[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-caries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-caries":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,81,0,25,[9,52,91,115,143,172,202,230,257,285,310,332,360,386,406,435,460,485,505,527,548,573,600,626,654],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100644631","effect-of-ozone-therapy-on-remineralization-of-initial-caries-lesions-in-children-100644631",false,"NCT07671651","Effect of Ozone Therapy on Remineralization of Initial Caries Lesions in Children","Effect of Ozone Therapy on the Remineralization of Initial Caries Lesions in Children: A Randomized Controlled Clinical Trial","OZONE-CARIES","Inclusion Criteria Children aged 6-12 years. Presence of at least one initial non-cavitated caries lesion. Systemically healthy children. Frankl Behavior Rating Scale score of 3 or 4. Written informed consent obtained from the parent or legal guardian. Exclusion Criteria Cavitated caries lesions requiring restorative treatment. History of allergy to any study material. Systemic diseases affecting oral health or salivary flow. Respiratory diseases (e.g., asthma) contraindicating ozone therapy. Use of medications affecting salivary flow or enamel remineralization. Uncooperative children (Frankl score 1 or 2). Parent or guardian unwilling to participate or unable to attend follow-up visits.","ALL","6 Years","14 Years",{"count":22,"type":23},80,"ESTIMATED","INTERVENTIONAL",[26],"NA","Initial caries lesions can be managed using non-invasive treatment approaches that promote remineralization and prevent lesion progression. Ozone therapy has been suggested as an adjunctive treatment because of its antimicrobial properties and its potential to enhance remineralization.\n\nThis randomized controlled clinical trial aims to evaluate the effect of ozone therapy on the remineralization of initial caries lesions in children. Participants will be randomly assigned to receive either ozone therapy followed by application of a remineralizing gel or application of the remineralizing gel alone.\n\nChanges in lesion status will be assessed over time using clinical and optical evaluation methods. The results of this study may contribute to the development of evidence-based minimally invasive approaches for the management of early caries lesions in pediatric patients.",[29,30],"Dental Caries","Early Caries Lesion",[32,33,34,35,36,37,38],"Ozone Therapy","Remineralization","Non-cavitated Caries Lesions","Pediatric Dentistry","Children","ROCS Medical Minerals","Early Caries Lesions","RECRUITING","2026-06-26",{"date":42,"type":43},"2026-06-30","ACTUAL",{"date":45,"type":43},"2026-06-01",{"date":47,"type":23},"2027-04-20",{"name":49,"class":50},"Neslihan Atmaca","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":18,"minAge":59,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":24,"phases":62,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":51},"100644993","breaking-the-cycle-real-time-family-oral-microbial-transmission-patterns-as-intervention-targets-100644993","NCT07674888","Breaking the Cycle: Real-Time Family Oral Microbial Transmission Patterns as Intervention Targets","Inclusion Criteria:\n\n* Families with at least two children aged 5-12 years living in the same household.\n* least one parent or guardian diagnosed with Stage II or III periodontitis requiring non-surgical periodontal therapy.\n* At least one child who has undergone caries treatment and is considered at high risk for disease recurrence.\n* Willingness of all participating household members to provide oral samples and participate in study procedures.\n* Ability of participants or their legal guardians to provide informed consent, and assent from children where applicable.\n\nExclusion Criteria:\n\n* Children living in multiple households or shared-custody arrangements during the study period.\n* Households unable to complete study visits or follow-up procedures.\n* Individuals unwilling or unable to comply with study procedures.\n* Individuals who do not provide informed consent or assent, where applicable.\n* Medical or behavioral conditions that, in the opinion of the investigators, would preclude safe participation in the study.",true,"5 Years",{"count":61,"type":23},225,[26],"This study aims to understand how oral bacteria that cause tooth decay and gum disease spread among family members and whether treating multiple family members can reduce the return of these bacteria after dental treatment.\n\nFamilies with children aged 5-12 years will be recruited from university dental clinics. Participants will be assigned to one of three treatment groups: treatment for the child only, treatment for the child and parents, or treatment for all family members. Researchers will collect oral bacterial samples from family members before and after treatment and will monitor close-contact interactions within the household using wearable proximity-tracking devices.\n\nThe study will also collect information about oral health habits, family interactions, and environmental factors that may influence bacterial transmission. By combining bacterial DNA analysis with information about family contact patterns, researchers hope to better understand how oral bacteria are shared within households and whether family-based treatment approaches can reduce bacterial recolonization after dental therapy.\n\nThe results of this study may help improve strategies for preventing childhood tooth decay and gum disease by addressing family-level sources of bacterial transmission.",[29,65,66,67],"Periodontitis","Oral Microbiome","Bacterial Transmission",[69,70,71,72,73,74,75,76,77,78,79,80,81],"family microbial transmission","Oral microbiome","Plaque recolonization","Pediatric oral health","Real-time proximity tracking","Ultrawide Band (UWB)","Oral bacterial transmission","Intergenerational pathogen transfer","Biofilm disruption","Periodontal disease","Family-based intervention","Microbial source tracking","Oral Health","NOT_YET_RECRUITING","2026-06-25",{"date":42,"type":43},{"date":86,"type":23},"2026-09-30",{"date":88,"type":23},"2028-06-30",{"name":90,"class":50},"University of Alberta",{"id":92,"slug":93,"hasResults":12,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":58,"sex":18,"minAge":98,"maxAge":59,"enrollmentInfo":99,"targetDuration":4,"studyType":24,"phases":101,"briefSummary":102,"conditions":103,"keywords":104,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":51},"100570906","comparing-stainless-steel-crowns-with-prefabricated-resin-crowns-in-primary-molar-teeth-100570906","NCT06713330","Comparing Stainless Steel Crowns With Prefabricated Resin Crowns in Primary Molar Teeth","A 36-Month Prospective Randomized Clinical Pilot Trial Comparing Stainless Steel Crowns With Prefabricated Resin Crowns in Primary Molar Teeth","Inclusion Criteria:\n\n* CCHMC pediatric dental patients between the ages of 2 years to 5 years and 11 months, at the time of recruitment, who present to any CCHMC dental clinic location and then are found to need full mouth dental rehabilitation.\n* Patients who speak the most common languages at CCHMC will be able to be recruited for the study.\n\n  o English, Spanish, Arabic, Uzbek, Nepali, Chinese Mandarin, Russian, French.\n* These patients must qualify for treatment at the CCHMC dental in-office general anesthesia (IOGA) area or the Procedure Center (PC). IOGA and the PC will be selected as a venue of treatment to control behavioral factors. This is not specific to the study and would occur due to their treatment needs.\n* Participants will have at least one pair of contralateral primary molars with the need for a full coverage restoration in the same arch.\n\n  * For example, tooth A \\& J, B \\& I, S \\& L, or T \\& K\n  * For each participant, a minimum of one SSC or one PRC will be randomly assigned via a split mouth design to be placed as part of the study.\n* Need for Full coverage and high caries risk will be defined by AAPD Best Practice Guidelines 2,16\n\n  o Teeth With\n  1. Extensive caries\n  2. Cervical decalcification\n  3. Developmental defects (e.g., hypoplasia, hypocalcification)\n  4. When failure of other available restorative materials is likely (e.g., interproximal caries extending beyond line angles, patients with bruxism)\n  5. Following pulpotomy or pulpectomy\n  6. For definitive restorative treatment for high caries-risk children as defined by the AAPD\n  7. For patients who exhibit high caries risk and whose treatment is performed under sedation or general anesthesia. This would be normal and not specific to the study.