[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"delayed-neurocognitive-recovery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:delayed-neurocognitive-recovery":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,51,89,112,142,166],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100641106","targeted-temperature-management-on-delayed-neurocognitive-recovery-in-older-patients-after-major-cancer-surgery-100641106",false,"NCT07655687","Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery","Intraoperative Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery: a Multicenter Randomized Trial","Inclusion Criteria:\n\n1. Age ≥ 65 years.\n2. Planned potentially curative initial cancer surgery with an expected duration of 2 hours or longer under general anesthesia.\n\nExclusion Criteria:\n\n1. Preoperative fever (tympanic temperature ≥ 38℃).\n2. Known or suspected preoperative infection.\n3. Previous schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or preexisting delirium.\n4. Inability to communicate due to coma, severe dementia, or hearing or speech impairment.\n5. Critically ill patients, defined as NYHA functional class \\> III or LVEF \\\u003C 30%, Child-Pugh class C, preoperative dialysis dependence, ASA physical status \\> IV, or expected survival \\\u003C 24 hours.\n6. Surgery for breast cancer, intracranial tumors, or rare cancers.\n7. Planned to undergo therapeutic hypothermia.\n8. Body mass index \\> 30 kg\u002Fm² (to facilitate temperature management).\n9. Previous enrollment in this study.\n10. Other conditions deemed unsuitable for study participation.",true,"ALL","65 Years",{"count":20,"type":21},1512,"ESTIMATED","INTERVENTIONAL",[24],"NA","With aging population, more older patients will receive major surgery for cancer. Older patients are at increased risk of postoperative neurocognitive complications including delayed neurocognitive recovery (dNCR), which is associated with prolonged hospital stay, raised complications, and impaired quality of life. Intraoperative hypothermia occurs in 57.1%-78.6% of patients undergoing major cancer surgery, especially in the elderly. Studies show that intraoperative hypothermia suppresses immune function, interferes with anesthetic metabolism, and delays anesthesia emergence. All these may be correlated with the occurrence of early postoperative dNCR. This study aims to verify whether intraoperative targeted temperature management (target core temperature: 36.8°C) compared with conventional temperature management (core temperature: 35.5°C) can reduce the incidence of dNCR in older patients undergoing major cancer surgery.",[27,28,29,30,31],"Elderly Patients","Cancer Surgery","Hypothermia, Accidental","Targeted Temperature Management","Delayed Neurocognitive Recovery",[33,34,35,36,37],"elderly patient","major cancer surgery","intraoperativ hypothermia","targeted temperature management","delayed neurocognitive recovery","NOT_YET_RECRUITING","2026-06-18",{"date":41,"type":42},"2026-06-23","ACTUAL",{"date":44,"type":21},"2026-06",{"date":46,"type":21},"2028-11",{"name":48,"class":49},"Peking University First Hospital","OTHER",2,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":18,"enrollmentInfo":59,"targetDuration":61,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":73,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100643122","the-effects-of-anesthesia-on-postoperative-cognitive-functions-in-patients-undergoing-sleeve-gastrectomy-100643122","NCT07637357","The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy","The Effects of Total Intravenous Anesthesia and Inhalational Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy","Inclusion Criteria:\n\nPatients of both sexes, Patients Aged between 18 and 65 years, Patients classified as ASA(American Society of Anesthesiologists) physical status I- III, Patients with a BMI (Body Mass Index) between 35 and 50 kg\u002Fm² scheduled to undergo sleeve gastrectomy as a type of bariatric surgery for the first time.\n\nExclusion Criteria:\n\nPatients classified as ASA physical status 4 or high, Patients with known allergy to any of the drugs used in the study, Patients with bleeding disorders, Patients with serum creatinine levels \\>2 mg\u002FdL, Patients with severe arrhythmias and EF\\\u003C30%, Patients with a known history of drug abuse are excluded.","18 Years",{"count":60,"type":21},60,"3 Months","OBSERVATIONAL","In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity. The investigators believe that the anesthesia method we apply with inhalation gases is also as reliable method as total intravenous anesthesia for postoperative cognitive functions in these patients who undergoe sleeve gastrectomy.\n\nThe anesthesia method applied intravenously and with inahalational gases have been applied safely for many years. Comparisons between these two anesthesia technics in obese individuals and for postoperative cognitive dysfunctions are limited.\n\nStudies on the examination of cognitive functions in postoperative patients have gained momentum with the use of neuropsychiatric tests performed on patients who have undergone cardiac surgery and these tests have also been performed on individuals who have undergone non-cardiac surgery. And yet, similar declines in cognitive functions have been observed. For these reasons, the effects of surgery itself and anesthesia methods on cognitive functions have been studied up to date.