[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"degenerative-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:degenerative-disease":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,77,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100566597","clinical-performance-and-safety-of-the-unicompartmental-univation-xf-pro-implant-100566597",false,"NCT06657248","Clinical Performance and Safety of the Unicompartmental Univation® XF Pro Implant","Prospective, Multicenter Study Evaluating the Midterm Clinical Performance and Safety of the Unicompartmental Univation® XF Pro Knee Implant","UNI_XF_PRO","Inclusion Criteria:\n\n* Indication for a primary medial unicompartmental knee endoprosthesis\n\nAcc. to Instructions for Use:\n\n* Both cruciate ligaments intact\n* Lateral ligaments intact\n* Leg axis amenable to passive correction\n* Varus deformity under 15°\n* Bending capability of at least 90°\n* Extension deficit no greater than 5-10°\n* Written informed consent of patient\n* Kellgran \\& Lawrence Score \\> II (only straight or varus\n* Patients with moderate radiological symptoms\n* Patients without clinical symptoms\n\nExclusion Criteria:\n\n* Pregnancy\n* Patient age \\\u003C18 and \\> 75 years\n* BMI ≥ 40\n* High risk patients ASA \\> III","ALL","18 Years","75 Years",{"count":21,"type":22},150,"ESTIMATED","OBSERVATIONAL","The study is designed as a prospective, observational, mid-term, multi-center follow-up study. It is planned to include 150 patients from 4 different study centres in Germany.",[26,27],"Gonarthritis","Degenerative Disease",[29,30,31],"Degenerative medial unicompartmental Gonarthrosis","Unicompartmental knee arthroplasty","Safety and Performance","RECRUITING","2026-05-05",{"date":35,"type":36},"2026-05-08","ACTUAL",{"date":38,"type":36},"2026-04-02",{"date":40,"type":22},"2032-10",{"name":42,"class":43},"Aesculap AG","INDUSTRY",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":76},"100330747","neuropsychological-and-brain-medical-imaging-study-in-patients-with-brain-damage-2-100330747","NCT03586258","Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2","Anatomical Clinical Correlations. Neuropsychological and Brain Medical Imaging Study in Brain Damage Subjects 2 (CORAC2)","CORAC2","Inclusion Criteria:\n\n* Age \\> 17 years\n* French language\n* Effective contraception for women during the study\n* Informed consent\n* No alcohol intake the day before the exam\n* For patients only, focal cerebral lesion (stroke, malformation, tumor, inflammatory, infectious, traumatic), neonatal pathology, developmental or degenerative disease with cognitive deficit\n\nExclusion Criteria:\n\n* For healthy volunteers: previous neurological history (except non complicated migraine or epilepsy), previous psychiatric history (except depression with good evolution or anxiety), or severe cranial traumatism\n* For patients: vigilance disorders, severe depression or anxiety.\n* For both: psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month, severe visual or auditory impairment, patient without judicial or administrative liberty, measure of legal protection or no capable to express their consent, pregnancy or breastfeeding, contraindication for MRI or GVS if applicable, participation in another trial or former involvement in another trial within one month.",true,{"count":54,"type":22},400,"INTERVENTIONAL",[57],"NA","Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative\u002Fdevelopmental disorders and selective cognitive disorders; (ii) healthy control subjects.\n\nThe objective of this project is to evaluate specific neuropsychological deficits and apply current brain imaging techniques (anatomical, diffusion, functional, magnetic stimulation) to patients suffering from these cognitive deficits due to brain damage, in order to elucidate the brain mechanisms underlying these deficits.",[60,61,27,62],"Cerebrovascular Disorders","Brain Lesion","Developmental Disability",[64,65],"Neuropsychological study","Brain imaging","2026-04-09",{"date":68,"type":36},"2026-04-13",{"date":70,"type":36},"2019-01-10",{"date":72,"type":22},"2030-06",{"name":74,"class":75},"University Hospital, Caen","OTHER",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":85,"targetDuration":87,"studyType":23,"phases":4,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":76},"100467390","thoracic-lumbar-arthrodesis--implanet-jazz-100467390","NCT05366140","Thoracic-Lumbar Arthrodesis- Implanet Jazz","Prospective Follow-up of Patients Undergoing Instrumented Thoracic and Lumbar Arthrodesis Supplemented by the Implanet Jazz System TM.","Inclusion Criteria:\n\n* Male and female patients, 18 years of age and older\n* Qualified candidate for hybrid thoracolumbar fixation with the Implanet Jazz System TM during arthrodesis surgery.