\n* Participants who consent to the study, and who can be available for follow-up recall appointments.\n* All participants will be ASA I or ASA II as defined by the American Society of Anesthesiologists.15\n\nExclusion Criteria:\n\n* Participants who do not meet inclusion criteria will be excluded.\n\n  * Participants whose teeth do not meet the inclusion criteria.\n  * Participants who do not wish to participate in the study.\n  * Patients who do not wish to or cannot reliably return for follow-up visits.\n  * Red dye allergy as patient will not be able to be plaque disclosed during follow-up visits.\n  * Participants who do not speak English, Spanish, Arabic, Uzbek, Nepali, Chinese Mandarin, Russian, French.","2 Years",{"count":100,"type":23},50,[26],"The main reason for this research study is to learn more about a new flexible white dental crown (BioFLX) by comparing it to an existing flexible metal crown (Stainless Steel Crown). It is of interest to see if this new white crown is clinically equivalent to the existing silver crown that is mainly used in pediatric dentistry. A potential participant for this study would have cavities that require a crown, a type of filling that covers the entire tooth, and recommended dental work be done under general anesthesia.",[29],[105],"Pediatric dentistry","2026-06-24",{"date":108,"type":43},"2026-06-29",{"date":110,"type":43},"2024-05-17",{"date":112,"type":23},"2027-12-29",{"name":114,"class":50},"Children's Hospital Medical Center, Cincinnati",{"id":116,"slug":117,"hasResults":12,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":58,"sex":18,"minAge":122,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":139,"leadSponsor":141,"locationsCount":51},"100642311","dental-caries-and-oral-hygiene-status-in-children-with-specific-learning-disabilities-100642311","NCT07611981","Dental Caries and Oral Hygiene Status in Children With Specific Learning Disabilities","SLD-OH","Inclusion Criteria:\n\n* Children aged 7-12 years\n* For the study group: diagnosis of specific learning disorder (SLD) confirmed by a psychiatrist\n* For the control group: confirmed healthy with no psychiatric diagnosis by a psychiatrist\n* Written informed consent obtained from the parent or guardian\n\nExclusion Criteria:\n\n* Children with additional psychiatric diagnoses (e.g., autism spectrum disorder, attention-deficit\u002Fhyperactivity disorder, intellectual disability)\n* Children with systemic disease or physical disability that may prevent participation in the study","7 Years","12 Years",{"count":125,"type":23},70,"OBSERVATIONAL","This study aims to evaluate dental caries and oral hygiene status in children aged 7-12 years with specific learning disabilities (SLD) and to compare the findings with healthy children. Clinical oral examinations, including dmft\u002FDMFT, ICDAS II, Plaque Index, and Gingival Index assessments, will be performed. In addition, questionnaire-based evaluations of oral hygiene habits, dietary habits, and parental supervision during toothbrushing will be conducted.",[129,29,130],"Specific Learning Disabilities","Oral Hygiene",[129,29,81,132,35,133,134],"dmft\u002FDMFT","Plaque Index","Gingival Index","2026-06-15",{"date":137,"type":43},"2026-06-16",{"date":135,"type":43},{"date":140,"type":23},"2026-10",{"name":142,"class":50},"Alanya Alaaddin Keykubat University",{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":12,"sex":18,"minAge":150,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":24,"phases":153,"briefSummary":154,"conditions":155,"keywords":158,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":4},"100642802","clinical-performance-of-cadcam-hard-hybrid-ceramic-inlays-versus-resin-composite-inlays-in-vital-molars-with-extensive-occluso-proximal-cavities-100642802","NCT07648485","Clinical Performance of CAD\u002FCAM Hard Hybrid Ceramic Inlays Versus Resin Composite Inlays in Vital Molars With Extensive Occluso-Proximal Cavities","Clinical Performance of CAD\u002FCAM Hard Hybrid Ceramic Inlays Versus Resin Composite Inlays in Vital Molars With Extensive Occluso-Proximal Cavities: Two-Year Randomized Clinical Trial","Inclusion Criteria:\n\n* Systematically healthy male or female subjects aged 16 to 50 years.\n* Patients with good oral hygiene.\n* Presence of a single vital molar with coronal destruction due to caries, defined as radiographic evidence of caries involving more than 50% of the total dentin thickness with loss of at least one proximal wall.\n* Cavitary preparation involving loss of at least one proximal walls (mesial and\u002For distal), with intact buccal and lingual walls, and all cavosurface margins located in enamel.\n* Presence of functional opposing teeth in stable occlusion\n\nExclusion Criteria:\n\n* Presence of systemic diseases (e.g., uncontrolled diabetes, immune disorders).\n* Current pregnancy or lactation.\n* Documented allergy to resin-based composites or adhesive systems.\n* Evidence of pulpal necrosis or previous endodontic treatment in the target tooth.\n* Presence of cracks or fractures involving the tooth structure.\n* Active localized or generalized periodontal disease.\n* Evidence of parafunctional habits, including bruxism or clenching.\n* High caries risk.","16 Years","50 Years",{"count":100,"type":23},[26],"this study aims to compare the clinical performance of hard hybrid ceramics and composite resin indirect restorations fabricated by CAD\u002FCAM technology for the vital teeth with occluso-proximal cavities. the clinical performance assessed include marginal adaptation primarily and in addition to Color match, marginal discoloration, aesthetic anatomic form, recurrent caries and restoration fracture and post-operative hypersensitivity. the clinical performance will be assessed after the restoration cementation, after 6, 12, 18 and 24 months.",[29,156,157],"Cavity, Dental","Proximal Dental Caries",[159,160,161,162,163],"indirect restoration","CAD\u002FCAM","clinical performance","inlay","hybrid ceramics","2026-06-13",{"date":137,"type":43},{"date":167,"type":23},"2026-08",{"date":169,"type":23},"2028-11",{"name":171,"class":50},"Cairo University",{"id":173,"slug":174,"hasResults":12,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":12,"sex":18,"minAge":180,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":24,"phases":184,"briefSummary":185,"conditions":186,"keywords":187,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":51},"100642397","3d-printed-resin-crowns-vs-stainless-steel-crowns-in-pulpotomized-primary-molars-100642397","NCT07648979","3D-Printed Resin Crowns vs Stainless Steel Crowns in Pulpotomized Primary Molars.","Clinical Evaluation of 3D Printed Resin Based Crowns Versus Stainless Steel Crowns in Pulpotomized Primary Mandibular Molars : A Randomized Controlled Clinical Trial","3DRSCVSSSC","Inclusion Criteria:\n\nChildren aged 4 to 8 years. Cooperative children who are able to accept dental treatment. Teeth diagnosed with reversible pulpitis. Children in good general health with no systemic conditions affecting oral health.\n\nParents\u002Fguardians willing to provide written informed consent and attend follow-up visits.\n\nExclusion Criteria:\n\nTeeth deemed non-restorable (e.g., gross carious destruction or fractures beyond restoration).\n\nParents\u002Fguardians unwilling to participate in the study or provide informed consent.","4 Years","8 Years",{"count":183,"type":23},26,[26],"The goal of this clinical trial is to learn whether 3D-printed resin-based crowns are an effective alternative to stainless steel crowns for restoring pulpotomized primary mandibular molars in children. The main questions it aims to answer are:\n\nDo 3D-printed resin-based crowns provide better gingival health than stainless steel crowns? Are there differences in plaque accumulation, crown retention, and child and parent satisfaction between the two crown types?\n\nParticipants will:\n\nReceive either a 3D-printed resin-based crown or a stainless steel crown after pulpotomy.