[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"degenerative-spondylolisthesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:degenerative-spondylolisthesis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,80,101,123,144],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100643078","role-of-intraoperative-computed-tomography-in-assessment-of-spine-instability-in-lumbar-degenerative-disease-100643078",false,"NCT07644507","Role of Intraoperative Computed Tomography in Assessment of Spine Instability in Lumbar Degenerative Disease","Analysis of Intraoperative Computed Tomography Images in the Assessment of Radiological Features of Lumbar Spine Instability in Patients Undergoing Surgery for Degenerative Disease: Validation of Diagnostic Parameters","INSIGHT-CT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Degenerative lumbar spine pathology requiring surgical treatment (e.g., degenerative spondylolisthesis, lumbar spinal stenosis, isthmic spondylolisthesis)\n* Planned or performed lumbar decompression with instrumented fusion\n* Available intraoperative computed tomography (CT) with comparative preoperative imaging (retrospective cohort), or intraoperative CT performed during the index surgery (prospective cohort)\n* No prior surgery at the spinal level under evaluation; previous surgery at other levels permitted\n* Stable general medical condition allowing planned clinical evaluation\n* Written informed consent prior to participation (prospective cohort only)\n\nExclusion Criteria:\n\n* Non-degenerative spinal pathology, including acute traumatic spinal injury, primary or metastatic spinal tumor, spinal infection (e.g., osteomyelitis, discitis), or inflammatory spinal disease (e.g., ankylosing spondylitis)\n* Inadequate or incomplete imaging data, including poor-quality intraoperative CT or absence of comparative preoperative imaging\n* Emergency or non-elective surgery\n* Revision surgery involving the same spinal level(s)\n* Inability to provide informed consent (prospective cohort only)\n* Neuromuscular or congenital spinal deformity significantly altering spinal biomechanics (e.g., scoliosis \\>20°, congenital segmentation anomalies)","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","This study examines how well computed tomography (CT) imaging performed during spine surgery - known as intraoperative CT - can detect instability in the lower (lumbar) part of the spine. Spinal instability means that the bones of the spine move more than they normally should, which can contribute to pain and may affect the outcome of surgery.\n\nBefore surgery, doctors usually check for this instability using X-rays taken while the patient bends forward and backward. These X-rays do not always show instability clearly. During surgery, the patient lies face down and the muscles are fully relaxed, which can change how the spine appears on imaging.\n\nThe purpose of this study is to learn whether CT images taken during surgery can identify signs of lumbar spinal instability as reliably as standard imaging performed before surgery, and whether they can reveal signs of instability that were not visible beforehand. To do this, the researchers will review imaging and clinical information from adults who are undergoing surgery for degenerative (wear-related) conditions of the lower spine.\n\nThis study does not change a patient's surgery or treatment. It only analyzes imaging and clinical information that are already part of standard care. The findings may help guide imaging and surgical decisions in lumbar spine surgery in the future.",[25,26,27,28],"Degenerative Lumbar Spine Diseases","Lumbar Spinal Instability","Degenerative Spondylolisthesis","Lumbar Spinal Stenosis","NOT_YET_RECRUITING","2026-06-10",{"date":32,"type":33},"2026-06-12","ACTUAL",{"date":35,"type":21},"2026-08-01",{"date":37,"type":21},"2027-12-01",{"name":39,"class":40},"4th Military Clinical Hospital with Polyclinic, Poland","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":41},"100441542","phase-4-regional-anesthesia-in-minimally-invasive-lumbar-spine-surgery-100441542","NCT05029726","Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery","Randomized, Placebo-controlled Trial of Erector Spinae Plane Blocks (ESPB) for Perioperative Pain Management for Minimally Invasive (MIS) Lumbar Spine Surgery","Inclusion Criteria:\n\n* Age 18-80\n* Undergoing one of 3 procedure types: 1) 2 or more levels of MIS decompression (e.g., discectomy, foraminotomy, laminectomy); 2) 1-3 levels of MIS transforaminal lumbar interbody fusion (TLIF) (with or without additional levels of MIS decompression for no greater than 3 total operative levels); 3) 1-3 levels of anterior lumbar interbody fusion (ALIF) or MIS lateral lumbar interbody fusion (LLIF) accompanied by posterior percutaneous instrumentation at the same levels\n* Willing and able to give consent\n\nExclusion Criteria:\n\n* Opioid