[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"delirium-postoperative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:delirium-postoperative":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,45,76,107,134,161,193,224,246,267],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100571558","phase-3-the-scope-trial-sleep-cognition-and-pain-bundle-vs-eras-cardiac-for-postoperative-delirium-100571558",false,"NCT06721819","The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium","SCOPE","Inclusion Criteria:\n\n* Planned cardiac surgery \\[CABG with or without valve, isolated valve surgery\\] requiring median sternotomy and full CPB at least 10 days in the future.\n\n  * 60 years of age.\n\nWillingness to use a provided tablet and wearable devices and commit at least 1 hour amount of time per day before surgery to complete interventions (psCBT\u002Fcognitive activity\u002Fexercise) if randomized to experimental group.\n\nExclusion Criteria:\n\n* Pre-operative left ventricular ejection fraction (LVEF) \\\u003C than 30%\n\nEmergent procedures\n\nIsolated aortic surgery\n\nLiver dysfunction (ALT or AST \\> 4 times the upper limit of local normal; all patients will have a baseline liver function test information or history and exam suggestive of jaundice or both)\n\nKnown hypersensitivity to the study drugs\n\nActive (in the past year) history of alcohol abuse (≥ 5 drinks\u002Fday for men or ≥ 4 drinks\u002Fday for women) Any history of alcohol withdrawal or delirium tremens\n\nDelirium at baseline\n\nEnglish language Limitations\n\nPhysician refusal\n\nChronic opioid use for chronic pain conditions with tolerance (total dose of an opioid at or more than 30 mg morphine equivalent for more than one month within the past year)\n\nSignificant visual impairment\n\nPrisoner\n\nSevere OSA in the past year (AHI is greater than 30 (more than 30 episodes per hour)) or ESS of 18 or more\n\nCo-enrollment with non-approved interventional trial\n\nSevere cognitive impairment (MOCA \\\u003C 10) or medications for cognitive decline\n\nRecent treatment for insomnia with CBT-I within the last 6 months","ALL","60 Years",{"count":19,"type":20},406,"ESTIMATED","INTERVENTIONAL",[23],"PHASE3","Sleep disturbances, cognitive reserve, and continuing pain and inflammation are other risk factors contributing to delirium (confusion and agitation) and neurocognitive decline (in the long term) following heart surgery. Investigators aim to test a bundle of sleep optimization, cognitive exercise before surgery, and extended pain relief for 48 hours with intravenous acetaminophen combined with enhanced recovery after surgery protocols (SCOPE bundle). SCOPE will fill significant gaps in evidence by testing the value of a patient and care-provider-focused intervention that can potentially minimize POD and improve outcomes (cognitive \\& physical function, sleep quality, pain, depression or anxiety, and survival) important to patients and families.\n\nThe SCOPE trial will address many heart surgery outcome-related questions commonly asked by patients:\n\nWhat can I do to reduce my chances of developing confusion, hallucinations, or delirium after surgery? How can I best prepare before surgery to improve my long-term health and avoid disability? Are there exercises I can participate in that improve my sleep, pain, and mood after surgery? Intellectual pursuits, physical activity, and social interactions support cognitive reserve, while poor health, poor sleep hygiene, poor nutrition, and mental health disease can diminish reserve. Various interventions with different intensities and timing to augment cognitive reserve have been associated with positive outcomes on neuropsychological testing. Adaptive video gaming for as little as 10 hours leads to the maintenance of independence in activities of daily living and sustained improvements in speed of processing, attention, and working memory in older people. Likely through the increased cognitive reserve, perioperative brain exercise aims to protect against morbid cognitive recovery after surgery.