[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-plaque\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-plaque":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,22,0,[8,50,80,104,126,147,172,212,245,272,305,326,352,381,408,439,467,487,516,540,559,580],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100642351","plaque-removal-efficiency-in-children-with-specific-learning-disabilities-100642351",false,"NCT07611942","Plaque Removal Efficiency in Children With Specific Learning Disabilities","Quantitative Analysis of Plaque Removal Efficiency in Children With Specific Learning Disabilities","PRE-SLD","Inclusion Criteria:\n\n* Diagnosis of specific learning disabilities confirmed by a child and adolescent psychiatry specialist for the study group\n* Confirmation by a child and adolescent psychiatry specialist that the control group participants are healthy and do not have any psychiatric diagnosis\n* Age between 7 and 12 years\n* Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* Children with additional psychiatric diagnoses such as autism spectrum disorder, attention deficit\u002Fhyperactivity disorder, or intellectual disability\n* Children with systemic health problems or physical disabilities that may interfere with participation in the study",true,"ALL","7 Years","12 Years",{"count":22,"type":23},70,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study aims to evaluate the effectiveness of toothbrushing education on plaque removal in children aged 7-12 years with specific learning disabilities (SLD) and to compare their plaque removal performance with healthy children. Participants will receive standardized toothbrushing education supported by visual and auditory materials. Plaque Index, Gingival Index, and photograph-based quantitative plaque analyses will be evaluated at baseline and after a 2-week follow-up period.",[29,30,31],"Specific Learning Disabilities","Dental Plaque","Oral Hygiene",[29,30,33,34,35,36,37],"Plaque Removal","Quantitative Plaque Analysis","Toothbrushing Education","ImageJ\u002FFIJI","Pediatric Dentistry","RECRUITING","2026-06-15",{"date":41,"type":42},"2026-06-16","ACTUAL",{"date":39,"type":42},{"date":45,"type":23},"2026-10",{"name":47,"class":48},"Alanya Alaaddin Keykubat University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":24,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":49},"100637598","comparison-of-the-effectiveness-of-miswak-and-manual-toothbrush-in-removing-dental-plaque-in-fixed-orthodontic-patients-100637598","NCT07619014","Comparison of the Effectiveness of Miswak and Manual Toothbrush in Removing Dental Plaque in Fixed Orthodontic Patients","Comparison of the Effectiveness of Miswak and Manual Toothbrush in Removing Dental Plaque in Fixed Orthodontic Patients: A Randomized Split-Mouth Clinical Trial","Inclusion Criteria:\n\n* Patients aged between 18 and 30 years old.\n* Presence of fixed orthodontic appliances (brackets and wires) on both upper and lower arches.\n* Good general systemic health with the absence of any medical conditions that might affect oral health status.\n\nExclusion Criteria:\n\n* Presence of advanced or aggressive periodontal diseases.\n* Current smokers.\n* Use of antimicrobial or antibacterial mouthwashes within 24 hours prior to the study session.\n* Systemic antibiotic intake within the past 2 weeks preceding the experiment.\n* Any physical or motor disability that could hinder the patient's capacity to perform proper tooth brushing.","18 Years","30 Years",{"count":60,"type":23},90,[26],"This study compares the immediate plaque removal efficacy of the natural Miswak versus a traditional manual toothbrush using the Modified Bass technique among orthodontic patients. The main question it aims to answer is: Are there statistically significant differences in the post-brushing plaque index reduction between the dental arch side cleaned with Miswak and the contralateral side cleaned with a manual toothbrush?",[30,64],"Orthodontic Patients",[66,67,68,69,64,70],"Toothbursh","Miswak","Siwak","Dental plaque","Braces","2026-05-31",{"date":73,"type":42},"2026-06-03",{"date":75,"type":42},"2026-05-01",{"date":77,"type":23},"2026-08-30",{"name":79,"class":48},"Al-Hawash Private University",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":24,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":49},"100624907","evaluation-of-a-toothpaste-containing-a-gum-health-active-in-participants-with-gingival-problem-100624907","NCT07415733","Evaluation of a Toothpaste Containing a Gum Health Active in Participants With Gingival Problem","A Randomized Clinical Study on the Effect of a Toothpaste Containing a Gum Health Active in Participants With Gingival Problem","Inclusion Criteria:\n\n* Participants need to be competent i.e., able to understand what is to take place and able to provide a free decision on agreeing to the activity\u002Ftaking part in the study on this.