\n\nIn this study, the investigators plan to evaluate patients who will undergo obesity surgery in both anesthesia methods by the recovery times from anesthesia and the residual effects of anesthesia, and after awakening they plan to evaluate their cognitive functions with neuropsychiatric tests that will be performed at certain intervals.",[65,66,67,68,69,31,70,71,72],"POCD - Postoperative Cognitive Dysfunction","Recovery Time","Postoperative Neurocognitive Disorder","Postoperative Delirium","Bariatric Sleeve Gastrectomy","Total Intravenous Anesthesia","Inhalational Anesthesia","Cognitive Functions",[74,75,76,77],"total intravenous anesthesia","inhalational anesthesia","sleeve gastrectomy","postoperative cognitive dysfunctions","RECRUITING","2026-06-04",{"date":81,"type":42},"2026-06-09",{"date":83,"type":42},"2025-09-30",{"date":85,"type":21},"2026-07-30",{"name":87,"class":49},"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital",1,{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":22,"phases":99,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":88},"100544928","digital-sleep-optimization-for-brain-health-outcomes-in-older-surgical-patients-100544928","NCT06375265","Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients","A Pilot Study of Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST)","SLEEP-BOOST","Inclusion Criteria:\n\n1. Adults ≥ 65 years old\n2. Scheduled for an elective orthopedic total joint replacement procedure (knee\u002Fhip)\n3. At least mild insomnia (ISI score of ≥10 on telephone screening or RedCap screening questionnaire)\n\n5\\. Own a smart phone 6. Willingness to use the dCBT-I app and actigraphy.\n\nExclusion Criteria:\n\n1. Current or previous CBT-I exposure in the last 6 months prior to the start of the study\n2. Rapidly progressive illnesses\u002Flife expectancy \\\u003C6 months\n3. Active psychosis\u002Fsuicidal ideation\n4. Irregular shift work\u002Fsleep patterns\n5. Moderate-severe sleep apnea (apnea\u002Fhypopnea index ≥15) without CPAP compliance per chart review\n6. Sleep disorders other than insomnia or apnea\n7. Cognitive impairment (diagnosis of dementia)\n8. Initiation, discontinuation, or dose change of sleep-affecting prescription medications within 1 month prior to study start or during the intervention period; not excluded if stable sleep-affecting medications in the prior month (by clinical review)\n9. No surgery within 12 months of consented, eligibility will be reassessed if surgery is delayed by more than 3 months",{"count":98,"type":21},50,[24],"The Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST) is a pilot randomized, controlled, singled-blinded (participant) trial in major orthopedic joint surgery patients that will build on a previously clinically tested cognitive behavioral therapy for insomnia (CBT-I) mobile application paired with a wearable device (wrist actigraphy).",[102,68,31,67],"Insomnia","2026-05-11",{"date":105,"type":42},"2026-05-14",{"date":107,"type":42},"2025-01-15",{"date":109,"type":21},"2026-12-31",{"name":111,"class":49},"Massachusetts General Hospital",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":122,"briefSummary":124,"conditions":125,"keywords":129,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":50},"100633180","phase-4-impact-of-esketamine-on-delayed-neurocognitive-recovery-in-older-patients-100633180","NCT07523334","Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients","Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients Undergoing Non-cardiac Surgery: a Two-center, Dose-exploring Pilot Trial","Inclusion Criteria:\n\n1. Aged \\>=65 but \\\u003C= 90 years;\n2. Scheduled to undergo non-cardiac surgery with an expected duration of \\>= 2 hours under general anesthesia;\n3. Requiring patient-controlled intravenous analgesia (PCIA) after surgery.\n\nExclusion Criteria:\n\n1. Unable to communicate preoperatively due to visual or auditory impairment, language barrier, or severe dementia;\n2. Comorbid with schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis;\n3. Traumatic brain injury or neurosurgery;\n4. Severe hepatic dysfunction (Child-Pugh Class C), severe renal dysfunction (receiving dialysis preoperatively), or American Society of Anesthesiologists physical status classification \\>= Ⅳ;\n5. Expected admission to the Intensive Care Unit with endotracheal intubation after surgery;\n6. Anaphylaxis to esketamine;\n7. Participation in other clinical studies, or any other conditions that are considered unsuitable to be involved in the study.","90 Years",{"count":121,"type":21},120,[123],"PHASE4","Esketamine is frequently used during the perioperative period for supplemental analgesia. Small sample size trials showed that subanesthetic dose esketamine may decrease postoperative neurocognitive complications. However, conflicting results exist and optimal dose of esketamine remains to be determined. This dose-exploring pilot trial is designed to evaluate the safety and efficacy of three different perioperative esketamine dosing regimens in older patients undergoing major non-cardiac surgery. The primary purpose is to explore the optimal dosing strategy that produce maximal neurocognitive benefits with minimal adverse neuropsychiatric