[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"delusional-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:delusional-disorder":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,54,88,124],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100585170","enhancing-veteran-clinical-collaboration-in-va-prrcs-100585170",false,"NCT06898879","Enhancing Veteran-Clinical Collaboration in VA PRRCs","Enhancing Veteran-Clinical Collaboration in VA Psychosocial Rehabilitation and Recovery Centers","EVCC VPRRC","Inclusion Criteria:\n\n1. be a Veteran currently receiving PRRC, MHICM and\u002For BHIP services at VA San Diego, Los Angeles, or Albuquerque (e.g., seen in the clinic in the past month or based on clinic criteria)\n2. meet SAMHSA criteria of serious mental illness; i.e., \"having (within the past year) a diagnosable mental, behavior, or emotional disorder that causes serious functional impairment that substantially interferes with or limits one or more major life activities,\" based on chart review and clinician consultation if needed\n3. Be age 18 or above\n4. Be fluent and literate in English.\n5. Agree to have a subset of VA mental health treatment appointments audiotaped\n\nExclusion Criteria:\n\n1. primary substance use or organic neurological disorder diagnosis determined by chart review\n2. are determined by clinician and\u002For study staff to be at significant risk of exacerbation of symptoms, suicidal ideation, or other risk due to study participation\n3. have a history and\u002For current risk of violence that clinicians and\u002For study staff determine to be too high risk to manage effectively in the study setting (e.g., poses a risk to Veterans or study staff).","ALL","18 Years",{"count":20,"type":21},119,"ESTIMATED","INTERVENTIONAL",[24],"NA","Over 60% of Veterans with serious mental illness have a service-connected disability that impairs their ability to work, go to school, and\u002For have successful personal lives. Although traditional treatments tend to focus on symptom remission, Veterans prioritize a range of treatment goals, including personal empowerment and gaining personally meaningful skills. Increasing Veteran-clinician collaboration can help effectively align care with each Veteran's goals and support an empowering therapeutic experience. This project will evaluate the effectiveness of a group-based intervention intended to increase Veterans' comfort, confidence, knowledge, and skills to collaborate with their treatment teams. Findings from this study will contribute important knowledge about this intervention's effectiveness and how to enhance its effectiveness, especially for Veterans from minoritized groups. If the decision-making intervention is effective, it would help Veterans with serious mental illness, and might also help Veterans with other chronic health conditions, like PTSD and chronic pain.",[27,28,29,30,31],"Schizophrenia","Schizoaffective Disorder","Delusional Disorder","Bipolar Disorder","Major Depressive Disorder",[33,34,35,36,37,38,39,40],"serious mental illness","psychosis","collaborative decision-making","shared decision-making","veterans","recovery","personal recovery","empowerment","NOT_YET_RECRUITING","2026-04-14",{"date":44,"type":45},"2026-04-15","ACTUAL",{"date":47,"type":21},"2026-07-01",{"date":49,"type":21},"2029-09-30",{"name":51,"class":52},"VA Office of Research and Development","FED",3,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":4},"100471268","shared-decision-making-for-antipsychotic-medications-100471268","NCT05416658","Shared Decision Making for Antipsychotic Medications","Examining the Effectiveness of a Shared Decision Making Intervention for Antipsychotic Medications to Improve Engagement in Treatment for People Experiencing Early Psychosis","Inclusion Criteria:\n\n* Ages 18 to 30 who have experienced nonaffective psychosis with a diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, other specified\u002Funspecified schizophrenia spectrum and other psychotic disorders (ICD-10-CM Diagnosis Code F20.x)\n* Current\u002Fpast experiences with antipsychotic medications (APM; e.g., currently taking any antipsychotic medication, stopped taking, or considering stopping).