\n\nSleep is vital for memory and cognitive function. Poor sleep traits in older adults that are potentially modifiable, including short\u002Flong duration, daytime napping, and associated sleepiness, led to an almost 2-fold increase in delirium risk. Patients will complete an evidence-based course on healthy sleep habits and will complete guided exercises designed to restructure behaviors and thinking. They are encouraged to follow a set of recommendations to improve their sleep (e.g., optimal sleep duration, advice for habits such as daytime napping, maintaining a regular sleep schedule, avoiding caffeine, regular daylight exposure, dimming lights or electronics and relaxation and thought exercises for optimal sleep); many of these sleep behaviors have been strongly linked to increased risk for cognitive decline. Investigators propose that sleep optimization before AND after (an established best practice sleep bundle) surgical insult will contribute to cognitive reserve leading to decreased delirium risk and key patient-centered outcomes (postoperative sleep, pain, cognition, mood, and survival).\n\nInadequate pain relief and opioids are both risk factors for delirium. Surgery on the chest is a significant pain source. Approximately 30-75% of patients suffer from moderate to severe pain in the postoperative period. Almost half of the patients have severe pain at rest, and three-quarters have severe pain during coughing and movement. Pain and inflammation are closely biochemically linked.\n\nSleep, brain exercise, and adequate pain control with opioid-sparing can be additive or synergistic interventions to prevent delirium following heart surgery.\n\nInvestigators propose three specific aims by conducting a 1:1 randomized controlled trial in 406 heart surgery patients 60 or older undergoing heart surgery. They will be administered perioperative sleep optimization, brain exercise training, and intravenous acetaminophen over 48 hours. A trained expert will administer the sleep and cognitive exercise protocols at least two weeks before surgery. This expert will handhold the patients for two weeks until the surgery. Thus, the gains made before surgery with better sleep quality and improved brain reserve will be sustained with postoperative pain control to lower the ongoing inflammation. Through this trial, investigators will evaluate if the SCOPE bundle can reduce 1) in-hospital delirium, 2) long-term (one, six, and twelve months) cognitive, physical, and self-care function, and 3) barriers to implementation of this bundle.\n\nCurrently, no options are routinely available to patients to optimize their sleep and cognition before cardiac surgery. The proposed research is significant because it will be the first to test the bundled behavioral intervention approach (sleep optimization, brain exercise) before surgery with extended, scheduled pain management with non-opioids following surgery. The SCOPE trial will yield relevant and immediately actionable data to improve care for over 900,000 adults in the U.S. each year.",[26,27],"Delirium, Postoperative","Delirium in Old Age",[29,30,31],"Delirium","PostOperative","Cardiac Surgery","RECRUITING","2026-04-10",{"date":35,"type":36},"2026-04-15","ACTUAL",{"date":38,"type":36},"2025-06-06",{"date":40,"type":20},"2030-03-31",{"name":42,"class":43},"Beth Israel Deaconess Medical Center","OTHER",3,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100524345","reducing-delirium-after-cabg-surgery-with-early-activation-and-sleep-promoting-routines-100524345","NCT06107517","Reducing Delirium After CABG Surgery With Early Activation and Sleep-Promoting Routines","DREAMS-OT Trial: Delirium Reduction Through Early Activation in Motivating and Sleep Promoting Routines: A Randomized Controlled Trial of Occupational Therapy for ICU Patients After Coronary Artery Bypass Graft (CABG) Surgery","DREAMS-OT","Inclusion Criteria:\n\n* Patients deemed medically suitable for elective CABG surgery\n* Patients aged 21 years and above\n* Patients who are English or Mandarin speaking.\n* Patients who are able to provide consent\n\nExclusion Criteria:\n\n* Patients who speak other languages are excluded due to the language requirements of certain outcome measures.\n* Patients with premorbid severe hearing impairment, severe cognitive impairment, progressive neurological disorders and psychological disorders will be excluded.\n* Patients with surgical complications resulting in profuse bleeding from any invasive sites, septic shock unresponsive to maximal treatment, and those who are moribund or have an expected mortality within 48 hours will be excluded.\n* Pregnant women will also be excluded from the study as well.