[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dehydration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dehydration":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,40,73,103,136,191,212,235,268,289,310,341,368,400,424,457,487,516,546],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100641162","validation-of-a-wearable-bioimpedance-sensor-for-hydration-monitoring-100641162",false,"NCT07655401","Validation of a Wearable Bioimpedance Sensor for Hydration Monitoring","Validation of a Wearable Bioimpedance Sensor for Non-Invasive Monitoring of Hydration Status","VAMOS","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Planned fluid management due to presumed dehydration\n* Expected duration of hospital stay ≥ 3 days\n\nExclusion Criteria:\n\n* Known allergies or skin sensitivities to electrode hydrogel and\u002For acrylic adhesives\n* Implantable pulse generators such as pacemakers and defibrillators, and\u002For use of other electrical medical equipment for which an interaction effect with the investigational device cannot be ruled out.\n* Scheduled MRI\n* Scheduled diathermy\n* Breached skin at device application areas (upper back, anterior thigh and upper arm)\n* Unconsciousness\n* Critically ill (presence of acute organ dysfunction requiring intensive monitoring and management)\n* Any medical or psychiatric condition, which in the opinion of the investigator precludes participation\n* Incapable of giving informed consent","ALL","65 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","The purpose of the project is to validate the performance of a wearable bioimpedance sensor (Re:Balans®) for monitoring hydration status. The study includes hospitalized patients aged 65 years or older who are admitted to the hospital with suspected dehydration. Data will be collected continuously throughout the hospital stay using one sensor placed on the back, one on the upper arm, and one on the front of the thigh. Sensor measurements will be compared with multiple reference methods for assessing hydration status, including blood tests, body weight and fluid balance charts. Agreement with these reference measures will form the basis for the performance evaluation.\n\nThe anticipated benefit of the project is the validation of a novel, user-friendly, and non-invasive tool for hydration monitoring, with the aim of improving patient care, preventing complications, and reducing the need for hospital readmissions.",[25,26],"Dehydration","Hypovolemia","NOT_YET_RECRUITING","2026-06-15",{"date":30,"type":31},"2026-06-17","ACTUAL",{"date":33,"type":21},"2026-08",{"date":35,"type":21},"2027-03-31",{"name":37,"class":38},"Mode Sensors AS","INDUSTRY",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100641443","hydration--female-life-stages-100641443","NCT07653620","Hydration & Female Life Stages","Effect of Female Life Stage on Rehydration With Water vs. an Electrolyte Solution After Overnight Fast\u002FFluid Restriction","Inclusion Criteria:\n\n* • Sex assigned female at birth.\n\n  * Recreationally active (engaged in light to moderate-intensity, intermittent, or steady-state exercise at least 3 days per week for at least 30 min at a time)\n  * Age 18-60 years, within the following life stage ranges specified below:\n  * Premenopausal:\n\n    * 18-35 years\n    * Self-report regular spontaneous menstrual cycle length (21-35 days) for the past 2 menstrual cycles\n    * Menstrual cycle length \\\u003C 7 days variation in consecutive cycles\n  * Perimenopausal:\n\n    * Perimenopause: 35-55 years\n    * If tracking cycles: self reported cycle irregularity (≥7 day difference from usual cycle length) for the past 2 menstrual cycles, not due to known pathology\n    * If not tracking cycles: clinician diagnosis\n  * Postmenopausal:\n\n    * Postmenopause: 45-60 years\n    * If tracking cycles: ≥12 consecutive months of spontaneous amenorrhea not due to pregnancy, lactation, or pathology\n    * If not tracking cycles: clinician diagnosis\n  * Healthy, with no known renal, cardiovascular, metabolic, or endocrine disorders that affect hydration or fluid regulation.\n  * Not currently taking medications known to influence fluid balance (e.g., diuretics, laxatives, weight loss agents, or other relevant medications) or the hypothalamus-pituitary-gonadal axis (e.g., ovulation induction agents, gonadotropins, IVF stimulation medications, or other relevant medications)\n\n    o See appendix 13.8 for list of medications, drugs, and\u002For medical conditions that may impair cognitive functioning, alter physiological responses relevant to the study outcomes, or increase the risk associated with participation.\n  * Not receive any fertility treatments within the past 6 months\n  * No hormonal contraceptives use within the past 6 months\n  * If using a paraguard copper IUD, it must be inserted for ≥ 3 months (if applicable)\n  * BMI ≤ 30 kg\u002Fm²\n  * Are not participating in a weight loss program\n  * Are not allergic to adhesives, stevia, and strawberry lime flavoring\n  * Willing to avoid strenuous activity and alcohol consumption 24 hours prior to all visits\n  * Willing to fast overnight (\\~12 hours) prior to the medical screening\n  * For visit 2 and 4:\n\n    * Willing to fast overnight (\\~12 hours)\n    * Willing to consume a minimum of 2.7 L of water 24 hours prior to visits 2 and 4, then 500 mL 2 hours before the start of the visits 2 and 4\n  * For visits 3 and 5:\n  * Willing to restrict all fluids (\\~18 hours)\n  * Willing to limit fluid consumption to 1 L the morning\u002Fafternoon prior to the start of the fluid restriction\n  * Willing to restrict food (\\~12 hours) the day prior to each visit Willing to eat a consistent diet the day prior\n  * Fluent in English (able to read, understand, and provide informed consent).\n  * Willing and able to provide informed consent to participate in the study and comply with all study procedures and scheduled visits\n\nExclusion Criteria:\n\n* • Currently pregnant or breastfeeding\n\n  * \\\u003C 6 months since giving birth (even if experiencing 2 regular menstrual cycles in a row)\n  * Smoking within the last 5 years\n  * History of adverse events (e.g., fainting) with blood draws\n  * Participants with large amount of internal metal (e.g., spinal rod) will be excluded from the DXA scan only (Brandenton)\n  * Participant has participated in a clinical trial within the past 30 days\n  * Participant has participated in any PepsiCo trial within past 3 months\n  * Participant has a condition or is taking medication that the investigator believes would interfere with his\u002Fher ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results, or put the person at undue risk\n  * Participant is employed by, or has a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If participant is unsure if a company would be considered a competitor to Gatorade, they will be asked to please let the study investigator know the name of the other company and the nature of their relationship to that company before they sign the informed consent.",true,"FEMALE","18 Years","60 Years",{"count":52,"type":21},72,"INTERVENTIONAL",[55],"NA","Female life stages including premenopausal, perimenopausal, postmenopausal, are characterized by changing concentrations and patterns of hormones. The premenopause stage represents the reproductive years with normal menstrual cycles lasting between 21-35 days. The perimenopause stage is the beginning of the menopause transition and can last up to 10 years. During this transition, menstrual cycles become longer and irregular in length (7 days or longer). After 12 consecutive months with no period, the transition is complete into the postmenopause stage.