[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-implants\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-implants":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,50,81,107,137,166,195,222,254,278,300,326,344,365,383,407,429,455,482],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100640017","autologous-demineralized-dentin-graft-with-or-without-melatonin-for-immediate-implant-osseointegration-100640017",false,"NCT07610876","Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration","Effect of Autologous Demineralized Dentin Graft With or Without Melatonin Gel on the Osseo Integration of Immediately Placed Implants: A Randomized Clinical Study","Inclusion Criteria:\n\n* Age above 20 years\n* Non-restorable maxillary premolar teeth\n* Candidates for immediate implant placement\n* Intact socket walls\n* Jumping gap \\>2 mm\n* Non-smokers or light smokers\n* No acute infection\n* Adequate bone for primary stability\n\nExclusion Criteria:\n\n* Heavy smokers\n* Bruxism or clenching\n* Uncontrolled systemic disease\n* Chemotherapy\u002Fradiotherapy\n* Immunocompromised patients",true,"ALL","20 Years",{"count":20,"type":21},16,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar region. Sixteen patients requiring extraction and immediate implant placement will be randomly allocated into two groups. Clinical and radiographic outcomes including implant stability, peri-implant probing depth, modified bleeding index, marginal bone loss, buccal bone thickness, and bone density will be evaluated over a 9-month follow-up period.",[27,28,29],"Dental Implants","Immediate Implant Placement","Osseointegration",[31,32,33,34,29,35,36],"Melatonin","Dentin graft","Immediate implant","ADDG","CBCT","Dental implant stability","RECRUITING","2026-05-20",{"date":40,"type":41},"2026-05-28","ACTUAL",{"date":43,"type":41},"2025-08-11",{"date":45,"type":21},"2026-11-10",{"name":47,"class":48},"Suez Canal University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":49},"100638497","comparison-of-anesthetic-efficacy-and-safety-between-inferior-alveolar-nerve-block-and-the-infiltrative-technique-for-the-treatment-of-peri-implant-diseases-in-posterior-mandibular-implants-100638497","NCT07590037","Comparison of Anesthetic Efficacy and Safety Between Inferior Alveolar Nerve Block and the Infiltrative Technique for the Treatment of Peri-implant Diseases in Posterior Mandibular Implants","Comparison of Anesthetic Efficacy and Safety Between Inferior Alveolar Nerve Block and the Infiltrative Technique for the Treatment of Peri-implant Diseases in Posterior Mandibular Implants: A Triple-blind Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult patients (≥18 years) requiring surgical treatment of peri-implantitis in the posterior mandibular sector.\n* Patients without relevant systemic disease (ASA II or lower).\n* Sufficient intellectual capacity to understand the study and informed consent and to complete the questionnaires adequately.\n\nExclusion Criteria:\n\n* Pregnant patients.\n* Patients with allergy or hypersensitivity to articaine or epinephrine.\n* Patients with uncontrolled systemic diseases.\n* Patients with coagulation disorders or medication that alters coagulation.\n* Patients who may be able to recognize the anesthetic technique used, such as dentists.\n* Drugs or systemic diseases (ASA III or higher) that contraindicate surgical intervention or the use of anesthetics and\u002For vasoconstrictors.\n* Patients with relative or absolute contraindication to conventional analgesic or anti-inflammatory regimens.","18 Years",{"count":59,"type":21},30,[24],"This triple-blind randomized clinical trial aims to compare the anesthetic efficacy and safety of two local anesthesia techniques for the surgical treatment of peri-implantitis in posterior mandibular implants: inferior alveolar nerve block (IANB) and infiltrative anesthesia with 4% articaine and epinephrine 1:100,000.\n\nPeri-implantitis is an inflammatory disease affecting the tissues around dental implants, characterized by progressive bone loss and clinical signs of inflammation. When non-surgical therapy is insufficient, surgical treatment is required, usually involving flap elevation, debridement of granulation tissue, implant surface decontamination, and, depending on the defect, resective, regenerative, or combined surgery.\n\nEffective local anesthesia is essential in these procedures, especially in the posterior mandible, where dense bone may limit anesthetic diffusion. IANB is the conventional technique for achieving profound mandibular anesthesia, but it may fail due to anatomical variations, accessory innervation, or technical difficulty. Infiltrative anesthesia has been proposed as an alternative, particularly with articaine because of its high diffusion capacity, although its predictability in complex mandibular surgery remains uncertain.\n\nThe main objective is to compare the efficacy of IANB and infiltrative anesthesia, measured by the need for re-anesthesia during surgery. Secondary objectives include assessing safety, intraoperative discomfort, postoperative pain, duration of anesthesia, patient satisfaction, and adverse events.\n\nAdult patients requiring surgical treatment for peri-implantitis in posterior mandibular implants at the Dental Hospital of the University of Barcelona will be included. Eligible participants must be ≥18 years old, medically fit for surgery, and able to understand the study and complete the questionnaires. Exclusion criteria include pregnancy, allergy to articaine or epinephrine, uncontrolled systemic disease, coagulation disorders or anticoagulant medication, ASA III or higher status, and contraindications to conventional analgesic or anti-inflammatory medication.\n\nParticipants will be randomly assigned to either the IANB group or the infiltrative anesthesia group. Randomization will be performed using a computer-generated sequence placed in opaque, sequentially numbered envelopes. The patient, surgeon, outcome assessor, and statistician will remain blinded to group allocation.\n\nThe study includes three visits. At the first visit, eligibility will be assessed and informed consent obtained. At the second visit, surgery will be performed after the assigned anesthetic technique. Patients will record pain using visual analogue scales at injection, during surgery, 2 h, 6 h, 12 h, 24 h, and daily until day 7, as well as rescue medication use and sick leave. At the third visit, 7-9 days after surgery, postoperative healing, complications, adverse events, pain diary, and patient satisfaction will be assessed.