[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"delirium---postoperative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:delirium---postoperative":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,44,70,99,130,154,183,208,228,249,272,294,316,337,359,384,410,438,466,488,509,537,565,601,623],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100644541","cerebral-autoregulation-and-delirium-study-100644541",false,"NCT07671404","Cerebral Autoregulation and Delirium Study","Reducing Delirium After Cardiac Surgery: Personalized Targeted Blood Pressure Management Strategy Using Cerebral Autoregulation Monitoring: A Pilot Study","AUTO-POD","Inclusion Criteria:\n\n• Consenting patients aged ≥ 60 years undergoing elective complex cardiac surgery (coronary artery bypass grafting plus valve surgery, double-valve surgery, triple-valve surgery, redo operations, or aortic arch surgery), or patients aged ≥ 70 years undergoing isolated coronary artery bypass grafting or single-valve repair\u002Freplacement surgery.\n\nExclusion Criteria:\n\n* Patients with symptomatic cerebrovascular disease.\n* History of delirium.\n* Major neurocognitive impairment (e.g., dementia or Mini-Mental State Examination score \\\u003C 10).\n* Schizophrenia.","ALL","60 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Approximately one in four elderly patients develops postoperative delirium (POD) after cardiac surgery. POD is associated with prolonged hospitalization, increased mortality, and higher health care costs. While patient-related risk factors are often difficult to modify, surgery- and anesthesia-related factors may be optimized to reduce the incidence of POD. One potentially modifiable factor is intraoperative blood pressure management. Current practice commonly relies on standardized blood pressure targets during cardiac surgery; however, this \"one-size-fits-all\" approach may not account for individual variability in cerebral perfusion requirements. This study proposes a personalized blood pressure management strategy based on real-time monitoring of cerebral autoregulation, with the goal of maintaining optimal cerebral perfusion and protecting the brain from both hypo- and hyper-perfusion",[28,29],"Delirium - Postoperative","Cardiac Surgery",[31],"Cerebral Autoregulation Monitoring","NOT_YET_RECRUITING","2026-06-22",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":22},"2026-06-01",{"date":40,"type":22},"2028-06-30",{"name":42,"class":43},"University Health Network, Toronto","OTHER",{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100643250","vr-based-cognitive-stimulation-games-for-delirium-prevention-100643250","NCT07641153","VR-Based Cognitive Stimulation Games for Delirium Prevention","Virtual Reality-Based Cognitive Stimulation Games for Enhancing Attention and Preventing Delirium in Older Surgical Patients With Cognitive Impairment","Inclusion Criteria:\n\n* Men and women ≥65 years of age\n* Have a pre-existing diagnosis of cognitive impairment (Montreal Cognitive Assessment Score of 15-24)\n* Elective or emergency major surgery with the expectation of admission to the Intensive Care Unit following the surgery for three days following surgery\n\nExclusion Criteria:\n\n* Pre-existing Intubation and invasive ventilation;\n* history of severe mental illness;\n* admission for a drug overdose;\n* severe vertigo;\n* history of severe postoperative nausea and vomiting;\n* hearing and visual impairment;\n* preexisting severe dementia (Montreal Cognitive Assessment Score \\\u003C 15; and\n* active delirium at the time of screening for eligibility criteria.\n* Active suicidal ideation or behavior Screen failure after surgery\n* Prolonged intubation after surgery (more than 24 hours)","65 Years",{"count":53,"type":22},90,[25],"This trial aims to evaluate the feasibility, safety, and acceptability of a virtual reality (VR)-based cognitive stimulation game to reduce postoperative delirium among older surgical patients at high risk due to pre-existing cognitive impairment.",[57,28,58],"Surgery","Delirium","RECRUITING","2026-06-08",{"date":62,"type":36},"2026-06-11",{"date":64,"type":36},"2026-04-24",{"date":66,"type":22},"2029-05-01",{"name":68,"class":43},"The Methodist Hospital Research Institute",2,{"id":71,"slug":72,"hasResults":12,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":12,"sex":18,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":98},"100640485","postoperative-gi-dysfunction-and-nutrition-in-malnourished-cancer-surgery-patients-100640485","NCT07622888","Postoperative GI Dysfunction and Nutrition in Malnourished Cancer Surgery Patients","Gastrointestinal Dysfunction, Nutritional Status, and Delirium in the Early Postoperative Period in Oncologic Surgical Patients With Pre-existing Malnutrition: A Prospective Two-Center Observational Cohort Study","GIDNUT","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Histologically confirmed malignant tumor of the abdomen or pelvis with planned radical or cytoreductive surgery.\n* Baseline malnutrition defined as NRS2002 ≥ 3 and at least one phenotypic and one etiologic GLIM criterion.\n* Expected postoperative hospitalization ≥ 7 days.\n* Ability to undergo baseline cognitive and nutritional assessments (MoCA, NRS2002, GLIM, PG-SGA) prior to surgery.\n* Signed informed consent for participation and data collection.\n\nExclusion Criteria:\n\n* Severe decompensated hepatic or renal failure rendering surgery infeasible.\n* Documented preexisting severe cognitive impairment or dementia precluding valid postoperative cognitive\u002Fdelirium assessment (e.g., MoCA \\\u003C 18 or documented dementia).\n* Pregnancy or breastfeeding.\n* Participation in another interventional randomized clinical trial within the prior 30 days that could confound outcomes.\n* Inability to ensure postoperative follow-up or reliable data collection (planned transfer without access, loss of contact).","18 Years",{"count":80,"type":22},120,"OBSERVATIONAL","This is a prospective two-center observational cohort study in adult patients undergoing major abdominal and\u002For pelvic oncologic surgery with pre-existing malnutrition. The study describes the course of postoperative gastrointestinal dysfunction and evaluates whether real-world exposure to parenteral serotonin as part of routine postoperative care is associated with a higher proportion of patients whose gastrointestinal dysfunction regresses to LIFE score less than or equal to 1 by postoperative day 5 (plus or minus 1 day), compared with patients not exposed to serotonin.\n\nAll treatment decisions, including the use of parenteral serotonin, metoclopramide, neostigmine, nutritional support, and other postoperative management, are made solely by the treating physicians in accordance with routine clinical practice. The protocol does not assign, randomize, require, or restrict any drug treatment; it records real-world care, daily LIFE assessments during postoperative days 1 through 7, nutritional status measures, body composition where available, delirium screening, complications, length of stay, and mortality.",[84,85,28,86,87],"Gastrointestinal Dysfunction","Malnutrition","Abdominal Neoplasm","Pelvic Neoplasm","2026-05-31",{"date":90,"type":36},"2026-06-03",{"date":92,"type":22},"2026-10-01",{"date":94,"type":22},"2029-03-01",{"name":96,"class":97},"Arma Ltd.","INDUSTRY",1,{"id":100,"slug":101,"hasResults":12,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":12,"sex":18,"minAge":78,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":108,"conditions":109,"keywords":113,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":4},"100639710","prospective-neuropsychological-evaluation-of-the-implementation-of-a-heart-valve-unit-hvu-neuro-100639710","NCT07626567","Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO)","HVU-NEURO","Inclusion Criteria:\n\n* Severe aortic valve stenosis\n* Indication for transcatheter valve therapy according to current guideline recommendations and\u002For Heart-Team consensus\n* Sufficient German language proficiency, as study-related tests, questionnaires, and instructions are administered in German\n* Age ≥18 years\n* Willingness to participate voluntarily with written informed consent\n\nExclusion Criteria:\n\n* Known pregnancy at the time of study inclusion\n* Life expectancy \\\u003C1 year due to non-cardiac disease\n* Pre-interventional psychiatric and neurological disorders (known and diagnosed dementia, depression, history of stroke or transient ischemic attack \\[TIA\\], migraine, epilepsy) with acute symptoms that may interfere with data collection",{"count":107,"type":22},500,"Transcatheter aortic valve implantation (TAVI) is an established treatment for severe aortic stenosis. Despite improved procedural outcomes, neurocognitive complications such as postoperative delirium (POD) and postoperative cognitive decline (POCD) remain clinically relevant.\n\nHeart Valve Units (HVU) are specialized interdisciplinary care structures designed to improve treatment pathways and healthcare quality. However, their impact on neuropsychological outcomes has not been sufficiently investigated.