\n\nHormones that change across the lifespan are known to influence systems that regulate thirst, fluid balance, and sodium balance. Yet, fluid balance across life stages remains poorly understood, with no direct comparisons across all three life stages. The purpose of this study is to evaluate the effect of female life stage on rehydration with water and electrolyte solution after overnight fast and fluid restriction",[25,58,59,60,61,62],"Menstruation","Pre-menopause","Peri-menopausal Women","Post-menopausal Women","Hydration","RECRUITING","2026-06-12",{"date":30,"type":31},{"date":67,"type":21},"2026-06",{"date":69,"type":21},"2026-12",{"name":71,"class":38},"PepsiCo Global R&D",2,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":80,"targetDuration":4,"studyType":53,"phases":82,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":98,"leadSponsor":100,"locationsCount":39},"100642861","hydration-intervention-to-decrease-side-effects-associated-with-glp---1-ra-therapy-100642861","NCT07641361","Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy","Hydration Intervention to Address Dehydration Associated With Use of GLP-1 Based Medications","Inclusion Criteria:\n\n* Adults aged 18-60\n* Recently prescribed a GLP-1RA (within one week of prescription)\n* Fluent in English\n* Willing to complete the study protocol\n\nExclusion Criteria:\n\n* Children and adults \\> 60 years of age\n* Those not taking a GLP-1RA\n* Those who have been on a GLP-1RA longer than one week\n* Not fluent in English\n* Those who are pregnant or planning on becoming pregnant during the duration of the study\n* Unwilling to comply with study protocol\n* People with cardiac implants",{"count":81,"type":21},30,[55],"This is a 17 - week study consisting of a one - week run - in period and a 16 - week intervention. The 16 - week pilot interventions aims to increase hydration in those beginning GLP - 1 RA therapy. Investigators aim to increase hydration to potentially decrease side effect severity, amount of side effects, and drug discontinuation associated with GLP - 1 RA therapy. The investigators are piloting to assess feasibility and preliminary efficacy of the intervention through examining participant retention, participant feedback, researcher and participant adherence to protocols, impact on hydration biomarkers, and participant reported GLP - 1 RA side effects.",[85,86,87,88,25],"Obesity & Overweight","Type 2 Diabetes","Type 2 Diabetes (Adult Onset)","Obesity Type 2 Diabetes Mellitus",[62,90,91,25,92,93],"GLP - 1 RA","GLP - 1 RA therapy","Hydration biomarkers","GLP - 1 RA side effects","2026-06-08",{"date":96,"type":31},"2026-06-11",{"date":28,"type":21},{"date":99,"type":21},"2027-02-01",{"name":101,"class":102},"State University of New York at Buffalo","OTHER",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":114,"conditions":115,"keywords":120,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":39},"100640255","balanced-crystalloid-vs-normal-saline-in-pediatric-acute-gastroenteritis-100640255","NCT07610382","Balanced Crystalloid vs Normal Saline in Pediatric Acute Gastroenteritis","Comparison of Early Biochemical and Clinical Outcomes of Balanced Versus Unbalanced Isotonic Crystalloid in Children Aged 6 Months to 5 Years Who Require Intravenous Rehydration for Acute Gastroenteritis: A Single-Center Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Age: 6 months to 5 years (60 months) inclusive\n* Clinical diagnosis of acute gastroenteritis: acute diarrhoea (3 or more loose stools per 24 hours) with or without vomiting; symptom duration 7 days or less\n* Clinician-initiated indication for intravenous rehydration\n* IV fluid order placed and treatment initiated independently by the treating physician, without research team influence\n\nExclusion Criteria:\n\n* Chronic systemic disease (congenital heart disease, chronic kidney disease, chronic lung disease, inborn errors of metabolism, primary immunodeficiency)\n* Hypernatraemic dehydration (serum sodium \\>= 150 mEq\u002FL at baseline)\n* Diabetic ketoacidosis, primary metabolic crisis, or suspected surgical abdomen\n* Bloody diarrhoea or suspected invasive enteric infection requiring alternative management algorithm\n* Hypoglycaemia (blood glucose \\\u003C 60 mg\u002FdL) at presentation\n* Symptom duration exceeding 7 days\n* Receipt of 20 mL\u002Fkg or more of IV fluid in the 24 hours preceding enrolment","6 Months","5 Years",{"count":113,"type":21},180,"Acute gastroenteritis (AGE) is among the most common reasons for paediatric emergency visits. Children with significant dehydration often require intravenous (IV) fluid therapy. Two main types of IV crystalloid solutions are currently used in clinical practice: 0.9% sodium chloride (normal saline, NS) and balanced crystalloids such as Isolyte-S, which contain acetate and gluconate as bicarbonate precursors.\n\nNormal saline has a high chloride content (154 mEq\u002FL), which may worsen the metabolic acidosis already present in many children with acute gastroenteritis. Balanced crystalloids have a chloride content closer to that of plasma (98 mEq\u002FL) and additionally contain acetate and gluconate, which are metabolised in peripheral tissues to consume hydrogen ions and thereby raise serum bicarbonate - a mechanism distinct from simply avoiding chloride overload.\n\nThis study prospectively observes and compares early biochemical and clinical outcomes in children with acute gastroenteritis who receive one of these two fluid types as part of their routine clinical care. The treating physician independently decides which fluid to use; the research team does not influence this decision and does not order any additional tests or procedures. Laboratory values used as outcomes are drawn solely from blood tests obtained as part of standard care.