[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-implant-failed\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-implant-failed":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,42,62,85,109,135,158,187,211,233],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100639381","immediate-implant-placement-with-subepithelial-connective-tissue-grafting-and-probiotics-100639381",false,"NCT07596758","Immediate Implant Placement With Subepithelial Connective Tissue Grafting and Probiotics","Comparative Evaluation of Platelet-Rich Fibrin Versus Probiotics as Adjuncts to Immediate Implant Placement Combined With Subepithelial Connective Tissue Grafting: Clinical, Biological, and Radiographic Peri-Implant Tissue Outcomes A Parallel-Arm Randomized Trial","Inclusion Criteria:\n\n* Adults aged 20 to 45 years.\n* Systemically healthy patients eligible for implant surgery.\n* Patients requiring extraction of a single non-restorable tooth indicated for immediate implant placement.\n* Implant sites located in the maxillary esthetic or para-esthetic zone.\n* Sites with sufficient apical and\u002For palatal bone to permit correct three-dimensional implant positioning and achieve adequate primary stability.\n* Sites suitable for simultaneous subepithelial connective tissue grafting.\n* Patients with acceptable oral hygiene and good compliance with periodontal and implant treatment.\n* Patients willing to attend all follow-up visits and comply with study instructions.\n\nExclusion Criteria:\n\n* Medically compromised patients or patients with systemic conditions that may contraindicate implant surgery or interfere with healing.\n* Smokers.\n* Pregnant or lactating women.\n* Patients with uncontrolled periodontal disease or poor oral hygiene.\n* Patients with acute infection at the intended implant site.\n* Patients with insufficient bone volume preventing immediate implant placement with adequate primary stability.\n* Patients with a history of head and neck radiotherapy or chemotherapy.\n* Patients receiving bisphosphonates or other medications known to affect bone metabolism or soft tissue healing.\n* Patients with parafunctional habits that may jeopardize implant stability or restorative success.\n* Patients unwilling or unable to complete the follow-up period.",true,"ALL","20 Years","45 Years",{"count":21,"type":22},22,"ESTIMATED","INTERVENTIONAL",[25],"NA","The present study aims to evaluate and compare the clinical, radiographic, and biological peri-implant tissue outcomes of platelet-rich fibrin versus probiotics as adjuncts to immediate implant placement combined with subepithelial connective tissue grafting in adults requiring single immediate implant placement.",[28],"Dental Implant Failed","NOT_YET_RECRUITING","2026-05-13",{"date":32,"type":33},"2026-05-19","ACTUAL",{"date":35,"type":22},"2026-05-14",{"date":37,"type":22},"2027-05-30",{"name":39,"class":40},"Kafrelsheikh University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":41},"100638213","guided-modified-socket-shield-with-hyaluronic-acid-for-black-triangle-management-100638213","NCT07586228","Guided Modified Socket Shield With Hyaluronic Acid for Black Triangle Management","Hyaluronic Acid With AI-Guided Immediate Implant Placement Using a Modified Socket Shield for Black Triangle Management: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adults (20-50) years old.\n* Single rooted maxillary anterior teeth with hopeless prognosis.\n* Periodontally compromised but with \\>50% remaining bone.\n* Presence of black triangle ≥2 mm.\n* Systemically healthy.\n\nExclusion Criteria:\n\n* Medically compromised patients and systemic conditions that complicate implant placement as uncontrolled diabetes, osteoporosis.\n* Alcoholic and Smokers patients.\n* Pregnant or lactating women.\n* Acute Pathology or infection at implant site\n* Patients with a history of chemotherapy, radiotherapy in head and\u002For neck region.\n* Patients on bisphosphonate or steroids therapy.","50 Years",{"count":51,"type":22},32,[25],"The Primary aim of this study will be to evaluate the clinical, esthetic, and radiographic outcomes of hyaluronic acid combined with immediate implant placement using AI-assisted and computer guided modified socket shield technique in maxillary anterior sites exhibiting black triangles.",[28],{"date":56,"type":33},"2026-05-15",{"date":58,"type":22},"2026-05-10",{"date":60,"type":22},"2027-06-15",{"name":39,"class":40},{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":16,"sex":17,"minAge":69,"maxAge":19,"enrollmentInfo":70,"targetDuration":4,"studyType":23,"phases":72,"briefSummary":73,"conditions":74,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},"100626306","l-prf-versus-sticky-bone-grafting-of-the-jumping-gap-in-ai-assisted-computer-guided-socket-shield-immediate-implantation-100626306","NCT07433920","L-PRF Versus Sticky Bone Grafting of the Jumping Gap in AI-assisted Computer-Guided Socket Shield Immediate Implantation","L-PRF Versus Sticky Bone Grafting of the Jumping Gap in AI-assisted\u002FComputer-Guided Socket Shield Immediate Dental Implantation: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Medically healthy patients according to the American Society of Anesthesiologists (ASA) physical status classification system; only patients belonging to ASA I and ASA II categories will be included in this study.