\n\nAttend follow-up visits for clinical evaluation over 12 months.",[29],[188,189,190,191,192,193,194],"Dental caries","3D-Printed Resin Crowns","Primary Molars","Pulpotomy","Stainless Steel Crowns","crown retention","Gingival Health","2026-06-11",{"date":135,"type":43},{"date":198,"type":23},"2026-07",{"date":200,"type":23},"2027-08",{"name":171,"class":50},{"id":203,"slug":204,"hasResults":12,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":58,"sex":18,"minAge":210,"maxAge":4,"enrollmentInfo":211,"targetDuration":4,"studyType":24,"phases":213,"briefSummary":214,"conditions":215,"keywords":218,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":51},"100516585","intraoral-scanners-as-periodontal-and-dental-pathologies-diagnosis-tools-100516585","NCT06006429","Intraoral Scanners as Periodontal and Dental Pathologies Diagnosis Tools","Digital Extraction and Scientific Visualization of Clinical Characteristics From 3D Data From Intraoral Scanners for Dental and Periodontal Pathologies Research : Computer Formalization and Feasibility Study","Odonto3D","Inclusion Criteria:\n\n* adultes\n* consulting the Dental Care Service of the university hospital of Reims\n* presenting at least one gingival recession\n* presenting at least 10 pairs of opposing teeth\n* speaking French\n* who signed the informed consent form\n* affiliated to the French Social Security system\n\nExclusion Criteria:\n\nPatients presenting :\n\n* pregnancy or breastfeeding\n* orthodontic treatments\n* patients under legal protection, trusteeship or guardianship\n* unable to understand auto-questionnary","18 Years",{"count":212,"type":23},30,[26],"Periodontal diseases and dental pathologies are highly prevalent oral diseases. Thirty-three to fifty percent of adult population presented at least one untreated caries and more than 50% of French population are affected by severe periodontitis. These diseases affect dental organ or periodontal attached system but could have negative impact on general health, quality of life, word and individual well-being. Association between chronic diseases as diabetes, rheumatoid arthritis, cardiovascular diseases, and oral health have been well investigated. Dental and periodontal diagnosis is dependent of various clinical parameters time consuming and dependent operator. It represents a public health challenge. Informatic analysis detecting diseases could be a time gain and a more precise diagnosis tool. Today, any software or algorithm allow automatized detection, clinical qualitative or quantitative indices recording while these informations are present in numeric models",[65,216,29,217],"Gingivitis","Diagnosis",[219,188,220,221],"Periodontal diseases","intra-oral camera","diagnosis",{"date":223,"type":43},"2026-06-12",{"date":225,"type":43},"2022-05-11",{"date":227,"type":23},"2027-12-11",{"name":229,"class":50},"CHU de Reims",{"id":231,"slug":232,"hasResults":12,"nctId":233,"briefTitle":234,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":58,"sex":18,"minAge":180,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":24,"phases":238,"briefSummary":239,"conditions":240,"keywords":242,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":51},"100571029","advancing-water-security-a-community-participatory-school-based-hydration-intervention-100571029","NCT06714929","Advancing Water Security: A Community Participatory School-Based Hydration Intervention","Inclusion Criteria:\n\n* Lunchroom observations: All students (K-5th \\[Pre-Kindergarten if applicable\\]) who eat lunch in the cafeteria on assessment days are eligible\n* BMI and dental caries assessments: 1) student enrolls in study while in 3rd grade (followed through 5th g)\n* Student surveys: Students in 4th-5th grade are eligible to complete surveys assessing beverage intake and perceptions of hydration practices within their school district.\n* Staff surveys: All staff in the target schools will be eligible to complete the Personnel Survey.\n\nExclusion Criteria:\n\n* Lunchroom observations: None.\n* BMI and dental caries assessments: Students are ineligible if they are unable to complete assessments due to developmental or physical reasons, 2) planning to move in the study duration\n* Student surveys: None.\n* Staff surveys: None.",{"count":237,"type":23},7200,[26],"The goal of this study is to determine the effectiveness and sustainability of a community-participatory hydration intervention over 3 years within a district that has newly installed hydration stations and is operating under a policy designed to enhance heathy hydration practices and promote equitable access to drinking water.",[29,241],"Obesity Prevention",[243,244,245,246,247],"hydration","water","sugar-sweetened beverages","dental caries","overweight and obesity","2026-06-08",{"date":250,"type":43},"2026-06-10",{"date":252,"type":43},"2024-08-14",{"date":254,"type":23},"2028-05-31",{"name":256,"class":50},"Virginia Commonwealth University",{"id":258,"slug":259,"hasResults":12,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":58,"sex":18,"minAge":122,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":24,"phases":267,"briefSummary":268,"conditions":269,"keywords":270,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":51},"100611474","oral-spray-bacillus-spore-probiotic-in-preventing-and-supporting-treatment-of-dental-caries-in-children-100611474","NCT07241052","Oral-Spray Bacillus Spore Probiotic in Preventing and Supporting Treatment of Dental Caries in Children","Evaluating Safety and Efficacy of Oral-Spray Bacillus Probiotic (LiveSpo® Smile CARE) in the Prevention and Adjunctive Treatment of Dental Caries in Children","Inclusion Criteria:\n\n* Children (male or female) aged 7-10 years, currently enrolled in primary school (grades 2-4).\n* At least one decayed tooth (any stage) at the time of screening.\n* Commitment to comply with study requirements, including refraining from using any other probiotic products for the ear, nose, and throat that could affect study outcomes.\n* Written informed consent obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\nParticipant-level exclusion:\n\n* Presence of severe chronic disease, allergy, or use of antibiotics within 1 month prior to study initiation.\n* Use of oral or throat probiotic sprays\u002Flozenges within the past 30 days (excluding gastrointestinal probiotics).\n* Participation in another clinical study within the past 30 days.\n* Acute oral conditions (e.g., abscess, severe gingivitis) interfering with examination or intervention.\n* Currently receiving dental treatment at specialized dental\u002Foral health facilities.\n* History of congenital immunodeficiency or infectious disease.\n* Psychiatric disorders or sleep disturbances.\n* Known sensitivity or allergy to components of the investigational product.\n\nTooth-level exclusion:\n\n* Hard tissue lesions not caused by dental caries.\n* Supernumerary teeth or teeth not part of the functional dental arch.\n* Carious teeth with pain lasting \\>10 seconds during examination.\n* Carious teeth with visible pulp hyperemia (high risk of pulp complications).\n* Teeth showing signs of pulp disease, pulp necrosis, or periapical pathology.\n* Teeth previously treated with endodontic therapy or permanently restored with crowns.\n* Primary teeth with mobility grade ≥2 (due to disease or natural exfoliation).","10 Years",{"count":266,"type":23},130,[26],"Despite advances in oral health care, cavities remain highly prevalent worldwide, especially among children. Conventional treatment methods focus on removing damaged tooth tissue but fail to completely eliminate or control pathogenic bacteria in the oral cavity, leading to a high risk of caries recurrence in the same or adjacent teeth. Probiotics are a promising biological therapy that can help restore balance in the oral microbiome.\n\nAmong probiotics, Bacillus species are unique because they form spores that make them stable under harsh conditions, such as heat and storage. They can also produce enzymes and natural compounds with antibacterial, anti-inflammatory, and protective effects. These features make Bacillus probiotics strong candidates for oral health applications.\n\nThis study is designed to evaluate the safety and efficacy of an oral-spray probiotic containing Bacillus subtilis ANA48 and Bacillus clausii ANA39 (LiveSpo® Smile CARE) in preventing and supporting the treatment of tooth decay in children. We hypothesize that this probiotic spray, when used regularly, will be safe and well-tolerated, while effectively reducing harmful bacteria in the mouth, preventing the progression of cavities, and improving overall oral health.\n\nStudy Design:\n\n* Sample Size: 130 participants\n* Study Location: a primary school in Hanoi, Vietnam Intervention Description: A total of 130 eligible participants will be randomly assigned to two groups (n = 65 per group).\n\nPlacebo Group will receive a 0.9% NaCl physiological saline, spray twice daily (morning and afternoon). Each application consists of two sprays at three sites (both dental arches and the front teeth), for a total of six sprays per use, continued for three consecutive months.