[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dementia-diagnosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dementia-diagnosis":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,63,97,123],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":35,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":62},"100608375","speech-based-artificial-intelligence-for-detection-of-dementia-in-danish-patients-detectai-100608375",false,"NCT07200739","Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)","Development of Deep Learning Models for Detection of Neurodegenerative Diseases Using Speech - a Danish Language-based Artificial Intelligence Study (DetectAI)","DetectAI","Inclusion Criteria:\n\nModel A (patient participants)\n\n* Age \\> 50 years\n* Fluent in Danish\n* Minimum of 7 years of schooling\n* A diagnosis of either MCI or AD, given at the SUH memory clinic within 6 months before enrollment\n\nModel A (cognitively healthy controls)\n\n* Age \\> 50 years\n* Fluent in Danish\n* Minimum of 7 years of schooling\n\nModel B:\n\n* Age \\> 50 years\n* Fluent in Danish\n* Minimum of 7 years of schooling\n\nExclusion Criteria:\n\nModel A:\n\nPatients:\n\n* Significantly impaired vision or hearing (to the extent that the patient cannot participate in the AI analysis)\n* MMSE score \\\u003C 16\n* Concomitant diagnoses which are expected to influence cognitive impairment (eg. depression)\n* Patients unable to give consent\n* Patients with alcohol consumption \\>21 standard alcohol units per week\n* Any history of speech or language impairment predating the current condition\n\nCognitively healthy controls:\n\n* Significantly impaired vision or hearing (to the extent that the patient cannot participate in the AI analysis)\n* MMSE \\\u003C 26 and ACE \\\u003C 90\n* Clinical, laboratory, or neuroradiological findings that could affect cognitive functions\n* Known diseases which are expected to impair cognitive functions\n* Any history of speech or language impairment predating the current condition\n* Patients with alcohol consumption \\>21 standard alcohol units per week.\n\nModel B:\n\n* Significantly impaired vision or hearing (to the extent that the patient cannot participate in the AI analysis)\n* MMSE score \\\u003C 16\n* Patients unable to give consent\n* Patients with concomitant psychosis or severe psychiatric comorbidities other than depression\n* Any history of speech or language impairment predating the current condition",true,"ALL","50 Years",{"count":21,"type":22},440,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn if an artificial intelligence (AI)-based speech analysis tool can identify which patients with memory problems need specialist evaluation at a memory clinic. The main questions it aims to answer are:\n\nCan the AI model accurately distinguish between patients who need referral to a memory clinic (those with dementia or Mild Cognitive Impairment) and patients who don't (those with normal cognition or memory problems from other causes like depression)? Which speech patterns and cognitive test features are most useful for making this distinction?\n\nResearchers will compare speech recordings and cognitive test results from patients diagnosed with dementia or MCI to those from patients with normal cognition or non-neurodegenerative cognitive impairment to see if the AI model can reliably predict who needs specialist dementia care.\n\nParticipants will:\n\nComplete standard cognitive tests at the memory clinic Perform structured speech tasks while being audio-recorded Receive their usual clinical evaluation and diagnosis from memory clinic specialists\n\nThe results of this study will help develop a tool that can assist doctors in making faster, more accurate decisions about which patients need specialist dementia evaluation, potentially leading to earlier diagnosis and better patient outcomes.",[26,27,28,29,30,31,32,33,34],"Dementia (Diagnosis)","Alzheimer Dementia (AD)","Vascular Dementia (VaD)","Lewy Body Dementia (LBD)","Frontotemporal Dementia (FTD)","Mild Cognitive Impairment (MCI)","Depression - Major Depressive Disorder","Stress","Cognitive Impairment",[36,37,38,39,40,41,42,43,44,29,30,31,45,46,47,48,34,49],"artificial intelligence","speech-based artificial intelligence","artificial intelligence in dementia diagnostics","artificial intelligence for dementia screening","artificial intelligence for dementia classification","speech based artificial intelligence","dementia","Vascular dementia (VaD)","Alzheimer dementia (AD)","Depression - Major Depressive disorder","Dementia (diagnosis)","machine learning","stress","deep learning","NOT_YET_RECRUITING","2026-04-28",{"date":53,"type":54},"2026-05-05","ACTUAL",{"date":56,"type":22},"2026-06-01",{"date":58,"type":22},"2028-07",{"name":60,"class":61},"Zealand University Hospital","OTHER",1,{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":17,"sex":18,"minAge":71,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":62},"100609468","early-phase-1-mild-cognitive-impairment-community-screening-and-early-intervention-via-stem-cell-therapy-and-wearable-brain-computer-interface-device-100609468","NCT07214974","Mild Cognitive Impairment Community Screening and Early Intervention Via Stem Cell Therapy and Wearable Brain Computer Interface Device.","Mild Cognitive Impairment Community Screening, Early Detection, and Therapeutic Intervention to Slow Down, or Stop the Progression of the Cognitive Impairment.","MCITestCare","Inclusion Criteria:\n\nAdults aged 55 years and older Residents of U.S. urban or suburban communities Able to provide informed consent Willing to participate