\n\nHVU-NEURO is a prospective observational cohort study evaluating neuropsychological outcomes before and after implementation of an HVU. Approximately 500 patients undergoing transcatheter valve therapy will be included.\n\nNeurocognitive function will be assessed before intervention, at hospital discharge, and three months after intervention. POD will be assessed using the Intensive Care Delirium Screening Checklist (ICDSC). The primary objective is to evaluate the effect of HVU implementation on postoperative cognitive decline at discharge from acute hospital care.",[110,111,28,112],"Aortic Valve Stenosis","Postoperative Cognitive Dysfunction (POCD)","Neurocognitive Disorders",[114,115,116,117,118,119,120],"TAVI","HVU","Postoperative Cognitive Decline","Postoperative Delirium","Neuropsychology","Transcatheter Aortic Valve Implantation","Intensive Care Delirium Screening Checklist","2026-05-29",{"date":123,"type":36},"2026-06-04",{"date":125,"type":22},"2026-05-25",{"date":127,"type":22},"2028-02",{"name":129,"class":43},"Heart and Brain Research Group, Germany",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":12,"sex":18,"minAge":78,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":23,"phases":139,"briefSummary":140,"conditions":141,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":4},"100619861","bis-in-icu-interventional-study-100619861","NCT07350122","BIS in ICU Interventional Study","Effect of BIS-Guided Sedation on Clinical Outcomes in Postoperative Cardiac Surgery ICU Patients: A Prospective, Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Undergoing cardiac surgery with subsequent admission to the intensive care unit (e.g., valve surgery, coronary artery bypass grafting, aortic surgery)\n* Planned or expected duration of invasive mechanical ventilation \\> 6 hours postoperatively\n* Requirement for continuous sedation during ICU stay\n\nExclusion Criteria:\n\n* Pre-existing neurological disorders affecting consciousness or sedation assessment (e.g., severe dementia, epileptic encephalopathy).\n* Acute neurological events in the perioperative period (e.g., stroke, intracranial hemorrhage).\n* Severe hepatic dysfunction (Child-Pugh Class C).\n* Participation in another interventional study potentially affecting sedation or cognitive outcomes.\n* Pregnancy or lactation.\n* Do-not-intubate (DNI)\u002FDo-not-resuscitate (DNR) orders or documented limitation of therapy.\n* Patients in whom short-term survival is deemed unlikely due to the clinical course.",{"count":138,"type":22},144,[25],"This study will test whether using a Bispectral Index (BIS) monitor to guide sedation can reduce the amount of sedative medication given to adults in the intensive care unit (ICU) after cardiac surgery. BIS is a non-invasive, EEG-based monitor that shows a number from 0-100 to reflect level of consciousness. Researchers will compare BIS-guided sedation to standard sedation guided by clinical scales (such as the Richmond Agitation-Sedation Scale, RASS).\n\nAbout 144 participants will be randomly assigned (1:1) to one of two groups at two hospitals in Austria (Medical University of Graz and Klinikum Wels-Grieskirchen). In the BIS group, clinicians will use BIS values and standard care to titrate sedation and will aim to avoid sustained BIS values below 50. In the control group, sedation will follow standard practices using clinical scales; BIS will be recorded but hidden from caregivers. The trial is open-label for treating staff; outcome assessors and data analysts will be blinded.\n\nParticipants will be in the study during their ICU sedation and mechanical ventilation period (typically more than 6 hours), with follow-up through ICU and hospital discharge. The primary outcome is the time-averaged dose of propofol (mg\u002Fkg\u002Fh) given during continuous ICU sedation until weaning (up to 72 hours). Secondary outcomes include duration of ventilation and sedation, depth of sedation measures, sedative and catecholamine doses, pulmonary infections (including ventilator-associated pneumonia), ICU and hospital length of stay, delirium, and in-hospital mortality.\n\nRisks are minimal and may include mild skin irritation from forehead electrodes. Possible benefits include improved sedation management; benefits are not guaranteed. Taking part is voluntary.",[142,143,144,28,145],"Cardiac Surgical Procedures (Postoperative Population)","Critical Illness","Postoperative Complications (Cardiopulmonary)","Pneumonia, Ventilator-Associated","2026-05-28",{"date":121,"type":36},{"date":149,"type":22},"2026-07",{"date":151,"type":22},"2027-06",{"name":153,"class":43},"Medical University of Graz",{"id":155,"slug":156,"hasResults":12,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":162,"sex":18,"minAge":78,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":23,"phases":165,"briefSummary":166,"conditions":167,"keywords":170,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":179,"leadSponsor":181,"locationsCount":98},"100633952","extended-emergence-strategy-on-post-anesthesia-care-unit-events-after-outpatient-orthopedic-surgery-100633952","NCT07533370","Extended Emergence Strategy on Post-Anesthesia Care Unit Events After Outpatient Orthopedic Surgery","Extended Emergence Trajectory on Post-Anesthesia Care Units Events in Ambulatory Lower-Extremity Orthopedic Surgery: A Randomized Controlled Trial","PACU-EMERGE","Inclusion Criteria:\n\n* Participants with American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for Elective Foot\u002FAnkle Orthopaedic surgery at Stanford Health under planned propofol-based intravenous anesthesia and regional nerve block for preoperative analgesia\n* Able and willing to complete all cognitive assessments and Brice Interview in PACU\n\nExclusion Criteria:\n\n* ASA physical status IV or V\n* Chronic opioid therapy\n* Chronic benzodiazepine use or ongoing treatment with strongly anticholinergic medications within 30 days prior to surgery.\n* Known major neuro-cognitive disorder, active psychotic disorder, or other severe psychiatric condition that, in the opinion of the investigator, would interfere with valid cognitive testing.\n* Active cardiac or neurological stimulators or pumps in use\n* Severe uncorrected visual or hearing impairment that precludes valid cognitive battery or interview completion.\n* Inability to speak and understand the study language sufficiently to provide informed consent and complete study assessments.\n* Inability to provide informed consent or lack of a legally authorized representative when required.\n* Concurrent participation in another interventional study that could confound PACU cognitive or delirium outcomes.",true,{"count":164,"type":22},300,[25],"The goal of this clinical trial is to learn if an extended emergence from anesthesia can improve recovery room (Post-Anesthesia Care Unit or PACU) outcomes in lower-leg or foot surgery with nerve blocks. The primary questions it aims to answer are:\n\n* Does a longer wake-up help participants think more clearly soon after surgery compared with usual approaches?\n* Does it lower pain scores, lower the amount of pain medications used, and shorten the time it takes to go home from recovery room?\n\nResearchers will compare 2 groups of adults who are having similar lower-extremity orthopaedic surgeries with regional and propofol anesthesia.",[168,169,28],"Perioperative Care","EEG Power Spectra",[171,172,173,174],"Post-anesthesia care unit (PACU)","Postoperative delirium","EEG-guided anesthesia","Neurocognitive outcomes","2026-05-19",{"date":177,"type":36},"2026-05-22",{"date":149,"type":22},{"date":180,"type":22},"2027-10",{"name":182,"class":43},"Harrison Shong-Wen Chow",{"id":184,"slug":185,"hasResults":12,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":4,"eligibilityCriteria":189,"healthyVolunteers":12,"sex":18,"minAge":190,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":23,"phases":193,"briefSummary":194,"conditions":195,"keywords":198,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":201,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":69},"100588237","how-bleeding-affects-delirium-in-older-patients-with-hip-fractures-the-improve-hip-study-100588237","NCT06938789","How Bleeding Affects Delirium in Older Patients With Hip Fractures: The IMPROVE-HIP Study","The Impact of Bleeding on Delirium Outcomes in Older Patients With Hip Fractures: A Single-Blind, Randomized Controlled Trial - The IMPROVE-HIP Study","Inclusion Criteria:\n\n* Hip fracture\n\nExclusion Criteria:\n\n* Pathological hip fracture\n* Periprosthtic fracture\n* Unable to speak or understand Danish\n* Does not wish to recieve blood transfusion\n* If the investigator finds the patient unable to cooperate to the study (e.g. in case of severe dementia and externalizing behaviour)","75 Years",{"count":192,"type":22},198,[25],"The goal of this clinical trial is to investigate whether early detection of bleeding and prompt blood transfusions can help prevent delirium in patients aged 75 and older who are admitted to the hospital with hip fractures. The main question the trial aims to answer is:\n\nDo patients aged 75 and older with hip fractures benefit from earlier treatment of anemia (low blood count) to reduce the risk of delirium?\n\nResearchers will compare early diagnosis and treatment of bleeding with standard care to determine if it helps lower the risk of developing delirium.\n\nParticipants will:\n\nUndergo blood tests, have their vital signs monitored, and be screened for delirium three times a day for the first 48 hours after surgery.\n\nReceive blood transfusions promptly if their hemoglobin levels fall below a specified threshold.\n\nAttend a follow-up visit at 30 days to assess cognitive function and overall quality of life.\n\nAttend another follow-up at 90 days to evaluate hospital readmissions and survival.",[196,197,28],"Bleeding","Hip Fracture",[199,58,200],"Hip fracture","Blood transfusion",{"date":177,"type":36},{"date":203,"type":36},"2025-04-24",{"date":205,"type":22},"2027-06-01",{"name":207,"class":43},"University of Aarhus",{"id":209,"slug":210,"hasResults":12,"nctId":211,"briefTitle":212,"officialTitle":212,"acronym":4,"eligibilityCriteria":213,"healthyVolunteers":12,"sex":18,"minAge":78,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":216,"conditions":217,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":98},"100640099","metabolomics-and-biomarker-research-on-the-mechanism-of-preoperative-sleep-disorders-affecting-postoperative-outcomes-in-cardiac-surgery-patients-100640099","NCT07588178","Metabolomics and Biomarker Research on the Mechanism of Preoperative Sleep Disorders Affecting Postoperative Outcomes in Cardiac Surgery Patients","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Scheduled for elective cardiac surgery\n\nExclusion Criteria:\n\n1. Has a history of neurosurgery, or has suffered from neurological diseases such as cerebral hemorrhage, cerebral infarction, delirium, dementia, etc.\n2. Has a history of mental disorders.\n3. Heavy alcohol consumption.\n4. American Society of Anesthesiologists (ASA) classification level IV or above.\n5. Complicated with severe liver dysfunction (Child-Pugh C grade) or renal dysfunction (chronic kidney disease stage 3-4).\n6. Unable to communicate due to hearing or language problems, or refuses to sign the informed consent form.","80 Years",{"count":138,"type":22},"This study is titled \"Metabolomics and Biomarker Research on the Mechanism of Preoperative Sleep Disorders Affecting Postoperative Outcomes in Adult Cardiac Surgery\". It aims to clarify the perioperative metabolic changes caused by preoperative sleep disorders in adult cardiac surgery patients, providing ideas for exploring the mechanism by which sleep disorders affect adverse outcomes after cardiac surgery. The study will be conducted at Fuwai Hospital, Chinese Academy of Medical Sciences. By collecting perioperative blood and fecal samples from adult cardiac surgery patients with and without preoperative sleep disorders, and simultaneously recording postoperative clinical outcome indicators (such as the incidence of delirium within 7 days after surgery, cognitive function scores, mechanical ventilation time, ICU stay time, hospital stay time, and severe cardiovascular adverse events), the study will explore the impact of preoperative sleep disorders on perioperative plasma metabolic substances, inflammatory levels, nerve damage, oxidative stress levels, and intestinal flora in adult cardiac surgery patients under general anesthesia, providing ideas and evidence for exploring the mechanism by which preoperative sleep disorders affect postoperative outcomes in adult cardiac surgery patients under general anesthesia.",[28,218],"Sleep Problems","2026-05-08",{"date":221,"type":36},"2026-05-14",{"date":223,"type":36},"2026-01-01",{"date":225,"type":22},"2026-12-31",{"name":227,"class":43},"Yan Fuxia",{"id":229,"slug":230,"hasResults":12,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":162,"sex":18,"minAge":78,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":23,"phases":238,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":245,"leadSponsor":247,"locationsCount":4},"100636595","effectiveness-of-electroencephalography-guided-anesthesia-100636595","NCT07567729","Effectiveness of Electroencephalography Guided Anesthesia","A Pilot Study to Evaluate the Feasibility of EEG-guided Anesthesia Protocol to Reduce POD","EEG Anesthesia","Inclusion Criteria:\n\nPart A Inclusion Criteria:\n\n* Signed and dated informed consent form prior to any study-specific procedures.\n* Willingness and ability to comply with all study procedures and availability for the duration of the study, including all scheduled assessments and follow-up visits.\n* Currently practicing anesthetic provider, defined as either:\n\n  * Attending anesthesiologist, or\n  * Certified Registered Nurse Anesthetist (CRNA).\n* Limited prior formal training in EEG interpretation for anesthetic depth, as self-reported by the participant (see Exclusion Criteria for details).\n* Fluent in English, to ensure comprehension of study materials and assessments.\n* Able to access and utilize required technology (e.g., computer or tablet with internet access) for completion of digital modules and online assessments.\n* In good general health and capable of fulfilling clinical duties, as self-reported and confirmed by site investigator review.\n* Willingness to be randomized to any of the study arms and to participate in all assigned educational interventions and assessments.\n* Willingness to adhere to the protocol-specified anesthetic management strategy during the real-case assessments.\n\nPart B Inclusion Criteria:\n\n* Provides written, signed informed consent prior to the surgical procedure.\n* Is age 60 years or older.\n* Is scheduled to undergo an elective, non-cardiac, non-neurologic surgical procedure expected to last at least two hours.\n* Is planned to receive general anesthesia.\n* Has an American Society of Anesthesiologists (ASA) physical status of I, II, or III.\n* Has intact skin on the forehead suitable for the application of EEG electrodes.\n\nExclusion Criteria:\n\nPart A Exclusion Criteria:\n\n* Fellowship training in neuroanesthesia or neurocritical care.\n* Participation in EEG-related research or formal EEG training within the past 12 months.\n* Inability to access or utilize required technology (e.g., computer or tablet with internet access) necessary for completion of digital modules and online assessments.\n* Any condition (physical, psychological, or cognitive) that, in the opinion of the site investigator, would preclude full participation in study activities or completion of the study protocol.\n* Known allergy or sensitivity to materials used in EEG electrodes (e.g., adhesives or gels), if applicable.\n* Non-practicing anesthetic providers (e.g., retired, not currently providing clinical care).\n\nPart B Exclusion Criteria:\n\n* Is unable to provide legally effective informed consent.\n* Is scheduled for emergency, cardiac, or neurologic surgery.\n* Has an American Society of Anesthesiologists (ASA) physical status of IV or greater.\n* Has a pre-existing diagnosis of dementia, significant cognitive impairment, or other major neurologic disease (e.g., epilepsy, Parkinson's disease).\n* Has a known allergy to the adhesives or gels used with EEG electrodes.\n* Has a condition, such as a craniofacial deformity or skin condition on the forehead, that would prevent proper placement or functioning of the EEG monitor.\n* Currently pregnant.",{"count":237,"type":22},225,[25],"This study will use brain wave information, known as electroencephalography (EEG), to help guide anesthesia delivery during surgery. It is believed that the use of EEG has the potential to reduce postoperative delirium - a common side effect of general anesthesia. Postoperative delirium is known to cause long lasting cognitive deficits and increase the chance of developing dementia in geriatric patients. This study aims to reduce these risks posed by modern day anesthesia practices through more efficient delivery of anesthesia utilizing brain wave activity information.",[28],"2026-04-30",{"date":243,"type":36},"2026-05-05",{"date":38,"type":22},{"date":246,"type":22},"2031-01-01",{"name":248,"class":43},"Stanford University",{"id":250,"slug":251,"hasResults":12,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":162,"sex":18,"minAge":51,"maxAge":4,"enrollmentInfo":256,"targetDuration":257,"studyType":81,"phases":4,"briefSummary":258,"conditions":259,"keywords":260,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":98},"100617847","correlation-between-perioperative-eeg-variability-and-postoperative-delirium-incidence-100617847","NCT07323940","Correlation Between Perioperative EEG Variability and Postoperative Delirium Incidence.","Correlation Between Multiscale Entropy Analysis of Electroencephalograms and Postoperative Delirium Incidence.","Inclusion Criteria:\n\n1. Patients undergoing general anaesthesia with single-lumen endotracheal tube placement;\n2. Age ≥65 years, gender unrestricted, body mass index (BMI) 18-28 kg\u002Fm²;\n3. Normal mouth opening and head\u002Fneck mobility;\n4. Pre-anaesthesia American Society of Anaesthesiologists (ASA) physical status classification of I or II and Mallampati airway classification of I or II.\n\nExclusion Criteria:\n\n1. Individuals with psychiatric disorders, literacy issues, or communication difficulties who are unable to cooperate with POD screening;\n2. Patients with severe lesions in vital organs, such as the heart, lungs, brain, liver or kidneys.\n3. Those undergoing cardiac or neurosurgical procedures during this admission;\n4. A history of alcohol abuse or recent use of sedatives or opioids;\n5. haemoglobin \\\u003C100 g\u002FL;\n6. Participation in any clinical research studies within the past 3 months.",{"count":53,"type":22},"8 Days","This clinical study aims to investigate whether multiscale entropy analysis of electroencephalogram data can distinguish between ordinary elderly surgical patients and elderly patients with postoperative delirium.This study may help identify postoperative delirium in surgical patients at an early stage.",[28],[172,261,262],"electroencephalogram","Multiscale Entropy","2026-04-14",{"date":265,"type":36},"2026-04-16",{"date":267,"type":36},"2025-12-12",{"date":269,"type":22},"2027-12-12",{"name":271,"class":43},"Xin Chen",{"id":273,"slug":274,"hasResults":12,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":12,"sex":18,"minAge":51,"maxAge":4,"enrollmentInfo":280,"targetDuration":4,"studyType":23,"phases":281,"briefSummary":284,"conditions":285,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":98},"100633891","phase-2-intranasal-insulin-to-prevent-intensive-care-unit-delirium-100633891","NCT07532577","Intranasal Insulin to Prevent Intensive Care Unit Delirium","Intranasal Insulin for the Prevention of Delirium in ICU Patients Undergoing Elective Cardiac Surgery: a Randomized, Double-blind, Placebo-controlled Pilot Trial (INSPIRE)","INSPIRE","Inclusion Criteria:\n\n1. Age ≥65 years\n2. Planned surgical admission to the ICU of the Radboudumc following complex cardiac surgery with CPB. Complex cardiac surgery is defined as all cardiac on-pump procedures except for isolated CABG\n3. Able to receive intranasal spray (no obstructive nasal pathology precluding administration)\n4. Informed consent from patient\n\nExclusion Criteria:\n\n1. Delirium at hospital admission\n2. Non-complex or off-pump cardiac surgery\n3. Known allergy\u002Fhypersensitivity to insulin or formulation excipients\n4. Contra-indication for nasal administration (severe nasal pathology, recent nasal\u002Fsinus surgery, active epistaxis, active rhinitis, obstruction of either one or both nostrils)\n5. Participating in other investigational medication trial",{"count":5,"type":22},[282,283],"PHASE2","PHASE3","This study aims to assess the feasibility, tolerability, and exploratory efficacy of intranasal insulin to prevent delirium in ICU patients aged ≥65 years after complex elective cardiac surgery with cardiopulmonary bypass",[28],"2026-04-09",{"date":265,"type":36},{"date":289,"type":22},"2026-04-15",{"date":291,"type":22},"2026-08-15",{"name":293,"class":43},"Radboud University Medical Center",{"id":295,"slug":296,"hasResults":12,"nctId":297,"briefTitle":298,"officialTitle":298,"acronym":4,"eligibilityCriteria":299,"healthyVolunteers":12,"sex":18,"minAge":78,"maxAge":4,"enrollmentInfo":300,"targetDuration":301,"studyType":81,"phases":4,"briefSummary":302,"conditions":303,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":4},"100632209","value-of-the-time-weighted-average-twa-of-mean-arterial-pressure-map-and-cerebral-oximetry-rso-as-predictors-of-postoperative-tissue-perfusion-impairment-in-patients-undergoing-cardiac-surgery-100632209","NCT07510711","Value of the Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) and Cerebral Oximetry (rSO₂) as Predictors of Postoperative Tissue Perfusion Impairment in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* Age \\>18 years\n* Undergoing cardiac surgery, with or without cardiopulmonary bypass\n* Written informed consent\n* Preoperative cognitive status: Glasgow Coma Scale score of 15; no history of dementia; no evidence of cognitive impairment on baseline assessment; patient oriented and cooperative prior to surgery\n* Continuous intraoperative monitoring of mean arterial pressure (MAP) and cerebral regional oxygen saturation (rSO₂)\n\nExclusion Criteria:\n\n* History of dementia or cognitive impairment\n* Emergency surgeries",{"count":80,"type":22},"3 Months","Neurological problems after heart surgery are common and include confusion, memory loss, and difficulty thinking clearly. These issues may appear hours or days after surgery and can negatively affect recovery.\n\nDuring heart surgery, blood flow and oxygen delivery to the brain may decrease, causing changes in blood pressure and cerebral oxygenation. Previous studies suggest that prolonged drops in mean arterial pressure (MAP) or cerebral oxygenation (rSO₂) are linked to worse postoperative outcomes. Continuous monitoring of blood pressure and cerebral oxygenation is standard in cardiac surgery.\n\nThis study aims to evaluate the duration and severity of intraoperative drops in MAP and cerebral oxygenation. These measures may provide a more accurate assessment of neurological risk than isolated measurements.\n\nThe primary objective is to determine whether decreases in MAP and cerebral oxygenation, as well as their duration and intensity during surgery, are associated with postoperative neurological complications.\n\nThis is a prospective, observational study in adult patients undergoing cardiac surgery, with or without cardiopulmonary bypass (CPB). CPB diverts blood through a machine that performs the work of the heart and lungs while the heart is operated on. All patients will receive standard monitoring, including continuous MAP and cerebral oxygenation measurements. No additional interventions will be performed.\n\nNeurological status will be assessed using validated clinical scales before and after surgery. Other outcomes include kidney function, ICU and hospital stay length, postoperative complications, and in-hospital mortality.\n\nValidating these measures as a predictive tool could enable early identification of patients at higher risk of neurological injury and allow more individualized intraoperative management to reduce morbidity, hospital stay, and healthcare costs.",[28,111,304,305,306],"Postoperative Acute Kidney Injury","Postoperative Morbidity","Intensity Care Unit Length of Stay","2026-03-30",{"date":309,"type":36},"2026-04-03",{"date":311,"type":22},"2026-05-01",{"date":313,"type":22},"2027-11",{"name":315,"class":43},"Hospital Universitari Vall d'Hebron Research Institute",{"id":317,"slug":318,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":12,"sex":18,"minAge":51,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":325,"conditions":326,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":98},"100628588","cerebral-oxygen-consumption-response-to-increased-oxygen-supply-and-postoperative-delirium-in-older-surgical-patients-100628588","NCT07463586","Cerebral Oxygen Consumption Response to Increased Oxygen Supply and Postoperative Delirium in Older Surgical Patients","Association Between Cerebral Oxygen Consumption Responsiveness to Increased Oxygen Supply and Postoperative Delirium: A Prospective Observational Study Using Functional Near-Infrared Spectroscopy","Inclusion Criteria:\n\n* Patients undergoing elective laparoscopic surgery under general anesthesia\n* Age 65 years or older\n\nExclusion Criteria:\n\n* Diagnosis of dementia or presence of delirium before surgery\n* Loss of capacity to provide informed consent\n* Moderate or severe cerebrovascular stenosis diagnosed before surgery\n* Moderate or severe obstructive or restrictive pulmonary dysfunction identified on preoperative pulmonary function testing\n* Requirement for supplemental oxygen therapy before surgery\n* History of neurological disorders (e.g., Parkinson's disease, stroke) or prior brain surgery\n* Severe hepatic dysfunction (AST or ALT \\> 120 IU\u002FL)\n* Severe renal dysfunction (estimated GFR \\\u003C 15 mL\u002Fmin\u002F1.73 m²)\n* Persistent severe hemodynamic instability (mean arterial pressure \\\u003C 60 mmHg)\n* Skin conditions preventing placement of the forehead fNIRS sensor\n* Combined surgical procedures performed concurrently\n* Planned postoperative admission to the intensive care unit",{"count":324,"type":22},80,"The goal of this observational study is to learn whether the brain's ability to use oxygen during surgery is associated with postoperative delirium in adults aged 65 years and older undergoing general anesthesia.\n\nThe main question it aims to answer is:\n\n\\- Does reduced cerebral oxygen consumption responsiveness during surgery increase the risk of postoperative delirium in older patients?\n\nParticipants who are undergoing elective laparoscopic surgery under general anesthesia as part of their routine medical care will have brain oxygen levels measured during surgery using a non-invasive forehead sensor, and will be assessed for delirium for up to three days after surgery.",[28,327],"Cerebral Oxygenation","2026-03-29",{"date":330,"type":36},"2026-04-02",{"date":332,"type":36},"2026-03-11",{"date":334,"type":22},"2028-05",{"name":336,"class":43},"Seoul National University Bundang Hospital",{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":12,"sex":18,"minAge":344,"maxAge":345,"enrollmentInfo":346,"targetDuration":4,"studyType":23,"phases":348,"briefSummary":349,"conditions":350,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":357,"locationsCount":98},"100627011","phase-2-effect-of-dexmedetomidine-dosage-on-postoperative-delirium-in-geriatric-orthopedic-surgery-100627011","NCT07443085","Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic Surgery","Dose-Effect Relationship of Dexmedetomidine on Delirium and Cognitive Function After Lower Limb Orthopedic Surgeries for Elderly Patients","Inclusion Criteria:\n\n* Elderly surgical patients.\n* ASA physical status grade II-III.\n* Planned major lower limb orthopedic surgery.\n\nExclusion Criteria:\n\n* pre-existing dementia or drug allergies","55 Years","70 Years",{"count":347,"type":22},75,[282],"This study evaluates the dose-response relationship of Dexmedetomidine (DEX) in reducing the incidence and severity of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) in elderly patients. The study compares different doses of DEX against a fentanyl control group in patients undergoing major lower limb orthopedic surgery under general anesthesia to determine the optimal dosage for cognitive protection.",[28],"2026-02-27",{"date":353,"type":36},"2026-03-02",{"date":355,"type":36},"2026-02-26",{"date":180,"type":22},{"name":358,"class":43},"Benha University",{"id":360,"slug":361,"hasResults":12,"nctId":362,"briefTitle":363,"officialTitle":364,"acronym":365,"eligibilityCriteria":366,"healthyVolunteers":12,"sex":18,"minAge":51,"maxAge":4,"enrollmentInfo":367,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":369,"conditions":370,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":98},"100624590","the-association-between-postoperative-inflammatory-and-neurological-serum-biomarker-concentrations-and-occurrence-of-postoperative-delirium-100624590","NCT07411612","The Association Between Postoperative Inflammatory and Neurological Serum Biomarker Concentrations and Occurrence of Postoperative Delirium","The Association Between Postoperative Inflammatory and Neuroogical Serum Biomarker Concentrations and Occurrence of Postoperative Delirium - a Prospective Observational Study","SPOT_ON_BRAIN","Inclusion Criteria:\n\n* Provide written informed consent\n* ≥ 65 years of age\n* Scheduled for elective major non-cardiac, non-intrcranial, non-vascular surgery with estimated time of surgery ≥ 2 hours\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery\n* History of diagnosed dementia\n* Language, vision, or hearing impairments that may compromise cognitive assessments\n* Preoperative delirium\n* ICU patients undergoing surgery",{"count":368,"type":22},1170,"Postoperative delirium is a frequent and serious complication in older surgical patients, linked to prolonged hospitalization and long-term cognitive decline. The pathogenesis of delirium possibly includes inflammation and blood-brain barrier disruption. Early identification of at-risk patients is limited by the lack of reliable biomarkers. Therefore, we will evaluate as our primary aim the association between S100B measured within 2 hours after surgery and the occurrence of postoperative delirium within the first three postoperative days in patients over the age of 65 undergoing major non-cardiac, non-intracranial and non-vascular surgery. We will further evaluate the association between NSE, IL-6 and Copeptin concentrations, measured within 2 hours after surgery, on the occurrence of delirium within the first three postoperative days. We will also evaluate the predictive value of S100B, NSE, IL-6 and Copeptin concentrations, measured within 2 hours after surgery, on the occurrence of delirium within the first three postoperative days. We will measure S100B, NSE, IL-6, and Copeptin preoperatively, within two hours after surgery and daily for the first three postoperative days. Delirium will be assessed twice daily in the morning and evening for the first three postoperative days.\n\nIn the course of this study we will establish a biobank of plasma and serum samples of patients, which are drawn preoperatively and within the first two hours after surgery.",[28,371,372,373,374],"Neuronal Damage","Blood Brain Barrier Defect","Postoperative Complications","Inflammation","2026-02-06",{"date":377,"type":36},"2026-02-17",{"date":379,"type":36},"2026-01-12",{"date":381,"type":22},"2030-01-18",{"name":383,"class":43},"Medical University of Vienna",{"id":385,"slug":386,"hasResults":12,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":162,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":391,"targetDuration":4,"studyType":23,"phases":392,"briefSummary":393,"conditions":394,"keywords":397,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":402,"lastUpdatePostDateStruct":403,"startDateStruct":405,"completionDateStruct":407,"leadSponsor":408,"locationsCount":98},"100623430","audio-recorded-messages-delivered-via-ipad-to-prevent-delirium-in-hip-fracture-patients-100623430","NCT07396532","Audio-Recorded Messages Delivered Via iPad to Prevent Delirium in Hip Fracture Patients","Nurse-Led Audio-Recorded Reorientation to Reduce Delirium in Elderly Hip Fractures: A Pilot Randomized Control Trial","Inclusion Criteria:\n\n* Older adults aged 60 years and above\n* Undergoing hip fracture repair surgery\n* No history of cognitive impairment as assessed by Abbreviated Mental Test (AMT)\n* Able to understand to any of the basic languages of Singapore (English, Malay, Mandarin, Tamil)\n\nExclusion Criteria:\n\n* Patients not admitted directly to orthopaedic (study) wards post-operation (such as those requiring post-operative high-dependency unit care)\n* Patients managed conservatively without surgical intervention.\n* Patients admitted for periprosthetic hip fracture repairs\n* Patients who are deaf and mute",{"count":5,"type":22},[25],"The goal of this pilot clinical trial is to learn if personalized audio-recorded reorientation messages can be successfully implemented in general hospital wards for elderly patients after hip fracture surgery. It will also explore whether this intervention might help prevent confusion (delirium) after surgery. The main questions it aims to answer are:\n\n* Can the intervention be successfully delivered by nursing staff in a busy orthopedic ward?\n* How many eligible patients can be recruited and retained in the study?\n* Do patients tolerate listening to the personalized audio messages without problems?\n* Does listening to personalized audio messages show any early signs of reducing confusion after surgery?\n\nResearchers will compare patients who receive personalized audio messages to those who receive usual care to see if the intervention is feasible to implement and whether it shows promise for preventing delirium.\n\nParticipants will:\n\n* Listen to 2-minute personalized audio-recorded reorientation messages played through an iPad and headphones three times daily for the first 3 days after surgery\n* Have their orientation and mental status checked daily for three times by nursing staff\n* Continue with all their regular medical care and treatments\n* Be monitored until discharge from the study wards.",[28,395,396],"Delirium and Post-operative Cognitive Dysfunction (POCD)","Delirium, Postoperative",[398,399,400,401],"delirium","nurse-led","reality reorientation","AI","2026-02-02",{"date":404,"type":36},"2026-02-09",{"date":406,"type":36},"2025-09-29",{"date":149,"type":22},{"name":409,"class":43},"Sengkang General Hospital",{"id":411,"slug":412,"hasResults":12,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":416,"eligibilityCriteria":417,"healthyVolunteers":12,"sex":18,"minAge":51,"maxAge":4,"enrollmentInfo":418,"targetDuration":4,"studyType":23,"phases":420,"briefSummary":421,"conditions":422,"keywords":423,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":436,"locationsCount":98},"100608488","effectiveness-of-the-delirium-zero-protocol-to-prevent-the-onset-of-delirium-in-patients-undergoing-hip-fracture-surgery-100608488","NCT07202208","Effectiveness of the Delirium Zero Protocol to Prevent the Onset of Delirium in Patients Undergoing Hip Fracture Surgery","Effectiveness of the Delirium Zero Protocol to Prevent the Onset of Delirium in Patients Undergoing Hip Fracture Surgery: Randomized Clinical Trial","DZ","Inclusion Criteria:\n\n* The participants will be patients over 65 years old\n* Admitted to the orthopedic hospitalization units of the La Fe University and Polytechnic Hospital (La Fe health department, Valencia, Spain).\n* Who are undergoing surgery for hip fracture\n* Accompanied by a family member\u002Fcaregiver who understands Spanish and knows how to read and write it.\n\nExclusion Criteria:\n\n* Have previously been diagnosed with severe cognitive impairment according to the Pfeiffer scale, which corresponds to a score of 8-10 points.\n* Have previously been diagnosed with any serious mental disorder (schizophrenic disorders, schizotypal disorders, persistent delusional disorders, substance-induced delusional disorders, schizoaffective disorders, other non-organic psychotic disorders, bipolar disorder, serious depressive episode with psychotic symptoms, and severe recurrent depressive disorders). - that they have delirium at the time of admission to the trauma room.\n* That they have a language barrier, deep aphasia, coma, or terminal illness.\n* That they have been previously enrolled in this study.\n* That before the surgery they were admitted to a different hospital unit than those participating in the study, although they may then be transferred to one of these trauma units.\n* That before entering the trauma hospitalization unit, they have been in the emergency room for more than 36 hours.\n* That they present brain alterations (tumors, occupying lesions).",{"count":419,"type":22},140,[25],"The main objective of this research will be to investigate whether the control of care provided by the family\u002Fcaregiver can prevent the onset of delirium in individuals undergoing surgical intervention for hip fracture.\n\nThe research will be a randomized, single-blind, parallel, two-arm clinical trial that compares two conditions: intervention group, hereafter IG (Delirium Zero protocol based on a space-temporal orientation poster for the patient, a clock hung on the wall next to the orientation poster, and a checklist for the preventive measures taken by the caregiver\u002Ffamily), and control group, hereafter CG (standard of care).\n\nThe participants will be patients over 65 years old, admitted to the trauma hospitalization units of the La Fe University and Polytechnic Hospital (La Fe Health Department, Valencia, Spain), operated on for hip fracture and accompanied by a relative\u002Fcaregiver.\n\nThe research will be carried out at the La Fe University and Polytechnic Hospital (La Fe Health Department, Valencia, Spain) because it is the reference hospital for the Valencian Community, and because the rooms in this center are private, which allows for no interference between the intervention under study (in GI) or the standard care (GC).",[197,28],[424,425,426,427,58,428],"hip fracture","Family","Care","Care Protocol","Caregiver","2025-09-23",{"date":431,"type":36},"2025-10-01",{"date":433,"type":36},"2025-01-15",{"date":435,"type":22},"2028-07-31",{"name":437,"class":43},"Cardenal Herrera University",{"id":439,"slug":440,"hasResults":12,"nctId":441,"briefTitle":442,"officialTitle":443,"acronym":444,"eligibilityCriteria":445,"healthyVolunteers":12,"sex":18,"minAge":78,"maxAge":4,"enrollmentInfo":446,"targetDuration":4,"studyType":23,"phases":447,"briefSummary":448,"conditions":449,"keywords":453,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":98},"100596870","responsive-nature-driven-imagery-to-reduce-delirium-after-cardiac-surgery-100596870","NCT07051096","Responsive Nature-Driven Imagery to Reduce Delirium After Cardiac Surgery","Responsive Nature-Driven Imagery to Reduce Delirium After Cardiac Surgery: A Pilot Randomized Controlled Trial","RESPITE","Inclusion Criteria:\n\n* Planned open-heart cardiac surgery (e.g. coronary artery bypass grafting, valve replacement surgery);\n* Able to understand study procedures and provide informed consent in English;\n* At least one delirium risk factor: 1) Age less than 65yrs; 2) History of delirium; 3) History of stroke\u002FTIA; 4) Known cognitive impairment; 5) Depression requiring medication.\n\nExclusion Criteria:\n\n* Severe pre-existing cognitive impairment (Montreal Cognitive Assessment \\[MOCA6\\]\\\u003C10)\n* Uncorrected visual impairment;\n* Significant impairment from psychiatric disease;\n* Enrolment in another clinical trial which may interfere with the study outcome measures.",{"count":21,"type":22},[25],"The goal of this clinical trial is to learn if a novel device (MindfulGarden) is beneficial in a population of patients undergoing cardiac surgery. The main questions it aims to answer are:\n\nIs a novel device (MindfulGarden) that uses responsive nature-driven imagery feasible in patients undergoing cardiac surgery? Will use of this device reduce the use of psychotropic medications, improve recovery experience, and improve delirium?\n\nParticipants will receive routine post-operative management and standard delirium reduction measures. They will be randomized into two groups where one receives the novel device (MindfulGarden) and the other does not.",[28,450,451,452],"Agitation","Anxiety","Cardiac Surgery Recovery",[454,58,455,456],"Randomized trial","Cardiac surgery","MindfulGarden","2025-06-26",{"date":459,"type":36},"2025-07-03",{"date":461,"type":22},"2025-09",{"date":463,"type":22},"2027-01",{"name":465,"class":43},"University of British Columbia",{"id":467,"slug":468,"hasResults":12,"nctId":469,"briefTitle":470,"officialTitle":471,"acronym":4,"eligibilityCriteria":472,"healthyVolunteers":12,"sex":18,"minAge":473,"maxAge":474,"enrollmentInfo":475,"targetDuration":4,"studyType":23,"phases":477,"briefSummary":478,"conditions":479,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":484,"completionDateStruct":486,"leadSponsor":487,"locationsCount":98},"100583677","preoperative-sleep-intervention-on-postoperative-delirium-in-school-aged-children-undergoing-congenital-heart-surgery-100583677","NCT06879431","Preoperative Sleep Intervention on Postoperative Delirium in School-aged Children Undergoing Congenital Heart Surgery","The Impact of Cognitive Behavioral Intervention On Postoperative Delirium In School-aged Children With Sleep Disorder Undergoing Congenital Heart Surgery: A Multicenter, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Age 0-36 months\n2. Scheduled to undergo elective corrective surgery for congenital heart disease under cardiopulmonary bypass.\n3. Sleep disorder assessed by Children's Sleep Habits Questionnaire (CSHQ) (CSHQ score \\>48)\n\nExclusion Criteria:\n\n1. Preoperative use of sleep therapy-related medications\n2. The risk adjustment in congenital heart surgery-1 (RACHS-1 classification) ≥4\n3. History of preoperative cardiac assist device, mechanical ventilation support, or asphyxia rescue\n4. Emergency surgery or preoperative ICU admission\n5. History of neurodevelopmental disorders such as autism spectrum disorder, attention deficit hyperactivity disorder, or psychiatric disorders such as depression\n6. Combined severe hepatic and renal dysfunction\n7. Combination of non-cardiac malformations (adenoid hypertrophy, tracheobronchial stenosis, polysplenism, anaplastic syndrome, Down syndrome, DiGeoge syndrome, diabetes mellitus, reproductive system abnormalities, anal atresia and Williams syndrome, eye disorders)\n8. History of preoperative cerebral ischemia and hypoxia\n9. Concurrent participation in other clinical trials\n10. Refusal of the family to sign the informed consent form or poor compliance by the child","6 Years","12 Years",{"count":476,"type":22},544,[25],"This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in sleep-disordered school-aged children undergoing congenital heart surgery. The study will include infants and toddlers undergoing elective cardiac surgery with sleep disorders, assessed by the Children's Sleep Habits Questionnaire (CSHQ). All participants will be randomly assigned to the intervention group and Controll group in a 1:1 ratio. The intervention group received a short intensive cognitive-behavioral intervention 7-14 days before surgery, and no intervention was imposed on the control group. The results of this study will provide suggestions for the prevention of delirium after cardiac surgery.",[28,218,480],"Congenital Heart Disease (CHD)","2025-05-27",{"date":483,"type":36},"2025-05-31",{"date":485,"type":36},"2025-04-28",{"date":225,"type":22},{"name":227,"class":43},{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":4,"eligibilityCriteria":494,"healthyVolunteers":12,"sex":18,"minAge":495,"maxAge":496,"enrollmentInfo":497,"targetDuration":4,"studyType":23,"phases":499,"briefSummary":500,"conditions":501,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":502,"lastUpdatePostDateStruct":503,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":508,"locationsCount":98},"100582337","preoperative-sleep-intervention-on-postoperative-delirium-in-infants-and-toddlers-undergoing-congenital-heart-surgery-100582337","NCT06861998","Preoperative Sleep Intervention on Postoperative Delirium in Infants and Toddlers Undergoing Congenital Heart Surgery","The Impact of Behavioral Intervention On Postoperative Delirium In Sleep-Disordered Infants and Toddlers Undergoing Congenital Heart Surgery: A Multicenter, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Age 0-3 years\n2. Scheduled to undergo elective corrective surgery for congenital heart disease under cardiopulmonary bypass.\n3. Children with sleep disorders who are screened by the Brief Infant Sleep Questionnaire-Revised short form (BISQ-R SF).\n\nExclusion Criteria:\n\n1. Infants and toddlers who have taken any relevant preoperative treatment for sleep problems\n2. The risk adjustment in congenital heart surgery-1 (RACHS-1 classification) ≥4.\n3. Preoperative history of cerebral ischemia and hypoxia, developmental disorders such as autism spectrum disorders, etc.\n4. Presence of any other preoperative acute or chronic medical condition (mechanical ventilation support, history of asphyxia rescue, severe hepatic or renal dysfunction, or comorbidities with other non-cardiac malformations)\n5. Concurrent participation in other clinical trials\n6. Refusal of the family to sign the informed consent or poor compliance of the child.","1 Day","3 Years",{"count":498,"type":22},452,[25],"This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in sleep-disordered infants and toddlers undergoing congenital heart surgery. The study will include infants and toddlers undergoing elective cardiac surgery with sleep disorders, assessed by the Brief Infant Sleep Questionnaire (BISQ). All participants will be randomly assigned to the intervention group and Controll group in a 1:1 ratio. The intervention group received sleep hygiene education and a bedtime routine based on touch, the control group received only sleep hygiene education. The primary outcome is the incidence of postoperative delirium within 7 days after surgery or before discharge, and secondary outcomes include postoperative sleep quality, pain score, perioperative organ injury (including AKI, acute lung injury, and postoperative liver dysfunction), clinical recovery and prognosis. The results of this study will provide suggestions for the prevention of delirium after cardiac surgery.",[28,218,480],"2025-05-24",{"date":504,"type":36},"2025-05-28",{"date":506,"type":36},"2025-04-30",{"date":225,"type":22},{"name":227,"class":43},{"id":510,"slug":511,"hasResults":12,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":4,"eligibilityCriteria":515,"healthyVolunteers":12,"sex":18,"minAge":51,"maxAge":4,"enrollmentInfo":516,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":518,"conditions":519,"keywords":523,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":528,"startDateStruct":530,"completionDateStruct":532,"leadSponsor":534,"locationsCount":4},"100590941","low--vs-normal-flow-anesthesia-and-delirium-after-hip-fracture-in-the-elderly-100590941","NCT06973967","Low- vs. Normal-Flow Anesthesia and Delirium After Hip Fracture in the Elderly","Evaluation of the Association Between Low-Flow and Normal-Flow Anesthesia and Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery","Inclusion Criteria:\n\nPatients aged 65 years and older who are scheduled to undergo surgical treatment for hip fracture, classified as ASA physical status I-IV, and who have signed the informed consent form will be included in the study.\n\nExclusion Criteria:\n\nPatients with complex fractures (multiple fractures, extremity, abdominal, pelvic or sacral trauma, head trauma, etc.), those with relative contraindications to general anesthesia (e.g., known difficult airway, malignant hyperthermia), patients requiring postoperative intubated intensive care follow-up, those with a history of dementia, sleep disorders, or psychosis, individuals with serious neurological diseases (e.g., Parkinson's disease, stroke sequelae), those with a history of opioid, alcohol, or substance use, patients with cerebrovascular disease, those who underwent surgery within the past 6 months, patients with hearing or vision impairment, bleeding disorders or those taking medications affecting coagulation, patients with hypoalbuminemia (\\\u003C3 g\u002FdL), preoperative anemia with hematocrit \\\u003C30%, known allergy to anesthetic drugs, severe cardiopulmonary failure, immobility, malnutrition, or those who are unable to comply with the study protocol will be excluded from the study.",{"count":517,"type":22},128,"The aim of this study is to investigate the relationship between low-flow and normal-flow anesthesia techniques and the development of postoperative delirium in elderly patients undergoing surgery for hip fracture.",[28,520,521,522],"Low Flow Anesthesia","Elderly Patients (>65 Years)","Hip Surgery",[398,524,525,526],"hip surgery","elderly patients","low-flow anesthesia","2025-05-14",{"date":529,"type":36},"2025-05-15",{"date":531,"type":22},"2025-05-08",{"date":533,"type":22},"2025-08-07",{"name":535,"class":536},"Gaziosmanpasa Research and Education Hospital","OTHER_GOV",{"id":538,"slug":539,"hasResults":12,"nctId":540,"briefTitle":541,"officialTitle":542,"acronym":4,"eligibilityCriteria":543,"healthyVolunteers":162,"sex":18,"minAge":51,"maxAge":544,"enrollmentInfo":545,"targetDuration":4,"studyType":23,"phases":547,"briefSummary":549,"conditions":550,"keywords":552,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":556,"lastUpdatePostDateStruct":557,"startDateStruct":559,"completionDateStruct":561,"leadSponsor":563,"locationsCount":98},"100589744","phase-4-effect-of-opioid-free-anaesthesia-on-postoperative-delirium-in-elderly-patients-undergoing-gastrointestinal-surgery-100589744","NCT06958393","Effect of Opioid-free Anaesthesia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery","Effect of Opioid-free Anaesthesia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery: a Single-centre, Prospective, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age ≥ 65 years\n2. American Society of Anesthesiologists (ASA) physical status classification I-III\n3. Scheduled for elective gastrointestinal surgery under general anaesthesia\n4. Body mass index (BMI) between 18.0 and 30.0 kg\u002Fm²\n\nExclusion Criteria:\n\n1. Refusal to undergo surgery\n2. Emergency surgery\n3. Language impairment or severe hearing or visual deficits that hinder effective communication with research or surgical staff\n4. History of neurological or psychiatric disorders, including Alzheimer's disease (AD), other forms of dementia, stroke, or psychosis\n5. Long-term use of psychotropic medications (e.g., clozapine, risperidone, olanzapine, haloperidol, chlorpromazine)\n6. Cardiac or craniocerebral surgery within the past year\n7. Participation in other interventional clinical studies within the past 3 months\n8. Preoperative cognitive impairment defined as a modified Telephone Interview for Cognitive Status (TICS-M) score ≤ 27\n9. Patients will only be enrolled once, even if a subsequent surgery related to the primary procedure is performed","90 Years",{"count":546,"type":22},406,[548],"PHASE4","Background Postoperative delirium (POD) is a common acute and transient form of brain dysfunction in elderly patients following surgery that can lead to serious adverse clinical outcomes and even death. Although existing studies have preliminarily investigated the effects of opioid-free anaesthesia (OFA) on POD, high-quality evidence on these effects for elderly patients undergoing gastrointestinal surgery remains limited. This study aims to investigate the effects of OFA on the development of POD in elderly patients following gastrointestinal surgery.\n\nMethods and analysis:\n\nThis single-centre, prospective, randomized controlled trial will be conducted at the First Affiliated Hospital of Shandong First Medical University, China. A total of 406 patients aged 65 years or older who are scheduled for elective gastrointestinal surgery will be randomly allocated to receive either opioid-free anaesthesia (OFA; dexmedetomidine, esmolol, and esketamine) or conventional opioid-based anaesthesia (OBA). The primary outcome is the incidence of POD 7 days after surgery. The secondary outcomes are all-cause mortality within 30 days after surgery, intraoperative haemodynamic changes, the 15-item quality of recovery (QoR-15) scores at 24 h, 48 h, and 72 h after surgery, complications during postoperative hospitalization, pain numerical rating scale (NRS) score at 72 h after surgery, incidence of nausea and vomiting at 72 h after surgery, morphine milligram equivalent for analgesics at 72 h after surgery, duration of anaesthesia (from induction to discontinuation), duration of surgery (from skin incision to the last suture), duration of post-anaesthesia care unit (PACU) stay, and length of hospital stay.\n\nDiscussion:\n\nThe results of this study may shed light on the effects of OFA on POD in elderly patients undergoing gastrointestinal surgery. The study is designed on the basis of the following key hypothesis: the use of opioid drugs for anaesthesia may increase the risk of POD through mechanisms such as blood-brain barrier destruction, neuroinflammatory responses, and central nervous system depression. Through the single-centre and prospective design of this randomized controlled trial, this study will directly analyse differences in the effects of OFA and conventional OBA on the incidence of POD, haemodynamic stability and long-term cognitive function in elderly patients.\n\ngastrointestinal surgery.",[28,551],"Opioid-Free Anaesthesia",[525,553,554,555],"opioid-free anaesthesia","postoperative delirium","gastrointestinal surgery","2025-05-03",{"date":558,"type":36},"2025-05-06",{"date":560,"type":22},"2025-05-20",{"date":562,"type":22},"2026-05-12",{"name":564,"class":43},"Qianfoshan Hospital",{"id":566,"slug":567,"hasResults":12,"nctId":568,"briefTitle":569,"officialTitle":570,"acronym":571,"eligibilityCriteria":572,"healthyVolunteers":12,"sex":18,"minAge":573,"maxAge":4,"enrollmentInfo":574,"targetDuration":4,"studyType":23,"phases":575,"briefSummary":576,"conditions":577,"keywords":583,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":594,"startDateStruct":596,"completionDateStruct":598,"leadSponsor":600,"locationsCount":98},"100565938","phase-2-lemborexant-to-prevent-post-operative-delirium-in-cardiac-surgery-patients-100565938","NCT06648681","Lemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients","A Randomized Trial of Lemborexant for the Prevention of Delirium After Cardiac Surgery (PROTEX): A Pilot Study","PROTEX","Inclusion Criteria:\n\n* Admitted to hospital following open cardiac surgery through midline sternotomy\n\nExclusion Criteria:\n\n* ● Known severe obstructive sleep apnea diagnosed by polysomnography or STOPBANG score \\> 5\n\n  * Periodic limb movement disorder or restless legs syndrome\n  * Narcolepsy\n  * Somnolence (Pasero Opioid Sedation Scale (POSS) \\>2)\n  * Current alcohol or substance use disorder as defined by the DSM-V\n  * Patient already taking moderate or strong CYP3A inhibitors\n  * Frequent use of medications for insomnia defined as \\>4 days per week.\n  * Liver failure (Child-Pugh score B or C)\n  * Renal failure (eGFR\\\u003C30 ml\u002Fmin\u002F1.73 m2)\n  * Pre-existing delirium (ICDSC score \\>3 or CAM\u002FCAM-ICU positive) at time of consent\n  * BMI\\>40 kg\u002Fm2\n  * Known allergy or hypersensitivity to study drug\n  * Inability to communicate in English","61 Years",{"count":21,"type":22},[282],"Post-operative delirium is a common complication following cardiac surgery and is associated with increased 1 year mortality. Currently there are no drug therapies to prevent delirium. Orexin is a neuromodulator thought to play an important role in disordered sleep, one of the instigators of delirium. Lembrorexant is an orexin antagonist, originally approved for sleep, that may also reduce the incidence of delirium. The Investigators propose a pilot study to determine the feasibility of a randomized controlled trial comparing Lembrorexant to placebo in patients following cardiac surgery in reducing the incidence of delirium, and improving sleep.",[28,29,578,579,580,581,582],"Cardiac Surgery Subjects","Orexin Antagonist","Feasibility Studies","Sleep","In-hospital Mortality",[584,117,585,586,587,588,589,590,398,591,592],"lemborexant","sleep medication","ICDSC","CAM","cardiac surgery","sleep aid","open heart surgery","sleep quality","Richards-Campbell Sleep Questionnaire","2025-04-18",{"date":595,"type":36},"2025-04-23",{"date":597,"type":22},"2025-05-01",{"date":599,"type":22},"2027-04-30",{"name":465,"class":43},{"id":602,"slug":603,"hasResults":12,"nctId":604,"briefTitle":605,"officialTitle":606,"acronym":4,"eligibilityCriteria":607,"healthyVolunteers":12,"sex":18,"minAge":51,"maxAge":4,"enrollmentInfo":608,"targetDuration":4,"studyType":23,"phases":610,"briefSummary":611,"conditions":612,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":614,"lastUpdatePostDateStruct":615,"startDateStruct":617,"completionDateStruct":619,"leadSponsor":621,"locationsCount":98},"100568231","effect-of-transcranial-direct-current-stimulation-on-postoperative-delirium-in-elderly-patients-100568231","NCT06678529","Effect of Transcranial Direct Current Stimulation on Postoperative Delirium in Elderly Patients","Effect of Transcranial Direct Current Stimulation on Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery","Inclusion Criteria:\n\n(1) aged ≥ 65 years; (2) scheduled for elective hip fracture, including femoral head fractures, femoral neck fractures, intertrochanteric or subtrochanteric fractures, femoral head replacement, total hip arthroplasty, or open or closed reduction; (3) platelet count \\> 80 × 10⁹\u002FL; (4) ASA classification ≤ Grade III; (5) Mini-Mental State Examination (MMSE) scores ≥ 18 points (13); (6) willingness to participate and sign the informed consent form.\n\nExclusion Criteria:\n\n(1) severe mental disorders,(e.g,depression or schizophrenia requiring medication treatment); (2) cranial or scalp injuries; (3) history of symptomatic cerebrovascular disease, including stroke, transient ischemic attack; (4) compound injuries, multiple fractures, periprosthetic fractures, and hip joint revisions; (5) drug or alcohol abuse; (6) severe visual or hearing impairments; (7) history of epilepsy or intracranial metal implants; (8) severe cardiovascular disease history and liver dysfunction, or kidney dysfunction; (9) coagulation abnormalities; (10) severe chronic obstructive pulmonary disease; (11) participation in other clinical studies within the past 3 months.",{"count":609,"type":22},160,[25],"To evaluate the efficacy of transcranial direct current stimulation (tDCS) in reducing the incidence of postoperative delirium (POD) in elderly patients undergoing hip fracture surgery.\n\nThis single-center, double-blind, randomized controlled trial will enroll participants aged 65 years and older, scheduled for elective hip surgery under spinal anesthesia. Participants will be randomly assigned to either the active-tDCS group or the sham-tDCS group. The active-tDCS group will receive two sessions: one pre-surgery and one post-surgery, with electrodes positioned over the left dorsolateral prefrontal cortex and the right supraorbital area. Each session includes 15-second ramp-up phase at the start, 20 minutes simulation with 2 mA current and 15-second ramp-down phase at the end. The sham-tDCS group will receive two sham procedures with no actual current delivered. Functional brain activity will be monitored before and after each session or sham procedure to assess changes in cortical activation and connectivity using functional near-infrared spectroscopy (fNIRS). The primary outcome measure will be the incidence of POD, assessed using the 3-Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM). Secondary outcomes include the severity of delirium, postoperative pain, anxiety, depression, cognitive function, and sleep quality.",[28,613],"Hip Fractures (ICD-10 72.01-72.2)","2025-04-03",{"date":616,"type":36},"2025-04-06",{"date":618,"type":36},"2024-11-01",{"date":620,"type":22},"2026-12-01",{"name":622,"class":43},"Huazhong University of Science and Technology",{"id":624,"slug":625,"hasResults":12,"nctId":626,"briefTitle":627,"officialTitle":628,"acronym":629,"eligibilityCriteria":630,"healthyVolunteers":12,"sex":18,"minAge":78,"maxAge":4,"enrollmentInfo":631,"targetDuration":633,"studyType":81,"phases":4,"briefSummary":634,"conditions":635,"keywords":638,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":645,"lastUpdatePostDateStruct":646,"startDateStruct":648,"completionDateStruct":650,"leadSponsor":651,"locationsCount":69},"100584813","electroencephalogram-predicts-post-operative-delirium-100584813","NCT06894238","Electroencephalogram Predicts Post-operative Delirium","Frontal-temporal EEG During Anesthesia Recovery Predicts Postoperative Delirium in Neurosurgery: a Single-center, Prospective, Observational Study","EPOD","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Planned elective neurosurgical surgery\n* ASA physical status I-II\n* Signed informed consent\n\nExclusion Criteria:\n\n* Known neurological or psychiatric disorders (e.g., epilepsy, Parkinson's disease)\n* Preoperative cognitive impairment (MMSE score \\\u003C 24)\n* Long-term use of central nervous system drugs (e.g., antidepressants, antipsychotics)\n* Language barriers\n* History of craniotomy within the last 12 months\n* Inability to place frontal-temporal electrodes due to conditions such as frontal skin injury, severe agitation, or a coronal incision for surgery\n* Pregnant or breastfeeding women",{"count":632,"type":22},137,"30 Days","The goal of this observational study is to investigate the predictive value of sub-hairline electroencephalography (EEG) during anesthesia recovery for postoperative delirium (POD). The main question to be answered is:\n\n* Can sub-hairline EEG measured during anesthesia recovery serve as a reliable predictor of POD? Adult patients undergoing elective craniotomy and admitted to the ICU will be enrolled. Sub-hairline EEG will be monitored until ICU discharge.",[636,28,637],"Neurosurgery","Brain Tumor Adult",[172,639,640,641,642,643,644],"electroencephalography","neurosurgical patients","Sub-hairline EEG","Confusion Assessment Method for ICU (CAM-ICU)","Delirium Observation Screening Scale (DOSS)","Fluctuating Mental Status Evaluation (FMSE)","2025-03-18",{"date":647,"type":36},"2025-03-25",{"date":649,"type":36},"2025-03-01",{"date":311,"type":22},{"name":652,"class":43},"Beijing Sanbo Brain Hospital"]