[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-anesthesia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100643682","mri-and-local-anesthesia-100643682",false,"NCT07602686","MRI and Local Anesthesia","MRI Evaluation of Local Anesthesia Administration","MRI and LA","Inclusion Criteria:\n\n* Adult age 18 or older\n* Health status of American Society of Anesthesiologists (ASA) class 1 or 2\n* Able to provide informed consent\n* Able to appear in person at OMRIC on the days indicated for the study\n\nExclusion Criteria:\n\n* ASA class 3 or higher\n* Pregnant patients\n* Taking any medication that would affect pain perception or interact with local anesthetic\n* Allergic\u002Fhistory of adverse reaction to local anesthetic or any component in the local anesthetic\n* Paresthesia in the area of innervation of Cranial Nerve V3\n* Active infection or abscess in the oral and maxillofacial region\n* History of temporomandibular disorder, maximum incisal opening less than 15mm\n* History of recent dental trauma (within the past 6 months)\n* Dental hypersensitivity\n* Claustrophobia and\u002For conditions of anxiety or motion disorder (for MRI purposes)\n* Metallic, electronic, or magnetic implants or devices classified as MR Unsafe or Conditional by the American College of Radiology\n* Unable to give informed consent","ALL","18 Years",{"count":20,"type":21},102,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this research is to investigate the utility of using dental-dedicated MRI as a measurement tool to observe and evaluate the administration of local anesthesia in dental patients.",[27],"Dental Anesthesia","NOT_YET_RECRUITING","2026-06-09",{"date":31,"type":32},"2026-06-10","ACTUAL",{"date":34,"type":21},"2026-07-15",{"date":36,"type":21},"2029-07-01",{"name":38,"class":39},"University of Minnesota","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100638249","phase-2-melissa-officinalis-aromatherapy-for-dental-anxiety-in-children-100638249","NCT07592130","Melissa Officinalis Aromatherapy for Dental Anxiety in Children","Anxiolytic Effect of Inhaled Melissa Officinalis Essential Oil During Mandibular Local Anesthesia in Pediatric Dental Patients: A Randomized Controlled Clinical Trial","No acronym","Inclusion Criteria:\n\n* Children aged 6 to 10 years at the time of enrollment.\n* Male or female pediatric patients in good general physical and mental health.\n* Require mandibular local anesthesia (inferior alveolar nerve block) for pulpotomy or pulpectomy of at least one primary molar.\n* No previous experience with dental local anesthesia.\n* Behavior classified as \"positive\" or \"negative but accepting\" (categories 2 or 3) according to the Frankl Behavior Rating Scale during the initial examination.\n* Ability of the child to understand simple verbal instructions appropriate for age.\n* Parent or legal guardian able and willing to sign written informed consent.\n* Child willing to provide verbal assent to participate in the study.\n\nExclusion Criteria:\n\n* History of previous dental local anesthesia.\n* Presence of dental emergencies (e.g., acute infection, severe pain, or swelling) requiring urgent treatment.\n* Known diagnosis of neurological, psychiatric, developmental, or behavioral disorders that may interfere with cooperation or with the assessment of anxiety and pain.\n* Systemic diseases or medical conditions (American Society of Anesthesiologists \\[ASA\\] physical status III or higher) that increase procedural risk or preclude participation according to the investigator's judgment.\n* Current acute upper respiratory conditions, such as common cold, rhinitis, sinusitis, or nasal allergy that could alter the sense of smell or breathing comfort.\n* Known allergy, hypersensitivity, or adverse reaction to Melissa officinalis, other Lamiaceae plants, essential oils, or components of the products used in the study.\n* Use of anxiolytics, antidepressants, sedatives, or other psychotropic medications within the last 30 days.\n* Behavior rated as definitely negative (Frankl category 1) or definitely positive (Frankl category 4) at baseline.\n* Inability of parents or guardians to understand the study information or provide informed consent.