\n* Age \\> 18 years.\n* Patients presenting with one non-restorable hopeless anterior tooth due to extensive caries, cervical\u002Froot fracture, vertical or oblique root fracture, multiple failed endodontic treatments, or root resorption.\n* Sufficient apical\u002Fpalatal bone to obtain primary implant stability.\n\nExclusion Criteria:\n\n* Patients belonging to ASA III, ASA IV and ASA V will be excluded.\n* Vertical root fracture involving the labial aspect of the root planned to be retained as the facial shield.\n* Horizontal root fracture that is too far apically located.\n* Presence of acute (active) periapical infection.\n* Large chronic periapical lesion.\n* Lack of sufficient bone apical to the extraction socket to obtain primary stability. \\* Ankylosed tooth positioned too apically in relation to adjacent teeth.","18 Years",{"count":71,"type":22},45,[25],"the rationale of the current study is to address a focused and clinically relevant gap in socket shield therapy: which biologic modality best supports healing of the shield-implant gap when SST is performed under a standardized, digitally guided workflow. The study will compare three shield-implant gap filling modalities: (i) L-PRF alone (without membrane), (ii) sticky tooth (autogenous dentin graft +i- PRF), and (iii) sticky bone (particulate graft + i- PRF) under AI-assisted, patient-specific guided implant placement based on IOS\u002FCBCT superimposition, with CBCT follow-up at immediate, 3 months, and 6 months. The working hypothesis is that biologically active, cohesive composites (sticky tooth and sticky bone) will provide superior hard- and soft-tissue dimensional stability compared with PRF alone by improving space maintenance and early wound stability in the shield-implant gap . The null hypothesis is that there will be no statistically significant differences between the three modalities in radiographic and digitally assessed clinical outcomes over the 6-month follow-up period .",[28],"RECRUITING","2026-03-16",{"date":78,"type":33},"2026-03-18",{"date":80,"type":33},"2026-02-23",{"date":82,"type":22},"2027-03-28",{"name":39,"class":40},2,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":16,"sex":17,"minAge":69,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":41},"100523746","clinical-performance-of-dual-cantilevered-single-implant-bridge-100523746","NCT06099717","Clinical Performance of Dual-cantilevered Single-implant Bridge","Clinical Performance of a Novel Implant-supported Fixed Dental Prostheses (iFDP): the Dual-cantilevered Single-implant Bridge (T-bridge)","T-bridge","Inclusion Criteria:\n\n* Age ≥ 20 years\n* Willingness to sign an informed consent and participate in the study\n* Three missing adjacent teeth in the posterior site.\n* Tooth gap of 21-24 mm.\n* Presence of natural or artificial opposing dentition\n* Sufficient vertical interocclusal space of an implant restoration (7mm)\n* Sufficient ridge height to place an implant of 10mm in length\n* Sufficient ridge width for the placement of a 4.1mm diameter implant. Simultaneous GBR to achieve a width of 6.5mm will be included.\n\nExclusion Criteria:\n\n* Any physical or mental disorder that would interfere with the ability to perform adequate oral hygiene or the capability of providing written informed consent and compliance with the protocol\n* Any disorder that would interfere with wound healing or represent a contraindication for implant surgery, such as but not limited to uncontrolled diabetes or conditions resulting in or requiring immunosuppression, radiation, chemotherapy, frequent use of antibiotics or antiresorptive medication such as bisphosphonates.