[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-crowding\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-crowding":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,37,73,100,130,160],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":25,"lastUpdatePostDateStruct":26,"startDateStruct":29,"completionDateStruct":31,"leadSponsor":33,"locationsCount":36},"100641592","validity-of-ashley-howes-analysis-for-the-prediction-of-the-extraction-treatment-decision-in-orthodontic-patients-at-the-permanent-dentition-stage-100641592",false,"NCT07660146","Validity of Ashley Howe's Analysis for the Prediction of the Extraction Treatment Decision in Orthodontic Patients at the Permanent Dentition Stage","Inclusion Criteria:\n\n* Maxillary models of cases with malocclusion.\n\nExclusion Criteria:\n\n\\-","ALL","12 Years",{"count":18,"type":19},50,"ESTIMATED","OBSERVATIONAL","This study is to evaluate the validity of Ashley Howe's analysis for the prediction of the extraction treatment decision in orthodontic patients at the permanent dentition stage",[23],"Dental Crowding","RECRUITING","2026-06-17",{"date":27,"type":28},"2026-06-22","ACTUAL",{"date":30,"type":28},"2026-02-01",{"date":32,"type":19},"2027-02-01",{"name":34,"class":35},"Cairo University","OTHER",1,{"id":38,"slug":39,"hasResults":11,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":4,"eligibilityCriteria":43,"healthyVolunteers":44,"sex":15,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100643395","clinical-performance-of-direct-printed-versus-thermoformed-aligners-100643395","NCT07637227","Clinical Performance of Direct-Printed Versus Thermoformed Aligners","Clinical Performance of In-Office Directly Printed Versus Thermoformed Aligners: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Adult patient with an age range of 15-30 with fully erupted all permanent dentitions excluding third molars, and a willingness to participate in the trial.\n2. Angle Class I non-extraction cases, presented with mild crowding or spacing (\\\u003C5 mm) and dental rotation \\\u003C30° .\n3. Good oral hygiene; no active caries\u002Fperiodontal disease, no history of trauma or root resorption.\n\nExclusion Criteria:\n\n1. Pregnancy, smoking, and systemic conditions affecting bone remodeling.\n2. Subject with poor oral hygiene, using simplified oral hygiene index (OHI-S ≥ 3.1 ) (Greene \\& Vermillion, 1963).\n3. Patient with malposed lower second molars (need orthodontic alignment).\n4. Allergy to materials used (resins, plastics, solvents).\n5. History of trauma, root resorption, and dilacerated roots.\n6. Previous extraction or history of previous orthodontic treatment.",true,"15 Years","30 Years",{"count":48,"type":19},34,"INTERVENTIONAL",[51],"NA","The goal of this study is to evaluate and compare the clinical effectiveness of in-office directly 3D-printed clear aligners versus conventional multilayered thermoformed aligners.\n\nThe main question it aims to answer is:\n\nDoes the use of in-office direct-printed shape-memory aligners result in superior clinical effectiveness, compared to established multilayer thermoformed aligner systems?\n\nResearchers will compare a Direct-Printed Aligner (DPA) group using Senertek Clear-A V2 resin to a Thermoformed Aligner (TFA) group using Zendura FLX multilayer sheets to see if the additive manufacturing process improves clinical outcomes and patient satisfaction.\n\nParticipants will:\n\n* Undergo initial records including intraoral digital scans, photos, and a panoramic radiograph for treatment planning.\n* Wear their assigned clear aligners (either direct-printed or thermoformed) for at least 22 hours per day, changing them every 7 days.\n* Attend follow-up appointments every 5 weeks.",[54,23,55],"Angle Class I Malocclusion","Tooth Spacing",[57,58,59,60,61,62],"In office aligners","3D printed aligners","Thermoformed Aligners","Tooth movement","Photopolymer Resin","Pain","2026-06-05",{"date":65,"type":28},"2026-06-09",{"date":67,"type":19},"2026-06",{"date":69,"type":19},"2027-10",{"name":71,"class":35},"University of Baghdad",3,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":15,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":49,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":36},"100642864","orthodontic-treatment-outcomes-of-self-ligating-system-compared-to-clear-aligner-system-100642864","NCT07638397","Orthodontic Treatment Outcomes of Self Ligating System Compared to Clear Aligner System","Orthodontic Treatment Outcomes of Self Ligating System Compared to Clear Aligner System : A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Good oral and general health; no systemic conditions affecting bone metabolism or pain perception.\n2. Age range between 16-32 years.\n3. Presence of full permanent dentition except the third molars.\n4. Class I canine and molar relationship moderate crowding in both arches (6-8 mm) requiring fixed orthodontic treatment.\n5. Without previous orthodontic treatment\u002F functional appliances.\n\nExclusion Criteria:\n\n1. Patients will be excluded from enrollment if they have a substantial skeletal discrepancy necessitating orthognathic surgery.\n2. Patient with class Ⅱ , Ⅲ malocclusion.\n3. Patient with external or internal root resorption.\n4. Patients with poor oral hygiene or active periodontal disease.\n5. 