\n\nSmile Care Group will receive an oral-spray probiotics containing ≥ 1 billion CFU\u002FmL × 20 mL of Bacillus subtilis and Bacillus clausii (LiveSpo Smile CARE). The dosage, frequency, and duration of use will be the same as in the placebo group.\n\nAll participants will receive the same standard dental care throughout the study, including the use of identical toothpaste, supervised weekly fluoride rinsing with 0.2% sodium fluoride (NaF), and scheduled follow-up visits. The probiotic and placebo sprays will be packaged in blinded bottles and administered according to the study protocol to maintain objectivity.\n\nStudy Duration: 12-18 months",[29],[188,36,271,272,273,274],"probiotics","Oral health","Oral-spray","Bacillus spores","2026-06-04",{"date":277,"type":43},"2026-06-05",{"date":279,"type":43},"2026-03-05",{"date":281,"type":23},"2027-05-01",{"name":283,"class":284},"Anabio R&D","INDUSTRY",{"id":286,"slug":287,"hasResults":12,"nctId":288,"briefTitle":289,"officialTitle":289,"acronym":290,"eligibilityCriteria":291,"healthyVolunteers":58,"sex":18,"minAge":19,"maxAge":181,"enrollmentInfo":292,"targetDuration":4,"studyType":24,"phases":293,"briefSummary":294,"conditions":295,"keywords":297,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":51},"100640997","the-effects-of-sodium-fluoride-and-chlorhexidine-use-on-salivary-il-6-and-matrix-metalloproteinase-levels-in-children-with-active-caries-100640997","NCT07609797","The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries","DentalCaries","Inclusion Criteria:\n\n* Children aged 6-8 years with all first permanent molars erupted\n* For active caries groups (Groups A, B, C): participants must meet at least one of the following criteria: dmft ≥ 6, or presence of at least one active caries lesion with an ICDAS code ≥ 3, or clinical evidence of active caries on ≥ 10 surfaces\n* For the dmft = 0 reference group (Group D): all surfaces caries-free and non-high-risk individuals (ICDAS II = 0); only baseline (T0) saliva sampling will be performed\n* No professional topical fluoride application or continuous CHX use within the past 3 months\n* No systemic chronic disease, immunodeficiency, or severe neuromotor disorder\n* No gingival redness, swelling, or bleeding\n* Written parental informed consent obtained\n\nExclusion Criteria:\n\n* Known allergy to fluoride compounds or varnish components\n* Behavioral problems that would prevent safe cooperation during application\n* Regular antibiotic use within the past 1 month\n* Individuals with infectious diseases\n* Those at high risk of endocarditis\n* History of substance dependence\n* Epilepsy\n* Renal failure or immunosuppression",{"count":22,"type":23},[26],"This study aims to compare salivary IL-6, MMP-8, MMP-9, and TIMP-1 levels between healthy children and caries-active children, and to evaluate the effects of 5% sodium fluoride (NaF) varnish and 2% chlorhexidine (CHX) used in caries prevention on these biomarkers.\n\nThe study will be conducted at Alanya Alaaddin Keykubat University, Faculty of Dentistry, Department of Pediatric Dentistry. Informed consent will be obtained from children and their parents\u002Fguardians. Investigator calibration will be performed using Cohen's kappa method prior to data collection. Sample size was calculated assuming 80% power (1-β = 0.80), α = 0.05, and Cohen's d ≈ 0.8, resulting in 20 participants per group using G\\*Power 3.1 software.\n\nStudy groups: Group A: 5% NaF varnish. Group B: 2% CHX + 5% NaF varnish. Group C: Standard oral hygiene education (negative control). Group D: Caries-free children (biological reference; baseline saliva sampling only).\n\nSaliva samples will be collected at T0 (baseline), T1 (30 minutes post-application), and T2 (1 month). Unstimulated whole saliva will be collected, centrifuged at 5,000 g for 10 minutes at 4°C, and stored at -80°C. IL-6, MMP-8, MMP-9, and TIMP-1 levels will be measured using CE-marked\u002FFDA-approved human saliva ELISA kits.",[29,296],"Dental Caries in Children",[188,298,299,300,301],"Matrix metalloproteinase","Interleukin-6","Sodium fluoride","Chlorhexidine",{"date":303,"type":43},"2026-06-02",{"date":305,"type":43},"2026-05-15",{"date":307,"type":23},"2027-06-30",{"name":309,"class":50},"Gül Keskin",{"id":311,"slug":312,"hasResults":12,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":58,"sex":18,"minAge":317,"maxAge":318,"enrollmentInfo":319,"targetDuration":4,"studyType":24,"phases":321,"briefSummary":322,"conditions":323,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":328,"leadSponsor":330,"locationsCount":331},"100638627","retention-and-caries-prevention-of-giomer-sealant-with-or-without-diode-laser-pre-treatment-a-randomized-controlled-trial-100638627","NCT07612540","Retention and Caries Prevention of Giomer Sealant With or Without Diode Laser Pre-treatment: A Randomized Controlled Trial","Retention Rate and Caries Prevention of Giomer Based Sealant With and Without Diode Laser Pre-treatment in Young Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Young adult Patients Aged 17-22.\n\n  * Good oral hygiene (plaque index score 0 or 1).\n  * Absence of abnormal occlusion habits (e.g. bruxism, nail biting, tooth clenching and mouth breathing).\n  * Patients approving to participate in the study.\n\nExclusion Criteria:\n\n* •Patients with known allergic or adverse reaction to the tested materials.\n\n  * Systematic disease that may affect participation.\n  * Xerostomic patients.","17 Years","22 Years",{"count":320,"type":23},111,[26],"This randomized controlled trial evaluates the effect of diode laser pre-treatment on the retention and caries prevention of giomer-based fissure sealants in young adults aged 17-22 years. The study compares sealant application with and without diode laser conditioning on molars with ICDAS 0-2 fissures over a 12-month follow-up period. Primary outcome is sealant retention using Simonsen's criteria, while secondary outcome is caries prevention using modified USPHS criteria. The study hypothesizes that diode laser pre-treatment may improve sealant retention and enhance caries prevention by modifying enamel surface characteristics and improving sealant penetration.",[29],"2026-05-21",{"date":326,"type":43},"2026-05-28",{"date":45,"type":23},{"date":329,"type":23},"2027-06-01",{"name":171,"class":50},3,{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":58,"sex":18,"minAge":98,"maxAge":122,"enrollmentInfo":339,"targetDuration":4,"studyType":24,"phases":341,"briefSummary":342,"conditions":343,"keywords":346,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":353,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":51},"100638379","luting-cements-for-prefabricated-zirconia-crown-retention-in-primary-anterior-teeth-in-children-100638379","NCT07611734","Luting Cements for Prefabricated Zirconia Crown Retention in Primary Anterior Teeth in Children","Comparison of Self-Adhesive Resin, Conventional Glass Ionomer, and Bioactive Resin-Modified Glass Ionomer Cements for Prefabricated Zirconia Crown Retention in Primary Anterior Teeth: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Healthy children aged 2 to 7 years\n2. One or more primary maxillary or mandibular incisors requiring full-coverage restoration due to caries or trauma\n3. Adequate remaining tooth structure following preparation, defined as greater than 50% of the clinical crown\n4. Parent or legal guardian able and willing to provide written informed consent and to commit to the 36-month follow-up schedule\n\nExclusion Criteria:\n\n1. Active periodontal disease at the index tooth, defined as a Löe Gingival Index score of 2 or higher\n2. Parafunctional habits such as bruxism, severe thumb-sucking, or tongue-thrust documented at screening\n3. Known allergy or hypersensitivity to zirconia, resin, glass ionomer, or any component of the assigned cement\n4. Inconsistent oral hygiene, defined as less than twice-daily toothbrushing per parental report\n5. Systemic disease affecting bone metabolism, tooth development, or wound healing\n6. Current participation in another interventional dental clinical trial",{"count":340,"type":23},120,[26],"The goal of this clinical trial is to compare the long-term clinical performance of three different luting cements used to bond prefabricated zirconia crowns (PZCs) on primary front teeth in young children. The trial will determine whether any single cement offers superior retention, gum health, or marginal sealing compared to the others over a 3-year period.