\n\nThe primary aim is to determine whether, at approximately 4 hours after IV fluid start, serum bicarbonate has changed more in children who received a balanced crystalloid compared with those who received normal saline. Secondary aims include comparing blood pH, chloride levels, need for additional IV boluses, time to first oral fluid intake, hospitalisation rate, and 72-hour return visits.",[116,25,117,118,119],"Gastroenteritis Acute","Acidosis, Metabolic","Diarrhea","Vomiting",[121,122,123,124,125,126,25],"balanced crystalloid","normal saline","bicarbonate","metabolic acidosis","pediatric emergency","Acute Gastroenteritis","2026-05-22",{"date":129,"type":31},"2026-05-28",{"date":131,"type":31},"2026-05-15",{"date":133,"type":21},"2027-03",{"name":135,"class":102},"Aydin Adnan Menderes University",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":47,"sex":17,"minAge":49,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":53,"phases":145,"briefSummary":146,"conditions":147,"keywords":172,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":187,"leadSponsor":189,"locationsCount":39},"100637694","assessing-the-effects-of-cool-roofs-on-indoor-environments-and-health-in-tavua-fiji-100637694","NCT07592117","Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji","A Cluster Randomised Controlled Trial (cRCT) Evaluating the Effects of Cool Roofs on Health, Environmental and Economic Outcomes in Tavua, Fiji","Inclusion Criteria:\n\n* Permanent household resident.\n\nExclusion Criteria:\n\n* Roof damage, inaccessible or instability of roof adversely affecting cool roof coating application.\n* Participant unable to provide written\u002Fverbal informed consent.",{"count":144,"type":21},800,[55],"Ambient air temperatures in Fiji are increasing due to climate change. Solutions are needed to build heat resilience in communities and adapt. Sunlight-reflecting cool roof coatings may passively reduce indoor temperatures and energy use to protect home occupants from extreme heat. Occupants living in poor housing conditions in Fiji are susceptible to increased heat exposure.\n\nHeat exposure can instigate and worsen numerous physical, mental and social health conditions. The worst adverse health effects are experienced in communities that are least able to adapt to heat exposure. By reducing indoor temperatures, cool roof use can promote physical, mental and social wellbeing in household occupants.\n\nThe long-term research goal of the investigators is to identify viable passive housing adaptation technologies with proven health benefits to reduce the burden of heat stress in communities affected by heat in Fiji. To meet this goal, the investigators will conduct a cluster-randomized controlled trial to establish the effects of cool roof use on health, indoor environment and economic outcomes in Tavua, Fiji.",[148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,25,164,165,166,167,168,169,170,171],"Resting Heart Rate","Blood Glucose Control","Depression","Heat-related Symptoms","Physician Diagnosed Heat-related Illnesses","Food Insecurity","Diet Quality","Health-Related Quality-of-Life","Indoor Thermal Comfort","Coping Ability","Life Satisfaction","Healthcare Provider Utilization","Hospitalization","Systolic Blood Pressure","Diastolic Blood Pressure","Inner Ear Canal Temperature","Sleep Quality","Cognition","Productivity","Aggression","Indoor Air Temperature","Indoor Relative Humidity","Indoor Heat Index","Household Energy Expenditure",[173,174,175,176,177,150,178,179,180,181,182],"Hot temperature","Humidity","Housing","Heart rate","Cardiovascular","Mental health","Blood glucose","Diabetes","Cool roof","Heat stress","2026-05-11",{"date":185,"type":31},"2026-05-18",{"date":185,"type":21},{"date":188,"type":21},"2027-09-01",{"name":190,"class":102},"Aditi Bunker",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":198,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":200,"conditions":201,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":210,"locationsCount":39},"100581203","genetic-risk-factor-for-heat-stroke-100581203","NCT06847256","Genetic Risk Factor for Heat Stroke","Exploring a Common Genetic Risk Factor for Heat Stroke and Dehydration","Inclusion Criteria:\n\n* Previously genotyped as a CF carrier or control\n* Comfortable speaking\u002Freading English\n\nExclusion Criteria:\n\n* Previously genotyped as a CF patient\n* Diagnosis of Type 1 or Type 2 diabetes\n* History of heart attack, stroke, heart failure, or atherosclerosis\n* Currently pregnant\n* Currently taking beta blockers or diuretics\n* Prisoner status\n* Unable to provide own written informed consent",{"count":199,"type":21},200,"The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid-and-electrolyte disorders in male and female adults.\n\nThe primary aim of the study is to estimate the risk of electrolyte disorders attributable to the CF carrier state in a genotyped cohort.\n\nThis will be accomplished with two smaller projects- Aim 1 and Aim 2.\n\nAim 1 will consist of 100 CF Carriers and 100 age- and sex-matched controls. Participants in this aim will be asked to complete a Participant Info and Temperature Survey consisting of questions about race, ethnicity, medical history, and how they experience heat.\n\nAim 2 will consist of a subset of 25 CF Carriers and 25 age- and sex-matched controls from Aim 1. Participants in this aim will be scheduled for a visit to complete a heat challenge. At this visit, they will also complete the Participant Info and Temperature Survey. They will also sit in a sauna at 62 - 63 degrees Celsius for 45 minutes.",[202,203,25],"Carrier State","Heat Stroke","2026-04-21",{"date":206,"type":31},"2026-04-27",{"date":208,"type":31},"2025-11-19",{"date":69,"type":21},{"name":211,"class":102},"University of Iowa",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":218,"eligibilityCriteria":219,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":220,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":222,"conditions":223,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":39},"100631478","methods-for-nutrition-inflammation-kidney-function-aging-body-composition-and-hydration-among-older-patients-100631478","NCT07501195","Methods for Nutrition, Inflammation, Kidney Function, Aging, Body Composition, and Hydration Among Older Patients","Methods for Assessing Nutrition, Inflammation, Kidney Function, Aging, Body Composition, and Hydration Among Older Patients - An Observational Study (MIKADO)","MIKADO","Inclusion Criteria:\n\n* 65 years or older (group 1, 4 and 5)\n* 90 years or older (group 3)\n* Acute admission (group 1, 2)\n* Cognitively able to cooperate (group 1)\n* Able to read and speak Danish (group 1, 2, 3, 4, 5, 6)\n* BMI ≥ 35 kg\u002Fm2 (group 4)\n* Prednisolon treatment for COPD (≥ 37,5 mg daily) (group 5)\n* Amputation(s) of crus or femur (non-traumatic) (group 6)\n\nExclusion Criteria:\n\n* Isolation (group 1, 2, 3, 4, 5, 6)\n* Terminal treatment (group 1, 2, 3, 4, 5, 6)\n* Suicidal (group 1, 2, 3, 4, 5, 6)\n* Active Immune suppressing treatment (group 2, 3, 4, 5, 6)\n* Oedemas (group 2, 3, 4, 5, 6)\n* In active treatment for cancer (group 2, 3, 4, 5, 6)",{"count":221,"type":21},500,"The goal of this observational study, is to improve the diagnostic assessment method of malnutrition and kidney diseases, amongst hospitalized and low priority patients, by evaluating modern methodology and biomarkers, with regards to an estimate of the nutritional status and kidney diseases, against current gold standards, and also investigate how body composition, hydration, inflammation and age affect the assessments.",[224,225,25],"Malnutrition Elderly","Kidney Diseases","2026-03-26",{"date":228,"type":31},"2026-03-30",{"date":230,"type":31},"2026-03-01",{"date":232,"type":21},"2035-09",{"name":234,"class":102},"Ove