[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-pain":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,54,87,113,141,167,196,225,253,284,312,341,365],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100644795","local-dexamethasone-administration-in-symptomatic-irreversible-pulpitis-100644795",false,"NCT07672873","Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis","Comparison of the Effects of Submucosal and Intraligamentary Dexamethasone Administration on Anesthetic Success and Pain Control in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial","SIPDEX","Inclusion Criteria:\n\n* Patients aged 18 to 65 years.\n* ASA I or ASA II systemic health status.\n* Symptomatic irreversible pulpitis in a mandibular molar tooth.\n* Positive response to pulp sensibility tests.\n* Preoperative pain score greater than 54 mm on the Heft-Parker Visual Analog Scale (HP-VAS).\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Pregnancy or lactation.\n* Allergy or contraindication to articaine, dexamethasone, or study-related medications.\n* Use of analgesics, anti-inflammatory drugs, or antibiotics within the previous 12 hours.\n* Presence of periapical radiolucency or diagnosis of pulpal necrosis.\n* Significant systemic disease (ASA III or higher).\n* Inability to complete pain assessment forms or follow study procedures.",true,"ALL","18 Years","65 Years",{"count":22,"type":23},84,"ESTIMATED","INTERVENTIONAL",[26],"NA","Symptomatic irreversible pulpitis is associated with a high incidence of inadequate pulpal anesthesia during endodontic treatment, particularly in mandibular molar teeth. Failure to achieve profound anesthesia may result in increased intraoperative pain and patient discomfort. Corticosteroids have been suggested as adjunctive agents to improve pain control and reduce inflammatory responses; however, the influence of different local administration techniques on anesthetic success and postoperative pain remains unclear.\n\nThe aim of this randomized controlled clinical trial is to compare the effects of submucosal and intraligamentary dexamethasone administration on anesthetic success and pain control in patients with symptomatic irreversible pulpitis. A total of 84 participants requiring root canal treatment of mandibular first or second molars diagnosed with symptomatic irreversible pulpitis will be randomly allocated to one of three groups: (1) inferior alveolar nerve block (IANB) followed by submucosal saline injection (control group), (2) IANB followed by submucosal dexamethasone injection, and (3) IANB followed by intraligamentary dexamethasone injection.\n\nAll participants will receive standardized endodontic treatment under local anesthesia. The primary outcome measure is anesthetic success during access cavity preparation and pulp extirpation. Secondary outcome measures include postoperative pain intensity at 6, 12, 24, 48, and 72 hours, and postoperative analgesic consumption. The results of this study may provide evidence regarding the effectiveness of different local dexamethasone administration techniques and contribute to improved pain management strategies in endodontic practice.",[29,30],"Symptomatic Irreversible Pulpitis (SIP)","Dental Pain",[32,33,34,35,36,37,38,39,40],"Inferior alveolar nerve block","Dexamethasone","Submucosal injection","Intraligamentary injection","Symptomatic irreversible pulpitis","Endodontic treatment","Postoperative pain","Heft-Parker Visual Analog Scale","HP-VAS","RECRUITING","2026-06-26",{"date":44,"type":45},"2026-06-29","ACTUAL",{"date":47,"type":45},"2026-06-15",{"date":49,"type":23},"2026-12-18",{"name":51,"class":52},"Marmara University","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":17,"sex":18,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":24,"phases":65,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":4},"100643491","kaleidoscope-compared-to-tell-show-do-for-reducing-children-pain-and-anxiety-during-pulp-therapy-100643491","NCT07595731","Kaleidoscope Compared to Tell-Show-Do for Reducing Children Pain and Anxiety During Pulp Therapy","Comparative Evaluation of Kaleidoscope Versus Tell-Show Do in Management of Dental Pain and Anxiety In Children Undergoing Pulp Therapy: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Children aged between 4-6 years old.\n* Healthy with no systemic illness or allergies.