[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-caries-in-children\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-caries-in-children":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,49,74,97,128,157,186,217,241,270,292],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100640997","the-effects-of-sodium-fluoride-and-chlorhexidine-use-on-salivary-il-6-and-matrix-metalloproteinase-levels-in-children-with-active-caries-100640997",false,"NCT07609797","The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries","DentalCaries","Inclusion Criteria:\n\n* Children aged 6-8 years with all first permanent molars erupted\n* For active caries groups (Groups A, B, C): participants must meet at least one of the following criteria: dmft ≥ 6, or presence of at least one active caries lesion with an ICDAS code ≥ 3, or clinical evidence of active caries on ≥ 10 surfaces\n* For the dmft = 0 reference group (Group D): all surfaces caries-free and non-high-risk individuals (ICDAS II = 0); only baseline (T0) saliva sampling will be performed\n* No professional topical fluoride application or continuous CHX use within the past 3 months\n* No systemic chronic disease, immunodeficiency, or severe neuromotor disorder\n* No gingival redness, swelling, or bleeding\n* Written parental informed consent obtained\n\nExclusion Criteria:\n\n* Known allergy to fluoride compounds or varnish components\n* Behavioral problems that would prevent safe cooperation during application\n* Regular antibiotic use within the past 1 month\n* Individuals with infectious diseases\n* Those at high risk of endocarditis\n* History of substance dependence\n* Epilepsy\n* Renal failure or immunosuppression",true,"ALL","6 Years","8 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to compare salivary IL-6, MMP-8, MMP-9, and TIMP-1 levels between healthy children and caries-active children, and to evaluate the effects of 5% sodium fluoride (NaF) varnish and 2% chlorhexidine (CHX) used in caries prevention on these biomarkers.\n\nThe study will be conducted at Alanya Alaaddin Keykubat University, Faculty of Dentistry, Department of Pediatric Dentistry. Informed consent will be obtained from children and their parents\u002Fguardians. Investigator calibration will be performed using Cohen's kappa method prior to data collection. Sample size was calculated assuming 80% power (1-β = 0.80), α = 0.05, and Cohen's d ≈ 0.8, resulting in 20 participants per group using G\\*Power 3.1 software.\n\nStudy groups: Group A: 5% NaF varnish. Group B: 2% CHX + 5% NaF varnish. Group C: Standard oral hygiene education (negative control). Group D: Caries-free children (biological reference; baseline saliva sampling only).\n\nSaliva samples will be collected at T0 (baseline), T1 (30 minutes post-application), and T2 (1 month). Unstimulated whole saliva will be collected, centrifuged at 5,000 g for 10 minutes at 4°C, and stored at -80°C. IL-6, MMP-8, MMP-9, and TIMP-1 levels will be measured using CE-marked\u002FFDA-approved human saliva ELISA kits.",[28,29],"Dental Caries","Dental Caries in Children",[31,32,33,34,35],"Dental caries","Matrix metalloproteinase","Interleukin-6","Sodium fluoride","Chlorhexidine","RECRUITING","2026-06-01",{"date":39,"type":40},"2026-06-02","ACTUAL",{"date":42,"type":40},"2026-05-15",{"date":44,"type":22},"2027-06-30",{"name":46,"class":47},"Gül Keskin","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":19,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":48},"100611328","clinical-and-radiographic-evaluation-of-injectable-composite-versus-packable-composite-in-restoring-of-primary-molars-100611328","NCT07239154","Clinical and Radiographic Evaluation of Injectable Composite Versus Packable Composite in Restoring of Primary Molars","Clinical and Radiographic Assessment of Injectable Composite Versus Packable Composite in the Restoration of Cavitated Primary Molars a Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients:\n\n  * Children aged 4-8 years.\n  * Medically free.\n\nTeeth:\n\n* Restorable Class II cavities.\n* Asymptomatic tooth.\n\nPre-operative radiographic examination:\n\n* Absence of periapical or inter-radicular radiolucency.\n* Absence of widening of periodontal ligaments space.\n* Absence of internal or external root resorption.\n\nExclusion Criteria:\n\n* Patients:\n\n  * Uncooperative children.\n  * Unable to attend follow-up visits.\n  * Parents refuse to sign the informed consent.\n  * Children participating in any other clinical trial involving fluoride therapy or other interventions that could directly influence caries development during the study period.\n\nTeeth:\n\n* Teeth which were previously restored.\n* Mobility.\n\nPre-operative radiographic examination:\n\n* Caries extending deep sub-gingivally.\n* The tooth is about to exfoliate.","4 Years",{"count":58,"type":22},32,[25],"This randomized clinical trial aims to compare the clinical and radiographic performance of injectable composite versus packable composite in restoring cavitated primary molars in children aged 4 to 8 years.