\n* Participants must be able to read and understand study instructions and any other relevant study documents.\n* Have at least 20 natural teeth without subgingival calculus, including 5 assessable teeth (excluding 3rd molars) in each quadrant.\n* Have a mean whole mouth BOP ≥ 10% at screening.\n* Willing to follow the lifestyle and dietary restrictions as detailed in the Information Sheet for study.\n\nExclusion Criteria:\n\n* Be pregnant or breastfeeding.\n* Participants who participated in gum health study within 3 months prior to screening.\n* Current participation in any other cosmetic studies, any dental clinical studies or clinical trials.\n* Participants who have used any gum health products in the 4 weeks prior to screening.\n* Obvious signs of untreated caries or significant periodontal disease, which in the opinion of the study dentist, will affect either the scientific validity of the study or if the participant to take part in the study would affect their wellbeing.\n* Have more than three sites with a probing pocket depth (PPD) of ≥ 5 mm.\n* Full or partial dentures wearers.\n* Current orthodontic treatment.\n* Smokers or those who have a recent smoking history, including e-cigarettes.\n* Diabetics.\n* Have had a dental prophylaxis in the month prior to enrolment or have one scheduled prior to the end of the study.\n* Medical condition and\u002For regular use of any medication which might affect the outcome of the study, as determined by the study dentist, principally a course of anti-inflammatory, antimicrobial or statin drugs within 4 weeks of screening.\n* Taking dietary supplements (e.g. multivitamins, antioxidants, fish oils, etc.).\n* Known allergy to any ingredient in study products.\n* The participant is a Unilever employee or a member of the study team.\n* Any participant who, in the judgement of the investigator, should not participate in the study.",{"count":88,"type":23},150,[26],"The primary objective of this clinical study is to evaluate the impact on gingival health when participants switch to a fluoride toothpaste without gum-health actives for 4 weeks after using a proven gum-health toothpaste for 13 weeks.",[92,93,30],"Gingival Inflammation","Gingival Bleeding","2026-04-29",{"date":96,"type":42},"2026-04-30",{"date":98,"type":42},"2026-02-27",{"date":100,"type":23},"2026-08",{"name":102,"class":103},"Unilever R&D","INDUSTRY",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":49},"100635633","intraoral-scan-and-cbct-aided-diagnosis-of-dental-plaque-and-caries-100635633","NCT07555223","Intraoral Scan and CBCT-Aided Diagnosis of Dental Plaque and Caries","Intra Oral Scan and CBCT Aided Diagnosis of Dental Plaque and Caries","Inclusion Criteria:\n\n* Adults aged 18 to 70 years\n* Not pregnant and not planning pregnant\n* At least 20 teeth present\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Conditions that prevent proper intraoral examination (e.g., severe gag reflex, limited mouth opening)\n* patient unable to provide informed consent","70 Years",{"count":113,"type":23},50,"OBSERVATIONAL","This prospective clinical study aims to evaluate the diagnostic accuracy of intraoral scans (IOS) for the detection of dental plaque and caries. The diagnostic performance of IOS will be compared with current clinical reference standards. For plaque assessment, IOS-based evaluation will be compared with plaque detection using disclosing agents. For caries detection, IOS (including white-light imaging and caries detection features) will be compared with conventional visual inspection and bitewing radiography. Adult patients aged 18 to 70 years will be included.",[30,117],"Dental Caries","2026-04-21",{"date":94,"type":42},{"date":121,"type":42},"2025-04-03",{"date":123,"type":23},"2027-07",{"name":125,"class":48},"University Ghent",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":18,"minAge":133,"maxAge":19,"enrollmentInfo":134,"targetDuration":4,"studyType":24,"phases":136,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":144,"leadSponsor":145,"locationsCount":4},"100634399","disclosing-agents-as-photosensitizers-in-apdt-for-biofilm-control-in-children-100634399","NCT07539181","Disclosing