[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-plaque-index\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-plaque-index":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100625365","3d-volumetric-plaque-assessment-on-teeth-composite-restorations-and-ceramic-veneers-using-an-intraoral-scanner-100625365",false,"NCT07421687","3D Volumetric Plaque Assessment on Teeth, Composite Restorations, and Ceramic Veneers Using an Intraoral Scanner","Differences in Plaque Accumulation on Natural Teeth, Composite Restorations, and Ceramic Veneers Assessed by Intraoral Scanner-Based 3D Volumetric Analysis","Inclusion Criteria:\n\n* 18 years or older. \n* Able and willing to provide written informed consent. \n* Generally healthy and not using regular systemic medications. \n* Have at least 6 teeth in each quadrant of the mouth. \n* Have low plaque levels at baseline (plaque index \\\u003C10%). \n* Do not have periodontal pockets deeper than 4 mm. \n* In the upper front teeth (maxillary anterior) on the outer (vestibular) surfaces, participants must fit one of these predefined surface types: Natural tooth surface (no restoration ), direct composite restoration, or Indirect ceramic veneer restoration. \n* No cavitated tooth decay on the surfaces to be assessed and no obvious surface defects that would clearly increase plaque retention.\n\nExclusion Criteria:\n\n* Diagnosis of gingivitis or periodontitis. \n* Regular use of mouthwash as part of daily oral hygiene. \n* Use of antibiotics within the last 6 months. \n* Smoking. \n* Pregnant or breastfeeding. \n* Presence of dental implants or removable dentures. \n* Any systemic disease or medical treatment that could affect oral health or healing (examples include diabetes, cancer, disorders affecting bone metabolism, immunosuppressive therapy, chemotherapy, radiotherapy, or other conditions\u002Fmedications affecting wound healing). \n* Having a pacemaker or an implantable defibrillator. \n* History of allergy or intolerance to study-related materials (e.g., ingredients of the plaque-disclosing agent or the lip\u002Fcheek retractor material). \n* Defective fillings\u002Frestorations on the assessed surfaces that could increase plaque retention. \n* Malocclusion or spacing between teeth (diastema). \n* Gum recession affecting more than one-third of the root length. \n* Wearing fixed orthodontic appliances (braces). \n* Any physical, mental, or psychiatric condition that could interfere with understanding the study or completing the procedures",true,"ALL","18 Years",{"count":20,"type":21},45,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to evaluate and compare a 3D intraoral scanner-based, computer-assisted approach for assessing dental biofilm\u002Fplaque accumulation on natural teeth and restorative surfaces with a conventional clinical plaque index (Turesky modified Quigley-Hein Plaque Index, TMQHPI) in systemically healthy adults. The main questions it aims to answer are:\n\n* How well does the plaque-covered surface measurement derived from 3D intraoral scanner data agree with TMQHPI scores after plaque disclosure?\n* How sensitively do the two methods detect changes in plaque levels after supervised toothbrushing?\n* Do plaque accumulation patterns differ between natural tooth surfaces and restorative materials (direct composite restorations and indirect ceramic veneers), and where are plaque-retentive areas most frequently located?\n\nParticipants (≥18 years) will receive routine professional mechanical plaque removal as part of standard clinical care. They will then be asked to avoid mechanical and\u002For chemical plaque control for 4 days. At the follow-up visit, participants will undergo:\n\n1. An intraoral scan and standardized photographs of the full dental arch,\n2. Plaque disclosure followed by repeat scanning\u002Fphotography and TMQHPI scoring by a periodontist,\n3. Supervised toothbrushing using the modified Bass technique for 2 minutes, followed by a final scan and photographs. Digital models will be used to quantify plaque-covered surface measures and to generate 3D maps of plaque-retentive areas.",[25,26,27,28,29],"Dental Plaque Accumulation","Oral Hygiene, Oral Health","Dental Materials","Dental Plaque Imaging Methods","Dental Plaque Index","NOT_YET_RECRUITING","2026-02-19",{"date":33,"type":34},"2026-02-23","ACTUAL",{"date":36,"type":21},"2026-03-16",{"date":38,"type":21},"2027-03-24",{"name":40,"class":41},"Trakya University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":42},"100581259","antimicrobial-effect-of-curcumin-versus-chlorohexidine-on-oral-microbiome-100581259","NCT06847984","Antimicrobial Effect of Curcumin Versus Chlorohexidine on Oral Microbiome","Antimicrobial Effect of Curcumin on Oral Microbiome Versus Chlorohexidine in High Caries Risk Individuals","Inclusion Criteria:\n\n* Provide informed consent.\n* Patients accept the one-year follow-up period.\n* Cooperative patients.\n* The study recruited volunteers of both genders\n* Age from 21 to 45 years\n* Patients classified at high risk of caries\n\nExclusion Criteria:\n\n* Patients undergoing orthodontic treatment.\n* Periodontal compromised patients.\n* Smokers.\n* Pregnant women.