\n* Indicated for pulp therapy in their lower primary molar.\n* Parents who agree to sign informed consent.\n\nExclusion Criteria:\n\n* Children with systemic or mental disorders.\n* Children without parental consent.\n* Children complaining of acute dental pain.\n* Children receiving analgesics within the last 48 hours.","4 Years","6 Years",{"count":64,"type":23},39,[26],"The goal of this clinical trial is to investigate if Kaleidoscope glasses help children feel less pain and worry during dental work. It will also explore if these glasses help children feel more comfortable with the dentist.\n\nKaleidoscope glasses are special glasses show bright, colorful shapes. The patterns change every time the child moves their head. This helps keep the child's mind off the dental work.\n\nThe main questions it aims to answer are:\n\nDo the glasses lower a child's pain during a numbing shot and tooth treatment?\n\nDo the glasses help a child feel less anxious during the visit?\n\nResearchers will compare the glasses to a method called \"Tell-Show-Do\" to see which works best. \"Tell-Show-Do\" is when a dentist explains and shows tools before using them.\n\nParticipants will:\n\nGet a nerve treatment (a \"baby root canal\") on a bottom baby tooth.\n\nWear the Kaleidoscope glasses, have the researcher use \"Tell-Show-Do,\" or do both.\n\nHave their pulse and pain levels checked before, during, and after the visit.\n\nTo keep the study fair, the child will be put into 1 of 3 groups by picking a sealed random envelope.\n\nThe groups are:\n\nGroup 1: The child wears Kaleidoscope glasses (the special glasses).\n\nGroup 2: The child wears Kaleidoscope glasses and the operator uses the \"Tell-Show-Do\" method during the visit with the child.\n\nGroup 3: The operator uses the \"Tell-Show-Do\" method during the visit with the child only.\n\nThis study helps make the dental visit easier and more comfortable for children. It aims to:\n\nLower pain during the tooth treatment. Help children feel less afraid of the dentist. Make children more willing to get the care they need. The research also helps dentists give better care by building trust with their young participants.\n\nRisks:\n\nThere are no serious risks in this study. In rare cases, a child may not want to wear the special glasses. If this happens, the researcher will stop using the glasses but will still finish the tooth treatment.",[68,30],"Dental Anxiety in Children",[70,71,72,73,74,75,76],"managing dental pain in children","dental pain","dental pain in children","children anxiety","dental anxiety in children","behavior management","dental distraction","NOT_YET_RECRUITING","2026-06-05",{"date":80,"type":45},"2026-06-08",{"date":82,"type":23},"2026-06",{"date":84,"type":23},"2027-05",{"name":86,"class":52},"Cairo University",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":17,"sex":18,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":24,"phases":98,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":53},"100641187","comparing-obturation-using-bioceramic-nano-coated-gutta-percha-with-bioceramic-sealer-versus-traditional-gutta-percha-with-resin-sealer-for-reducing-postoperative-pain-and-swelling-after-root-canal-treatment-in-necrotic-single-rooted-teeth-100641187","NCT07600099","Comparing Obturation Using Bioceramic Nano-coated Gutta-percha With Bioceramic Sealer Versus Traditional Gutta-percha With Resin Sealer for Reducing Postoperative Pain and Swelling After Root Canal Treatment in Necrotic Single-rooted Teeth.","Comparative Evaluation of Obturation Using Bioceramic Nano-coated Gutta-percha and Bioceramic-based Sealer Versus Gutta-percha and Resin-based Sealer on Postoperative Pain and Swelling: A Randomized Clinical Trial.","Inclusion Criteria:\n\nPatients aged 20-55 years. Patients with good oral hygiene, free of calculus, and with a probing depth not exceeding 2-3 mm.\n\nNecrotic single-rooted, single-canal permanent teeth with or without periapical lesions. If lesion is present, ranging from 2-5 mm in size.\n\nAbsence of swelling. Medically free patients.