Agents as Photosensitizers in aPDT for Biofilm Control in Children","Disclosing Agents as Photosensitizers in Antimicrobial Photodynamic Therapy for Biofilm Control in Children Aged 3 to 7 Years: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Children aged 3 to 7 years\n* Both sexes\n* Good general health status\n* Classified as high caries risk according to the CAMBRA protocol (score ≥ +4 or presence of at least one disease indicator associated with two or more biological risk factors)\n* Written informed consent obtained from a parent or legal guardian\n\nExclusion Criteria:\n\n* Presence of systemic diseases\n* Use of antibiotics within the last 30 days\n* Use of antimicrobial mouthwash within 48 hours prior to sample collection\n* Presence of structural dental alterations that may interfere with the standardization of the procedure\n* Uncooperative behavior preventing safe clinical examination and intervention","3 Years",{"count":135,"type":23},72,[26],"This randomized controlled clinical trial aims to evaluate the effectiveness of plaque disclosing agents used as photosensitizers in antimicrobial photodynamic therapy (aPDT) for the control of dental biofilm in children aged 3 to 7 years. Participants will be allocated into groups to receive different treatment protocols, and biofilm levels will be assessed before and after the interventions. The primary outcome is the reduction of dental biofilm, aiming to determine whether disclosing agents can be an effective alternative photosensitizer in aPDT for pediatric patients.",[30],"NOT_YET_RECRUITING","2026-04-13",{"date":142,"type":42},"2026-04-20",{"date":71,"type":23},{"date":77,"type":23},{"name":146,"class":48},"University of Nove de Julho",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":24,"phases":155,"briefSummary":156,"conditions":157,"keywords":158,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":49},"100620267","clinical-evaluation-of-the-neopill-device-for-reduction-of-oral-bacterial-load-in-patients-with-fixed-orthodontic-appliances-100620267","NCT07355400","Clinical Evaluation of the NeoPill Device for Reduction of Oral Bacterial Load in Patients With Fixed Orthodontic Appliances","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Currently wearing fixed orthodontic appliances\n* Able and willing to provide written informed consent\n* Able to comply with study procedures during a single study visit\n\nExclusion Criteria:\n\n* Use of systemic antibiotics within the past 2 weeks\n* Presence of active oral infections\n* Known immunocompromised status\n* Presence of systemic medical conditions that may affect oral bacterial flora",{"count":154,"type":23},15,[26],"This study evaluates the effectiveness of the NeoPill oral hygiene device in reducing oral bacterial load in adults wearing fixed orthodontic appliances. Maintaining oral hygiene is challenging for orthodontic patients due to limited access around brackets and wires, and current solutions often rely on chemical-based products and disposable tools.\n\nNeoPill is a reusable, battery-operated oral device designed to provide mechanical cleansing of the oral cavity. In this single-arm clinical evaluation, participants will undergo oral swab sampling before and immediately after a single 30-second application of the NeoPill device. The primary outcome is the change in aerobic bacterial load, measured as colony-forming units (CFUs), between pre- and post-treatment samples.\n\nParticipants will also complete a short questionnaire to assess usability, comfort, and overall experience with the device. The study aims to generate preliminary clinical and user-experience data to support further development of the NeoPill device.",[30],[69,159,160,161,162],"Oral bacterial load","Orthodontic appliances","Oral hygiene device","Mechanical oral cleaning","2026-04-08",{"date":165,"type":42},"2026-04-09",{"date":167,"type":42},"2025-12-09",{"date":169,"type":23},"2026-04",{"name":171,"class":103},"Neofunction d.o.o.",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":180,"minAge":57,"maxAge":4,"enrollmentInfo":181,"targetDuration":4,"studyType":24,"phases":183,"briefSummary":184,"conditions":185,"keywords":192,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":49},"100595200","effectiveness-of-coenzyme-q10-and-probiotics-in-periodontal-therapy-during-pregnancy-100595200","NCT07029360","Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy","Adjunctive