[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-diseases":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,46,70,97,123,148,170],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100555026","dental-dyschromia-and-quality-of-life-in-early-prolonged-hyperbilirubinemia-100555026",false,"NCT06506734","Dental Dyschromia and Quality of Life in Early Prolonged Hyperbilirubinemia","Prevalence of Dental Dyschromia and Impact on the Quality of Life of Participants With Prolonged Hyperbilirubinemia During Their Early Years","SMILE","Inclusion Criteria:\n\n* A patient with biliary atresia, progressive familial intrahepatic cholestasis, or Alagille syndrome\n* Patient or legal representative not opposed to participating in this research.\n\nExclusion Criteria:\n\n* Inability to understand and respond to quality of life questionnaires","ALL","12 Years","18 Years",{"count":21,"type":22},120,"ESTIMATED","OBSERVATIONAL","The main objective of this study is to assess the prevalence of dental discoloration (dental dyschromia) in children who experienced high levels of bilirubin in their blood (hyperbilirubinemia) during their early years. The study will also examine risk factors associated with this condition, such as the duration and severity of hyperbilirubinemia, underlying diseases, and treatments received.\n\nThe researchers hypothesize that the quality of life of individuals with dental dyschromia is lower than that of individuals without dyschromia. The results of this study will be used to discuss coverage for dental care with health insurance for children affected by this condition.",[26],"Dental Diseases",[28,29,30,31,32],"Hyperbilirubinemia","Biliary Atresia","Progressive Familial Intrahepatic Cholestasis (PFIC)","Alagille Syndrome","Tooth Discoloration","RECRUITING","2026-05-07",{"date":36,"type":37},"2026-05-12","ACTUAL",{"date":39,"type":37},"2026-04-07",{"date":41,"type":22},"2027-10-07",{"name":43,"class":44},"University Hospital, Toulouse","OTHER",9,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100492195","molar-mapping-oral-health-and-local-area-resources-100492195","NCT05688982","MOLAR: Mapping Oral Health and Local Area Resources","Inclusion Criteria:\n\n* To be eligible to participate in this study, an individual must meet all of the following criteria:\n\n  * No evidence of lack of capacity to provide verbal informed consent (as documented in the chart).\n  * Willing to comply with all study procedures and be available by phone for the duration of the study (as reported by the patient)\n  * Unmet oral health needs as ascertained by the Hope Home (adult) or Gazzaz (pediatric) questions\n  * Adult (age ≥18 years old) ED patient or pediatric ED patient (\\>1 year of age) presenting with parent or legal guardian. Parent will be the primary study participant but if age \\> 7 years, the child will provide assent for medical record review.\n  * Ability to communicate in English or Spanish (as reported by the patient)\n  * Emergency severity index (ESI) 2-5 (as documented in the electronic medical record)\n  * Residence within catchment area of 3-hospital region (defined by MGB home hospital catchment area) at initial enrollment (as reported by the patient)\n  * Working phone number\n\nExclusion Criteria:\n\n* Patients on involuntary holds (per electronic medical record review)\n* Presenting from carceral facilities (per electronic medical record review)\n* Presenting for acute mental health care under evaluation for Section 12 (per electronic medical record review)\n* Patients presenting for assistance with intimate partner violence (IPV) or care following sexual assault","1 Year",{"count":54,"type":22},2927,"INTERVENTIONAL",[57],"NA","The goal of this clinical trial is to test the impact of a screening and linkage intervention for adverse social determinants of health (aSDoH) on oral health linkage to care for emergency department patients. Researchers will compare three groups: Patients in Arm A will receive paper handouts with general oral health and aSDoH resources. Patients in Arm B will receive paper handouts with geographically-proximate oral health and aSDoH resources. Patients in Arm C will receive geographically-proximate