\n* Participation in another clinical trial within the previous 30 days.","6 Years","10 Years",{"count":52,"type":21},45,[54],"PHASE2","This clinical study will look at whether a plant-based essential oil called \"Melissa officinalis\" (lemon balm) can help reduce fear and stress in children during dental treatment. Children between 6 and 10 years old who need a mandibular injection for a pulpotomy or pulpectomy will be invited to participate. They will be randomly assigned to one of three groups: one group will receive aromatherapy with \\*Melissa officinalis\\* from brand A, another group will receive the same essential oil from brand B, and a third group will receive the usual behavioral management used in pediatric dentistry, but without aromatherapy.\n\nThe essential oil will be diffused in the dental room so that the child can gently inhale the aroma starting a few minutes before the injection and throughout the procedure. The study team will measure the child's dental anxiety using a child-friendly questionnaire with drawings of faces, observe pain behaviors during the injection, and record the child's own rating of pain with a faces scale. Heart rate and oxygen saturation will also be monitored as objective signs of stress. The goal is to find out whether \"Melissa officinalis\" aromatherapy is a safe, simple, non-invasive way to make dental visits less stressful and more comfortable for children, and whether there are meaningful differences between the two commercial products.",[57,27],"Emotional Anxiety and Stress During Pediatric Dental Treatment",[59,60,61,62,63],"Pediatric dental anxiety","Aromatherapy","PediMelissa officinalis","Essential oils","Pediatric oral anesthesia","2026-05-11",{"date":66,"type":32},"2026-05-18",{"date":68,"type":21},"2026-06-15",{"date":70,"type":21},"2027-02-25",{"name":72,"class":39},"Universidad Autonoma de San Luis Potosí",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":17,"minAge":49,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":40},"100597254","study-of-pain-perception-using-computer-controlled-versus-conventional-local-anaesthesia-in-children-undergoing-molar-extraction-100597254","NCT07056101","\"Study of Pain Perception Using Computer-Controlled Versus Conventional Local Anaesthesia in Children Undergoing Molar Extraction","Evaluation of Pain Perception Using Computer-Controlled Local Anaesthesia Delivery With Different Injection Speeds Versus Conventional Anaesthesia for Maxillary Primary Molars: A Randomized Controlled Trial","CCLAD-Pain","Inclusion Criteria:\n\n* Children aged from 6 to 8 years old\n* Both sexes\n* Healthy children classified as ASA I\n* Children with maxillary primary molars indicated for extraction\n* No previous dental experience\n* Mentally capable of communication and following instructions\n* No acute dental pain\n\nExclusion Criteria:\n\n* Uncooperative children or those with a behavioral management problem (Frankl rating 1 or 2)\n* Children with known allergies to the local anesthetic or dental materials used in the study\n* Children taking medications (e.g., antibiotics, analgesics) in the previous 48 hours that may alter pain perception\n* Children whose parents or legal guardians refuse to sign the informed consent form\n* Children experiencing acute dental pain",true,"8 Years",{"count":84,"type":21},76,[24],"This clinical trial aims to compare pain perception in children during dental procedures when using a computer-controlled local anesthesia device versus a traditional syringe. Children aged 6 to 8 years who need maxillary primary molar extraction will be randomly assigned to one of four groups: three groups using different speeds of the GENI computer-controlled device, and one group using a conventional syringe. The study will assess pain using facial expression scales and physiological measures such as heart rate. The goal is to find a more comfortable method for delivering anesthesia to pediatric dental patients.",[88,89,27,90],"Dental Phobia","Dental Anxiety","Dental Anesthesia Efficacy",[92,93,94,95,96,97],"GENI Device","Pain Perception","Local Anesthesia Technique","Articaine","Computer-Controlled Local Anesthesia","Dental Injections","2025-07-10",{"date":100,"type":32},"2025-07-14",{"date":102,"type":21},"2025-07-01",{"date":104,"type":21},"2025-10-31",{"name":106,"class":39},"Tarek MHD kher al saka amini"]