\n\nMain Questions:\n\nThe study aims to answer the following:\n\nAre conventional glass ionomer cement (GIC), bioactive resin-modified glass ionomer cement (BioCem™), and self-adhesive resin cement (SARC) equivalent in retaining prefabricated zirconia crowns on primary incisors over 36 months? Do these cements differ in their effect on gingival health, plaque accumulation, or marginal discoloration around the cemented crown?\n\nComparison:\n\nResearchers will compare three parallel groups of children whose primary incisors are restored with identical prefabricated zirconia crowns but cemented with one of the three different luting cements.\n\nParticipants will: Receive a clinical and radiographic dental examination at screening. Undergo placement of one or more prefabricated zirconia crowns on primary anterior teeth using their randomly assigned cement. Return to the clinic for blinded follow-up evaluations at 12, 24, and 36 months for assessment of crown retention, gingival health, plaque, and marginal staining.",[29,344,345],"Tooth Injuries","Primary Tooth Restoration",[347,348,349,350,351,352],"Prefabricated Zirconia Crown","Luting Cement","Glass Ionomer Cement","Bioactive Cement","Self-Adhesive Resin Cement","Crown Retention",{"date":326,"type":43},{"date":355,"type":23},"2026-05",{"date":357,"type":23},"2029-07",{"name":359,"class":50},"Murad Alrashidi",{"id":361,"slug":362,"hasResults":12,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":4,"eligibilityCriteria":366,"healthyVolunteers":12,"sex":18,"minAge":367,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":370,"conditions":371,"keywords":375,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":377,"lastUpdatePostDateStruct":378,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":4},"100639870","qlf-and-digital-imaging-for-caries-activity-assessment-after-orthodontic-treatment-100639870","NCT07608471","QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment","Diagnostic Performance of Smartphone, 3D Imaging, QLF-D, and ICDAS Clinical Criteria for Non-Cavitated Caries Activity Assessment in Post-Orthodontic Patients Under a Preventive Program","Inclusion Criteria:\n\n* Participants aged 11 to 46 years\n* Completed fixed orthodontic treatment\n* Presence of at least four active non-cavitated caries lesions (ICDAS 1-3)\n* Lesions located on vestibular surfaces of anterior teeth and\u002For premolars\n* Ability to attend follow-up visits during the three-month study period\n* Signed informed consent and\u002For assent form\n\nExclusion Criteria:\n\n* Systemic conditions affecting salivary flow or enamel structure\n* Extensive cavitated lesions requiring restorative treatment\n* Ongoing orthodontic treatment\n* Use of medications that significantly affect oral conditions\n* Inability to cooperate with imaging procedures or follow-up visits","11 Years","46 Years",{"count":212,"type":23},"This prospective longitudinal observational study aims to evaluate the diagnostic performance and agreement of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS clinical criteria for assessing non-cavitated caries lesion activity in post-orthodontic patients under a preventive follow-up program. Thirty participants aged 11 to 46 years with active initial caries lesions will be followed for three months. Clinical examinations, QLF-D imaging, smartphone photographs, and intraoral 3D scans will be obtained at baseline and follow-up visits combined with professional prophylaxis and oral hygiene reinforcement. The study will analyze changes in lesion activity, fluorescence parameters, and surface characteristics over time, as well as the agreement and diagnostic performance among the evaluated methods.",[29,372,373,374],"White Spot Lesions","Caries Lesion Activity","Post-Orthodontic Enamel Demineralization",[29,376,373,374],"Dental Caries White Spot Lesions","2026-05-20",{"date":379,"type":43},"2026-05-27",{"date":381,"type":23},"2026-07-21",{"date":383,"type":23},"2027-04-22",{"name":385,"class":50},"Universidad El Bosque, Bogotá",{"id":387,"slug":388,"hasResults":12,"nctId":389,"briefTitle":390,"officialTitle":391,"acronym":4,"eligibilityCriteria":392,"healthyVolunteers":58,"sex":18,"minAge":19,"maxAge":123,"enrollmentInfo":393,"targetDuration":4,"studyType":24,"phases":395,"briefSummary":396,"conditions":397,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":51},"100592866","longitudinal-evaluation-of-minimally-invasive-protocols-for-dental-caries-in-brazilian-schoolchildren-100592866","NCT06999005","Longitudinal Evaluation of Minimally Invasive Protocols for Dental Caries in Brazilian Schoolchildren","Longitudinal Evaluation of Minimally Invasive Protocols for the Prevention and Control of Dental Caries in Brazilian Schoolchildren: A Multicenter Study Protocol","Inclusion Criteria:\n\n* Children aged between 6 and 12 years at the time of enrollment\n* Presence of at least one erupted permanent first molar\n* Diagnosis of active caries lesions classified according to ICDAS (scores 1 to 6)\n* Written informed consent signed by a legal guardian and assent signed by the child\n* Ability to attend quarterly follow-up visits over a 24-month period\n\nExclusion Criteria:\n\n* Children requiring endodontic treatment or presenting extensive pulpal involvement\n* Presence of systemic diseases or medical conditions that contraindicate dental care\n* Known allergy to any material used in the study (fluoride varnish, high-viscosity glass ionomer cement)\n* Participation in other clinical dental studies that could interfere with the outcomes",{"count":394,"type":23},2500,[26],"This multicenter longitudinal interventional study aims to evaluate minimally invasive protocols for the prevention and control of dental caries in Brazilian schoolchildren under routine public health conditions. In the first phase, 50,000 children aged 6 to 12 years from public schools in five Brazilian cities will undergo dental screening using ICDAS criteria and receive preventive and educational oral health measures. In the longitudinal treatment phase, 2,500 children diagnosed with active carious lesions will be managed according to ICDAS-based minimally invasive treatment protocols. Participants will be followed every three months for up to 24 months.",[29],"2026-05-12",{"date":305,"type":43},{"date":401,"type":43},"2026-02-28",{"date":403,"type":23},"2028-12",{"name":405,"class":50},"University of Nove de Julho",{"id":407,"slug":408,"hasResults":12,"nctId":409,"briefTitle":410,"officialTitle":410,"acronym":411,"eligibilityCriteria":412,"healthyVolunteers":12,"sex":18,"minAge":413,"maxAge":414,"enrollmentInfo":415,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":417,"conditions":418,"keywords":422,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":4},"100408753","obesity-and-oral-diseases-in-adult-patients-100408753","NCT04602572","Obesity and Oral Diseases in Adult Patients","ObOd","Inclusion Criteria:\n\n* Obese adult patients.\n* Patients referred to the Obesity Clinic at the Hospital.\n\nExclusion Criteria:\n\n* Unwillingness to participate.","20 Years","70 Years",{"count":416,"type":23},400,"Overweight and obesity are among the major chronic disorders of the 21st century and one of the fastest growing health problems worldwide. Obesity is accompanied by a state of low-grade inflammation which may contribute to the occurrence of diabetes mellitus, cardiovascular disease, hypertension, stroke, and certain cancers. Furthermore, obesity has been associated with oral health problems as hyposalivation, dental caries and periodontitis.\n\nThe management and treatment of obesity is outlined in clinical guidelines from American Association of Clinical Endocrinologists\u002FAmerican College of Endocrinology and European Association for the Study of Obesity. The cornerstone is life-style modification programs aiming to reduce energy intake and increase physical activity, referred to as conservative treatment. All patients must undergo a thorough systematic work-up. The work-up concludes in a final multi-disciplinary meeting with a concrete individualized plan on how sustained weight-loss is to be achieved; either by a non-surgical or a surgical approach (Bariatric surgery).\n\nPeriodontitis is cited to be the sixth most prevalent chronic condition globally. The mechanisms by which obesity affects the periodontal tissues is poorly understood, and the understanding of the key role of adipocytes in the inflammatory response to infections is crucial in comprehending how periodontal disease susceptibility may be modified in obese individuals.