\n\nStudy Purpose\n\nTo determine whether injectable composite performs as well as packable composite in Class II restorations in primary molars clinically and radiographically.",[29],[63],"Decayed","NOT_YET_RECRUITING","2026-04-11",{"date":67,"type":40},"2026-04-15",{"date":69,"type":22},"2026-05-01",{"date":71,"type":22},"2027-05-01",{"name":73,"class":47},"Eslam samy abdel monaem kalboush",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":16,"sex":17,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100604672","different-luting-cements-for-pediatric-zirconia-crowns-100604672","NCT07152561","Different Luting Cements for Pediatric Zirconia Crowns","Effect of Two Different Luting Cements on Clinical Outcomes of Pediatric Zirconia Crowns: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients who had no history of allergies\n* Children who had at least two carious primary incisors.\n* Teeth with multi-surface carious lesion.\n* Teeth with no percussion or palpation sensitivity\n* Teeth with no abscess and\u002For fistula\n* Teeth with no prior pulpal treatment\n* Teeth with no mobility or signs of periodontal disease\n\nExclusion Criteria:\n\n* Children with congenital developmental defects (such as amelogenesis imperfecta and dentinogenesis imperfecta)\n* Children with a history of bruxism, trauma or infraocclusion\n* Children with a skeletal or dental malocclusion","3 Years","5 Years",{"count":84,"type":22},60,[25],"The study aims to compare the efficacy of using bioactive cement versus resin-cement for cementation of anterior pediatric zirconia crowns.",[29],"2025-08-26",{"date":90,"type":40},"2025-09-03",{"date":92,"type":22},"2025-08-28",{"date":94,"type":22},"2026-09-01",{"name":96,"class":47},"Cairo University",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":16,"sex":17,"minAge":105,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":23,"phases":109,"briefSummary":110,"conditions":111,"keywords":115,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":48},"100538105","targeting-of-preventive-treatment-for-adolescents-at-risk-of-oral-diseases-100538105","NCT06286501","Targeting of Preventive Treatment for Adolescents at Risk of Oral Diseases","Identification of Adolescent Patients at Risk of Oral Diseases and Targeting of Preventive Treatment, and the Use of Antibacterial Photodynamic Therapy as an Adjunctive Treatment Method","LumoPrevent","Inclusion Criteria:\n\n* 14-16 years old, and a junior high school 8th-grade pupil from the area of the Wellbeing Services of County Pirkanmaa\n* Agreement to participate in the study and to sign a written consent form, including either consent from caregiver(s) with pupils under 14 years, or information to caregiver(s) with pupils from 15 to 16 years old\n* Able to cooperate with the treatment\n\nExclusion Criteria:\n\n* Presence of any physical limitation or restriction that might restrict Lumoral use\n* Unwilling to participate in the study\n* Periodontal treatment within 3 months prior to study","14 Years","16 Years",{"count":108,"type":22},120,[25],"The aim of the study is to identify adolescent patients that are at risk of developing oral diseases, and to assess if targeted preventive oral treatment with antibacterial dual-light therapy as an adjunctive treatment method can have a positive impact in preventing oral diseases from emerging.",[29,112,113,114],"Dental Plaque","Tooth Decay","Periodontitis",[116,117,118],"Antibacterial","Preventive oral care","Lumoral","2025-08-05",{"date":121,"type":40},"2025-08-06",{"date":123,"type":40},"2024-04-18",{"date":125,"type":22},"2025-12-31",{"name":127,"class":47},"Wellbeing Services County of Pirkanmaa",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":135,"enrollmentInfo":136,"targetDuration":4,"studyType":23,"phases":138,"briefSummary":139,"conditions":140,"keywords":143,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":48},"100599964","3d-printed-ceromer-crowns-versus-stainless-steel-in-posterior-primary-molars-100599964","NCT07091331","3D-printed Ceromer Crowns Versus Stainless Steel in Posterior Primary Molars","Clinical Evaluation of 3D-printed Ceromer Crowns Versus Stainless Steel in Posterior Primary Molars","Inclusion Criteria:\n\n* Children aged 4 to 9 years with at least 2 primary molars affected by deep occlusoproximal caries.\n* Teeth may require pulp therapy (pulpotomy or pulpectomy) and be suitable for full-coverage restoration.\n* Teeth must have an antagonist and be located in opposing hemiarches.\n* The affected primary molars must be expected to remain in the mouth for at least 12 months.\n* The child must be in general good health.\n* Parents or legal guardians must sign informed consent, and the child must provide assent.\n* Patient does not come to control appointment or does not want to continue research.\n\nExclusion Criteria:\n\n* Children with systemic diseases or medical conditions affecting oral health.\n* Uncooperative behavior (Frankl scale 3 or 4).