\n\nThe primary outcome is anesthetic efficacy, defined as absence of need for re-anesthesia. Secondary variables include demographic factors, systemic disease, medication, smoking, dental anxiety, type and duration of surgery, surgeon experience, number and position of implants, intraoperative and postoperative pain, duration of anesthesia, adverse events, complications, and patient-reported experience measures.\n\nData will be analyzed using Stata\u002FIC 15.1. Quantitative variables will be described using means and standard deviations or medians and interquartile ranges, depending on normality. Qualitative variables will be presented as frequencies and percentages. Group comparisons will use appropriate statistical tests, with significance set at p \\\u003C 0.05.\n\nAs a pilot exploratory trial, the study will include 30 patients, 15 per group. Its aim is to assess feasibility, estimate preliminary event rates, and generate data for future confirmatory trials. The study will follow the Declaration of Helsinki and applicable data protection regulations. Participation will be voluntary, anonymous, and based on written informed consent.",[63,27,64],"Local Anesthesia","Periimplantitis",[66,67,68,69,70],"dental implants","articaine","periimplantitis","block nerve","local anesthesia","NOT_YET_RECRUITING","2026-05-19",{"date":74,"type":41},"2026-05-22",{"date":76,"type":21},"2026-09",{"date":78,"type":21},"2027-12",{"name":80,"class":48},"University of Barcelona",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":49},"100557496","dental-implant-healing-with-tnf-alpha-inhibitors-100557496","NCT06538870","Dental Implant Healing With TNF-Alpha Inhibitors","Dental Implant Healing in Patients Taking Tumor Necrosis Factor (TNF)-Alpha Inhibitors","Inclusion Criteria:\n\n* Over the age of 18\n* Require placement of implants to assist with dental restoration.\n* Half of the patients (15) will be recruited with the key criteria of a TNF-alpha inhibitor medication that they have been taking consistently without dose adjustment or other changes for at least 6 months. The other half will be recruited without a target medical condition but will be recruited to match the patients taking TNF-alpha inhibitors in age and gender.\n* All patients will be medically fit to withstand implant placement as judged by best practice applied by the study team.\n* The patients will be required to read and speak English\n* All patients must either provide their own independent consent for medical procedures or to attend study visits with a surrogate decision maker.\n\nExclusion Criteria:\n\nPatients will not be excluded on the basis of age (within the adult population), race, economic status, sex or gender, or other demographic factors. Patients will be excluded if:\n\n* They have periodontal disease (periodontal pockets above 4mm in the applicable arch or radiographic evidence of horizontal bone loss more than mild severity)\n* There is other evidence of pathology in the treated arch on pre-treatment review including radiographs, such as any evidence of cyst or tumor formation in the mandible.\n* They have uncontrolled diabetes (HbA1c \\>8.0) as confirmed by evaluating labs taken on anyone with diagnosed diabetes in the 6 months before the study enrollment.\n* They have history of head and neck radiation for any reason\n* They are taking any antiresorptive or antiangiogenic agents for any reason including osteoporosis, multiple myeloma, bone metastasis of other primary cancers\n* They are unable to seek outpatient medical care or are not medically fit to withstand implant placement, including those with critical findings or lab values. Medical exclusion of patients will be completed by the investigators based on standard of care for surgical procedures in dental medicine and based on specific implant guidelines.\n* Patients who have routinely used tobacco or tobacco products in the last 1 year will be excluded, as tobacco use is a known contributor to poor prognosis after implant placement. For this reason, dental implant placement is only recommended in patients who have quit or never used tobacco products.\n\n  * Pregnant women are unlikely to meet inclusion criteria as dental implant placement is considered an elective procedure and typically deferred in dentistry until after delivery.",{"count":59,"type":21},[24],"The goal of this pilot study is to learn about healing after dental implant placement in patients taking a class of biologic drug called Tumor Necrosis Factor or TNF-alpha antagonist or inhibitor. The main questions it aims to answer are:\n\nDo patients taking TNF-alpha inhibitors have any complications after the placement of dental implants? Do patients taking TNF-alpha inhibitor experience increased pain after dental implant placement compared to the expected levels when healing from this procedure? Researchers will recruit patients both taking these drugs and those not taking these drugs to compare the outcomes between the two groups.\n\nParticipants missing teeth will be recruited to receive dental implants to meet ideal dental status and will be followed before and after the implant placement to determine levels of health and ensure proper healing. Participants will be followed for a total of one year and follow up visits will consist of both clinical examination and radiographs (x-rays) to evaluate bone level and implant status. Participants will also be asked to rate their pain during clinic visits and at home on a diary and record the amount of pain control medication they take after the implant procedure.",[92,27,93],"Edentulism","TNF-alpha Inhibitors",[95,96,97,98],"Dental implants","TNF-alpha inhibitors","Biologic agents","Missing teeth","2026-05-18",{"date":38,"type":41},{"date":102,"type":41},"2025-06-28",{"date":104,"type":21},"2026-12",{"name":106,"class":48},"University of Pennsylvania",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":122,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":49},"100631275","immediate-restoration-of-a-new-implant-with-high-primary-stability-100631275","NCT07498556","Immediate Restoration of a New Implant With High Primary Stability","Immediate Restoration of a New Implant With High Primary Stability: A 1-year Follow-up - Clinical Study","CT","Inclusion Criteria:\n\n* Men and women between 18 and 70 years of age.\n* Ability to read, understand, and sign the informed consent form.\n* Need for placement of one or more implants for fixed prosthetic rehabilitation in either arch.