Andersen",{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":47,"sex":242,"minAge":243,"maxAge":244,"enrollmentInfo":245,"targetDuration":4,"studyType":53,"phases":247,"briefSummary":248,"conditions":249,"keywords":253,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":39},"100602084","effect-of-dehydration-on-sleep-quality-cognitive-skills-and-electromyographic-responses-in-combat-athletes-100602084","NCT07118904","Effect of Dehydration on Sleep Quality, Cognitive Skills, and Electromyographic Responses in Combat Athletes","The Effect of Acute Dehydration on Sleep Quality, Cognitive Skills, and Electromyographic Responses During Maximum Contraction in Combat Athletes","Inclusion Criteria:\n\n* Voluntary participation\n* Being combat athletes with prior rapid weight loss experience\n* No existing health conditions\n* No orthopedic injuries\n\nExclusion Criteria:\n\n* Using of sleep-related medications\n* Complications During the Intervention: Participants who experience any complications during experimental intervention.","MALE","17 Years","28 Years",{"count":246,"type":21},12,[55],"This study examines the effects of rapid dehydration-induced weight loss on combat athletes' sleep quality, cognitive skills, and isokinetic strength performance. The research documents both benefits and risks of weight-cutting practices for athletes, coaches, and medical staff in weight-class sports. Findings will guide safer weight management approaches and inform potential revisions to international weigh-in protocols, while contributing valuable insights to sports science.",[25,250,251,252],"Weight Loss","Weight Cycling","Sleep",[254,255,164,256,257,258],"Athletic Performance","Cognitive Skills","Isokinetic strength","EMG Response","Anticipation Time","2026-03-12",{"date":261,"type":31},"2026-03-16",{"date":263,"type":31},"2025-08-18",{"date":265,"type":21},"2026-08-30",{"name":267,"class":102},"Abant Izzet Baysal University",{"id":269,"slug":270,"hasResults":11,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":274,"eligibilityCriteria":142,"healthyVolunteers":47,"sex":17,"minAge":49,"maxAge":4,"enrollmentInfo":275,"targetDuration":4,"studyType":53,"phases":276,"briefSummary":277,"conditions":278,"keywords":280,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":288,"locationsCount":39},"100580253","assessing-the-effects-of-cool-roofs-on-indoor-environments-and-health-in-colima-mexico-100580253","NCT06834893","Assessing the Effects of Cool Roofs on Indoor Environments and Health in Colima, Mexico","A Cluster Randomised Controlled Trial (cRCT) Evaluating the Effects of Cool Roofs on Health, Environmental and Economic Outcomes in Colima, Mexico","REFLECT",{"count":144,"type":21},[55],"Ambient air temperatures in Mexico have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change. Sunlight-reflecting cool roof coatings may passively reduce indoor temperatures and energy use to protect home occupants from extreme heat. Occupants living in poor housing conditions in the northern zone of Mexico are susceptible to increased heat exposure.\n\nHeat exposure can instigate and worsen numerous physical, mental and social health conditions. The worst adverse health effects are experienced in communities that are least able to adapt to heat exposure. By reducing indoor temperatures, cool roof use can promote physical, mental and social wellbeing in household occupants.\n\nThe long-term research goal of the investigators is to identify viable passive housing adaptation technologies with proven health benefits to reduce the burden of heat stress in communities affected by heat in Mexico. To meet this goal, the investigators will conduct a cluster-randomized controlled trial to establish the effects of cool roof use on health, indoor environment and economic outcomes in Colima, Mexico.",[148,149,150,151,152,153,154,279,156,157,158,159,160,161,162,163,25,164,165,166,167,168,169,170,171],"Health-related Quality of Life",[281,174,175,176,177,150,178,179,180,181,282],"Hot Temperature","Heat Stress","2026-03-10",{"date":259,"type":31},{"date":286,"type":21},"2026-04-01",{"date":188,"type":21},{"name":190,"class":102},{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":274,"eligibilityCriteria":142,"healthyVolunteers":47,"sex":17,"minAge":49,"maxAge":4,"enrollmentInfo":295,"targetDuration":4,"studyType":53,"phases":297,"briefSummary":298,"conditions":299,"keywords":300,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":309},"100560653","assessing-the-effects-of-cool-roofs-on-indoor-environments-and-health-100560653","NCT06579950","Assessing the Effects of Cool Roofs on Indoor Environments and Health","The Effects of Cool Roofs on Health, Environmental, and Economic Outcomes: a Global Multi-center Cluster-randomized Controlled Trial",{"count":296,"type":21},3200,[55],"Ambient air temperatures in Asian, Latin American, African, and Pacific climate hotspots have broken record highs in 2024, driven by man-made climate change. Solutions are needed to reduce heat exposure in communities. Sunlight-reflecting cool roof coatings passively reduce indoor temperatures and energy use to protect home occupants from extreme heat. Occupants living in poor housing conditions globally - for example in informal settlements, slums, and low-socioeconomic households - are especially vulnerable to increased indoor heat exposure.\n\nHeat exposure can instigate and worsen numerous physical, mental and social health conditions. The worst adverse health effects are being experienced in communities least able to adapt to heat exposure. By reducing indoor temperatures, cool roof use can promote physical, mental and social wellbeing in occupants.\n\nThe long-term research goal is to identify viable passive housing adaptation technologies with proven health and environmental benefits to reduce the burden of heat stress in communities affected by heat globally. To meet this goal, the investigators will conduct a cluster-randomized controlled trial to establish the effects of cool roof use on health, indoor environment and economic outcomes in five urban climate hotspots: Ouagadougou, Burkina Faso; Colima, Mexico; Ahmedabad, India; Niue; and Tavua, Fiji.",[148,149,150,151,152,153,154,279,156,157,158,159,160,161,162,163,25,164,165,166,167,168,169,170,171],[281,174,175,176,177,150,178,179,180,181,282],"2026-02-25",{"date":303,"type":31},"2026-02-27",{"date":305,"type":31},"2024-09-04",{"date":307,"type":21},"2027-09-30",{"name":190,"class":102},5,{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":47,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":317,"targetDuration":4,"studyType":53,"phases":319,"briefSummary":320,"conditions":321,"keywords":326,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":39},"100622304","gel-aid-safe-and-effective-hydration-for-institutionalized-older-adults-100622304","NCT07381881","GEL-AID: Safe and Effective Hydration for Institutionalized Older Adults","Efficacy and Efficiency of GEL-AID Gelled Water for Hydration in Institutionalized Older People","Inclusion Criteria:\n\n* Age equal to or greater than 65 years.