[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"degenerative-disc-disease-lumbar\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:degenerative-disc-disease-lumbar":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,57,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100622663","biologic-injection-for-adults-with-lumbar-disc-herniation-100622663",false,"NCT07386548","Biologic Injection For Adults With Lumbar Disc Herniation","Bone Marrow Aspirate Concentrate Injection With MRI's - A Prospective Randomized Control Trial","BMAC","Inclusion Criteria:\n\n* Male or female patients ≥ 18 years of age\n* Clinically and\u002For radiographically (MRI) confirmed diagnosis of degenerative disc disease of the lumbar spine, lumbar disc herniation, and indication for lumbar microdiscectomy surgery\n* Unresponsive to conservative\u002Fnon-operative treatment for \\>3 months\n* Psychosocial, mental and physical ability to understand and to adhere to this protocol, especially adhering to the visit schedule follow-ups and observe the treatment plan\n\nExclusion Criteria:\n\n* Prisoners\n* Individuals who are not yet adults (infants, children, teenagers)\n* Individuals who are not able to clearly understand English\n* Adults with diminished capacity to consent\n* Major cognitive impairment causing to inability to understand and provide informed consent\n* Active malignancy\n* Active chronic or acute infection\n* Autoimmune disorder that impacts the lumbar spine (ankylosing spondylitis, lupus e.g.)\n* Bone marrow-derived or non-bone marrow-derived cancer\n* Low platelet count or clotting disorders\n* Prior surgery at the level to be treated or the adjacent level","ALL","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to find out whether adding a bone-marrow aspirate concentrate (BMAC) injection during surgery can improve recovery in adults undergoing lumbar microdiscectomy for a lumbar disc herniation.\n\nThe main questions it aims to answer are:\n\n* Does the BMAC injection lead to better disc tissue health after surgery (as seen on MRI scans)?\n* Does the BMAC injection lead to greater improvement in pain and disability compared to surgery alone?\n\nParticipants will be adults aged 18 and older who are scheduled for lumbar microdiscectomy surgery.\n\nResearchers will compare one group of participants receiving the standard-of-care surgery plus the BMAC injection with another group receiving the same surgery without the injection to see if the injection offers added benefit.\n\nParticipants will:\n\n* Have surgery (microdiscectomy) with or without the injection.\n* Complete pain and disability questionnaires at several times over 2 years.\n* Undergo MRI scans at baseline and follow-up to assess disc structure and tissue health.\n* Provide samples of leftover disc or bone-marrow tissue (as applicable) from surgery for analysis.",[27,28,29,30,31,32,33,34,35,36,37],"Degenerative Disc Disease","DDD","Degenerative Disc Disease Lumbar","Degenerative Disc Disease, Lumbar","Lumbar Disc Herniation","Disc Herniation, Lumbar","Bone Marrow Aspirate Concentrate","Intervertebral Disc Displacement","Low Back Pain","Chronic Low Back Pain (CLBP)","CLBP - Chronic Low Back Pain",[39,40,41,42,43],"degenerative disc disease","lumbar disc herniation","bone marrow aspirate concentrate","intervertebral disc displacement","low back pain","NOT_YET_RECRUITING","2026-04-14",{"date":47,"type":48},"2026-04-16","ACTUAL",{"date":50,"type":21},"2026-05-01",{"date":52,"type":21},"2030-12",{"name":54,"class":55},"Weill Medical College of Cornell University","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":17,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100570603","fusion-or-not---a-study-on-low-back-pain-100570603","NCT06709391","Fusion or Not - a Study on Low Back Pain","Fusion or Not- a Randomized Controlled Study on Low Back Pain","Inclusion Criteria:\n\n* Axial, mechanical, stabbing pain localized to the lower lumbar spine, persisting for at least 12 months, in which non-surgical treatments have been unsuccessful\n* A perceived improvement of back muscle strength after structured physical exercise, but severe, quality-of-life-reducing pain persists\n* No symptoms or clinical signs of radiculopathy or neurogenic claudication (spinal stenosis)\n* Numeric rating scale back pain of at least 5 (on a 0-10 (worst) scale)\n* Oswestry Disability index of at least 35 (on a 0-100 (worst) scale)\n* MRI-confirmed degenerative disc disease at L4\u002FL5 and\u002For L5\u002FS1.\n* 25-65 years of age\n* American Society of Anesthesiologists (ASA) classification 1 or 2.\n* No previous spine surgery, except for previous discectomy without fusion on the symptomatic level\n* Written informed consent\n\nExclusion Criteria:\n\n* Inability to give informed consent\n* Unable to understand Swedish\n* Unable to attend follow-up visits\n* Severe osteoporosis making the patient unfit for surgery\n* Severe cardiovascular, pulmonary or other chronic disease making the patient unfit for surgery\n* Isthmic or degenerative spondylolisthesis, grade 2 or larger\n* New or old fractures\n* Spondylodiscitis\n* Anchylosing spondylitis or other inflammatory process in the spine\n* Active neoplasm\n* Symptoms and clinical signs of nerve root compression or neurogenic claudication requiring decompressive surgery\n* Prior lumbar spine surgery (previous discectomy without fusion is not an exclusion criteria)","25 Years","65 Years",{"count":20,"type":21},[24],"Problems from the musculoskeletal system are one of the most common reasons for disability and sick leave. These problems include low back pain.