oral health and aSDoH resources plus active navigational assistance.",[26],"2026-04-06",{"date":62,"type":37},"2026-04-09",{"date":64,"type":37},"2023-08-25",{"date":66,"type":22},"2028-02-22",{"name":68,"class":44},"Massachusetts General Hospital",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":17,"minAge":19,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":55,"phases":81,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":69},"100315285","early-phase-1-antimicrobial-effect-of-tropolone-containing-versus-tropolone-free-mouthwash-100315285","NCT03384537","Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash","Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash - Randomized Clinical Trail","Inclusion Criteria:\n\n1. Patients should be between 18- 45 years of age.\n2. All the volunteers participated in this study will be healthy looking with free medical history.\n3. The volunteers will be asked to suspend their usual oral hygiene practice from two to four days before experiment studying.\n\nExclusion Criteria:\n\n1. Patients with a compromised medical condition.\n2. Volunteers that receive any antimicrobial agent during at least two weeks prior to study.\n3. Volunteer with fixed, removable prosthesis or orthodontics appliance.\n4. Volunteers with DMF above six will be excluded.",true,"45 Years",{"count":80,"type":22},30,[82],"EARLY_PHASE1","The objective of this study is to compare the effect of Tropolone containing mouthwash versus CHX 0.2% mouthwash in reducing intraoral microorganism. Randomized clinical trial study",[26],[86,87],"intra-oral microorganisms.","cariogenic microorganisms","2026-03-17",{"date":90,"type":37},"2026-03-19",{"date":92,"type":37},"2024-02-08",{"date":94,"type":22},"2026-12",{"name":96,"class":44},"Cairo University",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":77,"sex":17,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":55,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":69},"100530106","virtual-reality-distraction-for-dental-anxiety-rct-100530106","NCT06182462","Virtual Reality Distraction for Dental Anxiety (RCT)","The Effects of A Virtual Reality Game on Anxiety During Dental Procedures in Children (VR-TOOTH): A Randomized, Controlled Trial Protocol","Inclusion Criteria:\n\n1. Aged 6 to 17 years;\n2. Received the dentist's recommendation to participate;\n3. Required to undergo any dental procedure;\n4. Accompanied by a parent or a legal guardian who can understand, read, and write in either French or English.\n\nExclusion Criteria:\n\n1. Suffer from epilepsy,\n2. Paralysis or paresis of the hand\n3. Has any diagnosed eye disease\u002Fproblem,\n4. Any other conditions preventing them from using virtual reality (VR) (e.g., epidermolysis bullosa).","6 Years","17 Years",{"count":107,"type":22},88,[57],"The aim of this randomized clinical trial is to verify the efficacy of VR immersion over a muted cartoon on a wall-mounted TV to decrease dental fear and anxiety of children undergoing dental procedures. The study also aims to gain insight on the satisfaction of parents and healthcare providers on the use of VR during dental appointments.\n\nMain research question: Does VR immersion compare to a cartoon on a wall-mounted TV is more efficacious to decrease dental fear and anxiety of children requiring dental procedures?\n\nParticipants will be playing through a VR immersive game wearing a eye-tracking VR headset that requires no movement of the head to play, facilitating the dental procedure.\n\nThe investigators will take measures of the stress levels of participants and their parents using a validated stress scale and also by taking salivary samples to verify the levels of a stress biomarker (alpha-amylase).",[111,112,113,26],"Dental Anxiety","Dental Phobia","Dental Trauma","2025-08-18",{"date":116,"type":37},"2025-08-24",{"date":118,"type":37},"2023-11-01",{"date":120,"type":22},"2026-03",{"name":122,"class":44},"St. Justine's Hospital",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":55,"phases":133,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":69},"100535523","effectiveness-and-safety-of-collagen-membrane-formaaid-in-the-treatment-of-periodontal-regeneration-100535523","NCT06252935","Effectiveness and Safety of Collagen Membrane (FormaAid®) in the Treatment of Periodontal Regeneration","A Single-Center, Evaluator-blind, Randomized Control Study to Assess the Effectiveness and Safety of Collagen Membrane (FormaAid®) in the Treatment of Periodontal Regeneration","Inclusion Criteria:\n\n* Age between 18 70 years old, male or female\n* Non current smoker: A person who has not smoked more than 100 cigarettes from the past to the present and has not smoked in the last 30 days.