[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"deglutition-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:deglutition-disorders":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,52,90,132,155,180,203,225,248,275,296,320],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100641456","ai-enabled-mobile-app-for-safe-eating-in-older-adults-with-dysphagia-100641456",false,"NCT07654088","AI-Enabled Mobile App for Safe Eating in Older Adults With Dysphagia","Efficacy of an AI-enabled Mobile Application for Safe Eating in Community-dwelling Older Adults With Dysphagia: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 60 years or above\n* Community-dwelling (living in a home or community setting)\n* Suspected or clinically identified oropharyngeal dysphagia\n* Currently consuming food or liquids orally at texture-modified levels\n* Able to provide informed consent, or with caregiver support if mild cognitive impairment is present\n* Access to a smartphone or tablet, either independently or with caregiver assistance\n* Willing and able to participate in study procedures and follow-up assessments\n\nExclusion Criteria:\n\n* Exclusive dependence on non-oral feeding (e.g., tube feeding)\n* Severe cognitive impairment or severe visual impairment that prevents meaningful participation\n* Medical conditions or circumstances that make participation unsafe\n* Life expectancy less than 6 months\n* Current participation in another dysphagia-related interventional study\n* Use of other digital tools specifically designed for food texture classification during the study period","ALL","60 Years",{"count":19,"type":20},332,"ESTIMATED","INTERVENTIONAL",[23],"NA","Difficulty swallowing (called dysphagia) is common in older adults and can make eating and drinking unsafe. It may lead to serious problems such as choking, lung infections, poor nutrition, and reduced quality of life. One common way to reduce these risks is to modify food and drink textures (for example, making foods softer or liquids thicker). However, people often find it difficult to prepare food at the correct texture level in everyday life, especially at home, which may reduce the effectiveness of this approach.\n\nThis study aims to test whether a smartphone application powered by artificial intelligence (AI) can help older adults with swallowing difficulties eat more safely. The app allows users (or their caregivers) to take a photo of food or drinks, and the app then estimates the texture level and provides guidance to help ensure it is safe to swallow. It also gives simple prompts to double-check food texture when needed.\n\nIn this clinical trial, community-dwelling adults aged 60 years or above with swallowing difficulties will be randomly assigned to one of two groups. One group will receive usual care, which includes education about safe swallowing and written instructions on appropriate food textures. The other group will receive the same usual care plus access to the AI-enabled mobile app for 16 weeks. Participants will continue their daily eating routines at home.\n\nThe main question this study is trying to answer is: Does using the AI-enabled mobile app improve how often people eat foods that match their recommended safe texture level compared with usual care alone?\n\nThe study will also examine whether the app helps reduce swallowing-related problems (such as choking), improves quality of life, and supports better overall eating ability. In addition, the study will evaluate how easy the app is to use and whether it places any burden on users.\n\nHypothesis: The researchers hypothesize that participants who use the AI-enabled app, in addition to usual care, will more consistently follow recommended food texture guidelines and experience safer eating compared with those who receive usual care alone.",[26,27],"Deglutition Disorders","Dysphagia",[27,29,30,31,32,33,34,35,36,37,38],"Deglutition disorders","Swallowing disorders","Texture modified diet","Food texture assessment","Artificial intelligence in health care","Clinical decision support systems","Digital health intervention","Older adults","Aging population","Mobile health applications","NOT_YET_RECRUITING","2026-06-12",{"date":42,"type":43},"2026-06-17","ACTUAL",{"date":45,"type":20},"2028-01",{"date":47,"type":20},"2030-12",{"name":49,"class":50},"KAM Chi Shan Anna","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":51},"100643211","silent-aspiration-following-extubation-in-the-icu-100643211","NCT07635888","Silent Aspiration Following Extubation in the ICU","Incidence, Risk Factors, and Outcomes of Silent Aspiration Post Extubation in the ICU","SAFE-ICU","Inclusion Criteria:\n\n* Adult ICU patients requiring invasive mechanical ventilation for 5 days or longer\n* Successful extubation after invasive mechanical ventilation\n* Undergoing bedside nursing swallow screening after extubation\n* Ability