\n\nExclusion Criteria:\n\n* No exclusion criteria have been established.",{"count":318,"type":21},156,[55],"The objective of this clinical trial is to assess whether hydration with gelled water (GEL-AID) can improve fluid intake and reduce cases of dehydration, as well as the incidence of urinary and respiratory infections in institutionalized elderly individuals in nursing homes.\n\nThe main question this trial aims to answer is:\n\n• Do institutionalized elderly individuals hydrated with GEL-AID increase their daily fluid intake and reduce the incidence of dehydration, urinary infections, and respiratory infections?\n\nParticipants:\n\nThe control group will follow the center's usual hydration plan. Individuals with swallowing difficulties will receive thickened liquids and\u002For gelatin, while those without swallowing difficulties will be hydrated with unmodified liquids or gelatin.\n\nThe intervention group will receive hydration with GEL-AID. For participants with swallowing difficulties, thickened liquids and gelatin will be replaced by GEL-AID, with texture adapted to their needs. Those without swallowing difficulties will receive unmodified liquids and GEL-AID instead of gelatin.",[25,322,323,324,325],"Urinary Infections","Respiratory Infections","Daily Fluid Intake","Mortality",[327,328,329,330,331],"dehydration","aged","nursing homes","fluid intake","gelled water","2026-01-27",{"date":334,"type":31},"2026-02-02",{"date":336,"type":21},"2026-02-23",{"date":338,"type":21},"2027-12-31",{"name":340,"class":102},"Universitat de Lleida",{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":345,"acronym":346,"eligibilityCriteria":347,"healthyVolunteers":47,"sex":17,"minAge":348,"maxAge":18,"enrollmentInfo":349,"targetDuration":4,"studyType":53,"phases":351,"briefSummary":352,"conditions":353,"keywords":356,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":72},"100606711","adequate-hydration-and-health-outcomes-100606711","NCT07179107","Adequate Hydration and Health Outcomes","HYDRATE","Inclusion Criteria:\n\n* BMI 18.5-24.9 or 30.0-39.9 kg\u002Fm2\n* HbA1c ≤7%\n* Age 20-65 y\n* available for 8 consecutive weeks same day and time\n\nExclusion Criteria:\n\n* Diabetes\n* HbA1c \\>7% BMI ≤18.5, BMI of 25 to \\\u003C30, or ≥ 40 kg\u002Fm2\n* night shifting work\n* losing or gaining weight during the last 2 months (\\>5 lbs. fluctuation)\n* thyroid medication\n* bariatric surgery\n* Habitual strenuous exercise (\\>120 min\u002Fweek) Strenuous exercise is defined as activities that take hard physical effort and make you breathe much harder than normal.\n* Construction and other workers that spend signifant portion of their work day outdoors\n* Commuting by bicycle\n* Eating disorders\n* Use of aspirin during the duration of the study\n* Cancer\n* Renal disease (including kidney stones or recurrent urinary track infections\n* Hepatic disease\n* Cardiac conditions\n* Current infection requiring medication\n* Chronic, contagious, infectious diseases such as tuberculosis, Hepatitis A, B, C, or HIV\n* Medication that could affect appetite or body weight regulation\n* GLP1-RA medication\n* Anti-depressent SSRI medication\n* Testosterone replacement therapy\n* Participating in another study at the same time\n* Unable to abstain from alcohol during the study\n* Unable to limit caffeinated beverage intake to 1 cup per day\n* Donated blood during the past two months\n* Uneasibly acessable veins\n* Does not have smart phone","20 Years",{"count":350,"type":21},144,[55],"Cardiovascular diseases (CVD) are the leading cause of death in middle- and high-income countries, according to data from the World Health Organization (WHO). Epidemiological studies have associated low water intake and underhydration with diabetes, chronic kidney disease, and an increased risk of CVD. Similarly, the prevalence of chronic metabolic dysfunction is increasing dramatically worldwide, becoming both a significant public health concern and a global economic burden. Reports from the WHO indicate that the number of people with diabetes worldwide has risen from 108 million in 1980 to 422 million in 2014, representing 8.5% of adults. Therefore, there is an urgent need to identify modifiable risk factors that could help prevent metabolic dysfunction and mitigate the epidemic of type 2 diabetes (T2D). Evidence suggests that the hormone arginine vasopressin (AVP) may play a key role. AVP is the primary hormone responsible for regulating body fluid balance; however, increased AVP secretion, such as under conditions of low water intake, appears to be a risk factor for developing diabetes.\n\nIncreasing water intake may represent a simple and cost-effective way to improve glucose regulation and cardiovascular health. However, many individuals do not prefer drinking plain water, and although beverages with high sugar content may promote greater fluid intake, they also contribute additional calories that can negatively impact body weight and overall health. Thus, the central research question of this study is whether improving hydration with non-sugar-sweetened beverages can provide equivalent benefits for hydration and health outcomes in adults.\n\nAim 1: To explore the association between habitual fluid intake and fluid preferences (water and non-sugar-sweetened beverages), hydration biomarkers, and health outcomes in normal-weight and obese adults.\n\nAim 2: To compare the impact of increased total water intake, provided as plain water or non-sugar-sweetened beverages, on hydration, cardiovascular health, and glucose regulation in normal-weight and obese adults.",[25,354,355,177],"Dehydration (Physiology)","Glucose Abnormalities",[357,327,358,330,359],"hydration","underhydration","non caloric sweeteners","2026-01-26",{"date":332,"type":31},{"date":363,"type":31},"2025-09-29",{"date":365,"type":21},"2028-12-31",{"name":367,"class":102},"Arizona State University",{"id":369,"slug":370,"hasResults":11,"nctId":371,"briefTitle":372,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":11,"sex":17,"minAge":348,"maxAge":374,"enrollmentInfo":375,"targetDuration":4,"studyType":53,"phases":377,"briefSummary":378,"conditions":379,"keywords":385,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":395,"completionDateStruct":397,"leadSponsor":398,"locationsCount":39},"100621192","risks-of-ramadan-fasting-in-patients-with-primary-adrenal-insufficiency-treated-with-prednisolone-100621192","NCT07367425","Risks of Ramadan Fasting in Patients With Primary Adrenal Insufficiency Treated With Prednisolone.","Inclusion Criteria:\n\n* subjects with primary adrenal insufficiency known for at least one year, treated with a glucocorticoid and a mineralocorticoid, who wish to fast during Ramadan 2026.