\n\nThe main objectives of the present research project are to explore the association between obesity and oral diseases and further, to assess how weight changes following non-surgical and surgical interventions of obese patients may affect the cariological and periodontal health status.\n\nFour hundred patients referred to the Obesity Centre at Haukeland University Hospital, Norway will consecutively be screened and invited to participate in this prospective cohort study. At baseline, detailed medical and oral data will be obtained from health forms, questionnaires, clinical examinations, and by consulting the patient's care team. Following baseline examination, all patients will undergo a thorough systematic work-up consisting av interviews and consultations concluding in a final multi-disciplinary individualized non-surgical or surgical treatment plan on how sustained weight-loss can be achieved. New sets of medical, oral, and molecular data will be collected at 3-, 12- and 18-month following non-surgical\u002Fsurgical interventions.",[419,420,65,29,421],"Obesity","Oral Diseases","Dental Erosion",[419,423,65,424,425,272],"Overweight","Caries","Bariatric surgery","2026-05-04",{"date":428,"type":43},"2026-05-08",{"date":430,"type":23},"2026-11-01",{"date":432,"type":23},"2027-12-31",{"name":434,"class":50},"University of Bergen",{"id":436,"slug":437,"hasResults":12,"nctId":438,"briefTitle":439,"officialTitle":440,"acronym":4,"eligibilityCriteria":441,"healthyVolunteers":58,"sex":18,"minAge":210,"maxAge":442,"enrollmentInfo":443,"targetDuration":4,"studyType":24,"phases":445,"briefSummary":446,"conditions":447,"keywords":448,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":455,"completionDateStruct":457,"leadSponsor":458,"locationsCount":51},"100636040","assessment-of-digital-technologies-for-detection-of-dental-caries-100636040","NCT07560514","Assessment of Digital Technologies for Detection of Dental Caries","Assessment and Comparison of Diagnostic Technologies for the Detection of Dental Caries in Clinical Practice","Inclusion Criteria:\n\n* Age 18-65 years\n* Presence of permanent dentition only\n* Presence of primary or secondary carious lesions\n* Presence of all teeth in the lateral segment (teeth 4-7) in both maxilla and mandible\n* Signed informed consent including agreement with photodocumentation, bitewing radiographs, and use of AI-based diagnostic methods (including DIAGNOcam)\n\nExclusion Criteria:\n\n* Age under 18 or over 65 years\n* Extensive crown destruction affecting more than two-thirds of the tooth\n* Carious lesions reaching the dental pulp or threatening pulp vitality\n* Inability or refusal to undergo radiographic examination (bitewing radiographs)\n* Teeth with fixed prosthetic restorations in the examined area Refusal to participate or to use AI-based diagnostic methods (including DIAGNOcam)","65 Years",{"count":444,"type":23},100,[26],"This study aims to evaluate and compare different digital diagnostic technologies used for the detection of dental caries in clinical practice. The study focuses on assessing the diagnostic accuracy of various methods, including visual examination and digital diagnostic tools, in identifying dental caries in patients. The results will contribute to improving early detection and diagnostic strategies in dentistry.",[29],[246,449,450,451],"caries detection","digital technology","artificial intelligence","2026-04-27",{"date":454,"type":43},"2026-05-01",{"date":456,"type":43},"2025-11-30",{"date":167,"type":23},{"name":459,"class":50},"University Hospital, Martin",{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":466,"eligibilityCriteria":467,"healthyVolunteers":12,"sex":18,"minAge":468,"maxAge":181,"enrollmentInfo":469,"targetDuration":4,"studyType":24,"phases":470,"briefSummary":471,"conditions":472,"keywords":473,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":481,"completionDateStruct":482,"leadSponsor":484,"locationsCount":4},"100636094","injectable-bioactive-composites-vs-rmgi-for-proximal-cavities-in-primary-molars-100636094","NCT07561216","Injectable Bioactive Composites vs RMGI for Proximal Cavities in Primary Molars","Clinical Evaluation of Injectable Bioactive Composites Versus Resin Modified Glass Ionomer for Restoring Proximal Cavities in Primary Molars: A Randomized Clinical Tria","GIOMER-RCT","Inclusion Criteria:\n\n* Children aged 3-8 years of both genders\n* Cooperative behavior manageable by operators\n* Willing to sign informed consent\n* Accepts the follow-up period\n* Moderate to low caries risk according to Cariogram application\n* Posterior primary molar with proximal carious lesion (ICDAS 3 or 4) with no signs or symptoms of pulpal involvement\n* Radiographically extending to outer 1\u002F3 of dentin\n\nExclusion Criteria:\n\n* Allergy to any restorative materials\n* Patients undergoing orthodontic treatment with fixed appliances\n* Patients with debilitating systemic diseases\n* Children with special needs\n* Teeth with previous restorations\n* Periapical radiolucencies or sensitivity to percussion\n* Mobile teeth\n* External or internal resorption\n* Cervical carious lesions","3 Years",{"count":100,"type":23},[26],"This randomized clinical trial aims to evaluate and compare the clinical performance of injectable bioactive composite (Beautifil Flow Plus X, Shofu) versus Resin Modified Glass Ionomer (RMGI) in restoring proximal cavities (Class II) in primary molars of children aged 3-8 years over a 12-month follow-up period, using revised FDI criteria.",[29],[474,475,476,477,478],"Randomized Clinical Trial","Primary Dentition","Giomer","RMGI","FDI criteria","2026-04-24",{"date":454,"type":43},{"date":355,"type":23},{"date":483,"type":23},"2027-09",{"name":171,"class":50},{"id":486,"slug":487,"hasResults":12,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":58,"sex":18,"minAge":210,"maxAge":414,"enrollmentInfo":492,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":493,"conditions":494,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":51},"100635633","intraoral-scan-and-cbct-aided-diagnosis-of-dental-plaque-and-caries-100635633","NCT07555223","Intraoral Scan and CBCT-Aided Diagnosis of Dental Plaque and Caries","Intra Oral Scan and CBCT Aided Diagnosis of Dental Plaque and Caries","Inclusion Criteria:\n\n* Adults aged 18 to 70 years\n* Not pregnant and not planning pregnant\n* At least 20 teeth present\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Conditions that prevent proper intraoral examination (e.g., severe gag reflex, limited mouth opening)\n* patient unable to provide informed consent",{"count":100,"type":23},"This prospective clinical study aims to evaluate the diagnostic accuracy of intraoral scans (IOS) for the detection of dental plaque and caries. The diagnostic performance of IOS will be compared with current clinical reference standards. For plaque assessment, IOS-based evaluation will be compared with plaque detection using disclosing agents. For caries detection, IOS (including white-light imaging and caries detection features) will be compared with conventional visual inspection and bitewing radiography. Adult patients aged 18 to 70 years will be included.",[495,29],"Dental Plaque","2026-04-21",{"date":498,"type":43},"2026-04-29",{"date":500,"type":43},"2025-04-03",{"date":502,"type":23},"2027-07",{"name":504,"class":50},"University Ghent",{"id":506,"slug":507,"hasResults":12,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":4,"eligibilityCriteria":511,"healthyVolunteers":12,"sex":18,"minAge":468,"maxAge":181,"enrollmentInfo":512,"targetDuration":4,"studyType":24,"phases":513,"briefSummary":514,"conditions":515,"keywords":516,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":521,"lastUpdatePostDateStruct":522,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":526,"locationsCount":4},"100635395","injectable-bioactive-composite-vs-hall-technique-for-proximal-cavities-in-primary-molars-100635395","NCT07552129","Injectable Bioactive Composite vs Hall Technique for Proximal Cavities in Primary Molars","Clinical Evaluation of Injectable Bioactive Composites vs Hall Technique for Restoring Proximal Cavities in Primary Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\n* • Generally showing cooperative behaviour that could be managed by the operators.\n\n  * Willing to sign the informed consent.\n  * Accepts the follow-up period.\n  * Moderate to low caries risk according to cariogram application\n  * Posterior primary molar with proximal carious lesion with no sign and symptoms of pulpal involvement.\n  * Radiographically (bitewing radiograph) extending to the outer1\u002F3 of dentin\n  * ICDAS (3) and ICDAS(4).