\n\nExclusion Criteria:\n\nPatients with poor oral hygiene. Vital teeth. Necrotic teeth without periapical lesions. Primary teeth. Complex root morphology other than Type I. Internal or external root resorption. Vertical root fractures. Cracked teeth. Intraoral or extraoral swelling.","20 Years","55 Years",{"count":97,"type":23},30,[26],"A randomized clinical trial will compare two root canal filling approaches in necrotic single-rooted teeth. The test group will receive bioceramic mono-block obturation using bioceramic nano-coated gutta-percha with a bioceramic sealer, while the control group will receive traditional gutta-percha with a resin-based sealer. The main aim is to determine whether the bioceramic system can reduce postoperative pain and swelling within 48 hours after treatment compared with the conventional method. Patients aged 20-55 years who have necrotic single-rooted teeth and meet specific clinical and radiographic criteria will be recruited from the outpatient clinics of the Faculty of Dentistry, Cairo University.\n\nPostoperative pain will be measured using a visual analogue scale, and swelling will be assessed using a standardized swelling score at 24 and 48 hours. The study hypothesizes that the bioceramic mono-block technique, due to its improved sealing ability and bioactivity, may lead to less postoperative discomfort and better early clinical outcomes than the gold-standard resin-sealer technique. The findings are expected to provide evidence to guide clinicians on whether adopting bioceramic nano-enhanced obturation can improve patient-centered outcomes after root canal treatment.",[30,101],"Facial Swelling",[103,104],"bioceramic","monoblock","2026-05-18",{"date":107,"type":45},"2026-05-20",{"date":109,"type":23},"2026-09-01",{"date":111,"type":23},"2027-09-30",{"name":86,"class":52},{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":122,"conditions":123,"keywords":131,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":134,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":53},"100588957","exploration-of-the-utility-of-dental-dedicated-mri-for-dentistry-100588957","NCT06948162","Exploration of the Utility of Dental-dedicated MRI for Dentistry","Inclusion Criteria:\n\n1. Patient Age: 18 years old or older\n2. Receiving imaging for routine dental care\n3. Does not have a serious medical condition\n4. Is not pregnant or is not potentially pregnant\n5. Is willing and able to give consent in English\n6. Has the ability to manage their own calendar and schedule appointments\n7. Willing to have a separate 2-hour appointment to have an MRI\n\nExclusion Criteria:\n\n1. Unable to consent to participant in English\n2. Serious health condition, which includes but not limited to renal failure\u002Fon dialysis, unstable heart disease (uncontrolled arrhythmia, cardiomyopathy and\u002For unable to lay flat, within 1 month of cardiac catheterization or myocardial infarction), unstable cerebral vascular disease (within 1 month of stroke and\u002For stent placement), diabetes (type I or II) not controlled by medication or diet, uncontrolled seizures, uncontrolled hyperthyroidism, non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema), uncontrolled movement disorder, and liver failure\n3. Pregnant and\u002For intending to become pregnant,\n4. Prisoner and\u002For not able to manage their own scheduling\n5. Screen positive on MR safety questionnaire, specifically including people that have worked with or otherwise been exposure to metal particles and have the potential for such particles to be embed within them.",{"count":120,"type":23},300,"OBSERVATIONAL","This description observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images. The standard clinical dental images consist of radiographs, such as bitewings, periapical, panoramic, cone-beam CT, and medical CT, as well medical MRIs of the temporomandibular joints (TMJ).The conceptualization of research questions, study designing, and interpretation of imaging data has and will involve content expertise in all ddMRI research.",[124,125,30,126,127,128,129,130],"Dental Crowding","Dental Occlusion, Traumatic","TMD\u002FOrofacial Pain","TMD","Orthodontics","Endodontic Disease","Orthodontic Treatment",[132,133],"Diagnosis","Magnetic resounance imaging",{"date":107,"type":45},{"date":136,"type":45},"2025-03-14",{"date":138,"type":23},"2027-12-31",{"name":140,"class":52},"University of Minnesota",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":151,"conditions":152,"keywords":156,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":165,"locationsCount":53},"100627813","identification-of-possible-trigeminal-neuralgia-100627813","NCT07453511","Identification of Possible