[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-plaque-accumulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-plaque-accumulation":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,70,97,126,151],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100625365","3d-volumetric-plaque-assessment-on-teeth-composite-restorations-and-ceramic-veneers-using-an-intraoral-scanner-100625365",false,"NCT07421687","3D Volumetric Plaque Assessment on Teeth, Composite Restorations, and Ceramic Veneers Using an Intraoral Scanner","Differences in Plaque Accumulation on Natural Teeth, Composite Restorations, and Ceramic Veneers Assessed by Intraoral Scanner-Based 3D Volumetric Analysis","Inclusion Criteria:\n\n* 18 years or older. \n* Able and willing to provide written informed consent. \n* Generally healthy and not using regular systemic medications. \n* Have at least 6 teeth in each quadrant of the mouth. \n* Have low plaque levels at baseline (plaque index \\\u003C10%). \n* Do not have periodontal pockets deeper than 4 mm. \n* In the upper front teeth (maxillary anterior) on the outer (vestibular) surfaces, participants must fit one of these predefined surface types: Natural tooth surface (no restoration ), direct composite restoration, or Indirect ceramic veneer restoration. \n* No cavitated tooth decay on the surfaces to be assessed and no obvious surface defects that would clearly increase plaque retention.\n\nExclusion Criteria:\n\n* Diagnosis of gingivitis or periodontitis. \n* Regular use of mouthwash as part of daily oral hygiene. \n* Use of antibiotics within the last 6 months. \n* Smoking. \n* Pregnant or breastfeeding. \n* Presence of dental implants or removable dentures. \n* Any systemic disease or medical treatment that could affect oral health or healing (examples include diabetes, cancer, disorders affecting bone metabolism, immunosuppressive therapy, chemotherapy, radiotherapy, or other conditions\u002Fmedications affecting wound healing). \n* Having a pacemaker or an implantable defibrillator. \n* History of allergy or intolerance to study-related materials (e.g., ingredients of the plaque-disclosing agent or the lip\u002Fcheek retractor material). \n* Defective fillings\u002Frestorations on the assessed surfaces that could increase plaque retention. \n* Malocclusion or spacing between teeth (diastema). \n* Gum recession affecting more than one-third of the root length. \n* Wearing fixed orthodontic appliances (braces). \n* Any physical, mental, or psychiatric condition that could interfere with understanding the study or completing the procedures",true,"ALL","18 Years",{"count":20,"type":21},45,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to evaluate and compare a 3D intraoral scanner-based, computer-assisted approach for assessing dental biofilm\u002Fplaque accumulation on natural teeth and restorative surfaces with a conventional clinical plaque index (Turesky modified Quigley-Hein Plaque Index, TMQHPI) in systemically healthy adults. The main questions it aims to answer are:\n\n* How well does the plaque-covered surface measurement derived from 3D intraoral scanner data agree with TMQHPI scores after plaque disclosure?\n* How sensitively do the two methods detect changes in plaque levels after supervised toothbrushing?\n* Do plaque accumulation patterns differ between natural tooth surfaces and restorative materials (direct composite restorations and indirect ceramic veneers), and where are plaque-retentive areas most frequently located?