\n* Patients who develop delirium before initiation of the treatment are also excluded from the study.","21 Years","99 Years",{"count":56,"type":20},300,[58],"NA","The goal of this randomized-controlled trial (RCT) is to compare the effectiveness of the DREAMS-OT intervention with standard care in reducing post-Coronary Artery Bypass Graft (CABG) surgery delirium in patients undergoing CABG surgery.\n\nThe aims of the study are:\n\n1. To determine if early and intensive OT will lower the incidence of post-op delirium in CABG patients compared to standard are.\n2. To determine the cost effectiveness of the DREAMS-OT intervention.\n\nThe study team will compare intervention group and standard care group (control group) to see if there is a reduction in the incidence of delirium in patients 5 days post-CABG.",[26],[29,62,63,64,65],"Coronary Artery Bypass Grafting","Occupational Therapy","Intensive Care Units","Randomized Controlled Trial","2026-03-24",{"date":68,"type":36},"2026-03-30",{"date":70,"type":36},"2024-01-08",{"date":72,"type":20},"2026-08",{"name":74,"class":43},"National University Hospital, Singapore",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":75},"100592978","transcranial-doppler-as-a-predictor-of-postoperative-cognitive-dysfunction-following-cardiopulmonary-bypass-100592978","NCT07000461","Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass","Can Transcranial Doppler Predict Postoperative Cognitive Dysfunction After Cardiopulmonary Bypass","Inclusion Criteria:\n\n* Patients aged 18-70\n* Patients scheduled for isolated elective cardiopulmonary bypass surgery\n\nExclusion Criteria:\n\n* Patients with carotid stenosis ≥50%\n* Emergency patients or those with a history of reoperation\n* Patients with a history of cerebrovascular events\n* Patients who do not provide consent\n* Patients with temporal window failure\n* Patients with an ejection fraction (EF) \\\u003C40%\n* Patients with a Mini-Mental State Examination (MMSE) score \\\u003C23\n* Patients who require mechanical ventilation for more than 24 hours or those who are reintubated","18 Years","70 Years",{"count":86,"type":20},106,"OBSERVATIONAL","Neurological dysfunction either transient or permanent is a major cause of morbidity and mortality after cardiopulmonary bypass, and cognitive dysfunction is more frequent in cardiac surgery than in non-cardiac procedures. Variations in cerebral blood flow and oxygen extraction are considered key contributing factors. Although pulsatile flow during bypass has shown benefits for renal function and recovery, its effects on postoperative neurological dysfunction and delirium remain unclear due to limited research. This study aims to evaluate the impact of pulsatile versus non-pulsatile cardiopulmonary bypass flow on POCD in adult CABG patients by measuring middle cerebral artery (MCA) flow using transcranial Doppler.",[90,26],"Postoperative Cognitive Dysfunction",[92,93,94,95,96],"transcranial doppler","delirium","POCD","cerebral perfusion","CABG","2026-02-13",{"date":99,"type":36},"2026-02-17",{"date":101,"type":36},"2025-04-17",{"date":103,"type":20},"2026-04-30",{"name":105,"class":106},"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","OTHER_GOV",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":84,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":75},"100520117","sleep-and-circadian-rhythm-biomarkers-of-postoperative-delirium-100520117","NCT06052397","Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium","SLEEP-POD","Inclusion Criteria:\n\n* Age \\>= 70 years old\n* Scheduled to undergo major orthopedic surgery\n* Expected postoperative recovery of more than 24 hours as an inpatient\n\nExclusion Criteria:\n\n* Cognitive impairment leading to inability to consent\n* Patients with limited mobility or inability to wear an actigraphy watch\n* Patients with infection at the site of actigraphy watch, allergies to materials of watch\n* Patients with \\> two days in the ICU during the month prior to surgery\n* Renal or liver failure\n* Severe neurocognitive damage or history of psychiatric illness\n* Blindness or deafness\n* Patients who are non-English speaking",{"count":115,"type":20},150,"The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are:\n\n1. To define sleep\u002Fcircadian biomarkers of delirium (sleep duration, regularity, stability and timing of rhythm) in a prospective observational study.\n2. To determine if plasma Alzheimer's disease (AD) pathology\u002Finflammatory burden interacts with or moderates the relationship between a sleep\u002Fcircadian biomarker and post-operative delirium (POD) risk.