[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-adhesivesrestorations-performance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-adhesivesrestorations-performance":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100599971","a-split-mouth-clinical-trial-evaluating-the-bond-failure-rate-of-a-new-etch-free-orthodontic-adhesive-100599971",false,"NCT07091422","A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive","Inclusion Criteria:\n\nPatients aged 14 to 35 years\n\nRequiring comprehensive fixed orthodontic treatment with brackets on both arches\n\nGood general health with no contraindications to orthodontic treatment\n\nPresence of at least 10 permanent teeth per arch suitable for bracket bonding\n\nAbility and willingness to comply with study visits and follow-up for at least 12 months\n\nParent\u002Fguardian consent and child assent obtained as appropriate\n\nExclusion Criteria:\n\nPresence of systemic diseases or conditions that affect oral health or healing (e.g., uncontrolled diabetes, immunosuppression)\n\nTeeth with significant enamel defects, restorations, or caries in bonding areas\n\nPatients currently undergoing or who have undergone orthodontic treatment previously\n\nHistory of allergy or sensitivity to dental adhesives or related materials\n\nPatients with poor oral hygiene or active periodontal disease\n\nUse of medications known to affect tooth enamel or oral tissues (e.g., long-term corticosteroids)\n\nInability to attend follow-up visits or anticipated lack of compliance\n\nParticipation in another clinical trial that could interfere with study outcomes",true,"ALL","14 Years","35 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized, split-mouth clinical trial will evaluate a new orthodontic adhesive that eliminates the need for acid etching before bracket bonding. Conventional orthodontic bonding requires etching enamel with phosphoric acid, which can weaken the outer enamel layer and increase the risk of white spot lesions and enamel damage. The etch-free adhesive under investigation is designed to simplify the bonding procedure while preserving enamel integrity.\n\nTwenty orthodontic patients starting treatment with braces will participate. For each patient, one side of the mouth (left or right) will be randomly assigned to receive the etch-free adhesive, while the opposite side will receive the conventional adhesive with acid etching. This intra-patient design allows a direct comparison under identical oral conditions.\n\nParticipants will be followed for 12 months. Bracket failures, bonding time, ease of adhesive removal, enamel surface condition after debonding, and the presence of white spot lesions will be recorded. If effective, the etch-free adhesive may reduce enamel damage without compromising bond strength, providing a safer and more efficient bonding option for orthodontic patients.",[27,28,29,30],"Bracket Bonding","Orthodontic Treatment","Dental Adhesives\u002FRestorations Performance","White Spot Lesion of Tooth",[32,33,34,35,36,37],"Etch-Free Adhesive","Orthodontic Bonding","Bracket Failure","Split-Mouth Trial","White Spot Lesions","Orthodontics Clinical Trial","RECRUITING","2025-11-05",{"date":41,"type":42},"2025-11-10","ACTUAL",{"date":39,"type":42},{"date":45,"type":21},"2026-12-01",{"name":47,"class":48},"University of Maryland, Baltimore","OTHER"]