\n* Patients with physical or mental disability\n* Patient with removable prosthesis","21 Years","45 Years",{"count":53,"type":21},54,"INTERVENTIONAL",[56],"NA","Dental caries, one of the world's most common infectious diseases, is a biofilm-mediated, sugar-driven, dynamic disease. It has an impact on physical, mental, and social health and is extremely costly to society. It is a complex disease with microbiological, behavioral, genetic, and environmental components. Recently, it has been demonstrated in the literature that the development of dental caries is strongly related with the microbiota in the oral cavity. So, a detailed understanding of caries microbiology is needed.\n\nOral microbiome, oral microbiota or oral microflora refers to the microorganisms found in the human oral cavity that was first identified by the Dutchman Antony van Leeuwenhoek using a microscope constructed by him. In 1674, he observed his own dental plaque and reported \"little living animalcules prettily moving\".\n\nHuman microbiome consists of a core microbiome which is common to all the individuals and a variable microbiome that is unique to individuals depending on the lifestyle and physiological differences. Dental caries, as a process determined by lifestyle, may be subject to activation in each period of human life if hygiene and diet are neglected even for a period as short as a few weeks.\n\nPrevious hypotheses suggest that Streptococcus mutans is the primary pathogen in the development of dental caries in both children and adults. However, recently published papers provide a partially different perspective on the role of bacteria in the caries process, known as the \"extended caries ecological hypothesis,\" which attempts to demonstrate that the role of S. mutans in the initiation of dental caries may not be as dominant as previously assumed, but there is agreement that they have the highest cariogenic potential.\n\nIt is now believed that the disease is caused by microorganisms belonging to the natural flora of the oral cavity: the oral microbiome. There is a dynamic equilibrium between microorganisms as well as between the micro flora and the 7 host, and the disease develops as a result of a microbiological imbalance within the biofilm.\n\nTherefore, a better understanding of processes of oral biofilm formation and function is necessary to the development of novel, successful, rational approach for antimicrobial strategies and caries prevention and treatment.\n\nPrimary caries can be prevented, stopped and treated by regular plaque removal and remineralization mechanisms. Fluorides play a central role in the prevention of dental caries and are being used extensively and therapeutically for the inactivation of incipient carious lesions. However, regarding the high cost of dental clinic setting and difficult access to the oral health care service that is not well-covered in certain countries; the treatment strategy should move towards the preventive, simple, accessible, less costly methods.\n\nThe frequent use and abuse of the currently used therapeutic agents has led to the evolution of resistant strains of common pathogens as well as increased incidence of adverse effects associated with their usage. Therefore, natural phytochemicals extracted from plants used as traditional medicines are therefore seen as a good alternative source.\n\nPharmaceutical plants have been used throughout human history to treat a variety of diseases. According to the World Health Organization, almost 80% of the world's population relies on traditional medicinal plants for primary health care. In dentistry, there is a growing need to develop natural materials with anti-caries qualities.\n\nCurcumin (CUR), a dietary natural product extracted from the root of turmeric (the major constituent of Curcuma longa L. or turmeric), which is widely used as a flavoring and coloring agent has many pharmacological activities including anti-inflammatory and antitumor properties. In addition, CUR has been shown to have anti-bacterial, whitening, and antioxidative activities. Various studies on widespread Polyphenolic compounds suggest that curcumin inhibits the bacterial effect by reducing the production of acid and stopping the adherence of bacteria to the tooth surface. Song et al. found that curcumin could significantly inhibit the adhesiveness of S. mutans by its effects on collagen and fibronectin. The antibacterial action of curcumin involves the disruption of the bacterial membrane, inhibition of the production of bacterial virulence factors and biofilm formation, and the induction of oxidative stress. These characteristics also contribute to explain how curcumin acts a broad-spectrum antibacterial adjuvant. So, the aim of the following interventional study is to evaluate the effect of curcumin on oral microbiome obtained from salivary samples of high caries risk patients in vitro and assess the antiplaque and anticariogenic effect of curcumin mouth wash in high caries risk patients in a randomized controlled clinical trial compared to chlorohexidine mouth wash.",[59,29,60],"Dental Caries","Oral Microbiome",[62],"oral microbiome, curcumin, chlorohexidine, antimicrobial","2025-02-22",{"date":65,"type":34},"2025-02-26",{"date":67,"type":21},"2025-03-01",{"date":69,"type":21},"2026-03",{"name":71,"class":41},"Cairo University"]