\n* Patients who have decided to pay at their own expense and require guided tissue regeneration (GTR) for periodontal regeneration\n* The defect morphology of intrabony defects is 2 or 3 wall intrabony defect.\n* Periodontal pocket depth ≥ 5mm (probing periodontal depth, PPD, distance from gingival margin to the bottom of the defect).\n* The height of the bone defect in the X ray image is ≥ 3mm (according to the X ray film intraosseous defect)\n* The diagnosis of periodontal disease is stage III with either grade B or C.\n* Patients who are willing to adhere to the study protocol and sign the informed consent form.\n* Willing to accept evaluation during the trial period and return to clinic and treatment.\n* Not a person subject to a sentence of guardianship or subject to judicial guardians.\n\nExclusion Criteria:\n\n* Have a history of severe allergies or be allergic to collagen.\n* Those who are known to be positive for human immunodeficiency virus.\n* Poorly controlled diabetes (untreated or unstable disease status), blood test measurement of glycated hemoglobin greater than 7%\n* Undergoing chemotherapy three months before agreeing to this experiment.\n* Patients undergoing meat product desensitization treatment.\n* Have a documented history of osteoporosis.\n* Chronic disease, hypertension, hyperlipidemia, cardiovascular disease, and stroke not properly controlled (untreated or unstable disease condition) judged by the investigator at screening.\n* Suffering from autoimmune diseases or connective tissue diseases, such as systemic lupus erythematosus or dermatomyositis.\n* Coagulation disorder, lab test prothrombin time (PT) \\> 12 sec , or the use of anticoagulants that affects surgery judged by the investigator at screening.\n* The tooth for which guided tissue regeneration (GTR) surgery is to be performed is determined to be furcation involved by investigator from image evaluation\n* The tooth for which guided tissue regeneration (GTR) surgery is to be performed is considered unhealthy, exhibiting conditions such as apical lesion, needed endodontic therapy tooth, tooth fracture, etc. etc., as judged by the investigator f rom image evaluation\n* Oral mucosal abnormalities or poor periodontal health, making it unsuitable for GTR surgical treatment, such as white spots, erythema, oral submucosal fibrosis, lichen planus, verrucous hyperplasia, inflammation, infection, etc. judged by the investigator at screening.\n* Those whose periodontal cleaning is not in good condition or who are unable to cooperate with periodontal cleaning. Plaque control index (O'Leary index) \\>15%\n* The mobility of the teeth that are to undergo guided tissue regeneration (GTR) surgery is greater than or equal to\n* Teeth that are to undergo guided tissue regeneration (GTR) surgery have incomplete adjacent teeth on both sides, such as dental prostheses, crowns or bridges, artificial dental implants, or metal fillings. materials, etc., so as to affect the image evaluation.\n* Others who are not suitable to participate in or continue this clinical trial as assessed by a physician.","70 Years",{"count":132,"type":22},60,[57],"The goal of this clinical trial is to evaluate clinically and radiographically effectiveness and products safety of the collagen membrane (FormaAid®) in the treatment of periodontal regeneration using guided tissue regeneration (GTR) performed by the trained periodontists. The main question it aims to answer are:\n\n* The difference of periodontal status: clinical attachment level (CAL), periodontal pocket depth (PPD), gingival recession (GR), gingival Index (GI) and plaque index (PI).\n* The difference of intrabony defect height.