90o or more degree of tooth rotation.","16 Years","32 Years",{"count":83,"type":19},42,[51],"This study is a multi-center, prospective, parallel-group randomized controlled trial designed to compare the orthodontic treatment outcomes of a passive self-ligating bracket system (Damon Ultima) versus a clear aligner system. The primary objective is to evaluate and compare the total orthodontic treatment duration between the two systems in patients with Angle Class I malocclusion and moderate crowding. Secondary objectives include assessing alignment efficiency, patient pain perception at multiple time intervals, dental arch dimension changes, root volume loss percentage, and overall treatment quality using the American Board of Orthodontics Objective Grading System (ABO-OGS).",[87,23],"Angle Class I Maloclussion",[89,90],"Damon ultima","clear aligner","NOT_YET_RECRUITING","2026-06-04",{"date":94,"type":28},"2026-06-10",{"date":96,"type":19},"2026-05-15",{"date":98,"type":19},"2028-08-20",{"name":71,"class":35},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":44,"sex":15,"minAge":106,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":109,"conditions":110,"keywords":118,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":36},"100588957","exploration-of-the-utility-of-dental-dedicated-mri-for-dentistry-100588957","NCT06948162","Exploration of the Utility of Dental-dedicated MRI for Dentistry","Inclusion Criteria:\n\n1. Patient Age: 18 years old or older\n2. Receiving imaging for routine dental care\n3. Does not have a serious medical condition\n4. Is not pregnant or is not potentially pregnant\n5. Is willing and able to give consent in English\n6. Has the ability to manage their own calendar and schedule appointments\n7. Willing to have a separate 2-hour appointment to have an MRI\n\nExclusion Criteria:\n\n1. Unable to consent to participant in English\n2. Serious health condition, which includes but not limited to renal failure\u002Fon dialysis, unstable heart disease (uncontrolled arrhythmia, cardiomyopathy and\u002For unable to lay flat, within 1 month of cardiac catheterization or myocardial infarction), unstable cerebral vascular disease (within 1 month of stroke and\u002For stent placement), diabetes (type I or II) not controlled by medication or diet, uncontrolled seizures, uncontrolled hyperthyroidism, non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema), uncontrolled movement disorder, and liver failure\n3. Pregnant and\u002For intending to become pregnant,\n4. Prisoner and\u002For not able to manage their own scheduling\n5. Screen positive on MR safety questionnaire, specifically including people that have worked with or otherwise been exposure to metal particles and have the potential for such particles to be embed within them.","18 Years",{"count":108,"type":19},300,"This description observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images. The standard clinical dental images consist of radiographs, such as bitewings, periapical, panoramic, cone-beam CT, and medical CT, as well medical MRIs of the temporomandibular joints (TMJ).The conceptualization of research questions, study designing, and interpretation of imaging data has and will involve content expertise in all ddMRI research.",[23,111,112,113,114,115,116,117],"Dental Occlusion, Traumatic","Dental Pain","TMD\u002FOrofacial Pain","TMD","Orthodontics","Endodontic Disease","Orthodontic Treatment",[119,120],"Diagnosis","Magnetic resounance imaging","2026-05-18",{"date":123,"type":28},"2026-05-20",{"date":125,"type":28},"2025-03-14",{"date":127,"type":19},"2027-12-31",{"name":129,"class":35},"University of Minnesota",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":15,"minAge":80,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":49,"phases":140,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":157,"locationsCount":4},"100639211","treatment-outcome-of-elastomeric-and-nickel-titanium-separators-in-tooth-separation-100639211","NCT07591454","Treatment Outcome of Elastomeric and Nickel-Titanium Separators in Tooth Separation","Comparison Between The Efficiency Of Elastomeric And Nickel-Titanium Separators In Tooth Separation, Pain Perception, And Gingival Inflammation - A Randomized Controlled Trial","Inclusion Criteria:\n\n* Class I skeletal and dental malocclusion.\n* No history of previous orthodontic treatment.\n* All permanent teeth in both arches, except third molars.\n* Good oral hygiene and periodontal health.\n* Good interproximal tooth contacts at the site of separator placement as\n* checked by interdental floss.\n* No caries or restorations on the proximal surfaces of first and second permanent molars, and second premolars.\n\nExclusion Criteria:\n\n* Patients presenting with restorations or carious lesions on the proximal surfaces of the first or second molars or the second premolars.\n* Patients with uncontrolled gingival or periodontal inflammation.\n* Patients with a history of previous orthodontic treatment.\n* Patients are skeletally classified as Class II or Class III.