Trigeminal Neuralgia","Validating a Questionnaire for the Identification of Possible Trigeminal Neuralgia in Dental Practice","IDTN","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Attending the UCLH Facial Pain Service or Oral Surgery Clinic for their first appointment for facial or oral pain following referral from primary care\n\nExclusion Criteria:\n\n* Not experiencing facial or oral pain\n* Unable to understand English well enough to complete the questionnaire\n* Lacking capacity to provide informed consent\n* Insufficient time before their appointment to read the information sheet, provide consent, and complete the questionnaire",{"count":150,"type":23},250,"Trigeminal neuralgia (TN) is a severe type of non-dental orofacial pain that can feel like sudden electric shocks in the face and is often mistaken for tooth pain or other dental problems. This can lead to delays in referral and unnecessary, sometimes irreversible, dental treatment. The goal of this observational study is to evaluate how well a new questionnaire (IDentification of possible Trigeminal Neuralgia - IDTN) identifies adults with possible trigeminal neuralgia among patients attending hospital clinics with orofacial pain, with the aim of supporting its use in dental and general medical practice to improve early recognition and referral.\n\nThe main questions it aims to answer are:\n\n* How accurately does the IDTN questionnaire identify patients with possible trigeminal neuralgia compared with the specialist clinical diagnosis?\n* Which combination of questionnaire items best supports a practical screening score for use in dental and\u002For general medical practice?\n\nParticipants will:\n\n1. Complete the IDTN questionnaire before their clinical appointment (either electronically or on paper)\n2. Undergo their usual specialist clinical assessment, during which the final diagnosis will be recorded\n3. Allow the research team to compare questionnaire responses with the specialist diagnosis (the reference standard)\n\nA subset of participants will also be asked to complete the questionnaire again a few days later to assess test-retest reliability.",[153,154,30,155],"Trigeminal Neuralgia (TN)","Orofacial Pain","Questionnaire",[153,154,157,155,158],"Screening Tool","Dental pain","2026-03-18",{"date":161,"type":45},"2026-03-23",{"date":163,"type":23},"2026-04",{"date":84,"type":23},{"name":166,"class":52},"University College, London",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":17,"sex":18,"minAge":62,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":24,"phases":178,"briefSummary":179,"conditions":180,"keywords":183,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":4},"100627204","effect-of-play-dough-slime-and-plush-toys-on-dental-anxiety-and-pain-in-children-during-dental-treatment-100627204","NCT07445594","Effect of Play Dough, Slime, and Plush Toys on Dental Anxiety and Pain in Children During Dental Treatment","Evaluation of the Effectiveness of Play Dough, Slime, and Plush Toys on Dental Anxiety, Pain Perception, and Salivary Cortisol Levels in Children During Dental Treatment","PLAY-DENT","Inclusion Criteria:\n\n1. Children aged 6-10 years requiring restorative dental treatment.\n2. Indication for dental treatment under local anesthesia.\n3. Ability to understand and respond to dental anxiety and pain assessment scales (CFSS-DS and Wong-Baker Faces Scale).\n4. Children classified as ASA I or ASA II.\n5. No prior exposure to the distraction materials used in the study during dental treatment.\n6. Written informed consent obtained from parents or legal guardians.\n\nExclusion Criteria:\n\n1. Presence of systemic diseases or medical conditions affecting stress response or contraindicating routine dental treatment\n2. History of psychiatric, neurological, or developmental disorders that may impair cooperation or communication\n3. Use of medications influencing anxiety, pain perception, heart rate, or cortisol levels\n4. Requirement for sedation or general anesthesia for dental treatment\n5. Acute dental infection or emergency treatment requiring immediate intervention\n6. Refusal of participation by the child or parent\u002Flegal guardian","10 Years",{"count":177,"type":23},90,[26],"This study aims to evaluate the effectiveness of tactile distraction materials, including play dough, slime, and plush toys, on dental anxiety, pain