to undergo Fiberoptic Endoscopic Evaluation of Swallowing (FEES) within 72 hours after extubation\n* Provision of informed consent by the patient or legally authorized representative\n\nExclusion Criteria:\n\n* Presence of tracheostomy\n* Do-not-reintubate orders\u002FAllow natural death\n* Pregnancy\n* Absence of informed consent\n* Contraindication to FEES as determined by the treating physician (e.g., high bleeding risk or severe oxygen requirements)","18 Years",{"count":62,"type":20},274,"OBSERVATIONAL","Post-extubation dysphagia is common in critically ill patients and may lead to silent aspiration, which often remains undetected because patients do not exhibit overt clinical signs such as coughing or choking. Current bedside nursing swallow screening may fail to identify silent aspiration in patients recovering from prolonged mechanical ventilation.\n\nThe goal of this observational study is to learn about the incidence, risk factors, and clinical outcomes of silent aspiration in critically ill adult patients who require prolonged mechanical ventilation and are extubated in the ICU. The main questions it aims to answer are:\n\n* How often does silent aspiration occur in ICU patients intubated for 5 days or longer after extubation?\n* Can silent aspiration be present despite passing the routine bedside nursing swallow screen?\n* What clinical factors are associated with silent aspiration?\n* Is silent aspiration associated with worse clinical outcomes such as aspiration pneumonia, reintubation, prolonged ICU stay, ventilator-free days, or mortality? Participants who have been mechanically ventilated for 5 days or more will undergo routine bedside swallow screening followed by Fiberoptic Endoscopic Evaluation of Swallowing (FEES), considered the gold-standard diagnostic tool for detecting silent aspiration, within 72 hours after extubation. Researchers will compare bedside nursing swallow screening results with FEES findings to evaluate the diagnostic accuracy of bedside screening in detecting silent aspiration. Clinical data, swallowing assessment findings, and patient outcomes will also be collected and analyzed.",[66,67,26,68,69],"Silent Aspiration","Post-Extubation Dysphagia","Critical Illness","Mechanical Ventilation Complication",[71,72,73,74,75,76,77,78,79,80],"Silent aspiration","ICU extubation","Post-extubation dysphagia","FEES","Fiberoptic Endoscopic Evaluation of Swallowing","Mechanical ventilation","Swallow screening","Aspiration pneumonia","Critical care","Dysphagia screening","2026-06-03",{"date":83,"type":43},"2026-06-09",{"date":85,"type":20},"2026-06",{"date":87,"type":20},"2028-06",{"name":89,"class":50},"Cleveland Clinic Abu Dhabi",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":21,"phases":100,"briefSummary":101,"conditions":102,"keywords":111,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":131},"100641032","effectiveness-of-best-care-practices-in-acute-stroke-in-conventional-hospitalization-best-care-ictushc-100641032","NCT07627399","Effectiveness of Best Care Practices in Acute Stroke in Conventional Hospitalization (BEST CARE ICTUS_HC)","Effectiveness of Implementing Best Care Practices in the Management of Patients With Acute Stroke in Conventional Hospitalization: A Cluster-Randomized, Open, Stepped-Wedge Controlled Trial.","BESTCAREICTUS","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Clinical diagnosis of acute ischemic or hemorrhagic stroke.\n* Admission to conventional hospitalization units (Internal Medicine) in regional hospitals without specialized Stroke Units.\n\nExclusion Criteria:\n\n* Patients admitted for a cause other than stroke who develop a stroke during their hospital stay (in-hospital stroke).\n* Patients subjected to invasive neurological procedures.\n* Patients undergoing invasive procedures, such as thrombectomy, who require transfer to a referral hospital and remain there for more than 48 hours.\n* Patients with deterioration of the level of consciousness that prevents the performance of dysphagia testing.\n* Patients that have been taken care of by Nurses and Nursing Assistants with \\>4 weeks of work experience in Stroke Units in the last 12 months",{"count":99,"type":20},700,[23],"The goal of this clinical trial is to evaluate whether a multicomponent nurse-led intervention (BEST CARE ICTUS\\_HC) can reduce stroke-related complications and improve recovery in adults (18 years and older) hospitalized with an acute ischemic or hemorrhagic stroke in hospitals without specialized Stroke Units. The main questions it aims to answer are:\n\n1. Does the implementation of the program increase the early and correct detection of swallowing difficulties (dysphagia) to prevent pneumonia?\n2. Does the program reduce the severity of attention problems (hemineglect) and improve the patients' quality of life up to 6 months after discharge?