\n* Temporomandibular joint disorders or parafunctional habits (e.g., bruxism).\n* Absence of antagonist or adjacent teeth in the selected quadrants.\n* Children on long-term medication.\n* Patient with allergy to local anesthetic, nickel or chromium.","9 Years",{"count":137,"type":22},40,[25],"The aim of the study is to compare preformed metal crowns and 3D-printed ceromer crowns in primary molars of 4-9 years old children. The main questions it aims to answer are:\n\n* How does 3D-printed ceromer crowns compare clincally to stainless steel crowns when restoring posterior molars?\n* What is the level of satisfaction of the patient with both materials?\n* What is the level of parental satisfaction with both materials?\n\nStudy methodology:\n\nThis study is a split-mouth clinical trial where participants will receive at least one of each materials in different quadrants of the mouth.",[141,142,29],"Caries, Dental","Caries; Dentin",[144,145,146,147],"Printing, Three-dimensional","Pediatric Dentistry","Tooth, Deciduous","Esthetics, Dental","2025-07-22",{"date":150,"type":40},"2025-07-29",{"date":152,"type":22},"2025-07-30",{"date":154,"type":22},"2026-06-15",{"name":156,"class":47},"Universidad Autonoma de Baja California",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":16,"sex":164,"minAge":165,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":23,"phases":169,"briefSummary":170,"conditions":171,"keywords":172,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":48},"100593636","impact-of-oral-health-program-on-al-lith-childrens-kap-100593636","NCT07009015","Impact of Oral Health Program on Al-Lith Children's KAP","The Effect Of Health Education Intervention Program In Improving Knowledge, Attitude, And Practice Of Oral Health Among Male Primary School Children In Al-Lith Saudi Arabia: A Clustered Randomised Control Trial","Inclusion Criteria:\n\n* Primary school male students.\n* Aged 10 to 11 years old.\n* Students who have at least one of their parent's consents to participate in the study.\n\nExclusion Criteria:\n\n* Students who are medically ill at the time of conducting the study.\n* Students that are absent while conducting the study.","MALE","10 Years","11 Years",{"count":168,"type":22},430,[25],"Dental caries remains a significant global public health issue, particularly affecting children's health, development, and well-being, with inadequate knowledge, attitudes, and practices around oral health exacerbating these impacts. To address this, a cluster randomized controlled trial will be conducted in four primary schools in Al Lith City, Saudi Arabia, targeting children aged 10 to 11 years. The intervention involves interactive, classroom-based educational sessions led by a dental care professional, supplemented by take-home materials, focusing first on enhancing knowledge and attitudes, and then on developing behavioral skills for improved oral hygiene and eating habits. Participants' knowledge, attitudes, and practices will be assessed via questionnaires before, immediately after, and six months post-intervention, with data analyzed using SPSS through descriptive statistics, chi-square tests, One Way-ANOVA, and Generalized Estimating Equations. The study expects that school-based oral health education will significantly improve children's oral health knowledge and certain hygiene behaviors, as well as positively influence eating habits and patterns.",[29],[31,173,174,175,176],"Oral health status","Knowledge","Attitude","Practice","2025-07-09",{"date":179,"type":40},"2025-07-15",{"date":181,"type":40},"2024-03-01",{"date":183,"type":22},"2027-08-30",{"name":185,"class":47},"Universiti Putra Malaysia",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":16,"sex":17,"minAge":193,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":23,"phases":197,"briefSummary":199,"conditions":200,"keywords":202,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":216},"100371653","phase-4-sedation-versus-protective-stabilization-for-pediatric-dental-treatment-100371653","NCT04119180","Sedation Versus Protective Stabilization for Pediatric Dental Treatment","Sedation Versus Protective Stabilization for Dental Treatment of Children With Caries and Negative Behavior at the Dentist: a Non-randomized Clinical Trial","Inclusion Criteria:\n\n* Children presenting cavities that need dental restoration\n* ASA I (healthy) or II (mild and controlled systemic disease - persistent asthma, for example) children (ASA, 2015)\n* Medical history without neurological or cognitive impairment\n* Children who do not use medicines that may impair cognitive functions\n* Children at low risk for airway obstruction (Mallampati less than 2 and \u002F or tonsil hypertrophy occupying less than 50% of the oropharynx) (Mallampati et al., 1985)\n\nExclusion Criteria:\n\n* Children with positive or definitely positive behavior (Frankl et al. 1962) in the dental examination session\n* Non-attendance at the first intervention appointment after three scheduling attempts\n* Chronic use of systemic corticosteroids","1 