perception, and physiological stress responses in children undergoing dental treatment. Ninety children aged 6-10 years receiving restorative dental treatment under local anesthesia were randomly assigned to one of four groups: play dough, slime, plush toy, or control group without distraction. Dental anxiety and pain levels were assessed using validated psychometric scales, while physiological stress responses were evaluated through heart rate monitoring and salivary cortisol measurements. The study seeks to determine whether simple non-pharmacological distraction techniques can improve behavioral cooperation and reduce anxiety and pain perception during pediatric dental procedures. Findings may contribute to the development of child-friendly dental management strategies and enhance the quality of pediatric dental care.",[181,30,182],"Dental Anxiety","Behavioral Management",[181,184,30,185,186],"Distraction Techniques","Behavior Management","Salivary Cortisol","2026-02-27",{"date":189,"type":45},"2026-03-03",{"date":191,"type":23},"2026-02-17",{"date":193,"type":23},"2026-06-01",{"name":195,"class":52},"Afyonkarahisar Health Sciences University",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":203,"minAge":19,"maxAge":204,"enrollmentInfo":205,"targetDuration":4,"studyType":24,"phases":207,"briefSummary":208,"conditions":209,"keywords":211,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":53},"100611355","a-randomized-controlled-trial-evaluating-whether-pre-operative-trinase-reduces-post-operative-pain-in-patients-with-symptomatic-irreversible-pulpitis-compared-to-placebo-using-vas-scores-and-analgesic-intake-over-48-hours-100611355","NCT07239505","A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours.","The Role Of Trinase In Reducing Post-Operative Pain For Patients With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Systemically healthy male patients (ASA I or II)\n* Aged 18 to 50 years\n* Presenting with symptomatic irreversible pulpitis in a restorable mandibular molar\n* Preoperative moderate to severe pain (VAS ≥45 mm)\n* Normal periapical tissue (no radiolucency, pocket depth ≤5 mm, mobility ≤ Grade I)\n\nExclusion Criteria:\n\nMedically compromised patients (ASA III or higher)\n\n* History of allergy or intolerance to Trinase or any of its components (trypsin, bromelain, rutin)\n* Vertical root fracture\n* External or internal root resorption\n* Periodontal pocket depth \\>5 mm\n* Tooth mobility Grade II or III\n* Presence of periapical lesion (radiolucency)\n* Female patients (to standardize pain perception and hormonal factors)","MALE","50 Years",{"count":206,"type":23},182,[26],"This study aims to determine whether Trinase, an enzyme-based anti-inflammatory medication, can reduce pain after root canal treatment in patients with symptomatic irreversible pulpitis. A total of 182 male patients aged 18 to 50 years who present with moderate to severe tooth pain will be randomly assigned to receive either a Trinase tablet or a placebo 30 minutes before treatment. All root canal procedures will be performed in a single visit using standard endodontic techniques.\n\nPain levels will be measured on a Visual Analogue Scale (VAS) before treatment and at 6, 12, 24, and 48 hours after treatment. Patients will also record the number of pain-relief tablets they take during the first 48 hours. The goal of the study is to see whether Trinase can lower post-operative pain and reduce the need for analgesic medication compared with placebo. This information may help improve pain management for patients undergoing root canal therapy.",[29,210,129,30],"Postoperative Pain After Endodontic Treatment",[212,213,214,215],"Visual Analogue Scale (VAS)","Randomized Controlled Trial","Trinase","Postoperative Pain","2025-11-27",{"date":218,"type":45},"2025-12-01",{"date":220,"type":45},"2025-08-01",{"date":222,"type":23},"2025-12-15",{"name":224,"class":52},"Fayoum University",{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":232,"targetDuration":4,"studyType":24,"phases":234,"briefSummary":236,"conditions":237,"keywords":238,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":53},"100610748","phase-4-anesthetic-effectiveness-of-lidocaine-versus-articaine-in-dentistry-100610748","NCT07231614","Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry","Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry. A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients with clinical indications for simple extraction of upper and lower teeth using infiltrative anesthetic techniques.