\n* Receive FEP treatment in one of OnTrackNY clinics\u002Fsites randomized to intervention or treatment as usual (TAU) - Willing to participate in research interviews after each APM visit during the study period (3 months)\n\nExclusion Criteria:\n\n* Unable to provide informed consent\n* No experience with APM\n* Not fluent (speaking, reading, writing) in English","30 Years",{"count":63,"type":21},120,[24],"This study aims to provide an evidence-based shared decision making intervention for antipsychotic medications, the Antipsychotic Medication Decision Aid (APM-DA), for individuals experiencing early psychosis and provide, for the first time, an understanding of the shared decision making mechanism of action.",[27,28,67,29,68],"Schizophreniform Disorders","Other Specified Schizophrenia Spectrum and Other Psychotic Disorder",[70,34,71,72,73,74,75,76,77],"Shared decision making","schizophrenia","antipsychotic","medication","intervention","decision aid","coordinated specialty care (CSC)","randomized controlled trial (RCT)","2026-03-24",{"date":80,"type":45},"2026-03-30",{"date":82,"type":21},"2027-01-01",{"date":84,"type":21},"2027-06-30",{"name":86,"class":87},"New York State Psychiatric Institute","OTHER",{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":98,"phases":4,"briefSummary":99,"conditions":100,"keywords":105,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":121,"locationsCount":123},"100572985","biomarkersbiotypes-course-of-early-psychosis-and-specialty-services-100572985","NCT06740383","Biomarkers\u002FBiotypes, Course of Early Psychosis and Specialty Services","BICEPS","Inclusion Criteria:\n\n* Males and females, all races and ethnicities\n* 18-40 y\u002Fo\n* Meet DSM-5 criteria for a psychotic disorder, i.e. schizophrenia, schizophreniform, schizoaffective disorder, or bipolar I disorder or major depression with psychotic features, delusional disorder or psychosis N.O.S.\n* Able to read, speak, and understand English\n* Able and willing to provide written informed consent, and willing to commit to the study protocol\n* Illness duration from psychosis onset less than or equal to 4 years\n* At baseline only: receiving both psychopharmacology and psychotherapy\n\nExclusion Criteria:\n\n* Estimated premorbid intellectual ability \\\u003C70 (WRAT-4, Word Reading subtest, age-corrected standardized score)\n* Neurological or medical disorder that may affect brain function (seizure disorder, traumatic brain injury with a loss of consciousness greater than or equal to 30 min, history of stroke, AIDS, etc.)\n* Psychoses secondary to substance use i.e., Comorbid DSM-5 diagnosis of alcohol or substance use disorders that may explain the diagnosis of psychotic disorders (individuals with cannabis use disorders unrelated to psychosis onset will be allowed. Participants encouraged to abstain from substances for 24 hours prior to lab visits)\n\nMRI-Specific Exclusion Criteria:\n\n* Pregnant women\n* Presence of ferromagnetic objects in body\n* Weight or body size exceeding scanner capacity (\\>300 lbs)\n* Claustrophobia","40 Years",{"count":97,"type":21},320,"OBSERVATIONAL","The Biomarkers\u002FBiotypes, Course of Early Psychosis and Specialty Services (BICEPS) study aims to understand the early stages of psychotic disorders like Schizophrenia, Schizoaffective Disorder, and Bipolar I Disorder. It involves gathering mental health information, brain scans (MRI), eye movement patterns (Eye-Tracking), and brain electrical waves (EEG) data from individuals who have experienced these disorders in recent years. Participants will be involved for about a year, with four visits over this period. Screening procedures, lasting approximately 3 hours, include tests for drug use, a pregnancy test for eligible women, clinical interviews about feelings and experiences, psychiatric and family history interviews, and a medical history review. Research procedures for eligible participants include DNA collection, a neuropsychological test battery, EEG, eye-tracking, and MRI. These procedures will help researchers understand brain function, genetics, and cognitive abilities related to psychotic disorders. Follow-up visits at 1-month, 6-month, and 12-month intervals involve modified clinical interviews and repeating neuropsychological tests to track changes over time. Participants may opt to provide DNA samples for genetic analysis, undergo various cognitive tests, EEG to record brain waves, eye-tracking to monitor eye movements, and MRI scans to visualize brain structure. Follow-up visits at regular intervals will help researchers track changes in symptoms and cognitive function. This study provides comprehensive insight into the onset and progression of psychotic disorders and offers valuable information for patients, families, and healthcare providers involved in managing these conditions. Our goal is to better understand whether a combination of biological markers and different types of people (BT1, BT2, BT3) can help us predict how well individuals with early psychosis respond to specialized care. We expect that those in BT3 will have the best outcomes, BT2 will have intermediate outcomes, and BT1 will have the poorest outcomes. Even though BT1 and BT2 might start with similar cognitive issues, their biology might lead to different responses to treatment. This research can help us understand which treatments work best for different people with early