\n3. To determine whether sleep\u002Fcircadian regulation interacts with the genetic risk of AD to influence POD\u002Fcognitive decline.\n\nParticipants will be asked to:\n\n1. Donate several blood samples both intraoperatively and postoperatively\n2. Complete baseline and postoperative neurocognitive assessments\n3. Wear an actigraphy data collection watch for the two weeks prior to their surgery",[26,118,119],"Cognitive Decline","Dementia",[121,122,123,124,119],"Sleep","Postoperative Delirium","Circadian Rhythms","Cognition","2026-02-09",{"date":127,"type":36},"2026-02-11",{"date":129,"type":36},"2023-09-12",{"date":131,"type":20},"2027-09-30",{"name":133,"class":43},"Massachusetts General Hospital",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":141,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":21,"phases":144,"briefSummary":145,"conditions":146,"keywords":149,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":75},"100623430","audio-recorded-messages-delivered-via-ipad-to-prevent-delirium-in-hip-fracture-patients-100623430","NCT07396532","Audio-Recorded Messages Delivered Via iPad to Prevent Delirium in Hip Fracture Patients","Nurse-Led Audio-Recorded Reorientation to Reduce Delirium in Elderly Hip Fractures: A Pilot Randomized Control Trial","Inclusion Criteria:\n\n* Older adults aged 60 years and above\n* Undergoing hip fracture repair surgery\n* No history of cognitive impairment as assessed by Abbreviated Mental Test (AMT)\n* Able to understand to any of the basic languages of Singapore (English, Malay, Mandarin, Tamil)\n\nExclusion Criteria:\n\n* Patients not admitted directly to orthopaedic (study) wards post-operation (such as those requiring post-operative high-dependency unit care)\n* Patients managed conservatively without surgical intervention.\n* Patients admitted for periprosthetic hip fracture repairs\n* Patients who are deaf and mute",true,{"count":143,"type":20},30,[58],"The goal of this pilot clinical trial is to learn if personalized audio-recorded reorientation messages can be successfully implemented in general hospital wards for elderly patients after hip fracture surgery. It will also explore whether this intervention might help prevent confusion (delirium) after surgery. The main questions it aims to answer are:\n\n* Can the intervention be successfully delivered by nursing staff in a busy orthopedic ward?\n* How many eligible patients can be recruited and retained in the study?\n* Do patients tolerate listening to the personalized audio messages without problems?\n* Does listening to personalized audio messages show any early signs of reducing confusion after surgery?\n\nResearchers will compare patients who receive personalized audio messages to those who receive usual care to see if the intervention is feasible to implement and whether it shows promise for preventing delirium.\n\nParticipants will:\n\n* Listen to 2-minute personalized audio-recorded reorientation messages played through an iPad and headphones three times daily for the first 3 days after surgery\n* Have their orientation and mental status checked daily for three times by nursing staff\n* Continue with all their regular medical care and treatments\n* Be monitored until discharge from the study wards.",[147,148,26],"Delirium - Postoperative","Delirium and Post-operative Cognitive Dysfunction (POCD)",[93,150,151,152],"nurse-led","reality reorientation","AI","2026-02-02",{"date":125,"type":36},{"date":156,"type":36},"2025-09-29",{"date":158,"type":20},"2026-07",{"name":160,"class":43},"Sengkang General Hospital",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":16,"minAge":169,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":21,"phases":172,"briefSummary":173,"conditions":174,"keywords":178,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":44},"100536688","depth-of-anesthesia-on-postoperative-delirium-and-cognitive-after-surgery-100536688","NCT06268080","Depth of Anesthesia on Postoperative Delirium and Cognitive After Surgery","Preserving Brain Health After Surgery: Does Light General Anesthesia Reduce Postoperative Delirium and Cognitive Decline Compared With Deep General Anesthesia in Older Adults?","Balanced-2","Inclusion Criteria:\n\n* Patients aged ≥ 65 years, and Māori, Pacific or Indigenous participants aged ≥ 55 years who are undergoing major elective or non-elective surgery with expected surgical duration ≥ 2 hours and postoperative hospital stay ≥ 2 nights.