\n* Patients without systemic diseases (ASA I)\n* Patients with controlled systemic disease (ASA II)\n* Patients with no history of hypersensitivity to anesthetics or their components (epinephrine)\n* Patients with stable periodontal condition, without active infection that could affect the diffusion of the anesthetic.\n* Patients with the ability to understand the procedure and provide informed consent.\n\nExclusion Criteria:\n\n* Patients with uncontrolled systemic diseases ASA III and pregnant patients.\n* Patients requiring trunk techniques (Gow gates, Spix, Carrea)\n* Patients taking medication that affects the anesthetic response (tricyclic antidepressants, anticoagulants)\n* Patients with a history of neurological or psychiatric disorders that may influence the perception of pain or anxiety.\n* Patients with anatomical abnormalities in the orofacial region that interfere with the administration or action of anesthesia.\n* Patients with a history of recent substance abuse.",{"count":233,"type":23},100,[235],"PHASE4","Context: Lidocaine and articaine are two of the most commonly used local anesthetics in dentistry. Lidocaine has often been the anesthetic of choice in clinical practice, but in clinical experience, articaine has proven to be more effective in controlling pain during dental procedures. (Camps-Font, O. et al. 2020).\n\nThere are still unanswered questions, such as which of the two local anesthetics is more effective in reducing pain? This could lead us to discuss which one to choose to reduce costs in the dental office.\n\nObjective: The objective of this project is to determine and compare the effectiveness of lidocaine and articaine in clinical contexts such as tooth extraction with infiltrative techniques, seeking to provide answers that will optimize the choice of anesthetic based on the patient and the procedure, thus improving pain management and reducing costs in the dental office.\n\nDesign: Randomized double-blind experimental study, parallel groups. The control group received 2% lidocaine, and the experimental group received 4% articaine. The study will be conducted in accordance with the guidelines of the Consolidated Standards of Reporting Trials (CONSORT 2010). The probabilistic sampling technique is through simple randomization. The 100 patients who meet the inclusion criteria will be randomly assigned to the control and experimental groups in a 1:1 ratio.\n\nExpected results: articaine shows a lower percentage of extractions with anesthetic reinforcement and, therefore, a lower average number of additional tubes.",[30],[239,240,241,242,243],"nerve block","comparative study","exodontics","pain measurement","anesthesia infiltration","2025-11-14",{"date":246,"type":45},"2025-11-17",{"date":248,"type":23},"2025-12-20",{"date":250,"type":23},"2026-01-25",{"name":252,"class":52},"Universidad Austral de Chile",{"id":254,"slug":255,"hasResults":11,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":4,"eligibilityCriteria":259,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":24,"phases":262,"briefSummary":263,"conditions":264,"keywords":267,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":283},"100602995","intraligamentary-vs-inferior-alveolar-nerve-block-for-pulpitis-a-randomized-clinical-trial-100602995","NCT07130760","Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial","Is Intraligamentary Injection the Anesthesia of Choice for Symptomatic Irreversible Pulpitis in Mandibular Molars? A Multicenter Randomized Comparative Trial.","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Presenting with symptomatic irreversible pulpitis in a mandibular molar\n* Vital response to cold testing\n* Ability to understand and provide informed consent\n* Available for follow-up and data collection\n\nExclusion Criteria:\n\n* Known allergy to lidocaine or epinephrine\n* Pregnancy or breastfeeding\n* Use of analgesics or anti-inflammatory drugs in the previous 6 hours\n* Non-vital or previously treated teeth\n* Significant systemic disease (ASA III or above)\n* History of psychiatric or neurological disorders affecting pain perception",{"count":261,"type":23},52,[26],"This multicenter randomized trial compares the clinical