\n* Pregnancy or lactation\n* Heavy smoking habit with ≥ 10 cig\u002Fd\n* Severe bruxism or clenching habits, presence of oro-facial pain\n* Insufficient ridge width\u002Fheight for the study implant",{"count":94,"type":22},50,[25],"The study aims to evaluate the clinical performance (implant and prosthetic survival\u002F success rates) of a novel implant-supported fixed dental prosthesis design: the dual-cantilevered single implant bridge (T-Bridge) made out of monolithic zirconia bonded to a titanium base abutment (Variobase abutments)",[28],[99],"Dental implant","2026-02-16",{"date":102,"type":33},"2026-02-18",{"date":104,"type":33},"2024-06-30",{"date":106,"type":22},"2026-10",{"name":108,"class":40},"University of Bern",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":69,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":41},"100441163","early-phase-1-antiseptic-effects-on-the-dental-implant-internal-surface-microbiome-100441163","NCT05024760","Antiseptic Effects on the Dental Implant Internal Surface Microbiome","Inclusion Criteria:\n\n* Active duty military\n* 18-55 years old\n* Over 6 months remaining at local duty station\n\nExclusion Criteria:\n\n* Tobacco user\n* Medications that affect soft tissue or bone healing\n* Metabolic disorder that affects soft tissue or bone healing\n* Active periodontal disease","55 Years",{"count":117,"type":22},150,[119],"EARLY_PHASE1","Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.",[122,123,124,28],"Peri-Implantitis","Peri-implant Mucositis","Implant Infection","2024-12-19",{"date":127,"type":33},"2024-12-27",{"date":129,"type":33},"2022-07-28",{"date":131,"type":22},"2025-11",{"name":133,"class":134},"Madigan Army Medical Center","FED",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":16,"sex":17,"minAge":69,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":23,"phases":144,"briefSummary":145,"conditions":146,"keywords":147,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":41},"100559927","comparison-of-conventional-impressions-intraoral-scanners-and-digital-photogrammetry-for-full-arch-implant-prosthesis-100559927","NCT06570499","Comparison of Conventional Impressions, Intraoral Scanners and Digital Photogrammetry for Full-arch Implant Prosthesis.","Precision, Patient Satisfaction and Timing of Complete-arch Digital Implant Impression With a Conventional Impression, an Intraoral Scanner and a Photogrammetry Technique: A Prospective Clinical Comparative Study","Inclusion Criteria:\n\n* edentulous maxilla or mandible with 4 to 8 osseointegrated implants (NobelBiocare®) and transgingival abutments tightened to 35N\u002Fcm (Multi-unit, NobelBiocare®).\n\nExclusion Criteria:\n\n* Patients with non-osseointegrated implants\n* Patients with different implant systems\n* Patients with incomplete edentulism",{"count":143,"type":22},20,[25],"The aim of this clinical trial is to compare implant-supported definitive impressions in edentulous patients (mandible or maxilla) with 4 to 8 osseointegrated implants. The main questions it aims to answer are :\n\nThe primary outcome of this prospective clinical comparative study is to analyse the precision of a complete-arch impression.\n\nThe secondary aim is to obtain patient satisfaction with these new types of impression.\n\nThe different impressions (conventional, intraoral scanner and photogrammetry) will be taken twice on the same patient.",[28],[148],"accuracy, photogrammetry, dental implant","2024-08-23",{"date":151,"type":33},"2024-08-26",{"date":153,"type":33},"2024-06-18",{"date":155,"type":22},"2024-12-15",{"name":157,"class":40},"Centre Hospitalier Universitaire de Liege",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":17,"minAge":69,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":167,"conditions":168,"keywords":172,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":41},"100555730","characterizing-the-inflammation-around-dental-implants-bacterial-infection-hypersensitivity-or-both-100555730","NCT06515886","Characterizing the Inflammation Around Dental Implants: Bacterial Infection, Hypersensitivity or Both?","Inclusion Criteria:\n\n* Received at least one functional implant (implant restored with a prothesis);\n* Did not receive peri-implant mucositis and peri-implantitis treatment in the past three months.\n\nExclusion criteria:\n\n* Dental records with incomplete information;\n* Individuals with a weak immune system or chronic disease such as diabetes, heart, lung or kidney disease;\n* Pregnant women;\n* Individuals undergoing orthodontic therapy and those who have oral piercing.\n* History of diseases that modify or suppress the immune and inflammatory response, including rheumatoid arthritis, diabetes, lupus, and inflammatory bowel disease and metastatic cancer;\n* Taking medications that cause antiresorptive osteonecrosis of the jaw (including any dose of intravenous bisphosphonates, oral bisphosphonate intake for more than three years, receptor activator of nuclear factor kappa-B ligand inhibitors, or antiangiogenic medications);\n* Taking medications known to induce gingival hyperplasia including anticonvulsants, immunosuppressants, or calcium channel blockers;\n* Taking steroid medications, systemic or local antibiotics in the last three months (as this may affect the interleukins activity);\n* Received radiation therapy to the