tolerant at the time of the surgical procedure--defined as consuming greater than 30mg of morphine milligram equivalents (MME) daily (https:\u002F\u002Fwww.cdc.gov\u002Fdrugoverdose\u002Fprescribing\u002Fguideline.html)\n* Presence of an indwelling pain device (e.g., intrathecal opioid pump, spinal cord stimulator, dorsal root ganglion stimulator)\n* Known allergy to bupivacaine, clonidine or similar local anesthetics\n* Indication for surgery other than degenerative disease (e.g., neoplasm, infection, trauma)\n* Chronic kidney disease (stage 3 or greater), or hepatic failure\n* Active pregnancy\n* Disease process or mental illness that would preclude accurate evaluation of pain in the perioperative period\n* Active Worker's Compensation litigation","80 Years",{"count":51,"type":21},125,"INTERVENTIONAL",[54],"PHASE4","Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical patients. This study will serve to demonstrate the efficacy of the addition of regional analgesic techniques in reducing post-operative opioid requirements in patients undergoing common lumbar spinal surgical procedures.",[28,57,58,59,60,61,62,63,27,64],"Lumbar Disc Herniation","Lumbar Spondylolisthesis","Lumbar Spondylosis","Lumbar Radiculopathy","Lumbar Spine Instability","Synovial Cyst","Degenerative Disc Disease","Degenerative Intervertebral Discs",[66,67,68,69],"erector spinae plane block","minimally invasive spine surgery","regional anesthesia","randomized controlled trial","RECRUITING","2026-02-11",{"date":73,"type":33},"2026-02-17",{"date":75,"type":33},"2022-02-01",{"date":77,"type":21},"2027-04-30",{"name":79,"class":40},"John O'Toole",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":98,"locationsCount":41},"100611850","assessing-safety-of-cervical-spine-fusion-with-nmp-100611850","NCT07245940","Assessing Safety of Cervical Spine Fusion With NMP®","Assessing Safety of Cervical Spine Fusion With NMP® Graft Material: A Retrospective Chart Review","Inclusion Criteria:\n\n1. Patients treated with NMP® for Cervical (C2-T1) Interbody fusion (2022-2025) at the study site.\n2. Minimum of 90-day post-operative follow up data available\n\nExclusion Criteria:\n\n* Patients with no follow-up data within 3 months from the surgery date due to missed postoperative appointments.",{"count":88,"type":21},300,"The goal of this retrospective chart review study is to assess safety of NMP® in the treatment of cervical spine degenerative conditions by assessing the incidence and nature of AEs in follow-up (minimum of 90 days and up to 2 year post-operatively) as well as reoperation rates.",[63,27,91],"Spinal Stenosis Cervical","2025-11-17",{"date":94,"type":33},"2025-11-24",{"date":96,"type":21},"2026-01-15",{"date":35,"type":21},{"name":99,"class":100},"Red Rock Regeneration Inc.","INDUSTRY",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":108,"maxAge":49,"enrollmentInfo":109,"targetDuration":111,"studyType":22,"phases":4,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":41},"100546373","effect-of-degenerative-spondylolisthesis-on-the-clinical-outcome-of-unilateral-biportal-endoscopy-for-lumbar-spinal-stenosis-study-protocol-100546373","NCT06394089","Effect of Degenerative Spondylolisthesis on the Clinical Outcome of Unilateral Biportal Endoscopy for Lumbar Spinal Stenosis: Study Protocol","Effect of Degenerative Spondylolisthesis on the Clinical Outcome of Unilateral Biportal Endoscopy for Lumbar Spinal Stenosis: a Single-center, Prospective Cohort Trial Protocol","Inclusion Criteria:\n\n* Age range: 50-80 years\n* Diagnosis of LSS affecting 1-2 vertebral levels\n* Predominant manifestation of neurogenic intermittent claudication, with ineffective conservative treatment for at least 3 months\n* Presence of lumbar DS of less than grade II and absence of spine instability\n* Willingness to participate in the study and complete follow-up assessments.\n\nExclusion Criteria:\n\n* Diagnosis of isthmic lumbar spondylolisthesis or lumbar DS of grade ≥II\n* Evidence of instability at the affected vertebral level (intervertebral angle change \\> 15° and\u002For vertebral translation ≥ 4.5 mm in standing flexion-extension radiographs of the lumbar spine)\n* History of prior surgery at the affected vertebral level\n* Presence of scoliosis with a Cobb angle \\>20º\n* Presence of other conditions affecting the lumbar spine (infection, tumor, fracture, neurological diseases, and others)\n* Medical disorders that preclude surgical tolerance\n* Participation in other clinical research projects related to the treatment of lumbar spinal stenosis.","50 Years",{"count":110,"type":21},150,"2 Years","A single-center, prospective cohort trial aims to provide stronger evidence regarding the impact of degenerative spondylolisthesis on the clinical outcome of unilateral biportal endoscopy for lumbar spinal