\n* Having general anesthesia using total intravenous anesthesia (TIVA) with pEEG monitoring\n* Able to provide informed consent (including patients with mild preoperative neurocognitive disorders)\n\nExclusion Criteria:\n\n* Intracranial or cardiac surgery\n* Undergoing surgery with 'wake up' test\n* Previous enrollment in Balanced-2 study\n* Terminal illness with expected survival \\\u003C3 months\n* Emergency surgery within 6 hours of presentation to hospital\n* Cognitive impairment with no capacity to consent or activated enduring power of attorney\n* Clinically impaired and unable to consent due to acute pathology or preoperative delirium","55 Years",{"count":171,"type":20},2766,[58],"The goal of this clinical trial (Balanced-2 study) is to compare light to deep general anesthesia using widely available brain monitors, to see if 'light' anesthesia could reduce rates of delirium, cognitive decline, and disability in older adults undergoing major surgery.\n\nDelirium is the most common serious surgical complication, occurring in an estimated one in four older adults undergoing major surgery. Delirium causes significant distress to patients and family, and is associated with prolonged hospital stay, physical disability, progression to dementia-like illnesses, and discharge to long-term care. Between 10 - 30% of adults aged 70 years and above have surgery every year, and preserving brain health and wellbeing is an important priority during this time.\n\nOlder adults (aged ≥65 years, or Indigenous, Pacific patients aged ≥55 years) undergoing major surgery with general anesthesia (excluding heart and brain surgery) and able to provide consent will be able to participate. Participants will be randomized to two groups - a lighter general anesthesia group and a deeper general anesthesia group using processed electroencephalography (a brain monitor that provides information on depth of anesthesia using brain waves). The anesthesiologist will titrate anesthetic drugs according to the brain monitor. Participants will be followed up to determine if they experience delirium after surgery, and longer term impact of delirium such as cognitive and physical decline will also be measured.\n\nIf found to be effect, this simple, cheap, and widely available treatment could reduce disability, preserve brain health and wellbeing of many older adults undergoing surgery worldwide, and save millions in healthcare dollars.",[26,175,176,177,29,118],"Anesthesia","Surgery-Complications","Cognition Disorder",[179,180,181,182,183],"randomized controlled trial","multicentre","clinical trial","depth of anaesthesia","postoperative delirium","2025-09-22",{"date":186,"type":36},"2025-09-25",{"date":188,"type":36},"2024-05-20",{"date":190,"type":20},"2028-12-31",{"name":192,"class":106},"Auckland City Hospital",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":16,"minAge":200,"maxAge":201,"enrollmentInfo":202,"targetDuration":4,"studyType":21,"phases":204,"briefSummary":205,"conditions":206,"keywords":211,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":223},"100578895","effect-of-low-dose-esketamine-on-delirium-in-high-risk-elderly-patients-undergoing-elective-surgery-element-100578895","NCT06817239","Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)","Effect of Perioperative Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Major Non-cardiac Surgery: a Multi-center Randomized Trial (ELEMENT Trial)","Inclusion Criteria:\n\n* Age ≥65 years and \\\u003C90 years;\n* Scheduled to undergo major non-cardiac surgery.\n* Fulfill at least one of risk factors as follows: history of stroke; history of delirium; hypertension; congestive heart failure; coronary artery disease; atrial fibrillation; peripheral artery disease; chronic obstructive pulmonary disease; obstructive sleep apnea; diabetes; chronic kidney disease; anemia; malnutrition; hypoalbuminemia; chronic pain; anxiety and depression; poor sleep quality; smoke; alcoholism.\n* Scheduled to receive patient-controlled intravenous analgesia (PCIA).