head and neck or chemotherapy;\n* Received treatment to manage an inflamed implant, including management of peri-implantitis and peri-implant mucositis in the last three months.",{"count":165,"type":22},40,"OBSERVATIONAL","The use of titanium dental implants has become a common modern treatment to restore teeth. Although the success rate of dental implants is high, inflammation around the dental implant still occurs. The current study will investigate if the inflammation around the implant is due to bacterial infection, hypersensitivity or both.",[28,169,170,171],"Implant Complication","Implant Site Infection","Implant Site Reaction",[99,173,174,175,176,177],"Peri-implant inflammation","Inflammatory mediators","Bacterial infection","Hypersensitivity","peri-implantitis","2024-07-19",{"date":180,"type":33},"2024-07-23",{"date":182,"type":33},"2022-09-22",{"date":184,"type":22},"2025-12-01",{"name":186,"class":40},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":16,"sex":17,"minAge":69,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":23,"phases":197,"briefSummary":198,"conditions":199,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":84},"100464375","5-year-follow-up-study-on-the-comparative-performance-of-two-piece-zirconia-and-titanium-implants-100464375","NCT05326880","5-year Follow up Study on the Comparative Performance of Two-piece Zirconia and Titanium Implants","Comparative Performance of Two-piece Zirconia Tissue Level Implants vs. Titanium Bone Level Implants Placed With a Fully Digital Workflow - 5-year Follow up of a Randomized Clinical Trial","PostNCT0390817","Inclusion Criteria:\n\nfollowing criteria must be met for inclusion in the study:\n\n* Patients must have voluntarily signed the Informed Consent Form before any study related procedures are performed, are willing and able to attend scheduled follow-up visits and agree that the pseudonymized data will be collected, analyzed, and published.\n* Patients must be males or females who are a minimum of 18 years of age.\n* Patients, who have received a single tooth replacement with a study implant as per-protocol in the premolar-to-premolar area (excluding lower incisors) in the mandible and maxilla and restored with a screw retained ceramic crown.\n\nExclusion Criteria:\n\n* Patients with conditions or circumstances, in the opinion of the Investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance or unreliability.\n* Pregnancy or intention to become pregnant at any point during the study duration.",{"count":196,"type":22},60,[25],"A post-market, randomized-controlled, superiority clinical study to compare medium-term performance and safety of the Straumann PURE 2-piece Ceramic Implant with Straumann Bone Level Implant using a fully digital workflow.",[200,201,28],"Dental Implants","Single Tooth Lost","2023-11-19",{"date":204,"type":33},"2023-11-21",{"date":206,"type":33},"2022-01-03",{"date":208,"type":22},"2028-03",{"name":210,"class":40},"The University of Hong Kong",{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":16,"sex":17,"minAge":69,"maxAge":4,"enrollmentInfo":218,"targetDuration":4,"studyType":23,"phases":220,"briefSummary":221,"conditions":222,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":41},"100525552","sinus-floor-with-osseodensification-or-lateral-window-100525552","NCT06123221","SINUS FLOOR WITH OSSEODENSIFICATION OR LATERAL WINDOW","COMPARISON OF IMPLANT INSTALLATION USING THE TRANSCRESTAL APPROACH WITH OSSEODENSIFICATION OR THE LATERAL WINDOW TECHNIQUE WITH SINUS LIFT: A RANDOMIZED CONTROLLED TRIAL.","Inclusion Criteria:\n\n* Maxillary sinuses that have residual bone height between at least 3 mm and 5 mm;\n* Width of the residual bone ridge that allows the insertion of an implant with a diameter of 4 mm;\n* Tomographic thickness of Schneider's membrane with a maximum of 5 mm in the region to be operated;\n* Residual ridge with ≥2 mm of medullary bone in the bucco-palatal direction, with a 1\u002F1 ratio of medullary and cortical bone to achieve predictable plastic expansion;\n* Patients with adequate interarch space for placement of the prosthetic crown;\n* Good physical health status (ASA1 and ASA2, according to the Physical Status Classification System - American Society of Anesthesiologists);\n* At least 6 months since the last tooth loss in the region to be operated;\n\nExclusion Criteria:\n\n* \\- Those with sinus pathology;\n* Heavy smokers (more than 10 cigarettes a day);\n* Those with a history of head and neck radiotherapy;\n* Those who have already undergone bone augmentation in any of the targeted surgical areas;\n* Immunodeficiency of any nature;\n* Emotional instability and psychiatric problems;\n* Pregnancy;\n* Current use of oral bisphosphonates or history of using injectable bisphosphonate;\n* Patients with active periodontitis defined by the presence of subgingival bleeding greater than 10%;\n* Documented allergy to drugs or dental materials involved in the experimental protocol.",{"count":219,"type":22},38,[25],"This study will compare patient-reported outcomes, as well as the type and incidence of complications, and bone marginal loss after 12 months in implants installed using the transcrestal approach (tSFE) with an osseodensification system (performed according to the protocol by Huwais et al. 2018), or installed simultaneously using the lateral window technique (lSFE) with sinus lift. A blind, randomized, controlled clinical trial will be carried out with individuals over 18 years old, and with single tooth loss in the posterior maxilla, where the residual bone height (RBH) is 3 to 5 mm. The tSFE will be performed with osseodensification burs (Densa Bur, Versah, USA) using a counterclockwise motion, associated to synthetic biomaterial (hydroxyapatite and beta-tricalcium phosphate). The lSFE technique will require the sinus to be filled with the same biomaterial as the group using the other technique, and the antrostomy to be covered with a polydioxanone-based membrane. The patient's post-operatory perceptions will be evaluated by self-administered questionnaires quantifying social and professional isolation, physical appearance, duration and changes in quality of life, eating and speech, diet variations, and sleep deficiency for 2 weeks after the procedure. Pain will be assessed with the visual analogue scale (VAS). Immediately after prosthetic rehabilitation, cone beam tomography will be performed. Controls at 6 and 12 months will be performed. In these images, the marginal bone level in relation to a fixed reference point on the implants (upper part of the platform) will be measured mesially and distally in each implant, using a specific program (ImageJ - version 1.49v \u002F NIH software - Bethesda, MD, USA). Generalized estimating equations will be used to compare the two treatments overtime. The significance level used will be 0.05.",[223,28],"Sinus Tract","2023-11-03",{"date":226,"type":33},"2023-11-08",{"date":228,"type":33},"2022-10-01",{"date":230,"type":22},"2026-10-01",{"name":232,"class":40},"Federal University of Rio Grande do Sul",{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":17,"minAge":69,"maxAge":240,"enrollmentInfo":241,"targetDuration":4,"studyType":23,"phases":243,"briefSummary":245,"conditions":246,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":41},"100503677","phase-4-immediate-versus-delayed-loading-of-single-posterior-zirconia-implants-100503677","NCT05838365","Immediate Versus Delayed Loading of Single Posterior Zirconia Implants","Immediate Versus Delayed Loading of Single Posterior Zirconia Implants: A Multicenter Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Sistemically healthy patients\n* partial edentulism\n* premolar position\n* molar position\n* Bone width and height at least 6 and 10mm, respectively.\n* Keratinized tissue, at least 1 mm at implant site\n* Full understanding of the proposed surgical treatments and the protocol schedule\n* Full comprehension and availability to sign the informed consent form\n\nExclusion Criteria:\n\n* Heavy smokers (\\>10 cigarettes a day)\n* Serious kidney or liver diseases\n* Uncontrolled diabetes\n* Bisphosphonates intake\n* History of radiotherapy of the head and neck\n* Current antiblastic chemotherapy\n* Congenital (primary) or acquired (secondary) immunodeficiency\n* Pregnant women\n* Connective tissue disorders\n\nLocal exclusion criteria:\n\n* untreated stage III\u002FIV periodontitis\n* Autoimmune diseases\n* oral parafunctions","80 Years",{"count":242,"type":22},220,[244],"PHASE4","The main aim of the present study is to investigate implant success rate after 5 years of function of immediate (Test group; within 7 days of implant placement) versus delayed (Control group; 8 weeks after implant placement) loading of two-pieces zirconia implant, placed in pristine bone without bone regeneration. Implant success rate will be defined according to Buser's criteria. Secondary endpoints: Marginal bone level (MBL) evaluation by means of standardized radiographs; Clinical evaluation of biological (e.g. Plaque Index, PI; Probing Pocket Depth, PPD, Bleeding on Probing, BOP; suppuration upon probing\u002Fpalpation) and prosthetic\u002Ftechnical complications; Clinical evaluation of soft tissue width, keratinized tissue, marginal and interproximal soft tissue recession; Patient reported outcome measures (PROMs) by questionnaire administration:",[28,123,122],"2023-04-26",{"date":249,"type":33},"2023-05-01",{"date":251,"type":33},"2022-12-01",{"date":253,"type":22},"2029-06-01",{"name":255,"class":40},"University of Milan"]