\n\nParticipants (≥18 years) will receive routine professional mechanical plaque removal as part of standard clinical care. They will then be asked to avoid mechanical and\u002For chemical plaque control for 4 days. At the follow-up visit, participants will undergo:\n\n1. An intraoral scan and standardized photographs of the full dental arch,\n2. Plaque disclosure followed by repeat scanning\u002Fphotography and TMQHPI scoring by a periodontist,\n3. Supervised toothbrushing using the modified Bass technique for 2 minutes, followed by a final scan and photographs. Digital models will be used to quantify plaque-covered surface measures and to generate 3D maps of plaque-retentive areas.",[25,26,27,28,29],"Dental Plaque Accumulation","Oral Hygiene, Oral Health","Dental Materials","Dental Plaque Imaging Methods","Dental Plaque Index","NOT_YET_RECRUITING","2026-02-19",{"date":33,"type":34},"2026-02-23","ACTUAL",{"date":36,"type":21},"2026-03-16",{"date":38,"type":21},"2027-03-24",{"name":40,"class":41},"Trakya University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":42},"100624787","phase-4-6-month-clinical-investigation-assessing-the-efficacy-of-an-antimicrobial-mouthrinse-in-reducing-established-plaque-and-improving-gum-health-100624787","NCT07414173","6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health","Clinical Investigation to Assess the Efficacy of an Antimicrobial Mouthrinse in the Reduction of Established Plaque and the Improvement of Gum Health: a 6-month Clinical Study","Inclusion Criteria:\n\n1. Male and female subjects aged 18-70 years, inclusive.\n2. Availability for the 6-month duration of the clinical research study.\n3. Good general health based on the opinion of the study investigator.\n4. Signed Informed Consent Form.\n5. Minimum of 20 natural teeth (excluding third molars).\n6. Initial gingivitis index of at least 1.5 as determined by the use of the Loe and Silness Gingival Index.\n7. Initial plaque index of at least 1.5 as determined by the use of the Quigley and Hein Plaque Index (Turesky Modification).\n\nExclusion Criteria:\n\n1. Be under orthodontic treatment.\n2. Presence of partial removable dentures.\n3. Tumor(s) of the soft or hard tissues of the oral cavity.\n4. Participants with current moderate or severe periodontitis (periodontitis screening index \\[PSI\\] \\>2 in more than 2 sextants or PSI \\>3), and\u002For purulent exudate, tooth mobility, and\u002For extensive loss of periodontal attachment or alveolar bone.\n5. Five or more carious lesions requiring immediate restorative treatment.\n6. Antibiotic use any time during the one-month period prior to entry into the study.\n7. Participation in any other clinical study or test panel within the one month prior to entry into the study.\n8. Dental prophylaxis during the past two weeks prior to baseline examinations.\n9. History of allergies to oral care\u002Fpersonal care consumer products or their ingredients.\n10. On any prescription medicines that might interfere with the study outcome based on the examiner\u002FPI opinion.\n11. An existing medical condition that prohibits eating and\u002For drinking for periods up to 4 hours.\n12. History of alcohol and\u002For drug abuse.\n13. Self-reported pregnancy and\u002For lactating subjects.\n14. Subjects with other oral diseases (including gingival hyperplasia, diseases of the oral mucosa), or any condition that the dental examiner considers exclusionary from the study.\n15. Smokers or\u002Fand users of tobacco products.\n16. Enrolled in an undergraduate, postgraduate, or academic dentistry program","70 Years",{"count":52,"type":21},90,"INTERVENTIONAL",[55],"PHASE4","The goal of this clinical trial is to evaluate the clinical efficacy of an antimicrobial mouthrinse, with a particular focus on its effect on established plaque and the improvement of gum health.\n\nParticipants will:\n\n* Brush and rinse twice a day with the designated products for 6 months\n* Visit the clinic once every 3 months after baseline for reassessment.",[58,25],"Gingivitis","RECRUITING","2026-02-10",{"date":62,"type":34},"2026-02-17",{"date":64,"type":34},"2026-01-28",{"date":66,"type":21},"2026-11",{"name":68,"class":69},"Colgate Palmolive","INDUSTRY",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":16,"sex":17,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":53,"phases":81,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":42},"100606845","comparing-the-antiplaque-effects-of-novel-titania-nanoparticle-infused-fluoride-varnish-vs-conventional-fluoride-varnish-in-fixed-orthodontic-patients-100606845","NCT07180849","Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.","Comparing the Antiplaque Efficacy of Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients-A Triple Blind Randomised Controlled Trial.","Inclusion criteria:\n\n* Patients planned for fixed orthodontic treatment.