Use of Coenzyme Q10 and Probiotics to Improve Periodontal Health in Pregnant Women: A Randomized Controlled Trial","PREG-Q10","Inclusion Criteria:\n\n* Pregnant women between the 4th and 8th month of gestation\n* Age ≥ 18 years\n* Able to understand and communicate in Italian and\u002For English\n* Willing to provide written informed consent\n* Good compliance and willingness to follow study instructions\n\nExclusion Criteria:\n\n* Presence of cardiac pacemakers\n* Diagnosed psychological, neurological, or psychiatric disorders\n* Ongoing oncological therapy\n* Use of bisphosphonates within the last 12 months\n* Poor motivation or low compliance\n* Substance abuse (drugs or alcohol) or lifestyle incompatible with study requirements","FEMALE",{"count":182,"type":23},40,[26],"This randomized controlled clinical trial aims to evaluate the effectiveness of adjunctive coenzyme Q10 and probiotic supplementation (Limosilactobacillus reuteri Prodentis®) in improving periodontal health in pregnant women undergoing non-surgical periodontal therapy. Forty participants will be randomly assigned to two groups: the test group will receive professional oral hygiene every three months along with a coenzyme Q10-based toothpaste and daily probiotic supplementation; the control group will follow the same protocol without probiotics. The primary outcome is the reduction of the Plaque Index (PI), while secondary outcomes include Bleeding on Probing (BoP), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), gingival inflammation (MGI, PMGI), plaque distribution (PCR%, API), and gingival recession (R). The study duration is 6 months. The goal is to assess whether this combined therapy can promote a balanced oral microbiota and enhance periodontal health during pregnancy.",[186,187,188,30,189,190,191],"Pregnancy","Periodontal Disease","Gingivitis","Probiotics","Coenzyme Q10","Microbiota",[193,194,190,30,92,188,195,191,196,197,198,199,200,186,201,189,202],"Bleeding on Probing","Clinical Attachment Loss","Limosilactobacillus reuteri","Non-Surgical Periodontal Treatment","Oral Microbiota","Periodontal Therapy","Plaque Control","Plaque Index","Pregnant Women","Randomized Controlled Trial","2026-02-19",{"date":205,"type":42},"2026-02-20",{"date":207,"type":42},"2025-07-01",{"date":209,"type":23},"2026-06-10",{"name":211,"class":48},"University of Pavia",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":24,"phases":221,"briefSummary":222,"conditions":223,"keywords":226,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":49},"100620972","the-antiplaque-and-antigingivitis-effect-of-pure-green-tea-mouth-wash-compared-to-placebo-and-essential-oils-mouth-washes-100620972","NCT07364565","The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes","The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes: A Double Blinded Randomized Controlled Clinical Trial.","Inclusion criteria:\n\n* Non-smokers\n* Systemically healthy\n* At least 24 teeth in the functional dentition, excluding third molars\n* Clinical diagnosis of periodontal health (no periodontal pockets \\> 3 mm, bleeding on probing percentage \\\u003C 10%, and no attachment loss).\n\nExclusion criteria:\n\n* Smokers.\n* Medically compromised patients.\n* Pregnant woman.\n* Allergies to green tea or EO.\n* Any condition that might affect the periodontal tissues.\n* Patients with any carious lesions (initial or active).\n* Patients who have overhang restorations, poorly designed crowns or bridges, and ortho retainers.\n* Use of systemic antibiotics or anti-inflammatory medications within 3 months prior to enrolment.",{"count":220,"type":23},44,[26],"The goal of this clinical trial is to to evaluate the antiplaque and antigingivitis effect of pure green tea mouthwash compared to placebo and essential oils mouthwashes in healthy patients.\n\nThe main questions it aims to answer are:\n\n* Does pure green tea mouthwash effectively reduce dental plaque?\n* Does pure green tea mouthwash reduce gingival inflammation?\n\nResearchers will compare pure green tea mouthwash to Listerine Total Care, Listerine Green Tea, and placebo to see if there is a difference in plaque accumulation and gum inflammation reduction.