\n\nExclusion Criteria:\n\n* presence of diabetes, renal, hepatic, cardiac, or respiratory insufficiency; use of hypoglycemic agents (sulfonylureas), diuretics, use of any glucocorticoid other than the prescribed replacement therapy; poor disease control (asthenia, malaise, hyperpigmentation, discontinuation of treatment, etc.); pregnancy; breastfeeding; menstruation.","70 Years",{"count":376,"type":21},35,[55],"In primary adrenal insufficiency (PAI), there is a risk of hypoglycemia and dehydration. These risks seem to be increased during intermittent fasting. A previous study in patients with PAI treated with hydrocortisone at a dose of 20 mg\u002Fday showed that the prevalence of hypoglycemia was as high outside (63%) as during Ramadan fasting (71%), and that there was no risk of dehydration. We propose to evaluate the risk of complications during and outside of Ramadan fasting through a prospective study with subjects taken as their own controls, in 35 patients with PAI treated with prednisolone at a dose of 5 mg\u002Fday. Patients will undergo an interview, physical examination, blood sampling, and continuous glucose monitoring (CGM) during two weeks of fasting and two weeks of non-fasting.",[380,381,382,383,384,25],"Primary Adrenal Insufficiency","Ramadan Fasting","Prednisolone","Continuous Glucose Monitoring","Hypoglycemia Non-Diabetic",[386,387,388,389,327,390,391,392],"primary adrenal insufficiency","Ramadan fasting","continuous glucose monitoring","hypoglycemia","glucocorticoid replacement therapy","prednisolone","hypotension","2026-01-16",{"date":360,"type":31},{"date":396,"type":21},"2026-01-22",{"date":228,"type":21},{"name":399,"class":102},"Hopital La Rabta",{"id":401,"slug":402,"hasResults":11,"nctId":403,"briefTitle":404,"officialTitle":404,"acronym":4,"eligibilityCriteria":405,"healthyVolunteers":47,"sex":17,"minAge":49,"maxAge":406,"enrollmentInfo":407,"targetDuration":4,"studyType":53,"phases":408,"briefSummary":409,"conditions":410,"keywords":411,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":415,"lastUpdatePostDateStruct":416,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":39},"100536051","efficacy-of-a-smart-water-bottle-intervention-to-increase-fluid-consumption-in-college-students-100536051","NCT06259799","Efficacy of a Smart Water Bottle Intervention to Increase Fluid Consumption in College Students","Inclusion Criteria:\n\n* Participants must report currently drinking less than the European Food Safety Authority Recommendations for fluid, as determined by an online pre-screening survey (\\\u003C2.5 L per day for males; \\\u003C2.0 L per day for females).\n* Has access to a cell phone which can download the app associated with the Smart Water Bottle.\n\nExclusion Criteria:\n\n* Currently trying to gain or lose weight\n* Have had surgery of the digestive tract\n* Currently taking diuretics (e.g., Thiazide, Loop diuretics or potassium-sparing diuretics)\n* Currently taking centrally-acting medications (e.g., anesthetics, anticonvulsants, central nervous system stimulants\u002Famphetamines, muscle relaxants)\n* Report currently consuming at least the European Food Safety Authority Recommendations for fluid, as determined by an online pre-screening survey (\\>= 2.5 L per day for males, \\>=2.0 L per day for females).\n* Currently pregnant (females)","35 Years",{"count":81,"type":21},[55],"Approximately 60% of males and 40% of females do not meet current fluid intake recommendations, which is associated with adverse health consequences such as obesity, diabetes, and chronic kidney disease. Newer technologies have been designed to promote fluid intake. \"Smart Water Bottles\" use mHealth technology to capture fluid intake behaviors automatically and provide cues to encourage fluid consumption. Studies using Smart Water Bottles have helped some individuals increase fluid intake to help reduce kidney stone formation. However, limited research has assessed the efficacy of this technology on improving fluid intake in college students. College is a time with the potential to form healthy habits that carry into adulthood. Previous work has also identified daily changes in morning urine color, thirst perception, and body mass, as simple, inexpensive indicators of daily fluctuations in water balance. Tracking changes in these metrics has the potential to provide participants with evidence of adequate or inadequate fluid consumption. Thus, the combination of prompting from a smart water bottle, as well as daily self-monitoring changes in hydration status, may encourage college students to increase daily fluid consumption.",[25],[358,412,413,414],"copeptin","urine","water","2025-08-25",{"date":417,"type":31},"2025-09-02",{"date":419,"type":31},"2024-04-01",{"date":421,"type":21},"2026-04",{"name":423,"class":102},"Kennesaw State University",{"id":425,"slug":426,"hasResults":11,"nctId":427,"briefTitle":428,"officialTitle":429,"acronym":430,"eligibilityCriteria":431,"healthyVolunteers":47,"sex":17,"minAge":18,"maxAge":432,"enrollmentInfo":433,"targetDuration":4,"studyType":53,"phases":435,"briefSummary":436,"conditions":437,"keywords":443,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":448,"lastUpdatePostDateStruct":449,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":4},"100596321","effect-of-a-mobile-based-hydration-tracking-program-on-knowledge-attitudes-and-behaviors-in-older-adults-100596321","NCT07043933","Effect of a Mobile-Based Hydration Tracking Program on Knowledge, Attitudes, and Behaviors in Older Adults","The Effect of a Mobile-Compatible Web-Based Hydration Tracking Program on Hydration Knowledge, Attitudes, and Behaviors in Older Adults: A Randomized Controlled Trial","SIVI","Inclusion Criteria:\n\n* Daily water and other fluid intake below the recommended levels: less than 2.0 L\u002Fday for older adult men and less than 1.6 L\u002Fday for older adult women (ESPEN Guidelines, 2024) Aged between 65 and 84 years Having at least a primary school education Having sufficient motor skills Having the cognitive capacity, willingness, and experience necessary to use technology Willing to participate in the study Owning a mobile phone compatible with the application Having prior experience using mobile applications\n\nExclusion Criteria:\n\n* Diagnosed with moderate or severe cognitive impairment (MMSE \\\u003C 24)\n* Having vision or hearing impairments that prevent participation\n* Diagnosed with advanced stage chronic kidney disease (Stage 4-5)\n* Diagnosed with congestive heart failure (NYHA class III-IV)\n* Being on fluid restriction by medical order\n* Having a diagnosed urinary incontinence condition\n* Having a diagnosis of terminal illness or active cancer treatment\n* Participating in another hydration-related clinical study\n* Experiencing a disruption in app usage for one week or longer for any reason","85 Years",{"count":434,"type":21},70,[55],"This randomized controlled trial aims to evaluate the impact of a mobile-friendly, web-based hydration tracking application (named \"SIVI\") on hydration-related knowledge, attitudes, and behaviors in older adults. Inadequate fluid intake is a common and modifiable risk factor for dehydration in the elderly, leading to increased morbidity, hospitalizations, and functional decline. However, many older individuals forget to drink fluids or face barriers such as fear of incontinence, mobility limitations, or cognitive challenges.