psychosis.",[101,27,29,102,28,103,104],"Schizophrenia Spectrum and Other Psychotic Disorders","Bipolar 1 Disorder","Psychosis Not Otherwise Specified","Early Psychosis",[71,106,107,108,109,34,110,111,112,113],"bipolar disorder","schizoaffective disorder","schizophreniform","major depression","delusional disorder","Biotypes","Biomarkers","coordinated specialty care","RECRUITING","2026-03-06",{"date":117,"type":45},"2026-03-10",{"date":119,"type":45},"2023-01-01",{"date":84,"type":21},{"name":122,"class":87},"Beth Israel Deaconess Medical Center",6,{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":131,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":134,"briefSummary":135,"conditions":136,"keywords":139,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":154},"100516534","the-efficacy-of-metacognitive-skills-training-in-the-context-of-forensic-psychiatric-care-100516534","NCT06005766","The Efficacy of Metacognitive Skills Training in the Context of Forensic Psychiatric Care","Does Group-Based Metacognitive Skills Training Reduce Jumping to Conclusions Bias of Patients With Psychotic Disorders in the Context of Forensic Psychiatric Care","Inclusion Criteria (patients):\n\n* Willingness to participate in a scientific study\n* Diagnosis of a psychosis spectrum disorder\n* Finnish language skills due to questionnaires and psychological tests being in Finnish\n\nExclusion Criteria (patients):\n\n* Psychosis that severely deteriorates the ability to function\n* Cognitive problems that severely deteriorate the ability to function\n* Guardianship established for personal matters\n\nInclusion Criteria (non-patient controls):\n\n* Willingness to participate in a scientific study\n* Self-assessed sufficient Finnish language skills due to questionnaires and psychological tests being in Finnish\n\nExclusion Criteria (non-patient controls):\n\n* Diagnosis of a psychosis spectrum disorder\n* Cognitive problems that severely interferes with functioning",true,{"count":133,"type":21},85,[24],"Deficiencies in social cognition are part of the core symptomatology of psychotic disorders. And deficiencies in social cognition, the closely related concept of metacognition, and, for example, paranoid attitudes are all associated with violence. The link between social cognition and violence is also observed through rehabilitation, as both group-based Social Cognition Interaction Training (SCIT) and group-based Metacognitive Skills Training (MCT) have reduced violent behavior in patients with psychotic disorders. Thus, a better knowledge of social cognition and its rehabilitation in psychotic disorders can help to reduce risky behavior and to rehabilitate the significant social difficulties often found in psychotic disorders. This research study aims to examine factors underlying the efficacy of group-based MCT.\n\nThe goal of the metacognitive skills training group developed by Moritz and partners is to strengthen the social and metacognitive skills of the patients participating in the group. The group consists of 10 sessions during which exercises and discussion are emphasized. The themes of the group sessions are, for example, jumping to conclusions -bias, empathy, and memory. Detailed information is available from the MCT website (https:\u002F\u002Fclinical-neuropsychology.de\u002Fmetacognitive\\_training-psychosis\u002F). Overall there is meta-analysis-level evidence for the moderate effectiveness of MCT on positive symptoms of psychotic illnesses, such as delusions. Prior studies have argued that the unique factor underpinning MCT's efficacy is its impact on various cognitive biases, and that participating in the group especially reduces patients' tendency to jump to conclusions, which is a cognitive style associated with delusions and deficits in social perception and reasoning. As delusionality is related to the risk of violence, these results form a logical link between jumping to conclusions, delusionality, and violence.\n\nBut the results regarding the effectiveness of MCT are still somewhat conflicting, and studies seem to be of varying quality. Additional longitudinal research and research related to the jumping to conclusion bias are also needed. The hypothesis regarding this study is that the MCT group reduces patients' tendency to jump to conclusions. These reductions are presumed to be associated in one-year follow-up with fewer mood symptoms, delusions, paranoia, and more psychological flexibility.",[27,28,137,29,138],"Psychotic Disorders","Psychotic Depression",[140,141,142,143,144],"Social Cognition","Metacognitive Skills Training","Forensic Psychology","Forensic Psychiatry","Violence","2024-05-13",{"date":147,"type":45},"2024-05-14",{"date":149,"type":45},"2023-09-01",{"date":151,"type":21},"2026-12",{"name":153,"class":87},"University of Jyvaskyla",1]