\n\nParticipants will be prohibited from using any sort of oral hygiene parctice for the whole study period (3 weeks). Instead, they will rinse with 10 ml of their assigned mouthwash twice daily for 30 seconds. Plaque index, gingival index, and staining index will be examined at multiple intervals and participants will rate their sense of oral freshness and good breath.",[30,224,225,92,93,188],"Patient Reported Outcome","Gingival Inflammation and Bleeding",[227,228,229,230,231,232,233,234,235],"Green tea","Gingival inflammation","Plaque index","Essential oils","Mouthwash","Bleeding on probing","Camellia sinensis","Herbal medicine","Periodontal health","2026-01-21",{"date":238,"type":42},"2026-01-23",{"date":240,"type":42},"2025-12-01",{"date":242,"type":23},"2026-12",{"name":244,"class":48},"King Abdullah University Hospital",{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":11,"sex":18,"minAge":252,"maxAge":20,"enrollmentInfo":253,"targetDuration":4,"studyType":24,"phases":255,"briefSummary":256,"conditions":257,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":49},"100620380","probiotic-based-versus-ethyl-lauroyl-arginate-containing-mouthwashes-on-streptococcus-mutans-counts-dental-plaque-accumulation-and-salivary-ph-in-a-group-of-egyptian-school-children-100620380","NCT07356869","Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children","Comparative Evaluation of Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Healthy Egyptian schoolchildren aged 6-12 years.\n* Good general health.\n* Mild to moderate dental plaque accumulation.\n* Parental\u002Fcaregiver willingness to provide consent\n\nExclusion Criteria:\n\n* Antibiotic or antimicrobial use within the last month.\n* Allergies to the mouthwash components.\n* Systemic diseases affecting oral health.\n* Orthodontic appliances or extensive dental restorations.","6 Years",{"count":254,"type":23},66,[26],"This study aims to compare the efficacy of probiotic-based mouthwashes versus ethyl lauroyl arginate-containing mouthwashes in reducing Streptococcus mutans count, dental plaque accumulation, and salivary pH among a group of Egyptian schoolchildren.",[258,259,260,261,30,262,263],"Probiotic","Ethyl Lauroyl Arginate","Mouthwashes","Streptococcus Mutans","Salivary pH","Children","2026-01-13",{"date":236,"type":42},{"date":267,"type":42},"2025-08-15",{"date":269,"type":23},"2026-09-01",{"name":271,"class":48},"Al-Azhar University",{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":279,"targetDuration":4,"studyType":24,"phases":281,"briefSummary":282,"conditions":283,"keywords":284,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":303,"locationsCount":49},"100616600","clear-aligner-cleaning-brushing-chlorhexidine-and-bluem-effects-on-oral-microbial-ecology-and-periodontal-indices-100616600","NCT07307716","Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices","Investigating the Impact of Cleaning Protocols on Oral Microbial Ecology and Early Dysbiosis Markers on Orthodontic Clear Aligner Patients: A Randomized Cross-over Clinical Study","Inclusion Criteria:\n\n* Adults (≥18 years).\n* Undergoing or scheduled for treatment with clear aligners (CA).\n* Presence of upper and lower first molars and central incisors.\n* Periodontal health at baseline (no sites with PD ≥ 4 mm; no clinical attachment loss at index teeth; BI\u002FPI within normal limits).\n* No periodontal therapy within the previous 6 months.\n* Able and willing to comply with study instructions and follow-up visits; signed informed consent.\n* Sufficient remaining CA treatment (clinician-estimated): ≥ 14 weeks to safely cover three 1 month protocol periods plus washouts.\n\nMinimum planned aligners remaining: ≥ 11 aligners (assuming 10 days\u002Faligner) or equivalent continuous CA duration per treating orthodontist.\n\nExclusion Criteria:\n\n* Patients requiring orthognathic surgery\n* Uncontrolled systemic diseases (e.g., uncontrolled diabetes mellitus, autoimmune disease).\n* Pregnancy or lactation.\n* Use of systemic antibiotics and\u002For anti-inflammatory drugs within the last 3 months.\n* Periodontal therapy within the last 6 months.\n* Current tobacco use (smoking\u002Fsmokeless) or vaping.\n* Limited\u002Fexpress CA plans (e.g., ≤ 11 aligners or expected completion \\\u003C 14 weeks).\n\nAnticipated early completion of CA or major treatment changes (e.g., switch to fixed appliances) within the next \\~4 months.\n\n\\- Extensive caries, defective restorations, or prostheses affecting index teeth\u002Fsites.",{"count":280,"type":23},21,[26],"This randomized crossover study will assess how three aligner-cleaning methods affect early supragingival oral microbial ecology and periodontal health in adults using clear aligners. Each participant will complete three (1-month) periods in a randomized sequence with (1-week) washouts between periods:\n\n1. Mechanical toothbrushing with fluoride toothpaste (control),\n2. Chlorhexidine (CHX) mouthwash, and\n3. an oxygen-based cleanser (BlueM).