\n\nExclusion Criteria:\n\n* Refuse to participate;\n* Preoperative history of epilepsy, myasthenia gravis, Parkinson's disease, intracranial hypertension, delirium, schizophrenia, or other psychiatric diseases;\n* Inability to communicate in the preoperative period because of coma, profound dementia, or language barrier;\n* Preoperative uncontrolled severe hypertension (baseline SBP\\>180 mmHg or DBP\\>110 mmHg);\n* Preoperative history of hyperthyroidism and pheochromocytoma;\n* Acute cardiovascular event occurring within 30 days before surgery;\n* Severe hepatic dysfunction (Child-Pugh class C), renal dysfunction (required preoperative dialysis), or expected survival ≤24 hours;\n* Scheduled to undergo organ transplantation, vascular surgery, neurosurgery;\n* Receiving treatment with ketamine or esketamine;\n* Contradiction to ketamine or esketamine;\n* Other situations where the investigator or physician considers the patient ineligible for the study.","65 Years","90 Years",{"count":203,"type":20},1670,[58],"Delirium is an acutely occurred neurocognitive disorder characterized by fluctuating symptoms of inattention, altered consciousness and cognitive dysfunction. Delirium is reported to occur in 4% to 65% of postoperative patients depending on the population, and is especially common in older patients. Postoperative delirium is disturbing to patients and their families, and it is a strong predictor of both early and long-term worse outcomes including increased non-delirium complications, increased perioperative mortality, shortened overall survival, declined cognitive function, and lowered quality of life.\n\nAlthough ketamine\u002Fesketamine has anti-inflammatory and neuroprotective effects, evidence on its efficacy in reducing postoperative delirium remains inconsistent and inconclusive. Existing studies are limited by heterogeneity, small sample sizes, single-center designs, and a focus on specific type of surgery. Research on elderly high-risk patients is lacking, and most studies administer the drug intraoperatively, with limited exploration of postoperative use. The optimal dosing and timing for POD prevention are unclear. This study aims to carry out a multicenter, single-blind, placebo-controlled, large-sample randomized controlled trial assessing the effect of low-dose esketamine, given intraoperatively and postoperatively, on delirium in elderly high-risk patients undergoing major non-cardiac surgery.",[27,26,175,207,208,209,210],"Cognitive Dysfunction","Pain, Postoperative","Esketamine","Non-cardiac Surgery",[29,212,209,213],"Elderly patients","Non-cardiac surgery","2025-04-23",{"date":216,"type":36},"2025-04-27",{"date":218,"type":36},"2025-02-12",{"date":220,"type":20},"2027-07",{"name":222,"class":43},"Nanfang Hospital, Southern Medical University",6,{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":234,"conditions":235,"keywords":4,"overallStatus":236,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":75},"100546236","the-impact-of-smoking-on-the-prognosis-of-elderly-surgical-patients-100546236","NCT06392308","The Impact of Smoking on the Prognosis of Elderly Surgical Patients","The Impact of Smoking on Postoperative Delirium and Recovery Quality in Elderly Surgical Patients","Inclusion Criteria:\n\n* Age \\>60 years;\n* American Society of Anesthesiologists (ASA) preoperative anesthesia classification ASA Grades I and II;\n* Undergoing elective surgery;\n* Patients and their families are able to understand and complete various scoring scales and voluntarily sign informed consent.\n\nExclusion Criteria:\n\n* Mini-Mental State Examination (MMSE) score \\\u003C23;\n* Preoperative biochemical tests indicate renal dysfunction or active liver disease;\n* History of definite neurological or psychiatric disorders or history of taking corresponding medications before surgery;\n* History of alcohol abuse or drug dependency;\n* Taking antidepressant medications;\n* American Society of Anesthesiologists (ASA) preoperative anesthesia classification \\> Grade II.","80 Years",{"count":233,"type":20},121,"Postoperative delirium is a common complication that frequently occurs in elderly patients after surgery. It not only increases the length of hospital stays and healthcare costs but also raises the incidence of postoperative cognitive dysfunction and even mortality. However, the underlying mechanisms of its onset are not yet fully understood. Evidence suggests that smoking can lead to gut microbiota dysbiosis and metabolic dysfunction, and the gut microbiota and its metabolites play a crucial role in cognitive function through the gut-brain axis. Yet, no studies have reported whether smoking could affect the occurrence of postoperative delirium and the quality of postoperative recovery through the gut microbiota. This study aims to observe the incidence of postoperative delirium and the postoperative recovery quality scores between smokers and