[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"delayed-sleep-phase\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:delayed-sleep-phase":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100552306","pathophysiology-of-circadian-rhythm-delayed-sleep-wake-phase-disorder-100552306",false,"NCT06471374","Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder","Inclusion Criteria:\n\n* Delayed sleep wake phase disorder diagnosis\n* Altitude history: currently residing at Denver altitude or higher\n* BMI normal to moderately overweight\n\nExclusion Criteria:\n\n* Recent medical condition\n* Psychiatric disorder\n* Sleep disorder\n* Medication use",true,"ALL","16 Years","40 Years",{"count":20,"type":21},66,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this study is to understand factors that contribute to delayed sleep wake phase disorder (DSWPD). The investigators will examine whether patients with DSWPD exhibit alterations in circadian rhythms and sensitivity to light compared to healthy controls. The investigators will also test a new method of predicting circadian rhythms form a blood sample.",[27,28],"Delayed Sleep Phase Syndrome","Delayed Sleep Phase","RECRUITING","2026-06-15",{"date":32,"type":33},"2026-06-17","ACTUAL",{"date":35,"type":33},"2024-04-02",{"date":37,"type":21},"2028-07",{"name":39,"class":40},"University of Colorado, Boulder","OTHER",2,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":67},"100625597","effect-of-bright-light-therapy-on-idiopathic-scoliosis-100625597","NCT07424703","Effect of Bright Light Therapy on Idiopathic Scoliosis","Effect of Morning Bright Light Therapy on the Onset and Progression of Idiopathic Scoliosis: A Prospective, Single-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age between 10 and 15 years.\n2. Classified as evening chronotype based on the reduced Horne-Östberg Morningness-Eveningness Questionnaire (rMEQ), defined as a score \\\u003C 12.\n3. Has undergone radiographic evaluation (standing full-spine X-ray) for idiopathic scoliosis at the initial clinic visit.\n4. Skeletally immature (Risser sign 0-3) with a major Cobb angle \\\u003C 40 degrees at baseline.\n5. Written informed consent\u002Fassent provided by the participant and legal guardian.\n6. Willing and able to comply with the study protocol, including device use and scheduled follow-ups.\n\nExclusion Criteria:\n\n1. Plans to relocate outside the study area within the next 24 months.\n2. Use of medications that may interfere with circadian rhythm within the past 3 months (e.g., lithium, exogenous melatonin, melatonergic antidepressants).\n3. Trans-meridian travel across at least two time zones within the past 3 months or anticipated during the study period.\n4. Presence of any eye disease (e.g., glaucoma, retinal disease, macular degeneration) that could be exacerbated by or interfere with light therapy.\n5. Clinically diagnosed sleep disorder (e.g., narcolepsy, restless legs syndrome) or prominent medical condition known to interfere with sleep continuity and quality (e.g., moderate-to-severe eczema).\n6. Severe chronic health conditions that could confound study outcomes, including but not limited to:\n\n   * Known syndromic, neuromuscular, or congenital musculoskeletal causes of scoliosis.\n   * History of spine surgery or significant spinal trauma.\n   * Spinal tumor.\n   * Leg length discrepancy \\> 20 mm.\n   * Other severe chronic diseases (e.g., poorly controlled diabetes, chronic liver or renal disease, malabsorption syndromes).\n   * Severe obesity (body mass index z-score ≥ 3).","10 Years","15 Years",{"count":52,"type":21},120,[24],"This trial aims to investigate whether morning bright light therapy can reduce the progression rate of idiopathic scoliosis in children and potentially prevent its de novo development.",[56,57,28],"Idiopathic Scoliosis","Eveningness","2026-05-14",{"date":60,"type":33},"2026-05-19",{"date":62,"type":33},"2025-09-01",{"date":64,"type":21},"2028-09-01",{"name":66,"class":40},"Second Affiliated Hospital of Wenzhou Medical University",1,{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":67},"100526831","better-sleep-study-100526831","NCT06139861","Better Sleep Study","A Confirmatory Efficacy Trial of Engaging a Novel Sleep\u002FCircadian Rhythm Target as Treatment for Depression in Adolescents","Inclusion Criteria:\n\nExclusion Criteria:\n\n* mental health\u002Fbehavioral symptoms that would preclude productive engagement in study assessments or intervention (e.g., active psychosis; Bipolar Disorder; drug dependence\n* severe or unstable medical or psychiatric condition such that treatment has changed within the last month or is expected to change during the course of the study or that would preclude ability to adhere to study procedures (e.g. terminal end-stage cancer)\n* current use of medications or herbs with known effects on sleep\n* plan to undergo or have had medication change in the last 8 weeks","12 Years","18 Years",{"count":78,"type":21},200,[24],"The overall aim of this proposal is a confirmatory efficacy trial sufficiently powered and designed to test the hypothesis that improving the relationship between biological circadian timing and waketime, a novel modifiable target, improves depression outcomes in a subgroup of adolescents with depression and a misaligned relationship between biological circadian timing and waketime utilizing a cognitive-behavioral sleep intervention.",[82,28],"Depression in Adolescence",[84,85,86,87],"Depression","Adolescents","Sleep","Intervention","2026-05-07",{"date":90,"type":33},"2026-05-11",{"date":92,"type":33},"2024-03-15",{"date":94,"type":21},"2028-08-01",{"name":96,"class":40},"Children's Hospital Los Angeles"]