\n\nPrimary ecological outcomes focus on early dysbiosis indicators Fusobacterium nucleatum and Prevotella intermedia measured on retrieved aligner inner-surface biofilm and on supragingival plaque at the gingival margin. Secondary outcomes include periodontal indices (plaque index, gingival index, bleeding on probing) at index teeth and the host inflammatory marker MMP-8 in matrix-paired extracts (plaque and aligner).\n\nStudy visits occur at baseline and at the end of each 1-month period. Supragingival plaque is collected from the upper and lower first molars and central incisors; used aligners are swabbed immediately after removal. Participants are instructed to wear aligners about 22 hours\u002Fday, change trays every 10 days, remove aligners for meals and oral hygiene, and drink only water while aligners are in.\n\nLaboratory procedures include blinded culture enumeration under coded labels (performed by a single trained operator, FA), confocal laser scanning microscopy, and RNA isolation with species-specific qRT-PCR; microscopy is conducted unblinded after decoding. The study will determine whether chlorhexidine or an oxygen-based cleanser produces more favorable early ecological changes and periodontal outcomes than mechanical brushing alone in clear aligner therapy.",[188,30],[285,286,287,288,289,290,291,292,293,294,229,295,232,296],"Clear aligners","Chlorhexidine","BlueM","Oxygen-based cleanser","Mechanical toothbrushing","Supragingival plaque","Aligner biofilm","Fusobacterium nucleatum","Prevotella intermedia","MMP-8","Gingival index","Randomized crossover","2026-01-06",{"date":299,"type":42},"2026-01-08",{"date":301,"type":23},"2026-02",{"date":45,"type":23},{"name":304,"class":48},"Riyadh Elm University",{"id":306,"slug":307,"hasResults":11,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":312,"targetDuration":4,"studyType":24,"phases":314,"briefSummary":315,"conditions":316,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":49},"100612550","a-clinical-study-to-evaluate-the-effectiveness-of-an-experimental-toothpaste-in-improving-gum-health-and-reducing-plaque-accumulation-100612550","NCT07255040","A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation","A 24-Week, Randomised, Controlled, Examiner-blind, Clinical Study to Evaluate the Efficacy of an Experimental Stannous Fluoride Dentifrice in Improving Gingival Health and Reducing Plaque Accumulation","Inclusion Criteria:\n\n* Participant provision of a signed and dated informed consent document indicating that the participant has been informed of all pertinent aspects of the study before any assessment is performed.\n* Participant is of either sex and any gender who, at the time of screening, is at least 18 years old, inclusive.\n* A participant who is willing and able to comply with scheduled visits, treatment plan and other study procedures.\n* A participant in good general and mental health with, in the opinion of the investigator or medically qualified designee, no clinically significant or relevant abnormalities in medical history or upon oral examination, or condition, that would impact the participant 's safety, wellbeing or the outcome of the study, if they were to participate in the study, or affect the individual's ability to understand and follow study procedures and requirements.\n\nExclusion Criteria:\n\n* A participant who is an employee of the investigational site, either directly involved in the conduct of the study or a member of their immediate family; or an employee of the investigational site otherwise supervised by the investigator; or a Haleon employee directly involved in the conduct of the study or a member of their immediate family.\n* A participant who has participated in other studies (including non-medicinal studies) involving investigational product(s) within 30 days prior to study entry and\u002For during study participation.\n* A participant with, in the opinion of the investigator or medically qualified designee, an acute or chronic medical, psychiatric condition or laboratory abnormality or any other clinical serious or unstable conditions (example, cardiovascular diseases, diabetes, liver disorders, and kidney disorders) that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator or medically qualified designee, would make the participant inappropriate for entry into this study.