\n\nResearchers will compare patients receiving the BEST CARE ICTUS\\_HC program to patients receiving usual hospital care to see if this new approach improves patient safety and long-term functional recovery.\n\nParticipants will:\n\n* Receive either the usual hospital care for stroke or the BEST CARE ICTUS\\_HC nursing program, depending on the study phase of the hospital.\n* Be screened for swallowing problems using a standardized test before receiving any food or drink.\n* Be cared for in an adapted environment (FLECHA Project) that uses visual signs and room organization to help with orientation and safety.\n* Have their temperature, blood sugar, and blood pressure monitored under a strict specialized protocol.\n* Be contacted by phone 30 days and 6 months after leaving the hospital to answer questions about their health and quality of life.",[103,104,105,106,107,26,108,109,110],"Stroke","Acute Stroke","Ischemic Stroke","Hemorrhagic Stroke","Cerebrovascular Disorders","Perceptual Disorders","Unilateral Neglect","Pneumonia, Aspiration",[104,112,113,109,114,115,116,117,118,119,120],"Nursing Care","Dysphagia Screening","Multicomponent Intervention","Care Bundle","Stepped-Wedge Design","Deglutition","Quality of life","Hyperglycemia","Fever","RECRUITING","2026-05-29",{"date":124,"type":43},"2026-06-04",{"date":126,"type":43},"2026-05-12",{"date":128,"type":20},"2028-12",{"name":130,"class":50},"University of Malaga",4,{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":139,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":21,"phases":142,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":51},"100539600","clinical-trial-on-the-safety-and-efficacy-of-optimized-transcranial-direct-current-stimulation-for-the-swallowing-function-in-patients-with-post-stroke-dysphagia-100539600","NCT06305949","Clinical Trial on the Safety and Efficacy of Optimized Transcranial Direct Current Stimulation for the Swallowing Function in Patients With Post-Stroke Dysphagia","A Multi-center, Randomized, Double-blind, Pilot Study to Evaluate the Safety and Efficacy of Optimized Transcranial Direct Current Stimulation for the Transitory Improvement of Swallowing Function in Patients With Post-stroke Dysphagia","Inclusion Criteria:\n\n* men and women \\>19 years old\n* patients with stroke confirmed by neuroimaging\n* first-time stroke patients\n* patients in subacute or chronic phases of stroke with 3 weeks or more after onset\n* stroke patients with confirmed dysphagia through Videofluoroscopic Swallowing Study (VFSS).\n\nExclusion Criteria:\n\n* patients with recurrent stoke, traumatic brain injury, spine cord injury, and degenerative brain disease, such as Parkinson's disease, etc.\n* patients with deteriorated cognitive function unable to perform the clinical trial as instructed\n* patients with evidence of delirium, confusion, or other impairment of consciousness\n* patients with uncontrolled medical disease or surgical conditions\n* patients ineligible for Transcranial direct current stimulation (due to scalp condition, metallic material at the electrode attachment area, presence of a pacemaker or cochlear implant)\n* patients with previous experience within the last year using a stimulation device similar to the one use in this clinical trial or who have participated in related clinical trials\n* patients with severe neurologic disorder with concomitant major psychiatric disorder such as major depressive disorder and dementia\n* patients with history of uncontrolled epilepsy within 6 months\n* patients with medical contraindications for neuroimaging test, such as MRI;\n* patients who are taken contraindicated medications or require medication changes during the trial period that could influence cognitive\u002Fmotor function changes via brain activation changes\n* patients who are pregnant, breastfeeding, or planning pregnancy during the trial period\n* patients considered medically ineligible for participation in the present trial beyond the criteria listened above.","19 Years",{"count":141,"type":20},30,[23],"The goal of this clinical trial is to evaluate whether the application of optimized transcranial direct current stimulation is more effective compared to sham stimulation for temporary improvement of swallowing function in patients with post-stroke dysphagia.",[26],"2026-04-07",{"date":147,"type":43},"2026-04-09",{"date":149,"type":43},"2024-04-22",{"date":151,"type":20},"2026-06-30",{"name":153,"class":154},"NEUROPHET","INDUSTRY",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":159,"acronym":4,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":21,"phases":164,"briefSummary":165,"conditions":166,"keywords":170,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":51},"100631137","effects-of-different-frequency-electroacupuncture-on-suprahyoid-muscles-in-post-stroke-dysphagia-efficacy-and-neural-networks-100631137","NCT07496762","Effects of Different-Frequency Electroacupuncture on Suprahyoid Muscles in Post-Stroke Dysphagia: Efficacy and Neural Networks","Inclusion Criteria:\n\n* Diagnosis: Patients diagnosed with cerebral infarction confirmed by CT or MRI.