\n\nLow back pain affects as many as 8 out of 10 individuals at some point in life. In most people it is quickly transient with little, or only short-term, impact on function and quality of life. In some individuals, the problems can become long-lasting and significantly impair the quality of life.\n\nWhen analgesic and physiotherapeutic treatment have been tried and the problems are still not manageable, and have lasted more than a year, surgical treatment consisting of fusion surgery of the painful part of the spine may come in question. In Sweden, approximately 600 fusion surgeries are performed annually for low back pain.\n\nThere are a few randomized studies comparing fusion surgery for low back pain with non-surgical treatments, but these have showed different results. The effect of fusion surgery on low back pain is therefore uncertain.\n\nSurgical treatments brings with it a clear placebo effect. Other studies on pain in other parts of musculoskeletal system than the back has not been able to show that a surgical treatment is always better than placebo surgery. This has called into question the effect of surgery on many painful conditions of the musculoskeletal system. No placebo-controlled surgical studies have been done on fusion surgery for low back pain. A placebo surgical controlled study is the only way to ascertain whether fusion surgery is the right treatment for low back pain.\n\nIn this study, 90 individuals will undergo surgical treatment for low back pain. After surgical exposure, the surgeon will be informed whether fusion surgery should be performed or not. Half of the patients will undergo a fusion procedure with implants and the other half will not undergo the fusion procedure and will not receive implants.\n\nTreatment randomization will be performed during surgery, and the individuals undergoing treatment and the staff taking care of the individual after surgery will be blinded for treatment allocation during 6 months. That means that the individuals participating in the study and the staff who meet the individuals after surgery won't know if the individual had fusion surgery or no fusion surgery until after the 6 month follow-up.\n\nThe most important outcome of the study is the result of a questionnaire-based measure of back function answered by the participating individuals.",[70,29],"Low Back Pain, Mechanical",[72],"Low back pain, degenerative disc disease, lumbar spine, surgery","RECRUITING","2025-09-15",{"date":76,"type":48},"2025-09-16",{"date":78,"type":48},"2025-02-01",{"date":80,"type":21},"2037-12",{"name":82,"class":55},"Uppsala University",4,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":92,"enrollmentInfo":4,"targetDuration":4,"studyType":93,"phases":4,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":4,"completionDateStruct":4,"leadSponsor":116,"locationsCount":4},"100603518","celz-201-ddt-for-the-treatment-of-chronic-lower-back-pain-100603518","NCT07137559","CELZ-201-DDT for the Treatment of Chronic Lower Back Pain","Expanded Access Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain","ADAPT","Inclusion Criteria:\n\n* Confirmed diagnosis of chronic lower back pain due to degenerative disc disease.\n* No comparable or satisfactory alternative therapy available. Unable to participate in the ongoing CELZ-201-DDT clinical trial. Informed consent provided.\n\nExclusion Criteria:\n\n* Any medical condition that poses an unacceptable risk or would interfere with treatment safety or evaluation.\n* Known hypersensitivity to any component of the investigational product.\n\nHow to Request Access:\n\n* Contact the Expanded Access Coordinator to confirm eligibility and discuss feasibility.\n* Complete and submit FDA Form 3926 to the appropriate FDA review division.\n* Obtain IRB review (may be expedited or post-treatment for emergency use). Coordinate drug shipment and treatment schedule.","80 Years","EXPANDED_ACCESS","CELZ-201-DDT is an investigational (experimental) cell therapy currently being studied for people with degenerative disc disease who have chronic lower back pain.",[96,29],"Chronic Back Pain",[98,99,100,101,102,103,104,105,106,107,108,109,110,111],"CELZ-201-DDT","Allogeneic Umbilical Cord Sub-Epithelial Cell-Derived Mesenchymal Stromal Cells","Mesenchymal Stromal Cells (MSC)","Chronic Lower Back Pain","Degenerative Disc Disease (DDD)","Lumbar Degeneration","Chronic Pain","Expanded Access","Single Patient IND","Emergency Use IND","Non-Emergency Use IND","Compassionate Use","Regenerative Medicine","Stem Cell Therapy","AVAILABLE","2025-08-14",{"date":115,"type":48},"2025-08-22",{"name":117,"class":118},"Creative Medical Technology Holdings Inc","INDUSTRY"]