non-smokers.",[26],"NOT_YET_RECRUITING","2025-01-15",{"date":239,"type":36},"2025-01-16",{"date":241,"type":20},"2025-09-01",{"date":243,"type":20},"2025-12-31",{"name":245,"class":43},"Affiliated Hospital of Nantong University",{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":253,"targetDuration":4,"studyType":21,"phases":255,"briefSummary":256,"conditions":257,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":75},"100543851","phase-3-liraglutide-in-preventing-delirium-in-diabetic-elderly-after-cardiac-surgery-100543851","NCT06361238","Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery","Perioperative Application of Liraglutide for the Prevention of Postoperative Delirium Among Elderly Patients with Type 2 Diabetes Undergoing Cardiac Surgery: a Single-Center Randomized Controlled Study","Inclusion Criteria:\n\n1. Age ≥ 60 years\n2. Type 2 diabetes\n3. Patients undergoing elective cardiac surgery\n\nExclusion Criteria:\n\n1. History of neurological or psychiatric disorders, such as schizophrenia, epilepsy, Parkinson's disease, severe dementia, etc\n2. Patients with communication difficulties, such as severe visual, auditory, or speech impairments\n3. History of central nervous system damage or surgery\n4. Cardiac function NYHA Class IV\n5. Severe liver dysfunction (Child-Pugh Class C)\n6. Severe renal failure requiring renal replacement therapy\n7. History of pancreatitis\n8. Type 1 diabetes\n9. Patients whose blood sugar is difficult to control within 4-8 mmol\u002FL during the screening period\n10. Patients with medullary thyroid carcinoma or a family history of it\n11. Pregnant or breastfeeding women\n12. Intolerance or allergy to liraglutide\n13. Previous use of GLP-1A and SGLT2i\n14. Patients who refuse to sign the informed consent",{"count":254,"type":20},260,[23],"This study aims to clarify the preventive effect of perioperative liraglutide application on postoperative delirium in elderly patients with Type 2 diabetes undergoing cardiac surgery.",[26],"2024-12-17",{"date":260,"type":36},"2024-12-20",{"date":262,"type":36},"2024-11-19",{"date":264,"type":20},"2028-03-31",{"name":266,"class":43},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School",{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":141,"sex":16,"minAge":83,"maxAge":231,"enrollmentInfo":274,"targetDuration":4,"studyType":21,"phases":276,"briefSummary":277,"conditions":278,"keywords":281,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":75},"100556592","impact-of-sleep-quality-on-outcomes-after-cardiac-surgery-100556592","NCT06527105","Impact of Sleep Quality on Outcomes After Cardiac Surgery","The Effects of Non-pharmacological Interventions on the Quality of Sleep in Cardiac Surgical Patients","Inclusion Criteria:\n\n* Adult cardiac surgical patients aged above 18years undergoing elective cardiac surgery\n\nExclusion Criteria:\n\n* Not willing to give consent\n* Preoperative sleep medications use\n* Preoperative psychological disorders, on mechanical ventilation for \\>12hrs, dementia, cerebrovascular accident",{"count":275,"type":20},100,[58],"Sleep is a basic human need and is essential for good quality of life, good health. In fact, humans spend one third of their life time in sleeping or attempting to do so. However, sleep is not given due importance in intensive care unit (ICU)'s, although it is critical in healing process. Patient's usually get admitted to the hospital few days prior to the surgery, for complete evaluation, depending on the procedure planned. Hospital environment being, an entirely new place for inpatients, will invariably affect their sleep. Sleep deprivation is one of the major sources of anxiety and stress in all the patients during ICU stay. This means that most of patients are sleep deprived, by the time they are admitted to ICU.\n\nThe negative effects of sleep deprivation include postoperative brain dysfunction like inattention, restlessness, hallucinations, agitation, aggressiveness. The degree of cognitive impairment may range from subtle derangements in attention, reason, clarity of thought and capacity of decision making to confusion and delirium. Sleep deprivation can also induce hypertension, fatigue, metabolic disorders, cerebrovascular and cardiovascular disease",[121,279,26,280],"Atrial Fibrillation","Complications, Postoperative",[282,283],"Cardiac surgery","Sleep quality","2024-09-23",{"date":286,"type":36},"2024-09-25",{"date":288,"type":36},"2024-07-22",{"date":290,"type":20},"2025-01-31",{"name":292,"class":43},"Amrita Institute of Medical Sciences & Research Center"]