\n* Dysphagia Screening: Presence of varying degrees of dysphagia as screened by the Water Swallow Test (WST).\n* Clinical Status: Conscious and stable vital signs, with the ability to cooperate with the treatment.\n* Age: Aged between 18 and 80 years.\n* Consent: Signed informed consent form obtained from the patient or their legal representative.\n\nExclusion Criteria:\n\n* Dysphagia Etiology: Patients with dysphagia caused by etiologies other than cerebral infarction.\n* MRI Contraindications: Patients with metal implants or pacemakers in the body (contraindications for MRI).\n* Bleeding Risk: Patients with bleeding tendencies or coagulation disorders.\n* Blood Pressure: Patients with uncontrolled hypertension (systolic blood pressure \\> 180 mmHg or diastolic blood pressure \\> 120 mmHg).\n* Organ Failure: Patients with severe failure of vital organs (e.g., heart, liver, or kidney failure).\n* Disease Severity: Patients with critical or life-threatening stroke conditions.\n* Cooperation: Patients unable to cooperate with the treatment due to severe cognitive impairment, aphasia, or other reasons.","80 Years",{"count":163,"type":20},90,[23],"This randomized controlled study in patients with post-stroke dysphagia aims to determine the optimal stimulation frequency of electroacupuncture of the suprahyoid muscles and to elucidate the underlying neural mechanisms. Participants will be assigned to low-frequency (2 Hz), medium-frequency (50 Hz), or high-frequency (100 Hz) electroacupuncture groups. Therapeutic efficacy will be assessed using the Kubota water-drinking test, videofluoroscopic swallowing study (VFSS), and ultrasonography to identify the optimal frequency. In parallel, diffusion tensor imaging (DTI) will be used to evaluate changes in fiber connectivity between swallowing-related cortical regions (bilateral precentral gyrus, insula, supramarginal gyrus, and frontal lobe) and the medullary nucleus tractus solitarius, thereby exploring neural network remodeling and providing mechanistic evidence to inform clinical practice.",[167,26,168,169],"Stroke Sequelae","Acupuncture Therapy","Electroacupuncture",[167,26,168,169],"2026-03-23",{"date":173,"type":43},"2026-03-27",{"date":175,"type":20},"2026-04-21",{"date":177,"type":20},"2028-12-21",{"name":179,"class":50},"Kaili Chen",{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":21,"phases":188,"briefSummary":189,"conditions":190,"keywords":191,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":199,"leadSponsor":201,"locationsCount":51},"100613505","effectiveness-of-an-mhealth-intervention-based-on-rehabilitation-and-a-personalised-nutrition-plan-in-the-recovery-and-improvement-of-dysphagia-in-patients-diagnosed-with-stroke-100613505","NCT07267468","Effectiveness of an mHealth Intervention, Based on Rehabilitation and a Personalised Nutrition Plan, in the Recovery and Improvement of Dysphagia in Patients Diagnosed With Stroke","Inclusion Criteria:\n\n* Subjects aged 18 years or older.\n* Patients with any degree of impairment in swallowing\u002Foropharyngeal dysphagia to liquids following a stroke (ACV).\n\nExclusion Criteria:\n\n* Hospitalized patients presenting any type of visual barrier.\n* Patients in terminal palliative care.\n* Patients in the final days of life phase.\n* Patients with severe cognitive impairment.\n* Patients with a language barrier regarding the use of the App.\n\nSubject Withdrawal Criteria:\n\n* Revocation of consent. In this case, the subject will exit the study and will not be replaced by another subject, being considered a \"loss\".\n* Lack of adherence to the prescribed training plan exceeding 20% of the scheduled sessions.",{"count":187,"type":20},74,[23],"The goal of this clinical trial is to evaluate the efficacy of an mHealth intervention as a complement to usual clinical practice for the improvement and recovery of dysphagia in patients who have suffered a stroke. The main question it aims to answer is:\n\n\\- Does the mHealth intervention improve the recovery of dysphagia in post-stroke patients compared to usual care alone?\n\nResearchers will compare patients receiving the mHealth intervention plus usual care to see if the combined approach leads to better dysphagia outcomes, reduced negative consequences (e.g., malnutrition, pneumonia), and improved quality of life compared to usual care alone.\n\nParticipants will be recruited and:\n\n* Receive a diagnosis and usual care for post-stroke dysphagia.\n* Be assigned to either the mHealth intervention group (using a smartphone\u002Ftablet app for information and follow-up) or the control group (usual care only).