symptoms.",[126,127,31,68,128],"Elderly","Noncardiac Surgery","Esketamine",[130,131,132,133,128],"Older patients","Noncardiac surgery","Delayed neurocognitive recovery","Postoperative delirium","2026-04-09",{"date":136,"type":42},"2026-04-14",{"date":138,"type":21},"2026-04",{"date":140,"type":21},"2026-12",{"name":48,"class":49},{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":22,"phases":151,"briefSummary":152,"conditions":153,"keywords":156,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":163,"leadSponsor":165,"locationsCount":88},"100629826","phase-4-anesthesia-maintenance-with-target-controlled-infusion-of-propofol-and-remifentanil-at-fixed-ratio-100629826","NCT07479719","Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio","Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio on Neurocognitive Recovery in Older Patients After Surgery: a Randomized Trial","Inclusion Criteria:\n\n1. Aged ≥ 65 years.\n2. Scheduled to undergo noncardiac surgery expected to last ≥ 1 hour under general anesthesia.\n3. Require patient-controlled intravenous analgesia after surgery.\n4. Provide written informed consent.\n\nExclusion Criteria:\n\n1. Inability to communicate in the preoperative period because of coma, profound dementia, language barrier, or other reasons.\n2. Previous history of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis.\n3. Traumatic brain injury or neurosurgery.\n4. Severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m2), or critical illness (preoperative American Society of Anesthesiologists physical status classification ≥IV).\n5. Planned ICU admission with endotracheal intubation after surgery.\n6. Enrolled in the other studies.\n7. Other reasons that are considered unsuitable for study participation by the responsible surgeons or investigators.",{"count":150,"type":21},200,[123],"The impact of anesthesia depths on early postoperative neurocognitive complications after total intravenous anesthesia (TIVA) remains controversial. In some studies investigating TIVA, anesthesiologists mainly achieve the target depth of anesthesia by adjusting the dose of propofol, whereas the doses of opioids remains comparable between different anesthetic depth groups, possibly resulting inadequate analgesia. This study is aimed to investigate the impact of different anesthesia depths maintained by target-controlled infusion of propofol and remifentanil at a fixed ratio on the incidence of early postoperative neurocognitive complications in older patients undergoing noncardiac surgery.",[126,154,155,70,31],"Surgery","Depth of Anesthesia",[126,154,157,158,132],"Depth of anesthesia","Total intravenous anesthesia","2026-03-15",{"date":161,"type":42},"2026-03-18",{"date":138,"type":21},{"date":164,"type":21},"2027-01",{"name":48,"class":49},{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":173,"targetDuration":4,"studyType":22,"phases":175,"briefSummary":176,"conditions":177,"keywords":181,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":189,"leadSponsor":191,"locationsCount":192},"100553181","repetitive-transcranial-magnetic-stimulation-and-postoperative-neurocognitive-recovery-100553181","NCT06482749","Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery","Impact of Repetitive Transcranial Magnetic Stimulation on Postoperative Neurocognitive Recovery in Older Patients With Preoperative Cognitive Impairment: A Randomized, Double-blinded, Sham-controlled Trial","Inclusion Criteria:\n\n1. Aged ≥65 years;\n2. Patients with preoperative mild to moderate cognitive impairment, defined as 9\\\u003CMontreal Cognitive Assessment (MoCA)\\\u003C26;\n3. Scheduled for elective non-cardiac surgery under general anesthesia, with an expected surgical duration of \\>2 hours;\n4. Expected to stay in hospital for at least 5 days after surgery.\n\nExclusion Criteria:\n\n1. Left-handed;\n2. Primary school education level or below;\n3. Comorbid diseases including mental illness, intellectual disability, auditory and visual dysfunction, language impairment, severe neurological disorders, or other diseases that impede the completion of evaluation;\n4. Neurosurgery;\n5. Presence of contraindications to rTMS treatment, including epilepsy, pregnant or lactating women, or with a metal or electric implanted device (e.g., deep brain stimulator, ventriculoperitoneal shunt, aneurysm clip, pacemaker, cochlear implant, or surgical staples on the scalp);\n6. Other situations that are deemed unsuitable for inclusion in the study.",{"count":174,"type":21},568,[24],"Patients with preoperative cognitive impairment are at increased risks of delayed neurocognitive recovery (DNR) and postoperative neurocognitive disorder (POCD). Repetitive transcranial magnetic stimulation (rTMS) has been used to improve cognitive function in patients with cognitive impairement. This trial is designed to compare the effects of rTMS versus sham intervention on postoperative neurocognitive function in patients with preoperative cognitive impairment.",[178,179,180,31,67],"Older Patients","Cognitive Impairment","Repetitive Transcranial Magnetic Stimulation",[130,182,183,132,184],"Cognitive impairment","Repetitive transcranial magnetic stimulation","Postoperative neurocognitive disorder","2025-07-28",{"date":187,"type":42},"2025-07-31",{"date":185,"type":42},{"date":190,"type":21},"2029-02",{"name":48,"class":49},3]