effectiveness of intraligamentary injection versus inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis in mandibular molars. The goal is to determine which technique provides better pain control during endodontic treatment.",[29,30,265,266],"Inferior Alveolar Nerve Block Failure","Local Anesthesia",[32,268,269,36,270,271,158,272,273],"Pulpitis Mandibular molars","Emergency dental treatment","Randomized clinical trial","Endodontics","Local anesthesia","Intraligamentary anesthesia","2025-08-16",{"date":276,"type":45},"2025-08-19",{"date":278,"type":45},"2025-06-20",{"date":280,"type":23},"2027-07",{"name":282,"class":52},"Aula Dental Avanzada",2,{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":4,"eligibilityCriteria":290,"healthyVolunteers":17,"sex":18,"minAge":62,"maxAge":291,"enrollmentInfo":292,"targetDuration":4,"studyType":24,"phases":294,"briefSummary":295,"conditions":296,"keywords":299,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":53},"100569209","photobiomodulation-and-tooth-analgesia-100569209","NCT06691269","Photobiomodulation and Tooth Analgesia","Evaluation of a Photobiomodulation Device for Dental Analgesia in Pediatric Patients","Inclusion Criteria:\n\n* Healthy children, aged 6-12 years, requiring routine dental treatment\n\nExclusion Criteria:\n\n* Children with uncooperative behavior or signficant medical history","12 Years",{"count":293,"type":23},200,[26],"The purpose of this study is to test photobiomodulation (PBM) with a non-invasive light device for reducing discomfort during dental treatments in children. We plan to conduct a series of three clinical studies in 200 school-aged children requiring routine dental treatment. The first study aims to test if PBM works for tooth and soft tissue by assessing response to cold testing and probing of gums. The second study aims to test if use of PBM on soft tissues before injection reduces discomfort. The third study aims to test if PBM can be used to do simple dental fillings in baby teeth without numbing injection.",[297,30,298],"Dental Anaesthesia","Dental Analgesia",[300,301,302],"photobiomodulation","dental analgesia","dental anesthesia","2025-07-21",{"date":305,"type":45},"2025-07-25",{"date":307,"type":45},"2025-07-07",{"date":309,"type":23},"2027-06",{"name":311,"class":52},"University of Maryland, Baltimore",{"id":313,"slug":314,"hasResults":11,"nctId":315,"briefTitle":316,"officialTitle":317,"acronym":318,"eligibilityCriteria":319,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":320,"enrollmentInfo":321,"targetDuration":4,"studyType":24,"phases":323,"briefSummary":324,"conditions":325,"keywords":326,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":53},"100536790","a-combination-of-ibuprofen-with-curcumin-covered-with-liquorice-root-supplementation-in-the-management-of-postoperative-dental-pain-in-adults-100536790","NCT06269406","A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults","A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults, Randomized, Double- Blind, Parallel-Group, Placebo-Controlled Study","ICLID","Inclusion Criteria:\n\n* Removal of 2 to 4 impacted third molars\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Ibuprofen contraindications.\n* Allergy to any of the intervention components.","85 Years",{"count":322,"type":23},264,[26],"Dental pain, a common issue in stomatology, requires a multifaceted treatment approach. This study explores the efficacy of combining Ibuprofen with curcumin and liquorice root supplements for managing postoperative dental pain. Curcumin, known for its antioxidant and anti-inflammatory properties, along with liquorice root, may enhance pain relief beyond conventional NSAIDs like Ibuprofen. This randomized, double-blind, placebo-controlled trial aims to evaluate the safety and effectiveness of this combination therapy in adults undergoing the removal of impacted third molars. Participants, aged 18-85, were divided into groups receiving different doses of Ibuprofen and curcumin with liquorice root, compared to a control group receiving Ibuprofen and placebo. The primary outcome is the sum of pain intensity differences over 8 hours, with secondary outcomes including total pain relief and the occurrence of any adverse events. The anticipated sample size, considering a 20% dropout rate, is 264 participants, ensuring the study is powered to detect significant differences