\n* Be followed up to assess dysphagia recovery, reduction in negative outcomes (like aspiration pneumonia, dehydration), and changes in quality of life.",[103,26],[103,26,110,192,193,194],"Nutrition","Rehabilitation","mHealth","2026-01-30",{"date":197,"type":43},"2026-02-03",{"date":195,"type":43},{"date":200,"type":20},"2026-11-30",{"name":202,"class":50},"University of Cadiz",{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":16,"minAge":210,"maxAge":4,"enrollmentInfo":211,"targetDuration":4,"studyType":21,"phases":212,"briefSummary":213,"conditions":214,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":51},"100511144","occupational-therapy-rehabilitation-for-frail-elders-with-dysphagia-100511144","NCT05935618","Occupational Therapy Rehabilitation for Frail Elders with Dysphagia","No Food or Drink Does Any Good Until It is Swallowed: a Proof-of-concept Study on Occupational Therapy Rehabilitation for Frail Elders with Dysphagia","Inclusion Criteria:\n\n* A score of 5-18 on the Gugging Swallowing Screen.\n* Speaks and understands Danish.\n* Are able to cooperate in the intervention and give written informed consent; i.e. is oriented in time, place and own data, and able to perform four simple oral motor movements on request.\n\n  * Has given written informed consent.\n\nExclusion Criteria:\n\n* Esophageal dysphagia.\n* Progressive neurologenic dysphagia.\n* Psychiatric illness.\n* Delirious.\n* Infections that requires isolation.\n* Need for palliative care.","65 Years",{"count":141,"type":20},[23],"The goal of this proof-of-concept study is to assess the potential of a newly developed intervention with combined skill- and strength-based principles for maximizing swallowing-related outcomes and prevent further weakening of the swallowing muscles in older people with dysphagia (difficulty swallowing).\n\nThe main questions to be answered are:\n\n1. Does the intervention produce clinically significant improvement in ingestive skills during meals in older individuals with dysphagia?\n2. Does the intervention produce clinically significant improvements in tongue strength and orofacial function in older persons with dysphagia?\n3. Does the intervention produce clinically significant improvements in nutritional status and quality of life in older individuals with dysphagia?\n4. Is there an association between perceived autonomy support and intervention engagement when older individuals with dysphagia receive the intervention during hospitalization and continued in community-based rehabilitation after discharge?\n\nParticipants will be asked to perform goal-directed and task-specific swallowing exercises in eating and drinking activities where the intensity variables include advancing steps of an altered bolus volume and consistency according to a 17-level task hierarchy, which are introduced according to predetermined progression rules, as well as increases in swallowing repetitions. The dosage is 2-3 individual, face-to-face therapy sessions per week for up to a maximum of eight weeks. A therapy session lasts up to 45 min. In between therapy sessions, participants integrate the achieved level from therapy into their daily meals as self-training.",[215,26],"Dysphagia, Oropharyngeal","2025-03-11",{"date":218,"type":43},"2025-03-14",{"date":220,"type":43},"2023-08-07",{"date":222,"type":20},"2025-12-31",{"name":224,"class":50},"Hvidovre University Hospital",{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":232,"sex":16,"minAge":60,"maxAge":4,"enrollmentInfo":233,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":235,"conditions":236,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":247},"100532929","automatic-voice-analysis-for-dysphagia-screening-in-neurological-patients-100532929","NCT06219200","Automatic Voice Analysis for Dysphagia Screening in Neurological Patients","VOICED","Inclusion Criteria:\n\n* Patients with a diagnosis of stroke, Parkinson's disease, or amyotrophic lateral sclerosis, or healthy individuals.\n* Age higher than 18 years old.\n\nExclusion Criteria:\n\n* Cognitive impairment that do not allow participants to understand the requested vocal tasks.\n* Ear, nose,throat diseases and other disorders able to affect voice quality.",true,{"count":234,"type":20},400,"The proposed study suggests using automatic voice analysis and machine learning algorithms to develop a dysphagia screening tool for neurological patients. The research involves patients with Parkinson's disease, stroke, and amyotrophic lateral sclerosis, both with and without dysphagia, along with healthy individuals. Participants perform various vocal tasks during a single recording session. Voice signals are analysed and used as input for machine learning classification algorithms. The significance of this study is that oropharyngeal dysphagia, a condition involving swallowing difficulties in the transit of food or liquids from the mouth to the esophagus, generates malnutrition, dehydration, and