\n* Insertion torque ≥ 35 Ncm (lower values will be excluded from the study).\n* Adequate bone dimensions to receive an implant with diameter ≥ 3.75 mm and length ≥ 10 mm.\n* Bone type I to III at the insertion site.\n* Good oral hygiene: FMBS and FMPS ≤ 25%.\n* Systemic status classified as ASA I or II.\n\nExclusion Criteria:\n\n* Inability to attend follow-up appointments.\n* Systemic contraindications to oral surgery (ASA III or IV).\n* Pregnancy or breastfeeding.\n* Chronic use of corticosteroids, bisphosphonates, or RANKL inhibitors within the last year.\n* Alcohol or drug abuse.\n* Heavy smoking (≥ 10 cigarettes\u002Fday).\n* Previous radiotherapy in the cervicofacial region.\n* Untreated active periodontal disease.\n* Absence of antagonist teeth.\n* Local pathology at the planned implant site.\n* Uncontrolled diabetes mellitus (HbA1c \\> 7%).\n* Bone type IV at the surgical site.","70 Years",{"count":117,"type":21},50,[24],"The main objective of this scientific study is to evaluate the short-term (1-year) survival and success rates of dental implants restored immediately compared to implants restored after a three-month healing period.\n\nThe total duration of the study is 12 months following implant placement, during which clinical and radiographic evaluations will be carried out at different follow-up time points.",[27,121],"Immediate Dental Implant Loading",[66,123,124,125,126,127],"Immediate loading","Delayed loading","Implant survival rate","Marginal bone loss","Esthetic outcome evaluation","2026-04-28",{"date":130,"type":41},"2026-05-05",{"date":132,"type":21},"2026-07-01",{"date":134,"type":21},"2027-12-30",{"name":136,"class":48},"Universidade do Porto",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":16,"sex":17,"minAge":144,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":22,"phases":148,"briefSummary":149,"conditions":150,"keywords":153,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":49},"100619392","comparative-analysis-of-2-bone-graft-materials-in-socket-preservation-100619392","NCT07344025","Comparative Analysis of 2 Bone Graft Materials in Socket Preservation","Comparative Analysis of Healing Outcomes Between Two Bone Graft Materials in Socket Preservation Procedure","Inclusion Criteria:\n\n* • Systemically healthy individuals\n\n  * Non-smokers\n  * Age between 21 and 50 years\n  * Indicated for tooth extraction and socket preservation\n  * Good oral hygiene (full-mouth plaque score \\\u003C20%)\n  * Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* • Stage III or IV periodontitis\n\n  * Active periodontal or periapical infection\n  * Severely resorbed sockets (buccal bone height \\\u003C5 mm)\n  * Smoking more than 10 cigarettes per day\n  * Pregnancy\n  * Systemic conditions or medications affecting bone metabolism","21 Years","50 Years",{"count":147,"type":21},18,[24],"Socket preservation procedures after tooth extraction have been designed and implemented to maintain the volume of the bone and gingival tissues, which can decrease following the extraction of the teeth. In this clinical trial we will compare clinically and histologically the effectiveness of two distinct bovine bone graft materials; an allograft and a xenograft, in alveolar ridge preservation procedures following tooth extraction .",[151,152,27],"Socket Preservation","Alveolar Ridge Augmentation",[154,155,156],"Alveolar ridge preservation","Allograft","Bovine xenograft","2026-01-15",{"date":159,"type":41},"2026-01-20",{"date":161,"type":21},"2026-01",{"date":163,"type":21},"2026-04",{"name":165,"class":48},"Pharos University in Alexandria",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":176,"phases":4,"briefSummary":177,"conditions":178,"keywords":179,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":194},"100615787","movement-of-dental-implants-during-osseointegration-100615787","NCT07297147","Movement of Dental Implants During Osseointegration","Do Dental Implants Move During Osseointegration? A Prospective Multicenter Clinical Study Using Intraoral Scan Superimposition and Stability Analysis.","MOVs-OI","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Indication for a single implant-supported restoration.\n* Good general health and absence of active periodontal disease.\n* Willingness to provide written informed consent and to undergo two intraoral scans (immediately after implant placement - T0 - and before prosthetic loading - T1).\n\nExclusion Criteria:\n\n* Uncontrolled systemic disease or any medical condition contraindicating implant surgery.\n* High-risk antiresorptive therapy (e.g., intravenous bisphosphonates or denosumab).\n* Pregnancy or breastfeeding, if applicable to local policy.\n* Inability to attend the T1 follow-up visit or contraindication to intraoral scanning (e.g., limited mouth opening, severe gag reflex).",{"count":175,"type":21},100,"OBSERVATIONAL","Prospective multicenter observational study assessing whether dental implants undergo three-dimensional positional change between placement (T0) and pre-loading after osseointegration (T1). Two intraoral scans (STL) will be superimposed to quantify linear (mm) and angular (degrees) displacement. Clinical variables include insertion torque, primary and secondary ISQ, anatomical site, placement timing, operator-perceived bone density (Lekholm \\& Zarb), bruxism, and night guard use. The primary endpoint is the 3D displacement at \\~3-4 months. Multivariable analyses will explore associated factors.",[27,29],[95,29,180,181,182,183,184],"Intraoral scan","Micromotion","ISQ","Insertion torque","Bruxism","2025-12-09",{"date":187,"type":41},"2025-12-22",{"date":189,"type":21},"2026-01-01",{"date":191,"type":21},"2027-10-01",{"name":193,"class":48},"Aula Dental Avanzada",3,{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":176,"phases":4,"briefSummary":204,"conditions":205,"keywords":208,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":4},"100604720","creos-xenoprotect-pmcf-100604720","NCT07153185","Creos Xenoprotect PMCF","A Retrospective Multi-center, PMCF Study to Assess the Safety and Performance of a Biodegradable Dental Barrier Membrane (Creos Xenoprotect)","Inclusion Criteria:\n\n* Participant was treated before December 2023 (creos xenoprotect placement)\n\n  * Participant signed informed consent form and data protection consent form1\n  * Participant was at least 18 years old at the time of treatment\n  * Participant received guided bone regeneration combined with the use of creos xenoprotect according to one of the four indications\n  * Participant was treated according to instructions for use (IFU)\n  * Participant should have follow-up time of \\>9 months after placement of the investigational device\n\nExclusion Criteria:\n\n* In Group 3: Sinus floor augmentation (lateral approach): usage of creos xenoprotect to replace a ruptured Schneiderian Membrane",{"count":203,"type":21},200,"The goal of this retrospective PMCF study is to assess safety and performance of creos xenoprotect in all indications functioning as dental barrier membrane.\n\nThe primary endpoint of the study is the occurrence of major complications during 6 months after creos xenoprotect placement whereas the hypothesis is that these major complications occur in less than 5% within this timeframe.\n\nThis is a retrospective, multicenter clinical investigation with consecutive cases. Data will be collected on consecutive data cases from patient files, given that these patients were treated within a defined indication with creos xenoprotect in the past. Patients participating in this study do not have any obligations or need to come back for any intervention. A total of 11 centers are planned to be included. Sample size is n=200 patients and is distributed equally in four indication groups:\n\nGroup 1: Ridge augmentation (vertical and horizontal) Group 2: Alveolar ridge preservation Group 3: Sinus floor augmentation Group 4: Augmentation around implant or teeth",[206,27,207],"Bone Regeneration","Bone Grafting",[209,210,211],"Dental Barrier Membrane","PMCF Study","Retrospective","2025-08-25",{"date":214,"type":41},"2025-09-03",{"date":216,"type":21},"2025-11-01",{"date":218,"type":21},"2026-07-31",{"name":220,"class":221},"Nobel Biocare","INDUSTRY",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":115,"enrollmentInfo":230,"targetDuration":4,"studyType":22,"phases":232,"briefSummary":233,"conditions":234,"keywords":237,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":49},"100599760","natural-bioactive-gel-for-peri-implantitis-100599760","NCT07088679","Natural Bioactive Gel for Peri-Implantitis","Efficacy of a Natural Bioactive Gel as an Adjunct to Standard Therapy in the Treatment of Peri-Implantitis: A Randomized Controlled Split-Mouth Clinical Trial","PERISTER","Inclusion Criteria:\n\n* Patients aged between 18 and 70 years\n* Presence of peri-implantitis involving at least two dental implants located in different quadrants\n* Presence of bleeding and\u002For suppuration on probing\n* Increased probing depth (PD) and radiographic bone loss compared to previous examinations\n* In the absence of previous clinical data: PD ≥ 6 mm and bone loss ≥ 3 mm apically from the coronal portion of the intraosseous implant area (radiographically assessed)\n* Willingness and ability to comply with study protocol and follow-up visits\n* Written informed consent provided\n\nExclusion Criteria:\n\n* Patients with cardiac pacemakers or other implanted electronic devices\n* Neurological or psychiatric disorders that may interfere with study participation\n* Systemic diseases, metabolic disorders, or autoimmune conditions\n* Pregnancy or lactation Current participation in other clinical trials",{"count":231,"type":21},20,[24],"This study is a randomized controlled clinical trial using a split-mouth design to evaluate the effectiveness of a natural bioactive gel (Sterify Gel®) as an adjunct to standard non-surgical therapy for peri-implantitis. Peri-implantitis is an inflammatory disease that affects the tissues around dental implants and can lead to bone loss and implant failure. The goal of the study is to determine whether the application of Sterify Gel®, which contains polyvinyl polymers, hydroxytyrosol, magnesium ascorbyl phosphate, and nisin, can improve clinical outcomes when used in addition to conventional mechanical debridement and air-polishing.\n\nThe trial will include 20 patients, each with at least two implants in different quadrants affected by peri-implantitis. One implant will be treated with standard therapy plus the gel (test site), while the other will receive standard therapy alone (control site). Clinical outcomes will be measured over a 9-month period, including plaque levels, bleeding on probing, probing depth, suppuration, and bone loss. The results will help assess whether this gel enhances the effectiveness of routine non-surgical peri-implantitis treatment.",[235,27,236],"Peri-implantitis","Non-surgical Periodontal Therapy",[235,95,238,239,240,241,242,243,244],"Bioactive gel","Sterify Gel","Non-surgical therapy","Split-mouth design","Oral biofilm","Mechanical debridement","Randomized controlled trial","2025-08-17",{"date":247,"type":41},"2025-08-22",{"date":249,"type":41},"2025-07-30",{"date":251,"type":21},"2026-05-30",{"name":253,"class":48},"University of Pavia",{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":4,"eligibilityCriteria":260,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":261,"enrollmentInfo":262,"targetDuration":4,"studyType":176,"phases":4,"briefSummary":264,"conditions":265,"keywords":266,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":49},"100477729","clinical-and-radiographic-evaluation-of-dentsply-sirona-primetaper-implants-100477729","NCT05500755","Clinical and Radiographic Evaluation of Dentsply Sirona PrimeTaper Implants","Clinical and Radiographic Evaluation of Dentsply Sirona PrimeTaper Implants: A Prospective Medium Term Study","Inclusion Criteria:\n\n* All the patients whom received at least one DS Prime Taper implant.\n\nExclusion Criteria:\n\n* When dental implant surgery is contraindicated.","99 Years",{"count":263,"type":21},150,"The DS Prime Taper EV dental implant system was recently launched on the implant market by Dentsply Sirona (York, PA, USA).\n\nDental implant systems are undergoing rapid evolution, ultimately driven by their broad therapeutic indications. As manufacturers strive to keep up with the demands of a growing market, designs are changing faster than clinical evaluation. This means that the time needed to assess medium- and long-term clinical outcomes before designs change again cannot be met.\n\nClinicians need to have a \"real\" analysis of the clinical performance of implants before using them. Therefore, reporting of results is necessary to avoid use in patients without proper practical checks even before the recommended 10- and 15-year follow-up periods.",[27],[267,268,269],"Dental implant","Complication","DS Prime Taper","2025-08-16",{"date":272,"type":41},"2025-08-19",{"date":274,"type":41},"2022-07-29",{"date":276,"type":21},"2026-12-31",{"name":193,"class":48},{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":285,"targetDuration":4,"studyType":22,"phases":287,"briefSummary":288,"conditions":289,"keywords":290,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":49},"100598569","single-implant-crowns-supported-by-narrow-or-standard-diameter-implants-in-molar-sites-100598569","NCT07073196","Single Implant Crowns Supported by Narrow or Standard Diameter Implants in Molar Sites","Single Implant Crowns Supported by Narrow or Standard Diameter Implants in Molar Sites: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged ≥ 18 years.\n* Require replacement of single missing molar tooth with dental implant in fully healed sites.\n* Controlled oral hygiene (full-mouth plaque and bleeding scores ≤ 25% at baseline).\n* Intact adjacent teeth and opposing dentition.\n* Fully healed sites (≥ 6 months) with limited bone availability in the horizontal bucco-lingual dimension (residual bone width of ≤ 6 mm) and minimal height of 8 mm.\n* Good compliance and commitment to attend follow-up review appointments.\n* Willing to provide informed consent.\n\nExclusion Criteria:\n\n* Localized\u002Fgeneralized periodontitis.\n* Any medical condition that may contraindicate implant treatment (Bornstein et al., 2009).\n* Bone metabolic disease and\u002For taking medications that affect bone metabolism.\n* Long term use of non-steroidal anti-inflammatory medications.\n* History of malignancy, radiotherapy or chemotherapy.\n* Pregnant or lactating women.\n* Smokers.\n* Severe bruxism or parafunctional habits.\n* Large occlusal discrepancies.",{"count":286,"type":21},40,[24],"Standard dental implants require sufficient bone and spacing, which may not be available in all patients. To address these limitations, narrow diameter implants (≤3.5 mm) have been introduced as a less invasive alternative, especially useful for medically compromised patients or those avoiding bone grafts. However, narrow implants made of pure titanium have shown long-term biological and technical concerns.\n\nThe introduction of titanium-zirconium (TiZr) alloy has improved mechanical strength, and several studies have demonstrated favorable outcomes with narrow TiZr implants. Yet, evidence remains limited regarding their exclusive use in high-load posterior (molar) regions. Prior studies report conflicting failure rates, potentially linked to prosthetic design and occlusal forces, but lack quantitative analysis of bite forces or prosthetic angles.\n\nEmergence angle, prosthetic platform width, and implant-abutment connection may all influence implant stability and peri-implant tissue health. A newly introduced TorcFit™ connection may offer better stress distribution and torque resistance, but its clinical relevance-especially in narrow implants used for molars-remains untested.",[27],[95],"2025-07-09",{"date":293,"type":41},"2025-07-18",{"date":295,"type":21},"2025-10-01",{"date":297,"type":21},"2029-12-01",{"name":299,"class":48},"Mohammed Bin Rashid University of Medicine and Health Sciences",{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":307,"targetDuration":4,"studyType":22,"phases":309,"briefSummary":310,"conditions":311,"keywords":312,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":194},"100589903","study-evaluating-the-performance-and-safety-in-the-medium-and-long-term-of-global-d-zygofixu-system-100589903","NCT06960460","Study Evaluating the Performance and Safety in the Medium and Long Term of Global D ZygoFixU System","Prospective, Multicenter, European Clinical Investigation Evaluating the Short and Medium-term Performance and Safety of the Global D ZygoFixU Implant-prosthetic System","Inclusion Criteria:\n\n* Adult male or female patient,\n* Patient whose growth and development of the maxillary bone is complete according to the investigator's judgement,\n* Partially or completely edentulous patient,\n* Patient with advanced maxillary atrophy (grades IV, V and VI according to the Cawood and Howell classification if used),\n* Patient requiring implant treatment with Global D zygomatic implants (placement of two or four implants),\n* Patient with acceptable oral opening (\\>3 cm measured anteriorly),\n* Patient able to read, understand and answer the quality-of-life questionnaire of the investigation and able to give consent,\n* Patient agreeing to comply with the protocol design and to send his\u002Fher follow-up data, even in the event of a move,\n* Patient having signed the consent form,\n* In France, patient affiliated to a social security scheme.\n\nExclusion Criteria:\n\n* Patient's state of health at enrolment:\n\n  * General contraindications to implant surgery\n  * Patient with zygomatic bone disease\n  * Patient with untreated periodontal disease\n  * Patient with acute or chronic infection in the implant placement area, or systemic infection, including acute or chronic maxillary sinusitis\n  * Patient with acute or chronic inflammation in the implant placement area, or systemic inflammation,\n  * Patient with uncontrolled diabetes (unstable blood glucose)\n  * Patient with immunodeficiencies or using immunosuppressants\n  * Patient who received radiation of more than +70 Gy to the head and neck region\n  * Patient using intravenous aminobisphosphonates within 5 years prior to surgery\n* Patient who are smokers (\\>10 cigarettes\u002Fday) or with alcohol or drug addiction\n* Person placed under legal protection (this includes guardianship, curatorship and legal protection).\n* Pregnant or breastfeeding women",{"count":308,"type":21},99,[24],"Global D has developed an zygomatic implant prosthetic system (ZygoFixU range): zygomatic implants, prosthetic parts and associated instruments. These devices have a design similar to other zygomatic implants on the market and are therefore not innovative. These non-CE marked devices are assessed during investigation 2302-G-ZYGO-C for their performance and for their short- and medium-term safety. These implants will be placed using specific instruments, by oral or cranio-maxillofacial surgeons with significant experience in the placement of zygomatic implants and trained in clinical research.",[27],[313,314,315,316],"dental implant","survival rate","zygomatic","performance","2025-07-01",{"date":319,"type":41},"2025-07-02",{"date":321,"type":41},"2025-04-10",{"date":323,"type":21},"2031-12-31",{"name":325,"class":221},"Global D",{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":333,"targetDuration":4,"studyType":22,"phases":335,"briefSummary":336,"conditions":337,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":338,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":49},"100578250","variable-thread-versus-standard-dental-implants-for-replacing-missing-teeth-100578250","NCT06808854","Variable-thread Versus Standard Dental Implants for Replacing Missing Teeth","Variable-thread Versus Standard Dental Implants for Replacing Missing Teeth: a Randomized Controlled Trial","Inclusion criteria\n\n* Aged more than 18 years.\n* Good general health (ASA I or II, according to the American Academy of Anesthesiology).\n* Require replacement of a posterior single missing tooth with a dental implant.\n* Controlled oral hygiene (full-mouth plaque and bleeding scores ≤ 25% at baseline.\n* Good compliance and commitment to attend follow-up review appointments.\n* Willing to provide informed consent. Exclusion criteria\n* A healing period of less than four months postextraction at implant site.\n* Localized\u002Fgeneralized periodontitis.\n* Bone metabolic disease and\u002For taking medications that affect bone metabolism.\n* Long term use of non-steroidal anti-inflammatory medications.\n* History of malignancy, radiotherapy or chemotherapy.\n* Pregnant or lactating women.\n* Severe bruxism or parafunctional habits.\n* Large occlusal discrepancies.\n* Smokers.",{"count":334,"type":21},24,[24],"Background and objectives:\n\nPrimary and secondary implant stability remain the most relevant and reliable clinical indicator for long-term survival of dental implants. Hence modifications of surface characteristics and implant macro-designs were introduced over the last two decades to enhance osseointegration during the initial phase of healing. In this context, a variable-thread self-cutting implant design was recently introduced to improve primary stability. At present, there are limited number of studies that evaluated this variable-thread implant design. These studies were mostly experimental, of short duration and limited number of participants. Therefore, the aim of the present randomized controlled trial is to compare two implant designs (variable-thread versus standard) in terms of clinical, radiographic and patient-reported outcomes.\n\nMethods:\n\nA total of 24 participants, who require replacement of a posterior single tooth with dental implant, will be randomly allocated to two equal sized groups. In the test group, the participants will receive variable-thread implants, while standard implants will be placed to replace missing teeth in the control group. In addition to evaluating implant stability, the trial will also report on clinical and radiographic implant outcomes at various time points.",[27],{"date":317,"type":41},{"date":340,"type":21},"2025-08-01",{"date":342,"type":21},"2027-11-01",{"name":299,"class":48},{"id":345,"slug":346,"hasResults":11,"nctId":347,"briefTitle":348,"officialTitle":349,"acronym":4,"eligibilityCriteria":350,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":351,"targetDuration":4,"studyType":176,"phases":4,"briefSummary":353,"conditions":354,"keywords":355,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":364},"100436259","study-evaluating-the-performance-and-safety-in-the-medium-and-long-term-of-global-d-implant-prosthetic-systems-100436259","NCT04960904","Study Evaluating the Performance and Safety in the Medium and Long Term of Global D Implant-prosthetic Systems","Study Evaluating the Performance and Safety in the Medium and Long Term of Implant-prosthetic Systems Including Ranges of Dental Implants and Prosthetic Components Global D: In-Kone® U,In-Kone® P,twinKon®,EVL® S,EVL® K,EVL® C","Inclusion Criteria:\n\n* Male or female\n* Major (s) at the time of the implantation\n* Having needed implant surgery with one or more Global D devices:\n* between October 1, 2013 - June 30, 2015 for EVL® S, EVL® K and EVL® C, In-Kone® UNIVERSAL and In-Kone® PRIMO implants\n* between January 1, 2013 - June 30, 2015 for twinKon® implants\n* Affiliated or benefiting from French Social Security\n* Not opposing the use of their data\n* Having carried out his annual follow-up visit at 5, 7\u002F8 and 10 years or any other visit motivated by the removal of the implant during the 10 years\n\nExclusion Criteria:\n\n* Patient unable to understand information related to his\u002Fher participation in the study\n* Deceased patient, date of death after the date of implantation",{"count":352,"type":21},514,"This study is set up within the framework of the European Union regulation 2017\u002F745 on medical devices. Its objective is to confirm the performance and safety in the medium and long term of implant-prosthetic systems including Global D dental implants: In-Kone® UNIVERSAL, In-Kone® PRIMO, twinKon®, EVL® S, EVL® K and EVL® C.",[27],[313,314,316],"2025-03-27",{"date":358,"type":41},"2025-04-02",{"date":360,"type":41},"2019-11-12",{"date":362,"type":21},"2026-01-31",{"name":325,"class":221},2,{"id":366,"slug":367,"hasResults":11,"nctId":368,"briefTitle":369,"officialTitle":370,"acronym":4,"eligibilityCriteria":371,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":372,"targetDuration":4,"studyType":176,"phases":4,"briefSummary":373,"conditions":374,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":381,"locationsCount":4},"100577559","rfa-r-evolution-a-new-protocol-to-avoid-implant-failure-100577559","NCT06799871","RFA R-Evolution: a New Protocol to Avoid Implant Failure","Retrospective Single Cohort Mono-center Study on Trends in Implant Stability Measured by RFA","Inclusion Criteria:\n\n* Participant received implant treatment NobelReplace, NobelActive or NobelParallel implants on or after October 2021 (with TiUnite or TiUltra surfaces)\n* Participant was at least 18 years old at the time of surgery\n* Participant attended a follow-up visit at least 1-year after surgery\n* Implant stability was assessed by means of RFA at a minimum of three time-points\n\nExclusion Criteria:\n\n* 1-year follow-up data not available\n* Subject received major guided bone regeneration",{"count":175,"type":21},"The main objective of this study is to assess the impact of confounding factors such as jaw, implant position, indication, smoking status, implant dimension, and medical history on RFA trends. In addition, this study aims to explore correlations of RFA trend, with the goal of using ISQ trends as an indicator for treatment protocol decisions (e.g. time of loading). Participants have already received dental implant as per clinic's standard protocol. Information regarding Implant Stability Quotient (ISQ) measurements performed at any time point until 1-year follow-up will be collected. The principal investigator protocol regarding the use of ISQ measure to define time of implant loading will also be assessed. Only participants followed up at least until one year after implant placement will be included in the data collection.",[27],"2025-01-28",{"date":377,"type":41},"2025-01-29",{"date":379,"type":21},"2025-01",{"date":161,"type":21},{"name":382,"class":48},"Daniele Moretto",{"id":384,"slug":385,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":4,"eligibilityCriteria":389,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":390,"enrollmentInfo":391,"targetDuration":4,"studyType":22,"phases":392,"briefSummary":393,"conditions":394,"keywords":395,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":405,"locationsCount":49},"100556455","comparision-of-clinical-efficacy-of-immediate-implants-with-t-prf-and-bone-graft-versus-prf-and-bone-graft-100556455","NCT06525324","Comparision of Clinical Efficacy of Immediate Implants With T-PRF and Bone-graft Versus PRF and Bone-graft","Comparing The Effectiveness Of T-PRF And PRF With Bone-Graft[DMBM]TM Around Immediate Implants - A RANDOMISED CONTROL TRIAL","Inclusion Criteria:\n\n1. Patients between 18-55 years of age.\n2. Presence of non-restorable teeth (maxillary or mandibular) due to trauma, decayed, mobility, root resorption, root stumps, root fracture, over retained deciduous tooth, endodontic or periodontal failure in whom immediate implants can be placed.\n3. Good oral hygiene.\n4. Good patient compliance.\n5. Class I extraction socket defects according to modified Elian et al 2021.\n\nExclusion Criteria:\n\n1. Systemic complications (uncontrolled diabetes and severe cardiovascular or infectious diseases).\n2. Intravenous and oral bisphosphonate therapy.\n3. Patients who are psychologically unable to participate.\n4. Pregnant and lactating participants with bone diseases\n5. Patients on chemotherapy or radiotherapy\n6. Alcohol or drug abuse.","55 Years",{"count":231,"type":21},[24],"The normal architecture of the alveolar process is altered by periodontitis, which also causes the loss of alveolar bone surrounding the teeth. Untreated periodontitis may cause teeth to become mobile and leads to loss of teeth.\n\nIn such cases, one of the treatment modalities is extraction of the tooth and placement of immediate implant which reduces the waiting period. And due to the resorption of alveolar ridge the bone graft will be used along with T-PRF and PRF.\n\nSo this study aims at the placement of immediate implants along with T-PRF with bone graft and PRF with bone graft.",[27],[396,397],"PRF with bone graft","T-PRF with bone graft","2024-07-24",{"date":400,"type":41},"2024-07-29",{"date":402,"type":21},"2024-08",{"date":404,"type":21},"2025-10",{"name":406,"class":48},"Krishnadevaraya College of Dental Sciences & Hospital",{"id":408,"slug":409,"hasResults":11,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":4,"eligibilityCriteria":413,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":414,"enrollmentInfo":415,"targetDuration":4,"studyType":22,"phases":417,"briefSummary":418,"conditions":419,"keywords":420,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":4},"100555971","evaluation-of-soft-and-hard-tissue-healing-and-implant-stability-of-hydrophilic-versus-conventional-titanium-dental-implants-100555971","NCT06519019","Evaluation of Soft and Hard Tissue Healing and Implant Stability Of Hydrophilic Versus Conventional Titanium Dental Implants.","Comparative Evaluation of Soft and Hard Tissue Healing and Implant Stability Of Hydrophilic Versus Conventional Titanium Dental Implants - A Randomized Clinical Trial.","Inclusion Criteria:\n\n1. At least above 18 years of age.\n2. Patients who needs replacement of two or more teeth in mandible.\n3. Adequate bone volume to accommodate planned dental implants.\n\nExclusion Criteria:\n\n1. General contraindication to dental implant treatment. (Uncontrolled diabetes and severe cardiovascular or infectious diseases).\n2. Intravenous and oral bisphosphonate therapy.\n3. Presence of severe, moderate or mild untreated periodontal disease.\n4. Unwillingness to return for the follow-up examination.\n5. Smokers.\n6. Patients who are psychologically unable to participate.\n7. Poor oral hygiene.","75 Years",{"count":416,"type":21},10,[24],"Dental implants have become more common treatment for replacing missing teeth and aim to improve chewing efficiency, physical health and esthetic. Researchers always tried to improve design, mechanical and chemical properties of implant. Major benefit of surface modification are to improve hydrophilicity, cell to implant adhesion and cell proliferation. These modification improve osseointegration and reduce treatment duration. In this study investigators are evaluating healing capacity of hydrophilic implant compared to conventional implant.",[27],[27],"2024-07-19",{"date":423,"type":41},"2024-07-25",{"date":425,"type":21},"2024-07",{"date":427,"type":21},"2025-08",{"name":406,"class":48},{"id":430,"slug":431,"hasResults":11,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":435,"eligibilityCriteria":436,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":437,"enrollmentInfo":438,"targetDuration":4,"studyType":22,"phases":439,"briefSummary":440,"conditions":441,"keywords":443,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":49},"100550616","the-application-of-root-analogy-implant-in-immediate-implantation-100550616","NCT06449391","The Application of Root Analogy Implant in Immediate Implantation","A Clinical Exploratory Study of Root Analogy Implant","RAI","Inclusion Criteria:\n\n* Age:20-60 years old, gender unlimited\n* Good oral hygiene\n* No systemic diseases\n* There are irreparable residual roots, no obvious apical periodontitis, no looseness greater than degree II, and the tooth position includes four quadrant anterior teeth and premolars\n* Root length greater than 10 mm, and no significant bone resorption at the alveolar crest\n* There is no significant displacement of adjacent teeth and no significant elongation of opposing teeth\n* The bone density of the target implant area is Class II and Class III\n* The lateral bone wall of the lips (cheeks), palate (tongue) is intact and larger than 1mm\n* The subjects are able to understand the purpose of the experiment, willing to -cooperate with surgical treatment and follow-up, voluntarily participate in the experiment, and sign an informed consent form.\n\nExclusion Criteria:\n\n* Patients with moderate to severe periodontitis\n* Missing proximal and distal adjacent teeth in the target residual root\n* Residual roots with root adhesion\n* The target implant area has a bone density of Class I or IV\n* Acute infectious disease or metabolic bone disease activity period\n* Patients with diabetes history and poor blood glucose control (fasting blood glucose ≥ 8.8 mmol\u002FL L)\n* Patients with liver and kidney dysfunction (AST, ALT ≥ 1.5 times ULNULN, creatinine ≥ 1.5 times ULNULN)\n* Individuals with a history of osteoporosis\n* Individuals with a history of malignant tumors or other serious illnesses who are not suitable for surgery\n* Individuals with mental disorders and lack of autonomous behavior ability Pregnant women, lactating or menstruating women, and women with pregnancy plans within six months\n* Various possible causes of imaging artifacts in the surgical area\n* Receiving medication that may affect bone metabolism (such as bisphosphonates) within the past 3 months\n* The researchers estimate poor compliance or other factors that are not suitable for conducting this experiment.","60 Years",{"count":416,"type":21},[24],"The current clinical implant techniques used include immediate implantation, early implantation, and delayed implantation. With the acceleration of the current pace of life, immediate implantation is increasingly favored by patients due to its advantages such as fewer surgeries, shorter waiting times, and less impact on aesthetics. The research group has shown that the mismatch between traditional implants and extraction sockets in immediate implantation surgery has caused some complications. Therefore, it is believed that 3D printed personalized root shaped implants with certain roughness are more suitable for use in immediate implantation surgery.",[442,27,29],"Dental Implantation",[444,445],"root analogy implant","Immediate implantation","2024-06-06",{"date":448,"type":41},"2024-06-10",{"date":450,"type":41},"2024-04-01",{"date":452,"type":21},"2026-06-30",{"name":454,"class":48},"The Dental Hospital of Zhejiang University School of Medicine",{"id":456,"slug":457,"hasResults":11,"nctId":458,"briefTitle":459,"officialTitle":460,"acronym":4,"eligibilityCriteria":461,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":145,"enrollmentInfo":462,"targetDuration":4,"studyType":22,"phases":464,"briefSummary":465,"conditions":466,"keywords":467,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":473,"lastUpdatePostDateStruct":474,"startDateStruct":476,"completionDateStruct":478,"leadSponsor":480,"locationsCount":49},"100515250","peek-versus-titanium-customized-healing-abutments-100515250","NCT05989061","PEEK Versus Titanium Customized Healing Abutments","PEEK Versus Titanium Customized Healing Abutments: Evaluation of Peri-implant Soft Tissues and Sulcus Fluid Bacterial Load","Inclusion Criteria:\n\n1. Patients should be systematically free from any disease as according to Cornell Medical Index-Health Questionnaire .\n2. Both genders.\n3. Age from 20-50 years.\n4. Missing tooth in esthetic zone (Anterior\u002FPremolar) to be restored with standard implant, with no need for additional bone and soft tissue augmentation procedures.\n5. Implants primary stability ISQ ≥ 70 unites using the Osstell Mentor\n6. BuccoLingual bone width ≥ 6 mm.\n7. Mesio distal space ≥ 7 mm\n8. Sound Mesial and distal neighboring teeth.\n9. At least 6 natural teeth remaining in the same arch .\n10. Mouth opening ≥ 30mm.\n11. Enough keratinized mucosa.\n12. Thick phenotype.\n\nExclusion Criteria:\n\n1. Poor oral hygiene condition.\n2. Pregnant and lactating females.\n3. Smokers.",{"count":463,"type":21},26,[24],"The study suggests that if the investigators used customized healing abutments synthesized from PEEK may have a favorable effect on peri-implant soft tissues regarding decreased plaque accumulation and healing stimulation compared to the customized conventional titanium healing abutments.",[27],[468,469,470,95,471,472],"Customized Healing Abutment","PEEK","Peri-implant soft tissue","Titanium","Esthetic Zone","2024-06-03",{"date":475,"type":41},"2024-06-04",{"date":477,"type":41},"2023-09-01",{"date":479,"type":21},"2024-10",{"name":481,"class":48},"Ain Shams University",{"id":483,"slug":484,"hasResults":11,"nctId":485,"briefTitle":486,"officialTitle":487,"acronym":488,"eligibilityCriteria":489,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":490,"targetDuration":4,"studyType":22,"phases":492,"briefSummary":493,"conditions":494,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":364},"100464375","5-year-follow-up-study-on-the-comparative-performance-of-two-piece-zirconia-and-titanium-implants-100464375","NCT05326880","5-year Follow up Study on the Comparative Performance of Two-piece Zirconia and Titanium Implants","Comparative Performance of Two-piece Zirconia Tissue Level Implants vs. Titanium Bone Level Implants Placed With a Fully Digital Workflow - 5-year Follow up of a Randomized Clinical Trial","PostNCT0390817","Inclusion Criteria:\n\nfollowing criteria must be met for inclusion in the study:\n\n* Patients must have voluntarily signed the Informed Consent Form before any study related procedures are performed, are willing and able to attend scheduled follow-up visits and agree that the pseudonymized data will be collected, analyzed, and published.\n* Patients must be males or females who are a minimum of 18 years of age.\n* Patients, who have received a single tooth replacement with a study implant as per-protocol in the premolar-to-premolar area (excluding lower incisors) in the mandible and maxilla and restored with a screw retained ceramic crown.\n\nExclusion Criteria:\n\n* Patients with conditions or circumstances, in the opinion of the Investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance or unreliability.\n* Pregnancy or intention to become pregnant at any point during the study duration.",{"count":491,"type":21},60,[24],"A post-market, randomized-controlled, superiority clinical study to compare medium-term performance and safety of the Straumann PURE 2-piece Ceramic Implant with Straumann Bone Level Implant using a fully digital workflow.",[27,495,496],"Single Tooth Lost","Dental Implant Failed","2023-11-19",{"date":499,"type":41},"2023-11-21",{"date":501,"type":41},"2022-01-03",{"date":503,"type":21},"2028-03",{"name":505,"class":48},"The University of Hong Kong"]