\n* A female participant who is a pregnant (self-reported) or intending to become pregnant over the duration of the study or who is breastfeeding.\n* A participant with known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients.\n* A participant unwilling or unable to comply with the Lifestyle Considerations described in this protocol.\n* A participant who is a current smoker or an ex-smoker (including vaping) who stopped within 6 months of Screening or who is using smokeless forms of tobacco (example, chewing tobacco, gutkha, pan containing tobacco, nicotine-based e-cigarettes).\n* A participant who is diagnosed with xerostomia or is taking any medication that in the view of the investigator is causing xerostomia.\n* A participant who has a medical condition which could have directly influenced gingival bleeding (example, type 2 diabetes) or who has a bleeding disorder that could have affected study outcomes and\u002For participant safety.\n* A participant who has a recent history (within the last year) of alcohol or other substance abuse.\n* A participant who has a severe oral condition (example, acute necrotizing ulcerative gingivitis or oral or peri-oral ulceration including herpetic lesions) that could, in the opinion of the investigator, compromise study outcomes or the oral health of the participant\u002Fexaminer if they participate in the study.\n* Presence of a tongue or lip piercing, or any other oral feature that could interfere with the usage of a toothbrush.\n* Dental Exclusions:\n\n  1. A participant who has active caries that could, in the opinion of the investigator, compromise study outcomes or the oral health of the participant if they participate in the study.\n  2. A participant who has dentures (partial or full).\n  3. A participant who has fixed orthodontic appliances or is undergoing active or recent (within 3 months of Screening) orthodontic treatment, which in the opinion of the investigator, could interfere with study procedures, assessments or outcomes.\n  4. A participant who has other orthodontic devices (example, bands, fixed retainers, or removable retainers) that could, in the opinion of the investigator, interfere with study procedures, assessment or outcomes.\n  5. A participant who has numerous restorations in a poor state of repair.\n  6. A participant who has any dental condition (example, overcrowding) that could, in the opinion of the investigator, compromise study outcomes or the oral health of the participant if they participate in the study.\n  7. A participant who has had dental prophylaxis within 12 weeks of Screening.\n  8. A participant who has had teeth bleaching within 12 weeks of Screening.\n  9. A participant who has high levels of extrinsic stain or calculus deposits, in the opinion of the investigator, that could have interfered with plaque assessments.\n* A participant who has previously been enrolled in this study.\n* A participant who, in the opinion of the investigator or medically qualified designee, should not participate in the study.",{"count":313,"type":23},300,[26],"The aim of this 24-week clinical study is to evaluate the ability of an experimental dentifrice containing 0.454 percent (%) weight by weight (w\u002Fw) Stannous fluoride (SnF2); to improve gingival health, plaque reduction and prevention of plaque accumulation compared with a regular fluoride dentifrice (negative control) in participants with mild to moderate gingivitis.",[30,188],"2025-12-12",{"date":319,"type":42},"2025-12-19",{"date":321,"type":42},"2025-11-19",{"date":323,"type":23},"2026-07",{"name":325,"class":103},"HALEON",{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":17,"sex":18,"minAge":332,"maxAge":333,"enrollmentInfo":334,"targetDuration":4,"studyType":24,"phases":336,"briefSummary":337,"conditions":338,"keywords":339,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":49},"100602156","comparison-of-clinical-effects-of-listerine-and-chlorhexidine-mouth-wash-in-patients-undergoing-fixed-orthodontic-treatment-100602156","NCT07119840","Comparison Of Clinical Effects Of Listerine And Chlorhexidine Mouth Wash In Patients Undergoing Fixed Orthodontic Treatment","Inclusion Criteria:\n\n* Aged 13-40 years\n* Permanent dentition (including first molars)\n* Willing to undergo orthodontic treatment and follow instructions\n\nExclusion Criteria:\n\n* