[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"delirium-in-old-age\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:delirium-in-old-age":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,38,68,101,135,167,192,219,252],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100389770","quality-contract-prevention-of-postoperative-delirium-in-the-care-of-older-patients-qv-pod-2-100389770",false,"NCT04355195","Quality Contract: Prevention of Postoperative Delirium in the Care of Older Patients (QV-POD-2)","Quality Contract Prevention of Postoperative Delirium in the Care of Older Patients (QV-POD-2)","Inclusion criteria:\n\n* Age ≥ 70 years\n* male and female patients\n* Patients who are insured with BARMER, HEK, KKH, DAK, TK or hkk Health insurances\n* Patients eligible for inclusion: by the patient, preoperatively\n* Incapacitated patients for inclusion: Written informed consent by a legal representative\n* surgery (elective and not elective)\n\nExclusion criteria:\n\n* Moribund patients\n* Not enough language skills","ALL","70 Years",{"count":19,"type":20},18100,"ESTIMATED","OBSERVATIONAL","The project \"QV-POD-2\" is a prolongation based on \"QV-POD-1\", which was a quality contract program of the IQTIG - Institute for Quality and Transparency in Health Care. The aim is to improve inpatient care for older patients who are undergoing inpatient surgery and thus to specifically reduce the postoperative risk of delirium. This is achieved through the implementation of evidence-based and consensus-based measures to prevent postoperative delirium in a comprehensive structured concept in routine care. The transparent documentation in an electronic patient file enables the relationships between the symptoms to be depicted in accordance with the clinical circumstances and the genesis of the postoperative delirium to be recorded and treated at an early stage. The content of the additional elements from the routine data (see primary and secondary outcome measures) in QV-POD-2 is analysed internally.\n\nSubproject Retro-Pressure started in August 2022:\n\nRetrospective, exploratory cohort study using electronic anesthesia and hospital records from Jan 1, 2016 to Jan 1, 2020, including patients ≥70 years undergoing surgery with anesthesia. The objective is to quantify associations between intraoperative blood pressure dynamics-variability, rate of change, relative hypo-\u002Fhypertension versus baseline, and time-integrated BP (area under\u002Fabove reference)-and postoperative organ dysfunction Primary endpoints: Emergence delirium incidence (PACU\u002FITS) based on Nu-DESC scores and CAM-ICU scores; incidence of postoperative acute renal failure (creatinine and urea levels, as well as urine output); intraoperative blood pressure variation\\*; intraoperative blood pressure variation rate\\*; intraoperative blood pressure integral\\* Secondary endpoints: Blood count (hemoglobin and hematocrit values); intraoperative transfusions of blood reserves Addendum from the ethics amendment vote of 25\u002F07\u002F2022\n\nSubproject Delta-Scan started in August 2022:\n\nEvaluation of brain function using \"Delta Scan\" Primary objective: Evaluation of the prognostic significance of Delta Scan measurements in relation to postoperative delirium Secondary objectives: Examination of the delirium-related predictive relevance of individual influencing factors (directly but also indirectly through Delta Scan values) and examination of the effect of Delta Scan measurements on standard delirium screening methods. Study and control group's Inclusion criteria: Age \\>= 70 years and major surgery with anesthesia; additional exclusion criterion in the control group: Inclusion in the QV-POD-1 project (receipt of postoperative preventive measures) Addendum from the ethics amendment vote of 25\u002F07\u002F2022\n\nSubproject started in June,18th, 2026:\n\nFor selected patients who are scheduled to undergo a procedure in June, July or August 2026 as part of the QV-POD-2 study, a wristband called CardioWatch 287-2 (manufacturer: Corsano Health B.V., Wilhelmina van Pruisenweg 35, 2595 AN The Hague, The Netherlands, loaned by Medtronic, will be etsablished. For same-day surgery patients, monitoring begins before the operation and continues until discharge from the hospital. For pre-hospitalized patients, measurements can begin at least one day before surgery upon request. The recorded values include blood pressure, heart rate, heart rate variability, respiratory rate, oxygen saturation, body temperature, physical activity, and an electrocardiogram once a day.",[24],"Delirium in Old Age","RECRUITING","2026-06-22",{"date":28,"type":29},"2026-06-26","ACTUAL",{"date":31,"type":29},"2020-04-20",{"date":33,"type":20},"2029-06",{"name":35,"class":36},"Charite University, Berlin, Germany","OTHER",2,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":16,"minAge":45,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":67},"100571558","phase-3-the-scope-trial-sleep-cognition-and-pain-bundle-vs-eras-cardiac-for-postoperative-delirium-100571558","NCT06721819","The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium","SCOPE","Inclusion Criteria:\n\n* Planned cardiac surgery \\[CABG with or without valve, isolated valve surgery\\] requiring median sternotomy and full CPB at least 10 days in the future.\n\n  * 60 years of age.\n\nWillingness to use a provided tablet and wearable devices and commit at least 1 hour amount of time per day before surgery to complete interventions (psCBT\u002Fcognitive activity\u002Fexercise) if randomized to experimental group.\n\nExclusion Criteria:\n\n* Pre-operative left ventricular ejection fraction (LVEF) \\\u003C than 30%\n\nEmergent procedures\n\nIsolated aortic surgery\n\nLiver dysfunction (ALT or AST \\> 4 times the upper limit of local normal; all patients will have a baseline liver function test information or history and exam suggestive of jaundice or both)\n\nKnown hypersensitivity to the study drugs\n\nActive (in the past year) history of alcohol abuse (≥ 5 drinks\u002Fday for men or ≥ 4 drinks\u002Fday for women) Any history of alcohol withdrawal or delirium tremens\n\nDelirium at baseline\n\nEnglish language Limitations\n\nPhysician refusal\n\nChronic opioid use for chronic pain conditions with tolerance (total dose of an opioid at or more than 30 mg morphine equivalent for more than one month within the past year)\n\nSignificant visual impairment\n\nPrisoner\n\nSevere OSA in the past year (AHI is greater than 30 (more than 30 episodes per hour)) or ESS of 18 or more\n\nCo-enrollment with non-approved interventional trial\n\nSevere cognitive impairment (MOCA \\\u003C 10) or medications for cognitive decline\n\nRecent treatment for insomnia with CBT-I within the last 6 months","60 Years",{"count":47,"type":20},406,"INTERVENTIONAL",[50],"PHASE3","Sleep disturbances, cognitive reserve, and continuing pain and inflammation are other risk factors contributing to delirium (confusion and agitation) and neurocognitive decline (in the long term) following heart surgery. Investigators aim to test a bundle of sleep optimization, cognitive exercise before surgery, and extended pain relief for 48 hours with intravenous acetaminophen combined with enhanced recovery after surgery protocols (SCOPE bundle). SCOPE will fill significant gaps in evidence by testing the value of a patient and care-provider-focused intervention that can potentially minimize POD and improve outcomes (cognitive \\& physical function, sleep quality, pain, depression or anxiety, and survival) important to patients and families.\n\nThe SCOPE trial will address many heart surgery outcome-related questions commonly asked by patients:\n\nWhat can I do to reduce my chances of developing confusion, hallucinations, or delirium after surgery? How can I best prepare before surgery to improve my long-term health and avoid disability? Are there exercises I can participate in that improve my sleep, pain, and mood after surgery? Intellectual pursuits, physical activity, and social interactions support cognitive reserve, while poor health, poor sleep hygiene, poor nutrition, and mental health disease can diminish reserve. Various interventions with different intensities and timing to augment cognitive reserve have been associated with positive outcomes on neuropsychological testing. Adaptive video gaming for as little as 10 hours leads to the maintenance of independence in activities of daily living and sustained improvements in speed of processing, attention, and working memory in older people. Likely through the increased cognitive reserve, perioperative brain exercise aims to protect against morbid cognitive recovery after surgery.\n\nSleep is vital for memory and cognitive function. Poor sleep traits in older adults that are potentially modifiable, including short\u002Flong duration, daytime napping, and associated sleepiness, led to an almost 2-fold increase in delirium risk. Patients will complete an evidence-based course on healthy sleep habits and will complete guided exercises designed to restructure behaviors and thinking. They are encouraged to follow a set of recommendations to improve their sleep (e.g., optimal sleep duration, advice for habits such as daytime napping, maintaining a regular sleep schedule, avoiding caffeine, regular daylight exposure, dimming lights or electronics and relaxation and thought exercises for optimal sleep); many of these sleep behaviors have been strongly linked to increased risk for cognitive decline. Investigators propose that sleep optimization before AND after (an established best practice sleep bundle) surgical insult will contribute to cognitive reserve leading to decreased delirium risk and key patient-centered outcomes (postoperative sleep, pain, cognition, mood, and survival).\n\nInadequate pain relief and opioids are both risk factors for delirium. Surgery on the chest is a significant pain source. Approximately 30-75% of patients suffer from moderate to severe pain in the postoperative period. Almost half of the patients have severe pain at rest, and three-quarters have severe pain during coughing and movement. Pain and inflammation are closely biochemically linked.\n\nSleep, brain exercise, and adequate pain control with opioid-sparing can be additive or synergistic interventions to prevent delirium following heart surgery.\n\nInvestigators propose three specific aims by conducting a 1:1 randomized controlled trial in 406 heart surgery patients 60 or older undergoing heart surgery. They will be administered perioperative sleep optimization, brain exercise training, and intravenous acetaminophen over 48 hours. A trained expert will administer the sleep and cognitive exercise protocols at least two weeks before surgery. This expert will handhold the patients for two weeks until the surgery. Thus, the gains made before surgery with better sleep quality and improved brain reserve will be sustained with postoperative pain control to lower the ongoing inflammation. Through this trial, investigators will evaluate if the SCOPE bundle can reduce 1) in-hospital delirium, 2) long-term (one, six, and twelve months) cognitive, physical, and self-care function, and 3) barriers to implementation of this bundle.\n\nCurrently, no options are routinely available to patients to optimize their sleep and cognition before cardiac surgery. The proposed research is significant because it will be the first to test the bundled behavioral intervention approach (sleep optimization, brain exercise) before surgery with extended, scheduled pain management with non-opioids following surgery. The SCOPE trial will yield relevant and immediately actionable data to improve care for over 900,000 adults in the U.S. each year.",[53,24],"Delirium, Postoperative",[55,56,57],"Delirium","PostOperative","Cardiac Surgery","2026-04-10",{"date":60,"type":29},"2026-04-15",{"date":62,"type":29},"2025-06-06",{"date":64,"type":20},"2030-03-31",{"name":66,"class":36},"Beth Israel Deaconess Medical Center",3,{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":48,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":37},"100509588","researching-efficient-approaches-to-delirium-identification-sustaining-effective-translation-100509588","NCT05915377","Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation","READI-SET-GO:Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation to Create Gero Friendly Organizations","READI-SET-GO","Inclusion Criteria:\n\n* General medicine (hospitalist) service\n* Age 70 or older\n* Expected hospital length of stay of 3 or more days\n\nExclusion Criteria:\n\n* Inability to communicate adequately in English\n* Admitted for terminal care",{"count":77,"type":20},1050,[79],"NA","The goal of this step-wedge trial is to test the implementation of daily nurse screening for delirium in routine care and its impact on outcomes and complications in hospitalized older adults admitted to 6 general medicine\u002Fsurgery units at 3 hospitals in Pennsylvania and Massachusetts.\n\nThe main question\\[s\\] it aims to answer are:\n\n* 1\\. To test the fidelity, accuracy, and durability of implementing daily nurse screening for delirium using the UB-CAM in routine care.\n* 2\\. To evaluate the impact of UB-CAM delirium screening on patient and care partner centered outcomes assessed at one month follow-up interviews 3. To evaluate the impact of UB-CAM screening on rates of delirium complications (falls, pressure injury, aspiration) and adverse delirium management (psychoactive medication use, restraint use).\n\nParticipants (patients) will be assessed for delirium on study days 1, 2 and 3 (or until hospital discharge) and will be asked basic demographics. These patients will be contacted by phone 1 month after enrollment to collect information about inpatient facility use and to administer the Delirium Burden Patient Scale.\n\nParticipants (care partners) will be interviewed at the patient's discharge to complete the Alzheimer's Disease-8 scale. These care partners will be contacted by phone 1 month after enrollment to complete the Delirium Burden Caregiver Scale and to complete a Qualitative Interview which includes questions about communication and collaboration.",[55,24,82,83],"Delirium With Dementia","Delirium Superimposed on Dementia",[55,85,86,87,88,89,90,91],"Confusion","Altered Mental Status","Acute Metabolic Encephalopathy","Implementation","Screening","Acute Care","Electronic Health Record","2026-02-18",{"date":94,"type":29},"2026-02-20",{"date":96,"type":29},"2024-04-03",{"date":98,"type":20},"2028-05",{"name":100,"class":36},"Penn State University",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":55,"eligibilityCriteria":107,"healthyVolunteers":108,"sex":16,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":48,"phases":113,"briefSummary":114,"conditions":115,"keywords":118,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":134},"100578330","management-of-non-pharmacologic-delirium-with-the-use-of-a-nursing-led-e-health-project-a-randonmized-controlled-trial-100578330","NCT06809894","Management of Non-pharmacologic Delirium With the Use of a Nursing-led E-health Project: a Randonmized Controlled Trial","Improvement of the Delirium Management in Adult Patients Hospitalized Through the Use of Non-pharmacological Interventions","Inclusion criteria:\n\n* Age over 80 years\n* Three risk factor to develop delirium, for example: sex (men), polypharmacy,urinary tract infections (UTIs) or strictures.\n* Admission in geriatric unit.\n* Have social support\n\nExclusion criteria:\n\n* Age under 80 years\n* Eseeable death on admission not caused by delirium or delirium diagnosis on admission.",true,"80 Years","130 Years",{"count":112,"type":20},65,[79],"Application of an action protocol focused on the application of non-pharmacological interventions for managing delirium in the process of prevention, diagnosis and treatment, evaluated using an e-health intervention, with a tablet to introduce on it the data about the prevention, diagnostic and treatment process of each recluted patient, in the Igualada Hospital Center, once a day.",[116,117,24],"Delirium Treatment","Delirium Confusional State",[55,119,120,121,122,123],"SCA","CAM","Older pacient","non-pharmacologic treatment","nurse","NOT_YET_RECRUITING","2025-05-22",{"date":127,"type":29},"2025-05-29",{"date":129,"type":20},"2026-04-01",{"date":131,"type":20},"2027-06-15",{"name":133,"class":36},"Universitat de Lleida",1,{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":16,"minAge":142,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":48,"phases":146,"briefSummary":147,"conditions":148,"keywords":154,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":166},"100578895","effect-of-low-dose-esketamine-on-delirium-in-high-risk-elderly-patients-undergoing-elective-surgery-element-100578895","NCT06817239","Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)","Effect of Perioperative Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Major Non-cardiac Surgery: a Multi-center Randomized Trial (ELEMENT Trial)","Inclusion Criteria:\n\n* Age ≥65 years and \\\u003C90 years;\n* Scheduled to undergo major non-cardiac surgery.\n* Fulfill at least one of risk factors as follows: history of stroke; history of delirium; hypertension; congestive heart failure; coronary artery disease; atrial fibrillation; peripheral artery disease; chronic obstructive pulmonary disease; obstructive sleep apnea; diabetes; chronic kidney disease; anemia; malnutrition; hypoalbuminemia; chronic pain; anxiety and depression; poor sleep quality; smoke; alcoholism.\n* Scheduled to receive patient-controlled intravenous analgesia (PCIA).\n\nExclusion Criteria:\n\n* Refuse to participate;\n* Preoperative history of epilepsy, myasthenia gravis, Parkinson's disease, intracranial hypertension, delirium, schizophrenia, or other psychiatric diseases;\n* Inability to communicate in the preoperative period because of coma, profound dementia, or language barrier;\n* Preoperative uncontrolled severe hypertension (baseline SBP\\>180 mmHg or DBP\\>110 mmHg);\n* Preoperative history of hyperthyroidism and pheochromocytoma;\n* Acute cardiovascular event occurring within 30 days before surgery;\n* Severe hepatic dysfunction (Child-Pugh class C), renal dysfunction (required preoperative dialysis), or expected survival ≤24 hours;\n* Scheduled to undergo organ transplantation, vascular surgery, neurosurgery;\n* Receiving treatment with ketamine or esketamine;\n* Contradiction to ketamine or esketamine;\n* Other situations where the investigator or physician considers the patient ineligible for the study.","65 Years","90 Years",{"count":145,"type":20},1670,[79],"Delirium is an acutely occurred neurocognitive disorder characterized by fluctuating symptoms of inattention, altered consciousness and cognitive dysfunction. Delirium is reported to occur in 4% to 65% of postoperative patients depending on the population, and is especially common in older patients. Postoperative delirium is disturbing to patients and their families, and it is a strong predictor of both early and long-term worse outcomes including increased non-delirium complications, increased perioperative mortality, shortened overall survival, declined cognitive function, and lowered quality of life.\n\nAlthough ketamine\u002Fesketamine has anti-inflammatory and neuroprotective effects, evidence on its efficacy in reducing postoperative delirium remains inconsistent and inconclusive. Existing studies are limited by heterogeneity, small sample sizes, single-center designs, and a focus on specific type of surgery. Research on elderly high-risk patients is lacking, and most studies administer the drug intraoperatively, with limited exploration of postoperative use. The optimal dosing and timing for POD prevention are unclear. This study aims to carry out a multicenter, single-blind, placebo-controlled, large-sample randomized controlled trial assessing the effect of low-dose esketamine, given intraoperatively and postoperatively, on delirium in elderly high-risk patients undergoing major non-cardiac surgery.",[24,53,149,150,151,152,153],"Anesthesia","Cognitive Dysfunction","Pain, Postoperative","Esketamine","Non-cardiac Surgery",[55,155,152,156],"Elderly patients","Non-cardiac surgery","2025-04-23",{"date":159,"type":29},"2025-04-27",{"date":161,"type":29},"2025-02-12",{"date":163,"type":20},"2027-07",{"name":165,"class":36},"Nanfang Hospital, Southern Medical University",6,{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":16,"minAge":142,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":48,"phases":176,"briefSummary":178,"conditions":179,"keywords":180,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":190,"locationsCount":4},"100566306","phase-2-intravenous-acetaminophen-for-postoperative-delirium-in-older-patients-recovering-from-major-noncardiac-surgery-100566306","NCT06653465","Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery","Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery: a Randomised Controlled Study","Inclusion Criteria:\n\n1. Age ≥ 65 years.\n2. Scheduled for non-cardiac major surgery with general anesthesia that is expected to last more than 2h.\n3. ASA Physical Status I-III.\n4. Weight \\>50 kg.\n5. Written informed consent.\n\nExclusion Criteria:\n\n1. Pre-existing neuropsychiatric diseases (Alzheimer's disease, Schizophrenia, Parkinson's Disease, Seizures, etc.).\n2. Pre-existing cognitive impairment (MMSE\\\u003C18).\n3. Preoperative delirium.\n4. Severe circulatory instability (preoperative left ventricular ejection fraction less than 30%, unstable angina, severe coronary artery disease, sick sinus syndrome, etc.).\n5. Contraindication to the acetaminophen use, including serum creatinine \\> 177µmol\u002FL or aminotransferses \\> 3 times the upper limit of normal.\n6. Alcohol or drug abuse within a year before surgery.\n7. Inability to communicate because of severe visual\u002Fauditory dysfunction or language barrier.",{"count":175,"type":20},1930,[177,50],"PHASE2","Investigators propose this multi-center randomised controlled study to test the preventive effect of intravenouse acetaminophen in delirium over 5 postoperative days among older patients recovering from major non-cardiac surgery.",[24],[181,182,183],"postoperative delirium","acetaminophen","elderly patient","2025-04-01",{"date":186,"type":29},"2025-04-04",{"date":188,"type":20},"2025-06",{"date":163,"type":20},{"name":191,"class":36},"RenJi Hospital",{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":16,"minAge":199,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":48,"phases":202,"briefSummary":203,"conditions":204,"keywords":207,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":134},"100457884","a-study-of-huperzine-a-injection-in-reducing-postoperative-delirium-in-elderly-patients-undergoing-non-cardiac-surgery-100457884","NCT05242419","A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery","A Multi-center, Randomized, Double-blinded, Placebo-controlled Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery","Inclusion Criteria:\n\n* ≥ 75 years old.\n* Comply with the indication of non-cardiac surgery under general anesthesia.\n* Anesthesia grade of American Society of Anesthesiologist (ASA) as III\\~IV grade.\n* The estimated operation time ≥ 2 hours.\n* Voluntarily sign the informed consent form.\n\nExclusion Criteria:\n\n* Patients with impaired renal function (Cr is 1.5 times higher than the upper limit of the normal value of the central laboratory) or abnormal liver function (Alanine aminotransferase(ALT) and Aspartate aminotransferase(AST) are 2 times higher than the upper limit of the normal value of the central laboratory).\n* Patients who are positive for infectious diseases.\n* Patients accompanied with central nervous system injury.\n* Patients with previous history of delirium and epilepsy, long-term use of psychoactive drugs or preoperative assessment of delirium.\n* Patients who involved diseases with drug taboos, bronchial asthma, mechanical intestinal obstruction and urinary tract obstruction, or serious systemic diseases, especially circulatory diseases: such as myocardial infarction, heart failure, angina pectoris, history of sinus bradycardia.\n* Patients who are known to be allergic to narcotic drugs or Huperzine A Injection, or must use drugs that are not compatible with Huperzine An Injection.\n* patients who participated in other clinical trials within 3 months before this study, for any reason, who could not tolerate the test or cooperate with the examination, or who has any aphasia, audio-visual dysfunction, etc.\n* the investigators think that the patients is not suitable to participate in this study.","75 Years",{"count":201,"type":20},40,[79],"To observe and study the clinical effect of Huperzine A Injection on reducing postoperative delirium in elderly patients undergoing non-cardiac surgery",[205,153,24,206],"Injection","Post Operative Delirium",[208,181,153,209],"Huperzine A Injection","Elderly Patients","2025-03-27",{"date":212,"type":29},"2025-04-02",{"date":214,"type":29},"2022-06-10",{"date":216,"type":20},"2025-12-30",{"name":218,"class":36},"Second Affiliated Hospital of Wenzhou Medical University",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":16,"minAge":142,"maxAge":4,"enrollmentInfo":227,"targetDuration":229,"studyType":21,"phases":4,"briefSummary":230,"conditions":231,"keywords":237,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":134},"100567586","exploring-the-correlations-of-lung-ultrasound-with-delirium-and-outcomes-in-acute-geriatrics-world-a-multicenter-prospective-observational-study-from-the-greta-group-of-the-italian-society-of-gerontology-and-geriatrics-100567586","NCT06670118","Exploring the Correlations of Lung Ultrasound with Delirium and Outcomes in Acute GEriatrics World: a Multicenter, Prospective, Observational Study from the GRETA Group of the Italian Society of Gerontology and Geriatrics","EXPLORING the CORRELATION of the LUNG ULTRASOUND with DELIRIUM and OUTCOMES in ACUTE GERIATRICS WORLD (ECO-AGE): a MULTICENTER, PROSPECTIVE, OBSERVATIONAL STUDY from the GRETA GROUP (GRUPPO DI RICERCA in ECOGRAFIA TORACICA NELL' ANZIANO) of the ITALIAN SOCIETY of GERONTOLOGY and GERIATRICS (SIGG)","ECO-AGE","Inclusion Criteria:\n\n* Patients aged 65 years or older, admitted directly from the Emergency Room or Emergency Medical Services with acute respiratory symptoms or signs.\n\nPresence of acute respiratory symptoms, including:\n\n* Dyspnea or cough.\n* Oxygen saturation less than 94% or respiratory rate ≥ 22 breaths per minute, or PaO2\u002FFiO2 \\\u003C 300.\n* Clinical suspicion of acute respiratory illness (e.g., pneumonia, acute congestive heart failure, pulmonary edema, COPD, pleural effusion, pneumothorax).\n* Lung ultrasound (LUS) performed within 48 hours of admission for clinical reasons.\n* Signed informed consent for participation in the study.\n\nExclusion Criteria:\n\n* Presence of delirium upon admission.\n* Refusal to sign the informed consent form or consent to data collection.\n* Terminal illness with an estimated survival prognosis of no more than 3 months.\n* Previous open thoracic or cardiothoracic surgery compromising the quality of LUS images.\n* Lack of cooperation during the LUS examination.\n* Any condition determined by the investigators that could introduce bias into the study or compromise the quality of the LUS examination.",{"count":228,"type":20},480,"3 Months","The purpose of this observational study is to investigate the prognostic relevance of lung ultrasound (LUS) performed on older patients (aged 65 and above) admitted to the hospital with acute respiratory symptoms. The primary objective is to determine if LUS-detected pulmonary abnormalities upon hospital admission are associated with the development of delirium during hospitalization. Secondary objectives include assessing the association between LUS patterns and clinical outcomes such as oxygen supplementation duration, non-invasive ventilation use, mortality, and length of hospital stay. This study involves no interventions and will monitor patients using LUS as part of their regular clinical care in multiple centers.",[232,24,233,234,235,236],"Acute Respiratory Failure","Pneumonia","Acute Heart Failure (AHF)","Chronic Obstructive Pulmonary Disease (COPD)","Ultrasound Exams",[238,239,240,241,242],"Lung Ultrasound Abnormalities in Older Adults","Lung ultrasound","delirium","respiratory failure","geriatrics","2024-10-31",{"date":245,"type":29},"2024-11-01",{"date":247,"type":20},"2024-12-01",{"date":249,"type":20},"2026-12-01",{"name":251,"class":36},"University of Milano Bicocca",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":256,"acronym":257,"eligibilityCriteria":258,"healthyVolunteers":108,"sex":16,"minAge":142,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":48,"phases":261,"briefSummary":262,"conditions":263,"keywords":270,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":134},"100501881","yoomi-effect-of-gamified-physical-therapy-exercise-software-on-inpatient-mobility-100501881","NCT05815017","YOOMI: Effect of Gamified Physical Therapy Exercise Software on Inpatient Mobility","YOOMI","Inclusion Criteria:\n\n* \\>= 65 years of age\n* English-fluency in reading and speaking\n* Capacity to consent\n* Enrolled in HELP program\n* Attending physician confirms there are no medical contraindications to in-bed exercises\n\nExclusion Criteria:\n\n* Unstable Psychiatric Illness\n* Unstable\u002FCritically Ill Patients requiring ICU-level of care\n* Surgical tube present (e.g. JP drains)\n* Surgery during the hospitalization\n* Bed Rest Activity Order",{"count":260,"type":20},80,[79],"Patients admitted to the hospital often develop functional impairments due to being in bed most of the day. Each day of bedrest leads to significant muscle loss. As a result, many patients become dependent on others or require rehabilitation at a facility to improve mobility and function prior to returning home. Staff in the hospital is limited and often unable to mobilize patients every day while hospitalized. The investigators are testing a new experimental gamified physical therapy exercise software to see if it can be a fun, enjoyable way to help mobilize patients without the assistance of staff. The primary aim of this pilot\u002Fproof of concept study is to determine whether gamified physical therapy software can help inpatients exercise within the safety of their own beds and preserve pre-hospitalization function.",[264,24,265,266,267,268,269],"Weakness, Muscle","Muscle Atrophy or Weakness","Muscle Loss","Hospital Acquired Condition","Physical Disability","Physical Inactivity",[271,272,273,274,275,276],"Artificial Intelligence (AI)","Physical Therapy","Hospitalization related muscle atrophy","Hospitalization associated decline","Inpatient rehabilitation","AI driven physical therapy","2024-03-06",{"date":279,"type":29},"2024-03-08",{"date":281,"type":29},"2023-11-29",{"date":283,"type":20},"2024-12",{"name":285,"class":36},"Rutgers, The State University of New Jersey"]