\n\nThis study will include 70 community-dwelling older adults aged 65-84 years, recruited from a Family Health Center. Participants will be randomly assigned to either the intervention or control group. The intervention group will use the SIVI application for two months. The app is specially designed for older adults and includes features such as personalized fluid goals, reminders, hydration education modules, feedback, and a user-friendly interface with large fonts and high contrast. Participants will log their daily fluid intake, receive motivational messages, and access videos and information about healthy hydration habits. A water bottle will be provided to standardize measurement across groups.\n\nThe control group will receive only routine care. Both groups will complete questionnaires measuring demographics, hydration knowledge, attitudes, behaviors, and fluid consumption habits at baseline, one month, and two months.\n\nData collection will be conducted face-to-face by the researcher, and analysis will be performed using SPSS 22.0. Statistical tests will include descriptive statistics, Shapiro-Wilk for normality, chi-square for categorical data, and t-tests and ANOVA for comparisons over time.\n\nThe results are expected to show that the SIVI application improves older adults' hydration knowledge, fosters positive attitudes, and promotes healthy fluid intake behaviors, thus supporting self-management of hydration and potentially reducing dehydration-related health risks.",[25,438,439,440,441,442],"Older Adults (65 Years and Older)","Hydration Status","Self-management Behavior","Mobile Application","Web Based Intervention",[25,444,62,445,446,447],"Aged","Older Adults","Mobile Applications","Self-Management","2025-06-21",{"date":450,"type":31},"2025-06-29",{"date":452,"type":21},"2025-10-01",{"date":454,"type":21},"2026-02-01",{"name":456,"class":102},"Ezgi Atasoy",{"id":458,"slug":459,"hasResults":11,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":463,"eligibilityCriteria":464,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":4,"enrollmentInfo":465,"targetDuration":110,"studyType":22,"phases":4,"briefSummary":467,"conditions":468,"keywords":471,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":484,"locationsCount":486},"100579463","readmission-and-dehydration-prevention-in-patients-with-elective-ileostomy-100579463","NCT06824623","Readmission and Dehydration Prevention in Patients With Elective Ileostomy","Multicenter Prospective Observational Study to Prevent the Risk of REadmission and DEhydration of Patients With ileoSTOmy in Elective Colorectal Surgery","PREDESTO","Inclusion Criteria:\n\n* All patients with elective ileostomy performed during the study period for benign or malignant colorectal disease\n* Age \\> 18 years\n* Written consent\n\nExclusion Criteria:\n\n* Emergency surgery\n* Other ostomy than ileostomy",{"count":466,"type":21},300,"The goal of this prospective observational study is to evaluate the adherence to DRIP score calculation and the application rate of each proposed item to prevent dehydration and readmission in patients undergoing ileostomy creation after elective colorectal resection different Italian colorectal surgical centers.\n\nThe primary endpoint is to verifythe application rate of DRIP score calculation and protocol items.\n\nSecondary endpoints are 30, 90, and 180-day total and dehydration readmission rates.",[469,470,25],"Ileostomy - Stoma","Colorectal Surgery",[472,473,474,327,475,476],"ileostomy","colorectal cancer","inflammatory bowel disease","readmission","colorectal surgery","2025-06-08",{"date":479,"type":31},"2025-06-11",{"date":481,"type":21},"2025-06-01",{"date":483,"type":21},"2026-11-30",{"name":485,"class":102},"Multidisciplinary Italian Study group for STOmas (MISSTO)",7,{"id":488,"slug":489,"hasResults":11,"nctId":490,"briefTitle":491,"officialTitle":492,"acronym":493,"eligibilityCriteria":494,"healthyVolunteers":11,"sex":17,"minAge":495,"maxAge":4,"enrollmentInfo":496,"targetDuration":4,"studyType":53,"phases":498,"briefSummary":500,"conditions":501,"keywords":503,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":514,"locationsCount":4},"100576707","phase-2-effectiveness-of-a-wearable-hydration-device-100576707","NCT06788795","Effectiveness of a Wearable Hydration Device","Clinical Effectiveness of a Wearable Hydration Device","DRINK","Inclusion Criteria:\n\n* adult patients aged 55 and over\n* rresenting to the emergency department\n* clinical suspicion of dehydration\n* treatment of dehydration\u002Fsyncope with fluid resuscitation\n* English speaking\n\nExclusion Criteria:\n\n* Refusal or inability to give informed consent,\n* severe clinical symptom requiring escalation of care beyond fluid resuscitation (ex. vasopressors, invasive blood pressure monitoring)\n* presumed\u002Fconfirmed diagnosis of syncope secondary to a non-dehydration cause (ex. arrhythmia, stroke, pulmonary embolism, sepsis, valvular heart disease)\n* inability to lay flat for the test\n* body weight greater than 350 lbs\n* inability to fit measurement devices around the participant wrist\n* abnormal bodily fluid retention (lymphedema, ascites, pleural effusions, peripheral edema)\n* neuromotor disorders\n* current congestive heart failure exacerbation or heart attack\u002Fmyocardial infarction\n* any implantable electronic devices\n* skin on limbs in poor condition (excessively, dry or rough or abrasions or wounds that would preclude application of electrode adhesive)","55 Years",{"count":497,"type":21},150,[499],"PHASE2","Dehydration among older adults a costs billions of dollars in US healthcare every year because no robust solution exists to detect changes in hydration and prevent negative outcomes. In this project, TritonX Technologies Inc. and academic research partners plan to test whether a newly created wearable sensor that measures hydration in real time can promote hydration and prevent the dehydration illnesses.\n\nThe investigators will conduct a randomized controlled trial to examine the effectiveness of continuous home monitoring of fluid levels in a cohort of vulnerable older adult patients seen in the emergency care setting.\n\nThe goal of this randomized control trial is to examine the effectiveness of continuous home monitoring of fluid levels in older patients presenting to the emergency department for dehydration. The main questions it aims to answer:\n\n1. Can a wearable device accurately determine the severity of dehydration at home and\n2. can a wearable device and continuous feedback from the device change behavior in the outpatient setting that can lead to improved outcomes in the treatment of dehydration in the elderly?\n\nInvestigators will compare device readings, hydration diaries, vital signs, blood samples, return visits to the emergency department, and to see if feedback from the device decreases signs and symptoms of dehydration and changes home management of dehydration.