stenosis",[27,28],"2025-06-03",{"date":116,"type":33},"2025-06-06",{"date":118,"type":33},"2024-03-01",{"date":120,"type":21},"2027-02-28",{"name":122,"class":40},"Beijing Friendship Hospital",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":41},"100480625","short-term-clinical-outcome-of-cortical-bone-trajectory-compared-with-the-traditional-open-and-minimal-invasive-posterior-lumbar-interbody-fusion-100480625","NCT05538416","Short-term Clinical Outcome of Cortical Bone Trajectory Compared With the Traditional \"Open\" and Minimal Invasive Posterior Lumbar Interbody Fusion","Inclusion Criteria:\n\n* 18-75 years\n* Degenerative or spondylolytic spondylolisthesis\n* Neurogenic claudication and\u002For radicular leg pain\n* Low grade (Meyerding grade l and ll)\n* Persistent complaints for over 3 months\n\nExclusion Criteria:\n\n* Previous spine fusion surgery at the same level\n* Osteoporosis\n* Active infection or prior infection at the surgical site\n* Active cancer\n* Spondylolisthesis grade lll or greater\n* More than one symptomatic level that needs fusion\n* Pregnancy\n* Contraindication for surgery\n* Severe mental or psychiatric disorder\n* Substance abuse\n* Inadequate knowledge of Dutch language\n* Morbid obesity (body mass index \\>40)","75 Years",{"count":131,"type":21},180,"A combined prospective cohort study and retrospective analysis of previously collected data. Three different techniques for posterior lumbar interbody fusion (PLIF) are compared: CBT-PLIF, MI-PLIF and open PLIF. A total of 180 patients are included, who will be followed up to 6 weeks postoperatively.",[27,134],"Spondylolytic Spondylolisthesis","2025-05-01",{"date":137,"type":33},"2025-05-04",{"date":139,"type":33},"2022-09-19",{"date":141,"type":21},"2025-12",{"name":143,"class":40},"Jos M. A. Kuijlen",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":52,"phases":154,"briefSummary":156,"conditions":157,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":172},"100540750","mid--or-high-flex-rods-versus-low-flex-rods-of-spineshape-system-iv-for-treatment-of-degenerative-lumbar-spine-diseases-100540750","NCT06320899","Mid- or High-flex Rods Versus Low-flex Rods of SpineShape System IV for Treatment of Degenerative Lumbar Spine Diseases","Mid- or High-flex Rods Versus Low-flex Rods of SpineShape System IV for Treatment of Degenerative Lumbar Spine Diseases - a Prospective, Multicenter, Randomized Controlled Non-inferiority Study","Inclusion Criteria:\n\n* degenerative symptoms in 1 to 2 segments in the lumbar spine L1-S1\n* signed informed consent of participant\n* confirmation of the participant that the attendance of follow-up visits are intended\n* Body-Mass-Index \\\u003C 32\n* Pedicle screw axis distance \\\u003C 30mm\n* one or more of the following indications:\n\n  * (dynamic) stenosis in the spinal canal\n  * neuroforaminal stenosis\n  * facet joint syndrome \u002F spondylarthrosis\n  * discopathy (recurrent disc hernia)\n  * degenerative spondylolisthesis (Meyerding \\\u003C1)\n  * instability (hypermobility with antelishtesis, hypomobility with retrolisthesis if decompressed)\n\nExclusion Criteria:\n\n* missing bone structure, e.g. due to congenital anomalies or sever anatomical deformities that make anchoring of the implant impossible\n* damaged structural tissue, e.g. due to a bone fracture\n* application to the thoracic or cervical spine\n* pronounced idiopathic scoliosis\n* spondylolisthesis \\> Meyerding grad 1\n* isthmic spondolylysis\n* bone tumor\n* osteochondrosis modic type I, II or III\n* osteoporosis, which could impair screw anchoring\n* history with third party implants\n* patients with an active local or systemic infection\n* known allergy to titatnium alloys\n* skeleton in growth (epiphyseal joints not closed)\n* severe muscular neuronal or vascular disease\n* immunosuppresive therapy\n* long-term therapy with cortisone\n* heavy smokers (regular consumption of more than six cigarettes per day), drug addicts and alcoholics\n* chronic pain patients\n* incapable of judgment or emergency situation\n* implantation during pregnancy","99 Years",{"count":153,"type":21},126,[155],"NA","The purpose of this multi-center, randomized, clinical study is to show that the treatment of degenerative lumbar spine with high- or mid-flex rods is not inferior to the treatment with low-flex rods in terms of clinical and safety-related results.\n\nThe primary aim is to compare the reduction in back pain after the treatment with high- or mid-flex rods with that after treatment with low-flex rods. Secondary, the functionality after treatment with high- or mid-flex rods will be compared to that after treatment with low-flex rods.",[158,159,160,161,27,162],"Degenerative Lumbar Spinal Stenosis","Facet Joint Arthrosis","Spondylarthritis","Discopathy","Instability Lumbar Spine","2024-06-21",{"date":165,"type":33},"2024-06-25",{"date":167,"type":33},"2024-06-04",{"date":169,"type":21},"2031-08-31",{"name":171,"class":100},"SpineSave AG",2]