[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"degenerative-lumbar-spine-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:degenerative-lumbar-spine-diseases":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,77,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100643078","role-of-intraoperative-computed-tomography-in-assessment-of-spine-instability-in-lumbar-degenerative-disease-100643078",false,"NCT07644507","Role of Intraoperative Computed Tomography in Assessment of Spine Instability in Lumbar Degenerative Disease","Analysis of Intraoperative Computed Tomography Images in the Assessment of Radiological Features of Lumbar Spine Instability in Patients Undergoing Surgery for Degenerative Disease: Validation of Diagnostic Parameters","INSIGHT-CT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Degenerative lumbar spine pathology requiring surgical treatment (e.g., degenerative spondylolisthesis, lumbar spinal stenosis, isthmic spondylolisthesis)\n* Planned or performed lumbar decompression with instrumented fusion\n* Available intraoperative computed tomography (CT) with comparative preoperative imaging (retrospective cohort), or intraoperative CT performed during the index surgery (prospective cohort)\n* No prior surgery at the spinal level under evaluation; previous surgery at other levels permitted\n* Stable general medical condition allowing planned clinical evaluation\n* Written informed consent prior to participation (prospective cohort only)\n\nExclusion Criteria:\n\n* Non-degenerative spinal pathology, including acute traumatic spinal injury, primary or metastatic spinal tumor, spinal infection (e.g., osteomyelitis, discitis), or inflammatory spinal disease (e.g., ankylosing spondylitis)\n* Inadequate or incomplete imaging data, including poor-quality intraoperative CT or absence of comparative preoperative imaging\n* Emergency or non-elective surgery\n* Revision surgery involving the same spinal level(s)\n* Inability to provide informed consent (prospective cohort only)\n* Neuromuscular or congenital spinal deformity significantly altering spinal biomechanics (e.g., scoliosis \\>20°, congenital segmentation anomalies)","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","This study examines how well computed tomography (CT) imaging performed during spine surgery - known as intraoperative CT - can detect instability in the lower (lumbar) part of the spine. Spinal instability means that the bones of the spine move more than they normally should, which can contribute to pain and may affect the outcome of surgery.\n\nBefore surgery, doctors usually check for this instability using X-rays taken while the patient bends forward and backward. These X-rays do not always show instability clearly. During surgery, the patient lies face down and the muscles are fully relaxed, which can change how the spine appears on imaging.\n\nThe purpose of this study is to learn whether CT images taken during surgery can identify signs of lumbar spinal instability as reliably as standard imaging performed before surgery, and whether they can reveal signs of instability that were not visible beforehand. To do this, the researchers will review imaging and clinical information from adults who are undergoing surgery for degenerative (wear-related) conditions of the lower spine.\n\nThis study does not change a patient's surgery or treatment. It only analyzes imaging and clinical information that are already part of standard care. The findings may help guide imaging and surgical decisions in lumbar spine surgery in the future.",[25,26,27,28],"Degenerative Lumbar Spine Diseases","Lumbar Spinal Instability","Degenerative Spondylolisthesis","Lumbar Spinal Stenosis","NOT_YET_RECRUITING","2026-06-10",{"date":32,"type":33},"2026-06-12","ACTUAL",{"date":35,"type":21},"2026-08-01",{"date":37,"type":21},"2027-12-01",{"name":39,"class":40},"4th Military Clinical Hospital with Polyclinic, Poland","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":41},"100637970","tlip-block-versus-retrolaminar-block-on-quality-of-recovery-after-posterior-lumbar-spine-fusion-surgery-100637970","NCT07609212","TLIP Block Versus Retrolaminar Block on Quality of Recovery After Posterior Lumbar Spine Fusion Surgery","Thoracolumbar Interfascial Plane Block Versus Retrolaminar Block on Quality of Recovery After Posterior Lumbar Spine Fusion Surgery: A Prospective Randomized Controlled Trial","TLIP-RLB-QoR","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* Male and female patients\n* Scheduled for elective one- or two-level posterior lumbar instrumented fusion surgery under general anesthesia\n* ASA physical status I-III\n* BMI \\\u003C 35 kg\u002Fm²\n* Willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* Patient refusal to participate\n* Coagulopathy or anticoagulant therapy\n* Infection at the site of block injection\n* Known allergy to local anesthetics\n* Chronic opioid use (\\>3 months)\n* Severe hepatic, renal, or cardiac dysfunction\n* Neurological deficits interfering with pain assessment\n* Pregnancy or lactation","65 Years",{"count":52,"type":21},70,"INTERVENTIONAL",[55],"NA","This prospective randomized controlled study aims to compare the effects of ultrasound-guided thoracolumbar interfascial plane (TLIP) block versus retrolaminar block on postoperative quality of recovery in patients undergoing posterior lumbar spine fusion surgery. Despite advances in surgical techniques, lumbar spine fusion is associated with significant postoperative pain, which may delay recovery and increase opioid consumption.