pneumonia, significantly contributing to management costs and hospitalization durations. Currently, there is a lack of rapid and effective dysphagia screening methods for healthcare personnel, with only expensive invasive tests and clinical scales in use.",[26,237],"Neurological Disorder","2025-02-19",{"date":240,"type":43},"2025-02-20",{"date":242,"type":43},"2023-10-11",{"date":244,"type":20},"2025-12",{"name":246,"class":50},"Istituti Clinici Scientifici Maugeri SpA",2,{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":4,"enrollmentInfo":255,"targetDuration":4,"studyType":21,"phases":256,"briefSummary":257,"conditions":258,"keywords":260,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":247},"100356116","emst-in-patients-undergoing-crt-for-hnca-100356116","NCT03916809","EMST in Patients Undergoing CRT for HNCA","Impact of Expiratory Muscle Strength Training (EMST) on Swallowing Function in Persons Undergoing Radiotherapy With or Without Chemotherapy (CRT) for Cancers of the Head and Neck (HNCA)","Inclusion Criteria:\n\n* New diagnosis of cancer in the oral cavity, oropharynx, hypopharynx, or larynx;\n* Planned treatment with primary radiotherapy with or without chemotherapy;\n* Age 18 or older and able to provide consent;\n* Ability to use the EMST150 device (hold in mouth and maintain lip seal)\n\nExclusion Criteria:\n\n* Primary surgery to the head and neck (neck dissection is permitted);\n* Unknown primary tumor;\n* Primary cancers of the nasopharynx, paranasal sinuses, salivary glands and skin.\n* Progressive neurologic condition affecting muscle strength (e.g. amyotrophic lateral sclerosis (ALS), Parkinson's disease)\n* Dysphagia not related to HNCA (e.g. unresolved swallowing difficulty post-stroke or post--traumatic brain injury (TBI))\n* Prior history of head and neck radiotherapy",{"count":141,"type":20},[23],"This study is a randomized trial examining the impact of expiratory muscle strength training (EMST) on maintenance of safe and efficient oropharyngeal swallow function in persons with cancer of the head and neck (HNCA) undergoing treatment with radiation therapy or chemoradiotherapy (RT\u002FCRT).",[259,26],"Head and Neck Neoplasms",[261,262,263,264,265],"oropharyngeal cancer","laryngeal cancer","swallow","chemoradiation","expiratory muscle strength training","2024-12-03",{"date":268,"type":43},"2024-12-04",{"date":270,"type":43},"2017-07-12",{"date":272,"type":20},"2025-08-01",{"name":274,"class":50},"University of Wisconsin, Milwaukee",{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":281,"eligibilityCriteria":282,"healthyVolunteers":232,"sex":16,"minAge":60,"maxAge":4,"enrollmentInfo":283,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":285,"conditions":286,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":131},"100564502","a-new-ultrasound-score-for-swallowing-disorders-diagnosis-in-difficult-to-wean-tracheostomised-patients-100564502","NCT06630013","A New Ultrasound Score for Swallowing Disorders Diagnosis in Difficult-to-wean Tracheostomised Patients","Construction and Evaluation of a New Ultrasound Score for the Diagnosis of Swallowing Disorders in Difficult-to-wean Tracheostomised Patients","SHUBACA","Inclusion Criteria:\n\n* Patients admitted to ICU and tracheostomised for difficult-to-wean reasons ;\n* Patients with a medical indication for nasofibroscopy ;\n* Medical prescription for physiotherapy assessment ;\n* Ultrasound operator available ;\n* Patient at least 18 years old at the time of inclusion;\n* Oral, free, informed and express patient consent\n\nExclusion Criteria:\n\n* Patient with total laryngectomy;\n* History of swallowing disorders prior to critical care admission;\n* History of central nervous system disorders (stroke, Parkinson's disease, etc.)\n* Patient admitted to intensive care following central neurological injury;\n* Patient with spinal cord injury above C5 ;\n* Patient's refusal to participate in the study ;\n* Known pregnancy ;\n* Cognitive impairment incompatible with understanding instructions;\n* Patient under guardianship;\n* Patient with limited care.",{"count":284,"type":20},114,"Swallowing Disorders (SD) is commonly observed in intensive care unit (ICU) patients.\n\nDisruption to the upper airway by way of a tracheostomy may lead to physiological and\u002For biomechanical changes to the swallow, thereby increasing dysphagia risk. SD is independently associated with adverse outcomes including respiratory complications, nutritional compromise, and even death.\n\nExperts recommend a systematic bedside screening. Most algorithms include the water swallow test followed by expert comprehensive swallowing assessments of screening positive patients.\n\nHowever, the clinical examination lacks precision. Complementary examinations, such as videofluoroscopy or Fiberoptic Endoscopic Evaluation of Swallowing (FEES), are irradiating or invasive, consume numerous resources and are difficult to access. No current consensus exists on how to best approach to evaluate ICU patients at risk.