\n* Patients within age group 16-30 years.\n* Patient with no history of previous orthodontic treatment.\n* Patients with no active periodontal diseases.\n\nExclusion criteria:\n\n* Patient undergoing any antibiotic therapy.\n* Patients with any craniofacial abnormality.\n* Patient with mixed dentition","16 Years","30 Years",{"count":80,"type":21},20,[82],"NA","In this study the investigators aimed to explore the antibiofilm effect of fluoride varnish loaded with titania nanoparticles synthesized from moringa oleifera leaves extract vs conventional fluoride varnish in multibracket fixed orthodontic patients.",[25,85,86],"Nanoparticles","Fluoride Varnishes","2025-09-20",{"date":89,"type":34},"2025-09-25",{"date":91,"type":21},"2025-11",{"date":93,"type":21},"2027-12",{"name":95,"class":96},"Pakistan Institute of Medical Sciences","OTHER_GOV",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":53,"phases":108,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":42},"100595256","evaluation-of-a-novel-dual-headed-toothbrush-design-for-periodontal-health-split-mouth-randomized-blind-clinical-trial-100595256","NCT07030088","Evaluation of a Novel Dual-Headed Toothbrush Design for Periodontal Health: Split-Mouth Randomized Blind Clinical Trial","Clinical and Patient-Based Evaluation of a Novel Dual-Headed Toothbrush Design: Split-Mouth Clinical Trial","Inclusion Criteria:\n\n* • Dentists with a minimum of 26 natural teeth, good general health, and the ability to perform routine oral hygiene independently.\n\n  * No systemic diseases affecting oral hygiene.\n  * Record of mild-to-moderate plaque accumulation; PI score ≥ 1\n  * Rt handed dentists\n\nExclusion Criteria:\n\n* • Participants with active periodontal disease, orthodontic appliances, or having recent oral surgery\n\n  * Those currently enrolled in any other dental trial\n  * Smokers.","25 Years","40 Years",{"count":107,"type":21},40,[82],"The goal of this clinical trial is to evaluate the effectiveness and patient satisfaction of a novel dual-headed toothbrush design compared to a conventional single-headed toothbrush in adult dental professionals aged 22-45 years with healthy gingival conditions. The main questions it aims to answer are:\n\nDoes the dual-headed toothbrush improve plaque removal efficiency compared to a single-headed toothbrush? Does the dual-headed toothbrush enhance brushing comfort, reduce brushing time, and improve user satisfaction? Researchers will compare the side of the mouth (cleaned with a dual-headed toothbrush) with the other side (cleaned with a single-headed toothbrush) in a randomized split-mouth design to see if the novel design leads to superior plaque control and better user experience.\n\nParticipants will:\n\nReceive both toothbrush types (medium bristle) and identical toothpaste Be trained in the Bass brushing technique Use each toothbrush, twice daily, with the assigned toothbrush applied to its designated side of the mouth\n\nComplete post-trial questionnaires on comfort, ease of use, and brushing time",[25,111,112],"Oral Hygiene Education Methods","Toothbrushing",[114,115,116],"Dual-headed toothbrush","Single-headed toothbrush","Toothbrushing technique","2025-09-05",{"date":119,"type":34},"2025-09-11",{"date":121,"type":21},"2025-09",{"date":123,"type":21},"2025-12",{"name":125,"class":41},"Dar Al Uloom University",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":53,"phases":136,"briefSummary":137,"conditions":138,"keywords":139,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":42},"100591770","4-day-plaque-accumulation-model-evaluating-compound-containing-gum-100591770","NCT06984744","4-day Plaque Accumulation Model Evaluating Compound Containing Gum","Effect of an Active Compound Containing Gum on Dental Plaque Formation on a 4-day Accumulation Model","Inclusion Criteria:\n\n* Adult subjects between 18 and 65 years old\n* Willing to read and sign the IRB-approved informed consent.