in 3-year follow-up assessments Able to complete cognitive screening assessments Access to transportation for community-based appointments No prior formal diagnosis of dementia\n\nExclusion Criteria:\n\nAdults under 55 years of age Current diagnosis of moderate to severe dementia Severe psychiatric disorders that would interfere with assessment validity Active substance abuse disorders Severe visual or hearing impairments that cannot be corrected and would prevent assessment completion Terminal illness with life expectancy less than 3 years Current participation in other cognitive intervention research studies Inability to attend follow-up assessments due to geographic relocation plans Significant neurological conditions (stroke, traumatic brain injury, Parkinson's disease) that could confound cognitive assessment Institutionalized individuals (nursing home residents)","55 Years",{"count":73,"type":22},600,"INTERVENTIONAL",[76],"EARLY_PHASE1","This study aims to evaluate the efficacy of community-based early detection and targeted interventions, including stem cell therapy and wearable non-invasive brain-computer interface (BCI) devices, for Mild Cognitive Impairment (MCI) in adults aged 55 years and older residing in U.S. urban and suburban communities. Primary objectives include assessing improvements in MCI detection rates, cognitive outcomes, and progression delay compared to standard care.",[31,79,80,81,82,83,84,85,26,86],"Early Stages of Cognitive Decline","Alzheimer's Disease Dementia","Alzheimer's Disease Diagnosis","Alzheimer's Disease and Related Dementias","Parkinson's Disease","Parkinson's Disease (PD)","Parkinson's Disease With Wearing-off Motor Fluctuations","Dementia MCI (Mild Cognitive Impairment)","2026-03-06",{"date":89,"type":54},"2026-03-10",{"date":91,"type":22},"2026-09-01",{"date":93,"type":22},"2030-01-03",{"name":95,"class":96},"Noah Tech, Corp.","INDUSTRY",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":18,"minAge":105,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":62},"100609237","loneliness-as-risk-factor-for-dementia-100609237","NCT07211945","Loneliness as Risk Factor for Dementia","Loneliness as a Risk Factor for Dementia in Patients With Mild Cognitive Impairment: A Prospective Study","SOLETE","Inclusion criteria\n\nPatients may be included in the study if they meet all of the following criteria:\n\nMen and women aged 70 years or older.\n\nDiagnosis of mild cognitive impairment according to Petersen's criteria within the past 12 months.\n\nFollow-up of the condition under study at the Alzheimer's Disease and Other Dementias Unit of Garraf (UMAG) at the Consorci Sanitari Alt Penedès-Garraf (CSAPG).\n\nExpected follow-up of the condition at the study center.\n\nAbility to collaborate in the required assessments.\n\nLegal capacity to provide informed consent.\n\nSigned informed consent for inclusion in the study, either by the participant or their legal representative.\n\nExclusion criteria\n\nParticipants will be excluded from the trial if they meet any of the following criteria:\n\nDiagnosis of any of the following conditions:\n\nDementia: the evaluating physician will rely on the diagnostic criteria of the Spanish Society of Neurology (SEN) and the results of the neuropsychological assessment performed at the UMAG.\n\nParticipation in another study involving an experimental intervention during the present trial period and\u002For requiring a visit schedule incompatible with this trial.","70 Years",{"count":107,"type":22},300,"This study aims to determine whether loneliness is associated with a higher incidence of dementia in older adults with a prior diagnosis of mild cognitive impairment after 12 months of follow-up.",[31,26,110],"Loneliness",[112,113,110],"Cognitive Dysfunction","Dementia","2025-11-21",{"date":116,"type":54},"2025-11-26",{"date":118,"type":22},"2026-03",{"date":120,"type":22},"2028-09",{"name":122,"class":61},"Consorci Sanitari de l'Alt Penedès i Garraf",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":18,"minAge":130,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":74,"phases":133,"briefSummary":135,"conditions":136,"keywords":139,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":4},"100601735","enhancing-utility-of-neuropsychological-evaluation-for-earlier-and-effective-diagnosis-of-dementia-in-parkinsons-disease-100601735","NCT07114354","Enhancing Utility of Neuropsychological Evaluation for Earlier and Effective Diagnosis of Dementia in Parkinson's Disease","PDCogniCare","Inclusion Criteria:\n\n* People living with idiopathic Parkinson's disease, one year or more post-diagnosis, attending Movement Disorder Clinics\n\nExclusion Criteria:\n\n* People with severe Parkinson's disease who aren't able to communicate\n* People with comorbid neurological conditions (e.g. Stroke)","18 Years",{"count":132,"type":22},275,[134],"NA","Dementia is observed in 80% of people living with advanced stage Parkinson's disease, however, there are inadequate opportunities for early and effective diagnosis of dementia in current clinical practice. This study aims to identify whether a new tool called PDCogniCare, can improve detection of dementia in people living with Parkinson's disease, and to explore what factors might influence its use in healthcare services.",[26,137,138],"Parkinson Disease Dementia (PDD)","Parkinson Disease (PD)",[140,113,141,142],"Parkinson's disease","Cognitive evaluation","Implementation","2025-08-03",{"date":145,"type":54},"2025-08-11",{"date":147,"type":22},"2025-08-18",{"date":149,"type":22},"2026-12-31",{"name":151,"class":61},"The University of Queensland"]