\n\nExclusion Criteria:\n\n* • Allergy to any restorative materials.\n\n  * Patients undergoing orthodontic treatment with fixed appliances.\n  * Patients with debilitating systemic diseases.\n  * Children with special needs.\n  * Teeth with previous restorations.\n  * Periapical radiolucencies and sensitivity to axial or lateral percussion.\n  * Mobile teeth.\n  * External or internal resorption.\n  * Cervical carious lesions.",{"count":100,"type":23},[26],"This randomized clinical trial compares the survival rate and clinical performance of injectable bioactive giomer composite restorations versus the Hall Technique for managing proximal carious lesions (ICDAS 3-4) in primary molars of children aged 3-8 years over a 12-month follow-up period.",[29],[517,518,519,520],"hall technique","giomer","primary molars","proximal cavities","2026-04-20",{"date":452,"type":43},{"date":524,"type":23},"2026-04",{"date":502,"type":23},{"name":171,"class":50},{"id":528,"slug":529,"hasResults":12,"nctId":530,"briefTitle":531,"officialTitle":532,"acronym":4,"eligibilityCriteria":533,"healthyVolunteers":12,"sex":18,"minAge":210,"maxAge":151,"enrollmentInfo":534,"targetDuration":4,"studyType":24,"phases":536,"briefSummary":537,"conditions":538,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":539,"lastUpdatePostDateStruct":540,"startDateStruct":542,"completionDateStruct":544,"leadSponsor":546,"locationsCount":51},"100635070","clinical-performance-of-bioactive-bulk-fill-in-class-ii-restorations-100635070","NCT07547904","Clinical Performance of Bioactive Bulk-Fill in Class II Restorations","Clinical Performance of a Bioactive Bulk-Fill Composite in Class II Restorations: A Prospective Split-Mouth Study","Inclusion Criteria:\n\n* Adults aged between 18 and 50 years\n* Patients requiring at least two comparable Class II restorations in posterior teeth\n* Good general and oral health\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Patients with systemic diseases affecting oral health\n* Pregnant or lactating women\n* Poor oral hygiene or high caries risk\n* Teeth with pulp involvement or periapical pathology\n* History of allergy to dental materials used in the study",{"count":535,"type":23},34,[26],"This prospective split-mouth clinical study aims to compare the clinical performance of a bioactive bulk-fill composite with a conventional microhybrid composite in Class II posterior restorations. In each participant, two comparable Class II cavities will be treated using different restorative approaches. In the experimental condition, a bioactive bulk-fill composite (Activa BioACTIVE Bulk Flow) will be placed at the gingival base and covered with a microhybrid composite (Filtek Z250). In the control condition, restorations will be completed entirely with the microhybrid composite (Filtek Z250).\n\nClinical performance will be evaluated according to FDI World Dental Federation criteria at baseline, 6 months, and 12 months. Primary outcomes include marginal adaptation, retention, and overall clinical success of the restorations. Secondary outcomes include surface properties and marginal staining.\n\nThe split-mouth design allows direct intra-individual comparison, thereby minimizing inter-individual variability and increasing the reliability of the findings. The results of this study are expected to provide evidence on the effectiveness of bioactive bulk-fill composites in improving the clinical performance of posterior restorations.",[29],"2026-04-17",{"date":541,"type":43},"2026-04-23",{"date":543,"type":43},"2026-02-05",{"date":545,"type":23},"2027-08-30",{"name":547,"class":50},"Bezmialem Vakif University",{"id":549,"slug":550,"hasResults":12,"nctId":551,"briefTitle":552,"officialTitle":553,"acronym":4,"eligibilityCriteria":554,"healthyVolunteers":58,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":555,"targetDuration":4,"studyType":24,"phases":557,"briefSummary":558,"conditions":559,"keywords":561,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":566,"lastUpdatePostDateStruct":567,"startDateStruct":568,"completionDateStruct":569,"leadSponsor":571,"locationsCount":51},"100633757","occlusal-changes-after-modified-hall-technique-in-molars-affected-by-molar-incisor-hypomineralization-100633757","NCT07530835","Occlusal Changes After Modified Hall Technique in Molars Affected by Molar-Incisor Hypomineralization","Evaluation of the Occlusal Effects of Stainless Steel Crowns Placed Using the Modified Hall Technique in Permanent Molars Affected by Molar-Incisor Hypomineralization","Inclusion Criteria for Participants\n\n* Absence of any skeletal anomalies\n* ASA physical status I or II according to the American Society of Anesthesiologists classification\n* Frankl behavior rating score of 3 or 4\n* All permanent first molars erupted and in contact at maximum intercuspation\n* Emergency dental needs (e.g., toothache or acute conditions) previously managed\n* Presence of at least one permanent first molar with an MIH-TNI score of 2 or 4 requiring SSC restoration\n* No pain, clicking, or functional limitation in the temporomandibular joint region\n* Children and their legal guardians who read, understand, and provide written and verbal informed consent Inclusion Criteria for Tooth\n* Permanent first molars with MIH Treatment Need Index (MIH-TNI) score of 2 or 4 indicating the need for SSC restoration\n* Occlusal contact with the opposing tooth maintained at maximum intercuspation despite post-eruptive enamel breakdown, with a noticeable reduction in posterior occluso-vertical dimension\n* Absence of clinical and radiographic signs or symptoms associated with irreversible pulp inflammation or necrosis\n* Absence of gingival or periodontal pathology in the surrounding soft tissues\n\nExclusion Criteria\n\n* Individuals with serious systemic or psychological conditions\n* Participants who fail to attend follow-up appointments\n* Those who exhibit excessive fear or anxiety reactions and are unable to cooperate during treatment",{"count":556,"type":23},46,[26],"Molar-incisor hypomineralization (MIH) frequently affects permanent first molars and increases the risk of rapid post-eruptive breakdown and restorative failure. Stainless steel crowns (SSCs) are considered a reliable treatment option for severely affected molars; however, SSC placement may temporarily alter the occlusal vertical dimension and occlusal contacts. Quantitative evidence describing the occlusal adaptation process following SSC placement in MIH-affected permanent molars is limited.\n\nThis prospective longitudinal clinical study aims to evaluate occlusal adaptation after SSC placement using the modified Hall technique in MIH-affected permanent first molars. Forty-six children will be included. Intraoral scans will be obtained at baseline, immediately after treatment, and during follow-up visits up to 3 months. Digital models will be superimposed to measure three-dimensional changes in cusp position, occluso-vertical dimension, and occlusal contact area. Temporomandibular joint function and periodontal parameters will also be assessed. The results are expected to provide quantitative evidence on occlusal adaptation following SSC treatment in MIH-affected molars.",[29,560,35],"Dental Occlusion",[562,563,564,565],"Hall Technique","Occlusal adjustment","Occlusal vertical dimension","Intraoral scanning","2026-04-14",{"date":539,"type":43},{"date":45,"type":23},{"date":570,"type":23},"2027-12-01",{"name":572,"class":50},"Ankara Yildirim Beyazıt University",{"id":574,"slug":575,"hasResults":12,"nctId":576,"briefTitle":577,"officialTitle":577,"acronym":578,"eligibilityCriteria":579,"healthyVolunteers":58,"sex":18,"minAge":580,"maxAge":581,"enrollmentInfo":582,"targetDuration":4,"studyType":24,"phases":584,"briefSummary":585,"conditions":586,"keywords":588,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":592,"lastUpdatePostDateStruct":593,"startDateStruct":594,"completionDateStruct":596,"leadSponsor":598,"locationsCount":51},"100574006","mothers-action-project-for-child-health-100574006","NCT06753669","Mothers' Action Project for Child Health","MAP-CH","Inclusion Criteria:\n\n* Mother:\n\n  * Age \\>=18;\n  * Speaks and reads\u002Fwrites Bengali or Hindi\u002FUrdu;\n  * Mother born in a South Asian country;\n  * Mother is primary caretaker of child\n* Child:\n\n  * Aged \\>=12 and \\\u003C=48 months\n  * Has Medicaid or CHIP (NYS health plan for low income families not qualifying for Medicaid)\n\nExclusion Criteria:\n\n* Mother:\n\n  * Unable to provide informed consent,\n  * Lack of availability--either plans to travel for \\> 1 month during 12 month initial study period or other barriers to attendance;\n  * Mother has exclusionary health condition--either intellectual\u002Fcognitive or medical.