[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-implant-healing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-implant-healing":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100622498","phase-4-application-of-topical-oxygen-therapy-around-customized-healing-collar-100622498",false,"NCT07384403","Application of Topical Oxygen Therapy Around Customized Healing Collar","Evaluation of Linear and Volumetric Soft Tissue Changes Following the Application of Topical Oxygen Therapy Around Customized Healing Collars: Case Series","Inclusion Criteria:\n\n* Adults aged 21 years and above.\n\n  * Indicated for customized healing collar placement after second-stage surgery.\n  * Good general health.\n  * Able and willing to provide written informed consent.\n  * Committed to follow-up visits.\n\nExclusion Criteria:\n\n* Individuals below 21 years old.\n* Systemic diseases affecting healing.\n* Smokers\u002Ftobacco users.\n* Pregnant\u002Flactating women.\n* Medications affecting soft tissue healing.\n* Chemotherapy\u002Fradiotherapy patients.","ALL","21 Years",{"count":19,"type":20},6,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The preservation and enhancement of peri-implant soft tissues are essential for the long-term success and esthetic integration of dental implants. Customized healing abutments have been introduced to support individualized soft tissue shaping; however, optimizing soft tissue healing around implants remains a clinical challenge. Oxygen plays a critical role in wound healing by promoting angiogenesis, fibroblast proliferation, and collagen synthesis. Topical oxygen therapy has shown promise in accelerating tissue regeneration, yet its application in oral implantology, particularly in conjunction with customized healing abutments, has not been adequately studied. This study aims to provide clinical evidence regarding the effectiveness of topical oxygen therapy in improving linear and volumetric soft tissue changes around dental implants. The findings may guide clinicians in refining soft tissue management protocols and contribute to establishing evidence-based practices in implant dentistry.",[26,27,28,29],"Soft Tissue","Healing Abutment Influence on Gingival Volume","Soft Tissue Healing","Dental Implant Healing",[31,32,33],"Oxygen gel","volumetic change of soft tissue","implant","RECRUITING","2026-01-25",{"date":37,"type":38},"2026-02-03","ACTUAL",{"date":40,"type":38},"2026-01-01",{"date":42,"type":20},"2026-09",{"name":44,"class":45},"Cairo University","OTHER"]