\n\nParticipants will be asked to:\n\n* wear the device and monitor hydration status\n* record the amount of home hydration\n* return in 7-10 days for reassessment of dehydration\n\nThe successful outcome of this study will include evidence for the effectiveness of the home, wearable hydration monitoring device, data necessary for the FDA 510(k) and related regulatory processes and substantial enhancements to both our knowledge of older adult needs and device functionality.",[25,502],"Syncope and Collapse",[327,504,505,506],"total body water","bioimpedence","emergency department","2025-03-10",{"date":509,"type":31},"2025-03-13",{"date":511,"type":21},"2025-04-01",{"date":513,"type":21},"2026-12-31",{"name":515,"class":102},"MetroHealth Medical Center",{"id":517,"slug":518,"hasResults":11,"nctId":519,"briefTitle":520,"officialTitle":520,"acronym":4,"eligibilityCriteria":521,"healthyVolunteers":47,"sex":17,"minAge":522,"maxAge":523,"enrollmentInfo":524,"targetDuration":4,"studyType":53,"phases":526,"briefSummary":527,"conditions":528,"keywords":529,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":538,"lastUpdatePostDateStruct":539,"startDateStruct":541,"completionDateStruct":543,"leadSponsor":545,"locationsCount":39},"100566164","efficacy-of-education-versus-education-plus-prescribed-fluid-intake-on-hydration-status-in-high-school-athletes-100566164","NCT06651619","Efficacy of Education Versus Education Plus Prescribed Fluid Intake on Hydration Status in High School Athletes","Inclusion Criteria:\n\n1. Females and males between the ages of 13-19 years old\n2. Non-smoker\n3. Currently enrolled in the IMG sports program\n4. Able to give verbal and written informed consent for participation as well as obtain parental consent if \\\u003C18 years of age\n5. Must be fluent in English reading, writing, and speaking\n6. Parental permission\n\nExclusion Criteria:\n\n1. Expulsion from school for any reason\n2. Leaving the IMG sports program\n3. Pregnant or planning to become pregnant\n4. Illness or injury that impacts sport participation or fluid balance\n5. Taking any medication that impacts fluid balance\n6. Participation in a clinical trial within past 30 days\n7. Participation in any PepsiCo trial within past 6 months\n8. Any condition the study investigator believes would interfere with eligibility following the study protocol, effect the study results, or put the subject at undue risk","13 Years","19 Years",{"count":525,"type":21},108,[55],"Sports science testing by investigators at Gatorade Sports Science Institute has revealed that many athletes arrive at practice with a high urine specific gravity indicating they are hypohydrated. Though the data showed that most athletes don't lose more than 2% of their body weight in sweat during a training session, it is not known what the cumulative effects of living and training in a hot environment are over the course of a week. Previous research has indicated that prescribing fluid intake is more effective than education in improving drinking behavior during exercise. No studies to date have compared the impact of fluid intake prescription versus education in adolescent boys and girls playing outdoor and indoor sports.\n\nComparing sexes and training environment may provide more clarity around potential barriers and challenges to proper hydration for each environment.",[25],[357,530,531,532,533,534,535,536,537],"hypohydration","adolescent","athlete","sports","exercise","behavior","education","high school","2024-10-21",{"date":540,"type":31},"2024-10-23",{"date":542,"type":31},"2024-10-01",{"date":544,"type":21},"2025-06-30",{"name":71,"class":38},{"id":547,"slug":548,"hasResults":11,"nctId":549,"briefTitle":550,"officialTitle":551,"acronym":4,"eligibilityCriteria":552,"healthyVolunteers":47,"sex":17,"minAge":49,"maxAge":406,"enrollmentInfo":553,"targetDuration":4,"studyType":53,"phases":555,"briefSummary":556,"conditions":557,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":39},"100472157","clinical-study-to-evaluate-the-effects-of-two-novel-hydration-beverage-formulas-on-rehydration-in-healthy-adults-100472157","NCT05428228","Clinical Study to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults","A Randomized, Placebo Controlled, Semi-Blind, Crossover Study to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults","Inclusion Criteria:\n\n* Healthy adult male and female participants who are between 18 and 49 years of age (inclusive). Are in good general health (no active or uncontrolled diseases or conditions) and can ingest the assigned amount of fluid at each visit. Have a body mass index (BMI) between 17.0 and 29.9 kg\u002Fm2 (inclusive). Exercise regularly as per physical activity guidelines for Americans \\[structured exercise for a minimum of 150 cumulative minutes per week (low end) to 500 cumulative minutes of exercise per week (high-end)\\] and willing to maintain the same level of physical activity throughout the study period. Can maintain their exercise status at the beginning of the study throughout the study period. Can achieve a peak VO2 at screening that is at least 60% of their age and gender matched normative value per American College of Sports Medicine recommendations. Have normal or acceptable to the investigator vital signs (BP and HR) at screening. Individuals with childbearing potential: Agree to have urine pregnancy test performed on each trial day. Able to agree to the requirements and restrictions of this study, willing to give voluntary consent, able to understand and read the questionnaires, and carry out all study-related procedures.\n\nExclusion Criteria:\n\n* Female participants who are lactating, pregnant or planning to become pregnant during the study. Carry a diagnosis of diabetes. Weigh less than or equal to 80 pounds at any visits. Answer \"yes\" to any of the questions asked on the screening questionnaire (Appendix 10.2.1). Have a history of a diagnosis of celiac disease, chronic pancreatitis, steatorrhea, unstable thyroid disease, major affective disorder, psychiatric disorder that required hospitalization in the prior year, immune disorder (i.e., HIV\u002FAIDS), cancer (except localized skin cancer without metastases or in situ cervical cancer within 5 years prior to screening visit). Use any dietary supplements that may impact hydration status within the 30 days prior to the baseline visit (Familiarization Trial\u002FVisit 2). Participants must observe a 30-day washout period of no supplementation to be eligible. Consume more than two standard alcoholic drinks per day. Use of inhalables, smokables, or the like (e.g., cigarettes, vaporizers, water pipes, or cannabis) within 30 days prior to the first dose of the study product or for the duration of the study. Have a medical condition that may impact ability to exercise or ability to ingest prescribed fluid volume. Smoking tobacco products.",{"count":554,"type":21},16,[55],"The aim of the clinical trial is to evaluate the efficacy of two novel hydration products on rehydration following exercise.",[25,558,559,560,561],"Rehydration","Exercise Performance","Exercise Recovery","Cognitive Performance","2024-07-26",{"date":564,"type":31},"2024-07-29",{"date":566,"type":31},"2022-10-01",{"date":568,"type":21},"2024-09-01",{"name":570,"class":102},"Liquid I.V."]