\n* Patients are currently using opioid analgesics or have chronic pain conditions requiring regular analgesic intake.","25 Years",{"count":139,"type":19},30,[51],"Patients seeking fixed orthodontic treatment that requires band placement will be enrolled in this study. This trial aims to compare the efficiency of rectangular cross-section nickel-titanium separators with elastomeric separators in creating sufficient interdental space for orthodontic band placement. In addition, the impact of both separator types on pain perception and gingival health during a 3-day placement period will be evaluated. Participants will be allocated to two groups in a split-mouth design. On the experimental side, nickel-titanium separators will be used, while elastomeric separators will be used as the control on the other side. Outcomes will include separation efficacy, pain perception over time, gingival inflammation, analgesic consumption, and separator loss.",[23,143],"Malocclusion, Angle Class I",[145,146,147,148,149,150,151],"Orthodontic separators","Nickel-Titanium","Elastomeric","Tooth separation","Pain perception","VAS","Gingival inflammation","2026-05-13",{"date":96,"type":28},{"date":155,"type":19},"2026-06-01",{"date":32,"type":19},{"name":158,"class":159},"3D-Aligners","INDUSTRY",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":15,"minAge":106,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":49,"phases":169,"briefSummary":170,"conditions":171,"keywords":174,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":36},"100600455","evaluating-the-clinical-efficacy-of-collagen-scaffold-ossix-volumax-with-piezo-surgical-decortication-in-enhancing-orthodontic-treatment-outcomes-a-randomized-controlled-trial-100600455","NCT07097714","Evaluating the Clinical Efficacy of Collagen Scaffold (Ossix VOLUMAX) With Piezo-Surgical Decortication in Enhancing Orthodontic Treatment Outcomes: A Randomized Controlled Trial","Gingival Phenotype: Participants must be diagnosed with a thin phenotype of gingiva. This could be measured using a periodontal probe to assess the thickness of the gingiva, typically less than 1 mm is considered thin. In this area may be gingival recession 1,2 Cairo type.\n\nDental Health: Participants must have a sufficient number of teeth and bone support to undergo orthodontic treatment. A minimum number of teeth or specific dental conditions may be outlined to ensure that the treatment can be applied effectively.\n\nMalocclusion: Participants must be diagnosed with malocclusion, specifically requiring correction in the mandibular incisors. The type and severity of malocclusion can be classified according to a recognized system such as the Angle classification or the Index of Orthodontic Treatment Need (IOTN).\n\nMedical History: Participants must not have any contraindications to dental surgery or orthodontic treatment, such as uncontrolled diabetes, bisphosphonate therapy, or a history of radiation to the jaws.\n\nConsent: Participants must be able to understand the nature of the study and provide informed consent to participate in the trial.\n\nAvailability: Participants must be available for the duration of the study and able to attend all scheduled appointments for treatment and follow-up assessments.\n\nPeriodontal Health: Participants should have good periodontal health or controlled periodontitis. This may involve a preliminary periodontal assessment, ensuring that there are no active diseases that could complicate the orthodontic treatment or surgical interventions.\n\nOrthodontic Treatment Status: Participants must not have undergone any orthodontic treatment in the past six months to ensure that any previous treatments do not affect the outcomes of the current study.\n\nNo Concurrent Dental Procedures: Participants should not be undergoing concurrent dental procedures that could affect the outcomes of the orthodontic treatment, such as implants or extensive restorative work, not coordinated with the current treatment plan Radiographic Evaluation: Suitable candidates must have clear radiographic evidence that supports the diagnosis of malocclusion and allows for the assessment of alveolar bone volume and gingival thickness. This may include recent CBCT scans or panoramic radiographs.\n\nNon-smoker Status:\n\nNon-smokers or individuals who have smoke less than 10 cigarettes per day may be included to avoid the confounding effects of smoking on periodontal health and healing.\n\nExclusion criteria:\n\nExisting Periodontal Disease: Individuals with active periodontal disease or significant periodontal bone loss that contraindicates orthodontic treatment.","50 Years",{"count":168,"type":19},70,[51],"Recent advances in orthodontic treatment have explored various materials to enhance treatment efficacy, particularly focusing on collagen scaffolds. Collagen, being a primary component of the bone matrix, has garnered attention for its biocompatibility, cell adhesion, and osteoconductivity properties. Studies have shown that collagen scaffolds undergo natural degradation, mimicking biological processes, and play a significant role in tissue engineering (International Journal of Implant Dentistry, 2023). This aligns with the growing interest in minimally invasive methods that accelerate orthodontic treatment and improve tissue regeneration.\n\nIn this context, the application of collagen scaffolds, such as Ossix VOLUMAX, in conjunction with piezo-surgical decortication, presents a novel approach. This study aims to build upon the existing knowledge, exploring the efficacy of collagen scaffolds in enhancing orthodontic treatment outcomes, especially in patients with specific dental conditions like a thin gingival phenotype and malocclusion. The study\\'s hypothesis is grounded in the promising properties of collagen-based materials in dental and orthodontic applications, as evidenced by recent research in the field.",[23,172,173],"Gingival Recession","Thin Phenotype",[175],"Corticotomy, Soft Tissue Augmantation, Bone Augmentation, Ossix Volume, Collagene Scaffold, Orthodontics, Piezocision","2025-07-24",{"date":178,"type":28},"2025-07-31",{"date":180,"type":28},"2024-06-25",{"date":182,"type":19},"2026-09-25",{"name":184,"class":35},"NMSI DENTMASTER"]