in pain management efficacy.",[30],[327,328,329,330,331],"Postoperative Dental Pain","Curcumin and Licorice Root","Ibuprofen","Anti-inflammatory Properties","molars","2025-06-06",{"date":334,"type":45},"2025-06-08",{"date":336,"type":23},"2025-07-28",{"date":338,"type":23},"2025-09-28",{"name":340,"class":52},"S.LAB (SOLOWAYS)",{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":348,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":350,"conditions":351,"keywords":352,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":53},"100466236","dental-block-for-pain-relief-in-ed-dental-pain-patients-100466236","NCT05351099","Dental Block for Pain Relief in ED Dental Pain Patients","Efficacy of ED Provider-Performed Dental Block for Pain Relief in Patients Presenting With Dental Pain","Inclusion Criteria:\n\n* Adult patients (\\>= 18-years-old) presenting to Community Regional Medical Center emergency department with a complaint of dental pain in whom the ED practitioner plans to perform a dental nerve block\n\nExclusion Criteria:\n\n* Patient with previous dental block within 24 hours prior to arrival at the ED\n* Refusal of dental block\n* Patient in law enforcement custody\n* Patient unable to be properly informed of study purpose or able to complete pain VAS score due to physical\u002F mental condition (altered mental status, unstable psychiatric patient)\n* Patient unable to be properly informed of study purpose or able to complete pain VAS score due to language barrier (not English- or Spanish-speaking)\n* Patient with other acute non-dental painful condition making evaluation of dental pain severity vs non-dental pain severity not possible\n* Patient with pain in multiple areas of mouth needing dental block in \\> 1 anatomic area\n* Patient to have Dental \u002F OMFS ED consult for procedure",{"count":349,"type":23},195,"This will be a prospective, observational cohort study assessing immediate pain relief from dental block in ED patients presenting with dental pain. The study will be conducted in the Community Regional Medical Center ED. The aim of this study, then, is to prospectively determine if dental block provides minimal clinically important difference in pain relief to these patients.",[30],[353,32,354,355],"Dental Block","Posterior superior alveolar nerve block","supraperiosteal nerve block","2025-02-25",{"date":358,"type":45},"2025-02-28",{"date":360,"type":45},"2022-03-11",{"date":362,"type":23},"2026-03-11",{"name":364,"class":52},"University of California, San Francisco",{"id":366,"slug":367,"hasResults":11,"nctId":368,"briefTitle":369,"officialTitle":370,"acronym":4,"eligibilityCriteria":371,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":372,"enrollmentInfo":373,"targetDuration":4,"studyType":24,"phases":375,"briefSummary":376,"conditions":377,"keywords":379,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":384,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":4},"100570197","phase-4-meloxicam-versus-ibuprofen-for-pain-control-after-third-molar-exodontia-in-adult-patients-100570197","NCT06704113","Meloxicam Versus Ibuprofen for Pain Control After Third Molar Exodontia in Adult Patients","Analgesic Efficacy of Meloxicam Versus Ibuprofen for Pain Control After Third Molar Extraction in Adult Patients: Randomized Clinical Trial","Inclusion Criteria:\n\nMaxillary or mandibular third molar with semi or fully erupted crown.\n\nExclusion Criteria:\n\nPatients with Systemic pathologies. Presence of third molar localized infection. Completely included third molar crown. Periodontal compromise. Pregnant or breastfeeding women. Patients with hypersensitivity to NSAIDs. Patients with a history of drug abuse. Patients who had taken any drug in the previous 24 hours. Intervention (exodontia) time longer than 45 minutes.","59 Years",{"count":374,"type":23},68,[235],"Third molar extraction is a common dental procedure, offently related with pain and swelling. The purpose of this study is to evaluate if Meloxicam has a better effect relieving pain after the extraction than Ibuprofen, one of the most common pain relieving drugs administered after this procedure.",[30,378],"Sensation Disorders",[380,381,382,329],"Tooth Extraction","Molar, Third","Meloxicam","2024-11-22",{"date":385,"type":45},"2024-11-25",{"date":387,"type":23},"2024-12-15",{"date":389,"type":23},"2025-01-20",{"name":252,"class":52}]