\n\nExclusion Criteria:\n\n* Individuals who have not yet reached the age of 18.","100 Years",{"count":86,"type":22},300,"5 Years","Establish a data repository of patients who have undergone single, two-, or three-level lumbar instrumented arthrodesis procedures supplemented by the Implanet Jazz System.",[90,91,27],"Spondylolisthesis","Spinal Stenosis",[93,94,95],"Thoracic-Lumbar Arthrodesis","Spinal fusion","back pain","2025-10-23",{"date":98,"type":36},"2025-10-27",{"date":100,"type":36},"2022-02-03",{"date":102,"type":22},"2028-09",{"name":104,"class":75},"Francis Farhadi",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":55,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":135},"100522995","rehabilitation-program-on-genetic-and-degenerative-ataxia-100522995","NCT06089863","Rehabilitation Program on Genetic and Degenerative Ataxia","Evaluation of the Effect of PAMPERO Rehabilitation Program in Collaboration With Patient Partner on the Symptom Intensity, Activity, and Quality of Life on Genetic and Degenerative Ataxia","RAPP","Inclusion Criteria:\n\n* ≥ 18 years\n* Patients with genetic and degenerative cerebellar ataxia\n* Diagnostic of cerebellar ataxia confirmed by anatomic MRI\n* Affiliated to a social insurgence regime or similar\n* Patients who have given their free, informed and express consent\n* Walking patients (who can walk unsupervised on flat ground with the help of proper technique : categories greater than 4 on the New Functional Ambulation Classification scale)\n\nNon inclusion Criteria:\n\n* Patients who have already benefited from a hospitalization of more than 3 weeks for rehabilitation during the last 12 months\n* Patients participating simultaneously in another research whose objective would be the evaluation of a therapy, medicinal or not, likely to improve neurological or functional recovery\n* Pregnants, parturient or breastfeeding\n* Patients deprived of their liberty by a judicial or administrative decision\n* Psychiatric care patients\n* Patients admitted to Patients admitted to a health or social establishment for purposes other than research for purposes other than research\n* Major patients protected by the Law",{"count":114,"type":22},48,[57],"Cerebellar ataxia is a pathology linked to the lesion of the cerebellum or the afferent and\u002For efferent cerebellar pathways. The aetiology can be an acquired cerebral lesion, following a chemical poisoning or a genetic degenerative lesion (for example : Friedreich's ataxia, spinocerebellar ataxias, etc.). As reported by the latest estimate available, genetic degenerative cerebellar ataxias affect approximately 6,000 patients in France (Orpha.net). Symptoms suffered by ataxic patients are : problems and gait disorders along with difficulties in coordination resulting in ataxia, uncoordinated movements.\n\nThese symptoms cause a decrease in the quality of life on patients with spinocerebellar ataxia. The symptoms improvement linked to the cerebellar syndrome is based on rehabilitation that can be supplemented by use of technical aids. Current scientific knowledge confirms that intensive rehabilitation by physiotherapy and occupational therapy in patients with degenerative ataxias improves cerebellar symptoms. Nevertheless, the choice rehabilitation technique stay at the appreciation of the therapist.\n\nFrom the observation, the investigators have designed an intensive multidisciplinary rehabilitation program, called PAMPERO, with partner patients member of two genetic degenerative ataxia patient organisations. This 5-weeks program has been used in clinic during 3 years on 28 patients. It appears to be the only one in France.\n\nThe preliminary results show a positive effect on ataxia symptom. Nevertheless, the duration of the benefice over time and the effect on the quality of life stay unknown.\n\nHowever, the quality of life is mainly affected by the participation restriction due to the risk of falling. The most frequent complaint from partner patient is the diminution of the social interaction resulting of the incapacity to move without risk.\n\nThe present protocol aimed at evaluating the Rehabilitation Program in collaboration with partner patient on the symptom intensity, activity and quality of life on genetic and degenerative ataxia.\n\nThis PAMPERO program's effect will be assessed by comparing the difference of Intensity of symptom measured by to Scale for the Assessment and Rating of Ataxia (SARA) at inclusion and 3 months after the end of rehabilitation.",[118,27,119],"Ataxia","Genetic Disease",[121,122,123,124],"Genetic ataxia","Degenerative ataxia","Rehabilitation","Cerebellar ataxia","NOT_YET_RECRUITING","2024-01-15",{"date":128,"type":36},"2024-01-17",{"date":130,"type":22},"2024-02-01",{"date":132,"type":22},"2027-10-01",{"name":134,"class":75},"Hospices Civils de Lyon",3]