\n\nIn this context, US imaging has garnered increased interest for assessing swallowing disorders. Recognised for its non-invasive nature and its ability to overcome conventional constraints, this approach, enabling both qualitative and quantitative analysis of multiple structures, would enhance the precision in targeting structures for rehabilitation.\n\nThe researchers intend to create an ultrasound diagnostic model for difficult-to-wean trahceostomised patients. Additionally, they aim to evaluate the reliability and accuracy of this model.\n\nDuring an nineteen-months period, we will enrolled one hundred and nineteen difficult-to-wean tracheostomised patients at Forcilles's Hospital, Universitary Hospital of Dijon, Béthune Hospital and Bourgon Jallieu Hospital.\n\nAll patients will have a FEES evaluation. The ultrasonographer will be blinded to the patient's status and prior clinical or imaging assessments. Ultrasound assessment will focus on evaluating the movements or morphology of structures such as the tongue, laryngeal movement, or suprahyoid muscles.\n\nA global ultrasound diagnostic model will be developed after selecting variables in logistic multivariable regression. Its sensitivity and specificity and prediction value will be estimated. The constructed model will be transformed in an easy-to-use scoring system.\n\nThe study anticipates establishing an association between ultrasound markers and swallowing disorders, aiming to enhance early detection for tailored management strategies, providing a non-invasive alternative to videofluoroscopy or FEES.",[26],"2024-10-04",{"date":289,"type":43},"2024-10-08",{"date":291,"type":43},"2024-07-09",{"date":293,"type":20},"2026-04-01",{"name":295,"class":50},"Hopital Forcilles",{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":210,"enrollmentInfo":303,"targetDuration":305,"studyType":63,"phases":4,"briefSummary":306,"conditions":307,"keywords":308,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":4},"100544473","ultrasound-study-of-the-submentonian-musculature-and-its-relationship-in-dysphagia-100544473","NCT06369337","Ultrasound Study of the Submentonian Musculature and Its Relationship in Dysphagia","Ultrasound Study of the Submentonian Musculature and Its Relationship in the Development of Dysphagia After Invasive Mechanical Ventilation: a Single-center Cohort Study","Inclusion Criteria:\n\n* • Subjects \\>18 years old.\n\n  * Having received an episode of orotracheal intubation for \\>48h\n\nExclusion Criteria:\n\n* • Congenital or acquired conditions of the Central Nervous System (CNS) such as stroke, traumatic brain injury, Parkinson's, multiple sclerosis, amyotrophic lateral sclerosis (ALS) or any other condition that may bias the attribution of dysphagia to factors other than exclusively clinical ones.\n\n  * Involvement of the cranial nerves or the Peripheral Nervous System (PNS) as well as diseases of the neuromuscular junction such as Myasthenia Gravis or any other condition that may bias the attribution of dysphagia to other factors that are not exclusively clinical.\n  * Neck morphology incompatible with exploration through ultrasound procedures.\n  * Secondary musculoskeletal injuries, including vertebral fractures, unstable extremity fractures or any condition that requires absolute bed rest as prescribed by a doctor.\n  * Malignant tumor lesions or previous head and\u002For neck surgeries.\n  * Medical-surgical history due to pathology of the larynx, oropharynx and\u002For esophagus.\n  * Diagnosis of dysphagia or swallowing disorders prior to the intubation episode with IMV.\n  * Patients unable to eat orally, at least partially.\n  * Known prior cognitive impairment upon admission to the ICU.",{"count":304,"type":20},150,"1 Year","Acquired dysphagia is one of the most frequent complications suffered by patients in intensive care units (ICU) after orotracheal extubation. Ultrasound has proven to be a useful method in the morphological and kinematic exploration of the main swallowing structures. AIM: to evaluate, through ultrasound procedures, the evolution of the morphology of the tongue and muscles of the floor of the mouth and the hyolaryngeal kinematics in patients intubated \\>48h and to correlate these measurements with the possible development of acquired dysphagia. The incidence of dysphagia and ICU acquired weakness (ICUAW) in subjects with \\>48h of intubation and the relative risk factors associated with baseline characteristics and clinical variables will be described. METHODOLOGY: Design: Single-center cohort study (Ramón y Cajal University Hospital). Participants: subjects \\>18 years old, admitted to an intensive care unit (ICU), with \\>48 hours of orotracheal intubation who meet eligibility criteria. Outcomes: the study of socio-demographic and clinical variables related to ICU admission will be included. The physical function variables will be analyzed through the Medical Research Council (MRC) and Functional Status Score (FSS), as well as swallowing function variables through the Volume-Viscosity Swallow (VVS-T) and Functional Oral Intake Scale scales. (FOIS) and Gugging Swallowing Screen (GUSS). Measurements will be made of the thickness and echogenicity of the submental and tongue muscles, as well as hyolaryngeal kinematics",[215,26,69],[27,309,29,310,76],"Ultrasonography","Diagnostic Imaging","2024-06-27",{"date":313,"type":43},"2024-07-01",{"date":315,"type":20},"2024-06",{"date":317,"type":20},"2025-06",{"name":319,"class":50},"Universidad Europea de Madrid",{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":324,"acronym":325,"eligibilityCriteria":326,"healthyVolunteers":232,"sex":16,"minAge":17,"maxAge":327,"enrollmentInfo":328,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":330,"conditions":331,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":4},"100550302","design-and-development-of-a-functional-plant-based-beverage-formulated-according-to-the-main-nutritional-guides-for-early-elderly-requirements-to-improve-nutritional-status-and-immunity-for-the-early-elderly-people-to-get-well-healthy-ageing-100550302","NCT06445309","Design and Development of a Functional Plant-based Beverage Formulated According to the Main Nutritional Guides for Early Elderly Requirements to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing","IMMUGOLD","Inclusion criteria:\n\n\\- Men or women ≥60 years old \\\u003C75 years old; Written informed consent provided prior to the sensory tasting study.\n\nExclusion Criteria:\n\n* Type 2 diabetes\n* Chronic alcoholism\n* Early community-dwelling seniors\n* Failure to comply with study guidelines.\n\nSelection criteria\n\nVolunteers will be recruited through several ways:\n\n* general databases of participants from previous clinical trials of the NFOC-Salut group\n* Leaflets with study information, as well as contact information, will be distributed in health centers, civic centers and social centers.\n* The information will be disseminated through brochures with contact information among the people who are registered in the IMSERSO to select those who meet the inclusion criteria according to the study population in order to reach the largest number of subjects possible.","75 Years",{"count":329,"type":20},80,"Populations around the world are aging and this demographic transition will impact almost every aspect of society. Furthermore, the COVID-19 pandemic has highlighted the seriousness of gaps in policies, systems and services. According to the World Health Organization (WHO) plan for 2021-2030, a decade of concerted global action on healthy ageing is urgently needed to ensure that older people can realize their potential in dignity and equality in nutritional requirements. An effective way to address the inherent demographic change, which translates into the health status of older people, is through the maintenance of adequate nutritional status. Public health services require new funding to address this problem, but if we bring new strategies to health policies, by improving nutrition, we could impact the reduction of costs at the level of medical care in the ageing population. In older people, according to the latest guidelines on nutritional requirements in geriatrics from the Spanish Nutrition Foundation (FEN), the British Nutrition Foundation and The European Society for Clinical Nutrition and Metabolism (ESPEN), multinutrient strategies instead of mononutrient strategies, are gaining importance due to relevant scientific evidence based on controlled and randomized clinical trials. Therefore, following the nutritional requirements in healthy ageing, an important aspect is to strengthen immunity in this population.\n\nConsequently, the food industry is booming in the development of new functional alternatives, such as plant-based beverages, which are well positioned in the market and can offer healthy functional beverage options to people of early elderly age (60 to 75 years) as a target population due to the ease with which they are ingested. Therefore, investments in small and medium-sized companies to encourage the incorporation of trained doctoral personnel and add innovation value to this type of product are essential for resilience.\n\nTherefore, the present proposal hypothesizes that, following the nutritional needs for healthy ageing, a multinutrient-optimized beverage as a functional food can improve immunity and reduce inflammation and oxidation in women and men in the elderly population.",[26],"2024-06-03",{"date":334,"type":43},"2024-06-06",{"date":336,"type":20},"2024-09",{"date":338,"type":20},"2025-02",{"name":340,"class":50},"University Rovira i Virgili"]