\n* The difference of gingival tissue thickness and gingival tissue volume.\n* The incidences of safety indicators.\n\nParticipants will be randomized into either experiment group or control group, undergo guided tissue regeneration (GTR) surgery at week 1, and re-visited on week 3, 5, 13 and 27 after the GTR surgery.\n\nResearchers will compare if the test product is non-inferior to Bio-Gide.",[136,137,26],"Guided Tissue Regeneration","Collagen Membrane","2025-05-06",{"date":140,"type":37},"2025-05-09",{"date":142,"type":37},"2024-07-30",{"date":144,"type":22},"2025-10-31",{"name":146,"class":147},"Maxigen Biotech Inc.","INDUSTRY",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":77,"sex":17,"minAge":19,"maxAge":78,"enrollmentInfo":155,"targetDuration":4,"studyType":55,"phases":157,"briefSummary":158,"conditions":159,"keywords":4,"overallStatus":160,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":4},"100572201","soft-tissue-graft-over-immediately-placed-dental-implant-in-maxillary-molar-socket-100572201","NCT06730191","Soft Tissue Graft Over Immediately Placed Dental Implant in Maxillary Molar Socket","Free Buccal Pad Graft Versus Free Palatal Gingival Tissue Graft for Primary Soft Tissue Closure Over Immediately Placed Dental Implant in Maxillary Molar Socket","Inclusion Criteria:\n\n* class one molar extraction socket\n\nExclusion Criteria:\n\n* pregnant females psychiatric problems",{"count":156,"type":22},2,[57],"Compare between free tissue graft of buccal pad of fat BFP and free palatal gingival tissue graft for primary soft tissue closure over immediately placed dental implant",[26],"NOT_YET_RECRUITING","2024-12-08",{"date":163,"type":37},"2024-12-12",{"date":165,"type":22},"2025-07-11",{"date":167,"type":22},"2026-07-11",{"name":169,"class":44},"Mai Ahmed Haggag",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":55,"phases":178,"briefSummary":179,"conditions":180,"keywords":182,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":69},"100529391","clinical-evaluation-of-full-contour-zirconia-chairside-cadcam-crowns-100529391","NCT06173167","Clinical Evaluation of Full Contour Zirconia Chairside CAD\u002FCAM Crowns","Inclusion Criteria:\n\n* at least 18 years of age\n* at least one carious lesion, defective restoration, or fractured portion of the tooth to be restored on a maxillary or mandibular premolar or molar tooth - Each lesion, fracture, or defective restoration should exhibit sufficient size or loss of tooth structure requiring a full crown restoration.\n* tooth should have at least one opposing tooth in occlusion and one adjacent tooth with an intact proximal contact\n* No more than ten teeth that are endodontically treated may be included in the study, equally divided between the two groups of crowns. All remaining teeth in the study will test vital and be asymptomatic at the beginning of treatment.\n* No more than two restorations will be placed per patient\n\nExclusion Criteria:\n\n* Sensitive teeth\n* Teeth with a history of direct or indirect pulp capping procedures\n* Patients with significant untreated dental disease to include periodontitis and\u002For rampant caries\n* Women who self-report that they are possibly pregnant, pregnant, or lactating, as elective dental treatment is not indicated at these times\n* Patients with a self-reported history of allergies to the materials to be used in the study including composite resin cements or zirconia restorative materials\n* Patients unable to return for the recall appointments",{"count":177,"type":22},70,[57],"This investigation will be a randomized, prospective, longitudinal clinical trial to study the clinical performance of a new monolithic, zirconia material with shade, translucency and material graduation for chairside CAD\u002FCAM crowns. The restorations will be luted either with a self-adhesive luting material or a conventional cement. The crowns will be evaluated for a period of two years.",[181,26],"Dental Disorders Hard Tissues of Teeth",[183],"Dental Caries, Caries","2024-03-27",{"date":186,"type":37},"2024-03-28",{"date":188,"type":37},"2024-01-08",{"date":190,"type":22},"2026-12-31",{"name":192,"class":147},"Ivoclar Vivadent AG"]