such as laminoplasty, is a common procedure to treat this condition, as it decompresses the spinal canal to relieve pressure on the spinal cord. Laminectomy with lateral mass fixation is another option of management.",[81,23],"Cervical Stenosis",[83,84],"Laminoplasty","Lateral mass fixation","NOT_YET_RECRUITING","2025-09-16",{"date":88,"type":34},"2025-09-17",{"date":90,"type":19},"2025-10-04",{"date":92,"type":19},"2027-03-01",{"name":94,"class":41},"Assiut University"]