\n* Healthy, as determined by pertinent medical history at the study dentist's discretion.\n* A minimum of 20 natural teeth (excluding third molars) with at least two scorable surfaces per tooth (teeth with full crowns, large\u002Fextensive restorations on the interproximal areas, and orthodontic bands will not be included in the tooth count)\n* PLI of 2 or greater (Based on the Turesky modification of the Quigley and Hein Plaque Index) calculation based on a whole mouth plaque score.\n* Willing to comply with the study procedures.\n\nExclusion Criteria:\n\n* Presence of any acute or chronic condition, organ system disease, or medication that, in the principal investigator's opinion, could compromise the subjects' ability to participate in the study.\n* Gross oral pathologies, including caries, calculus, or soft tissue conditions that show evidence of chronic neglect.\n* Evidence of acute periodontal conditions or periodontitis with pockets greater than 5 mm on more than one site\n* Use of antibiotics 30 days prior to or during the study\n* Requiring the need for antibiotic premedication prior to dental procedures\n* Sensitivity to bovine products (lactoferrin) or any of the listed inactive ingredients\n* Orthodontic appliances or any removable, except lingual bar retainers\n* Self-reported pregnant, wanting to get pregnant, or breast-feeding female,\n* Self-reported allergy to disclosing solution ingredients (red dye #28)\n* Acute Temporomandibular Disorders (TMD)\n* Subject who has participated in other studies (including non-medicinal studies) involving product(s) within 30 days before study screening.\n* Subject who has previously been randomized in this study\n* An employee of the study site directly involved with the study","65 Years",{"count":135,"type":21},32,[82],"This will be a single-blind, single-center, 3-way crossover, randomized controlled clinical trial with 3 treatment periods utilizing 32 subjects. (Fig 1, in protocol) Each treatment period will be 4 days (96 hours +\u002F-3 hours) in accordance with the plaque accumulation model using one of the following treatment groups: an active compound MIIP-E2 gum (experimental regimen), an inactive compound gum (negative control regimen), and a no-gum (control regimen).",[25],[140,141],"dental plaque","gum chewing","2025-08-26",{"date":144,"type":34},"2025-08-27",{"date":146,"type":34},"2025-06-23",{"date":148,"type":21},"2026-02-27",{"name":150,"class":69},"Lactea Therapeutics, LLC",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":53,"phases":162,"briefSummary":163,"conditions":164,"keywords":166,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":42},"100575976","adjunctive-oral-hygiene-aids-in-reducing-oral-hygiene-parameters-among-orthodontic-patients-100575976","NCT06779279","Adjunctive Oral Hygiene Aids in Reducing Oral Hygiene Parameters Among Orthodontic Patients","Adjunctive Oral Hygiene Aids in Reducing Commonly Seen Oral Hygiene Parameters Among Orthodontic Patients: a Randomized Controlled Trial","D-F-H-17-Dec","Inclusion Criteria:\n\n* Participants aged 18-35 years undergoing orthodontic treatment and\n* systemically healthy without habits\n\nExclusion Criteria:\n\n* Participants not undergoing orthodontic treatment and participants undergoing orthodontic treatment in the included age category but with systemic conditions prevalent\n* missing teeth and\n* treated previously for periodontal conditions","35 Years",{"count":161,"type":21},102,[82],"Adult orthodontic patients aged 18-30 were included in a randomised, singleblind clinical research using a split-mouth design at a dental clinic. Both theWaterflosser® and the Super-Floss® water flossers are manufactured by Oral-B.",[165,25],"Gingival Bleeding",[167,168,169,170],"waterflosser","superfloss","gingival bleeding","Dental Plaque","2025-01-19",{"date":173,"type":34},"2025-01-22",{"date":175,"type":21},"2025-02-10",{"date":177,"type":21},"2025-03-26",{"name":179,"class":41},"sudhir rama varma"]