\n\nRecent approaches emphasize multimodal analgesia and opioid-sparing strategies, including regional anesthesia techniques. Interfascial plane blocks, such as TLIP and retrolaminar block, have gained attention due to their safety and effectiveness in targeting the dorsal rami of spinal nerves supplying the posterior spinal structures.\n\nThe primary outcome of this study is postoperative quality of recovery assessed using the Quality of Recovery-15 (QoR-15) questionnaire at 24 hours. Secondary outcomes include pain scores, opioid consumption, time to ambulation, time to oral intake, and postoperative complications.",[58,59,25],"Postoperative Pain","Spinal Fusion Surgery",[61,62,63,64,65,66,67],"TLIP Block","Retrolaminar Block","Regional Anesthesia","Quality of Recovery","QoR-15","Lumbar Spine Surgery","Postoperative Analgesia","2026-05-21",{"date":70,"type":33},"2026-05-27",{"date":72,"type":21},"2026-06",{"date":74,"type":21},"2027-06",{"name":76,"class":40},"Assiut University",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":17,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":53,"phases":88,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":41},"100603223","digital-health-for-lumbar-degeneration-100603223","NCT07133724","Digital Health for Lumbar Degeneration","Digital Health for Aging: A Multimodal AI-Based Smart Assessment and Rehabilitation Training System for Lumbar Degeneration","Inclusion Criteria:\n\n1. Age between 50-80 years to capture the typical characteristics of lumbar degeneration in this age group.\n2. No history of low back pain lasting more than one week or severe enough to interrupt work within the past year.\n3. Normal lumbar functional mobility.\n4. Ability to walk independently for more than 10 meters.\n\nExclusion Criteria:\n\n1. Presence of systemic joint diseases such as ankylosing spondylitis, rheumatoid arthritis, or multiple sclerosis, which may significantly affect lumbar mobility and gait patterns.\n2. Central nervous system disorders (e.g., spinal cord injury, stroke, or Parkinson's disease) that may influence gait and motor control.\n3. Vestibular system disorders, to avoid balance abnormalities interfering with gait testing.\n4. History of spinal or lower limb surgery, as postoperative changes may affect the accuracy of gait data.\n5. Inability to communicate or follow instructions.",true,"50 Years","80 Years",{"count":20,"type":21},[55],"This study will integrate wireless wearable sensors, smartphone imaging, and multimodal artificial intelligence (AI) to address the rehabilitation needs of patients with lumbar degeneration. Patients will undergo comprehensive functional assessments, and individualized exercise instruction with real-time feedback will be provided through a smartphone application. The goals of this research are to: (1) develop a multimodal AI-based digital health system combining IMU sensors and smartphone cameras for real-time assessment and interactive rehabilitation training, (2) construct biomechanics- and gait-analysis models to support personalized rehabilitation for patients with lumbar degeneration, and (3) investigate the mechanisms and clinical efficacy of pelvic control exercise training combined with real-time smartphone feedback in improving function and quality of life for aging patients.",[25],[92,93,94],"degenerative lumbar spine disease","real-time detection","artificial Intelligence","RECRUITING","2025-08-14",{"date":98,"type":33},"2025-08-21",{"date":100,"type":33},"2025-08-01",{"date":102,"type":21},"2028-07-31",{"name":104,"class":40},"National Taiwan University Hospital",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":112,"targetDuration":114,"studyType":22,"phases":4,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":41},"100557604","outcomes-of-surgery-for-degenerative-lumbar-spine-diseases-100557604","NCT06540274","Outcomes of Surgery for Degenerative Lumbar Spine Diseases","Outcomes and Complications of Surgery for Degenerative Lumbar Spine Diseases in Elderly Patients Above 65 Years.","Inclusion Criteria:\n\n* Patients of both genders with age above 65 years with Low Back Pain and disability.\n* Pt with clinical diagnosis of degenerative lumbar spine disease.\n* Pt with MRI showing Degenerative lumbar spine disease need surgical intervention.\n\nExclusion Criteria:\n\n* Patients having malignancy, vertebral fractures, trauma, inflammatory illnesses, and infection.\n* Patients with degenerative conditions in the cervical and \u002For thoracic spine.",{"count":113,"type":21},49,"1 Year","The purpose of this study is to determine the effectiveness of surgery on the elderly patients with DSD.",[25],"2024-08-05",{"date":119,"type":33},"2024-08-06",{"date":121,"type":21},"2024-08-15",{"date":123,"type":21},"2026-04-30",{"name":76,"class":40}]