Year","7 Years",{"count":196,"type":22},152,[198],"PHASE4","There is a lack of evidence on the effectiveness of moderate sedation in pediatric dentistry, compared to protective stabilization, which remains routinely used in the Brazilian context despite moral questions. The objective of this prospective nonrandomized clinical trial is to evaluate the effectiveness of the use of moderate sedation, compared to the protective stabilization, in the dental care of children with fear \u002F anxiety and \u002F or dental behavior problem, and associated factors. The study will be carried out in outpatient clinics of the Dental Schools of the Federal University of Goiás (UFG) and University of São Paulo (USP), with the support of professors from King's College London through the partnership CEDACORE - Children Experiencing Dental Anxiety: Collaboration on Research and Education. Participants will be 152 children under 7 years of age with dental caries, who need specialized dental treatment due to a history of non-cooperation with dental care. The interventions to be compared are moderate sedation with oral administration of ketamine and midazolam (UFG) and protective stabilization (USP). The primary endpoint 'behavior \u002F anxiety of the child during treatment will be assessed using the Ohio State University Behavioral Rating Scale. The secondary outcomes are: dental behavioral and anxiety evolution of the child, child' pain during procedure, impact on the quality of life related to oral health, parents and dentists' satisfaction and stress, adverse events for sedated participants, longevity of composite and glass ionomer cement restorations, chronotype and physiological stress of these children. A cost-efficacy analysis will be produced at the end of the study from the perspective of the Sistema Único de Saúde. Additionally, at the end of 36 months, the investigators expect to contribute to the identification of psychosocial aspects related to dental behavior problems in children in early childhood. It is important to highlight the perspective of technological innovation, with the creation of a digital platform that will allow the registration of data related to the dental care of children worldwide and favor analyzes in the methodology of data science.",[201,29],"Child Behavior",[203,28,204,205,206],"Dental Anxiety","Conscious Sedation","Physical Restraint","Cost-Efficacy Analysis","2024-12-07",{"date":209,"type":40},"2024-12-10",{"date":211,"type":40},"2020-01-30",{"date":213,"type":22},"2026-02-28",{"name":215,"class":47},"Universidade Federal de Goias",2,{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":17,"minAge":224,"maxAge":225,"enrollmentInfo":226,"targetDuration":4,"studyType":23,"phases":228,"briefSummary":230,"conditions":231,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":4},"100506490","phase-3-aesthetic-restorations-in-deciduous-anterior-teeth-100506490","NCT05875064","Aesthetic Restorations in Deciduous Anterior Teeth","Aesthetic Restorations in Deciduous Anterior Teeth - Study Protocol for a Randomized Clinical Trial","Inclusion Criteria:\n\n* Children ranging in age from 12 to 60 months with at least one active cavitated caries lesion involving more than 2 surfaces (C+ score) in deciduous upper incisors will be included.\n\nExclusion Criteria:\n\n* Patients with special needs, with general health conditions that may affect the oral cavity, whose guardians do not sign the Inform Consent Form will be excluded. In addition, teeth with pulp exposure, spontaneous pain, mobility, presence of swelling or fistula near the tooth and teeth with previous restorations; less than 2\u002F3 of root (radiographically assessed), teeth without an antagonist, teeth with previous restorations and children with bruxism and\u002For deep bite.","12 Months","60 Months",{"count":227,"type":22},194,[229],"PHASE3","This study proposes to conduct a randomized clinical trial (RCT), composed of a sample of 194 deciduous central and lateral incisors with active cavitated lesions, simplified ICDAS C+ score, with involvement of more than two surfaces. This sample will be divided into two experimental groups, both with selective removal of carious tissue: a group in which conventional restoration will be performed using opaque resins; and another group with monochromatic resin with chameleon effect and polyvinyl crowns.",[29],"2024-11-20",{"date":234,"type":40},"2024-11-22",{"date":236,"type":22},"2025-01-26",{"date":238,"type":22},"2026-11-30",{"name":240,"class":47},"University of Nove de Julho",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":16,"sex":248,"minAge":249,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":23,"phases":252,"briefSummary":253,"conditions":254,"keywords":256,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":48},"100559040","technology-enabled-anticipatory-guidance-and-peer-support-in-empowering-parents-to-prevent-early-childhood-caries-100559040","NCT06558955","Technology-enabled Anticipatory Guidance and Peer Support