\n* Child:\n\n  * Weighed \\\u003C 5lbs at birth,\n  * Has an exclusionary health condition and\u002For is taking long term (\\>1 m) antibiotics;\n  * Not the youngest eligible child in family","12 Months","45 Years",{"count":583,"type":23},460,[26],"This randomized controlled trial will recruit Bangladeshi mothers and their young children into a 12 month intervention that provides child health and oral health education and seeks to build social networks among mothers.",[29,587],"Obesity Risk",[589,590,591],"early childhood caries","child obesity","social network intervention","2026-04-09",{"date":566,"type":43},{"date":595,"type":43},"2026-02-01",{"date":597,"type":23},"2029-03-30",{"name":599,"class":50},"University of Massachusetts, Worcester",{"id":601,"slug":602,"hasResults":12,"nctId":603,"briefTitle":604,"officialTitle":605,"acronym":606,"eligibilityCriteria":607,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":608,"enrollmentInfo":609,"targetDuration":4,"studyType":24,"phases":611,"briefSummary":612,"conditions":613,"keywords":616,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":620,"lastUpdatePostDateStruct":621,"startDateStruct":623,"completionDateStruct":624,"leadSponsor":625,"locationsCount":51},"100633214","vertical-dimension-changes-after-bioflx-vs-stainless-steel-crowns-in-primary-molars-100633214","NCT07523776","Vertical Dimension Changes After Bioflx vs Stainless Steel Crowns in Primary Molars","Vertical Dimension Changes and Mean Biting Force Following Bioflx Placement Over Pulp-treated Primary Molars Versus Stainless Steel Crowns: A Randomized Controlled Trial.","BIOFLX-SSC-RCT","Inclusion Criteria:\n\n* Pulp-treated primary molars (pulpotomy)\n\n  * Asymptomatic teeth after pulp therapy with no signs of infection, mobility, or radiographic pathology, such as internal resorption or periapical lesions\n  * Age 6 years to 9 years\n  * Male or female\n  * Cooperative child with positive Frankl behavior rating\n  * No missing teeth\n  * Normal occlusion, including normal overjet and overbite\n  * Free from systemic disease to allow continuity of follow-up\n\nExclusion Criteria:\n\n* Medically compromised or uncooperative children\n\n  * Tooth indicated for extraction because of root resorption, teeth near exfoliation, or deep subgingival caries that prevents proper coronal seal\n  * Teeth with more than two-thirds root resorption\n  * Previous pulp therapy\n  * Parafunctional habits, including bruxism, thumb-sucking, or other habits that may affect occlusal force measurements\n  * Inability to attend follow-up visits or parental refusal to participate","9 Years",{"count":610,"type":23},18,[26],"this randomized controlled trial will compare Bioflx crowns and stainless-steel crowns in children with pulp-treated primary molars. The study will evaluate changes in vertical dimension and mean biting force after crown placement and will also assess parental satisfaction with esthetics and treatment impact. Eligible children aged 6 to 9 years will be randomly assigned in a 1:1 ratio to receive either a Bioflx crown or a stainless-steel crown. Measurements will be taken at baseline, immediately after crown placement, at 1 week, and at 4 weeks.",[614,29,615],"Early Childhood Caries","Pulp-Treated Primary Molars",[617,618,191,35,619],"Bioflx Crown","Stainless Steel Crown","T-Scan","2026-04-06",{"date":622,"type":43},"2026-04-13",{"date":524,"type":23},{"date":167,"type":23},{"name":171,"class":50},{"id":627,"slug":628,"hasResults":12,"nctId":629,"briefTitle":630,"officialTitle":631,"acronym":4,"eligibilityCriteria":632,"healthyVolunteers":12,"sex":18,"minAge":180,"maxAge":181,"enrollmentInfo":633,"targetDuration":4,"studyType":24,"phases":635,"briefSummary":636,"conditions":637,"keywords":638,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":645,"lastUpdatePostDateStruct":646,"startDateStruct":648,"completionDateStruct":650,"leadSponsor":652,"locationsCount":4},"100631723","clinical-performance-of-four-restorative-materials-in-primary-molars-100631723","NCT07504393","Clinical Performance of Four Restorative Materials in Primary Molars","Clinical Evaluation of an Alkasite Restoration Material (Cention N) and Self-cure Composite (Stela; SDI) Compared to Conventional Composite and Resin-modified Glass Ionomer in Primary Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Age 4-8 years old.\n2. Primary molars indicated for restorative treatment.\n3. No pulp involvement or history of dental pain.\n4. Cooperative children (Frankl: +ve or ++ve).\n\nExclusion Criteria:\n\n1. Pulp exposure after caries removal or clinical signs of irreversible pulpitis\u002Fnecrosis.\n2. Severe developmental enamel defects or insufficient enamel for bonding.",{"count":634,"type":23},92,[26],"This randomized clinical trial aims to compare the clinical and radiographic performance of four direct restorative materials used for restoring carious primary molars in children. Eligible children aged 4-8 years with posterior primary molars requiring direct restoration will be randomly allocated (1:1:1:1) to receive one of the following materials: an alkasite restorative material (Cention N), a self-cure bulk-fill resin composite (Stela; SDI), a conventional light-cured nanohybrid resin composite (Beautifil II), or a resin-modified glass ionomer cement (Riva Light Cure). Restorations will be evaluated using the Fédération Dentaire Internationale (FDI) World Dental Federation criteria. Postoperative sensitivity will be assessed at 48 hours using a 0-10 visual analogue scale (VAS). Clinical and radiographic follow-up assessments will be conducted at baseline and at scheduled recall visits",[29,190],[639,640,105,641,642,643,644,478],"stela","Primary molars","Direct restoration","Cention N","Nanohybrid composite","Resin-modified glass ionomer","2026-03-27",{"date":647,"type":43},"2026-03-31",{"date":649,"type":23},"2026-04-01",{"date":651,"type":23},"2026-11",{"name":653,"class":50},"Al-Azhar University",{"id":655,"slug":656,"hasResults":12,"nctId":657,"briefTitle":658,"officialTitle":659,"acronym":4,"eligibilityCriteria":660,"healthyVolunteers":58,"sex":18,"minAge":210,"maxAge":442,"enrollmentInfo":661,"targetDuration":4,"studyType":24,"phases":663,"briefSummary":664,"conditions":665,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":645,"lastUpdatePostDateStruct":668,"startDateStruct":670,"completionDateStruct":672,"leadSponsor":673,"locationsCount":51},"100595392","comparison-of-clinical-performance-of-partial-restorations-fabricated-with-three-dimensional-printer-and-cad-cam-100595392","NCT07031856","Comparison of Clinical Performance of Partial Restorations Fabricated With Three-Dimensional Printer and CAD-CAM","Comparison of Clinical Performance of Partial Restorations Fabricated With Three-Dimensional Printer and CAD-CAM: A Split-Mouth Randomized Clinical Trial","İncluiding:\n\n\\-- Patients with periodontally stable and appropriate oral hygiene habits without serious systemic diseases that preclude restoration. - Male and female patients with hard tissue loss in their mouth or with 2 teeth in need of restoration replacement (eligibility for split-mouth design). - People who can comply with the treatment and volunteer for follow-up for 2 years-\n\nExclusion Criteria:\n\nPatients with systemic conditions that may affect the study process (e.g. diabetes, autoimmune diseases).\n\n* Patients with excessive bruxism or parafunctional habits.\n* Pregnant or lactating women.\n* Patients with gum disease or severe bone loss.\n* Patients with a history of allergic reactions.",{"count":662,"type":23},12,[26],"The aim of this clinical study is to compare CAD-CAM and 3D restorations in individuals with two hard tissue losses or restorations in their mouths. The main question it aims to answer is: Is there a difference between CAD-CAM and 3D restorations according to FDI criteria? Researchers will compare participants to see if there is a difference between the two restorations according to FDI criteria. In this split-mouth study, participants will be randomized to receive a CAD-CAM partial restoration on one tooth and a 3D partial restoration on the other tooth.",[29,666,667],"Dental Restoration, Permanent","Tooth Diseases",{"date":669,"type":43},"2026-04-02",{"date":671,"type":43},"2025-07-01",{"date":651,"type":23},{"name":674,"class":50},"Cukurova University"]