in Empowering Parents to Prevent Early Childhood Caries","Technology-enabled Anticipatory Guidance and Peer Support in Empowering Parents to Prevent Early Childhood Caries: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Mother is currently expecting or has an infant below 3 months of age\n* Biological mother of the child\n* Mother with internet access and a mobile device\n* Mother can communicate in English\n* Mother aged 21 years and above\n\nExclusion Criteria:\n\n* Child with disqualifying medical condition (e.g., tube feeding, severe neuromuscular disability) that would limit oral dietary intake, at-home oral hygiene practices, or receipt of dental examinations\n* Child with serious congenital syndrome that is expected to adversely affect the development of primary teeth\n* Family plans to emigrate within 3 years","FEMALE","21 Years",{"count":251,"type":22},600,[25],"Early Childhood Caries (ECC) is a significant clinical and public health challenge that the world and the Singapore population are facing. This study seeks to test the effectiveness of technology-enabled anticipatory guidance and peer support in empowering parents to establish proper childcare practices and prevent ECC.",[28,29,255],"Diet Habit",[257,258,259,260,28],"Anticipatory Guidance","Peer Support","Oral Health","Technology","2024-08-15",{"date":263,"type":40},"2024-08-19",{"date":265,"type":40},"2024-06-15",{"date":267,"type":22},"2028-09-01",{"name":269,"class":47},"National University of Singapore",{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":4,"eligibilityCriteria":276,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":277,"targetDuration":4,"studyType":23,"phases":279,"briefSummary":280,"conditions":281,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":48},"100544720","comparative-evaluation-of-melatonin-versus-mta-on-vital-pulp-therapy-in-young-permanent-first-molars-an-in-vivo-study-100544720","NCT06372561","Comparative Evaluation of Melatonin Versus MTA on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study","Comparative Evaluation of Melatonin Versus Mineral Trioxide Aggregate on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study","Inclusion Criteria:\n\n* 1- Apparently healthy and medically free children. 2- Their age ranges from 6-8 years. 3- Both boys and girls will be included. 4- Children should have mandibular permanent first molars with the following clinical and radiographic criteria. 4.1Restorable young permanent first molars. 4.2Absence of clinical evidence of pulp degeneration:\n* No history of spontaneous pain, history of night pain or pain that not relieved by analgesics.\n* No pain on percussion.\n* No mobility.\n* Absence of abscess, purulent sinus or soft tissue edema.\n* Bleeding should stop within 5 minutes after the amputated pulp stumps.\n\nExclusion Criteria:\n\n* Internal root resorption.\n* External root resorption.\n* Inter radicular or periapical bone destruction (radiolucency)\n* A deep carious lesion radiologically that approaches the pulp",{"count":278,"type":22},45,[25],"The process of dental caries is dynamic and can be either reversible or irreversible depending on the balance between protective and pathologic factors in the oral cavity. Untreated dental caries causes pulpal injury, inflammation, and necrosis. Melatonin plays an essential role in the regulation of bone growth. The actions that melatonin exerts on odontoblasts may be similar to its action on osteoblasts.",[29,282],"Vital Pulp Therapy","2024-08-01",{"date":285,"type":40},"2024-08-02",{"date":287,"type":40},"2023-05-20",{"date":289,"type":22},"2024-10-02",{"name":291,"class":47},"Suez Canal University",{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":298,"eligibilityCriteria":299,"healthyVolunteers":11,"sex":17,"minAge":82,"maxAge":194,"enrollmentInfo":300,"targetDuration":4,"studyType":23,"phases":302,"briefSummary":303,"conditions":304,"keywords":306,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":4},"100535609","clinical-and-radiographic-evaluation-of-zirconomer-restorative-100535609","NCT06254053","Clinical and Radiographic Evaluation of Zirconomer Restorative","Clinical and Radiographic Evaluation of Zirconomer Restorative Material Versus a Glass Ionomer Cement in Restoration of Primary Molars A Randomized Clinical Trial","Zirconomer","* Inclusion criteria:\n\n  1. Children having carious primary molars(class1) without pulp exposure and normal radiograph.\n  2. Children between age 5 and 7 years.\n  3. Both male and female are included.\n  4. Cooperative Children.\n\n     Exclusion criteria:\n\n  \u003C!-- -->\n\n  1. Patients with systemic diseases.\n  2. Parent refuse to participate.",{"count":301,"type":22},24,[25],"Is zirconomer restorative material more effective than a glass ionomer cement in restoration of primary molars",[29,305],"Dental Materials",[307],"GIc\u002FZirconomer","2024-07-21",{"date":310,"type":40},"2024-07-23",{"date":312,"type":22},"2024-10-01",{"date":314,"type":22},"2025-01-03",{"name":96,"class":47}]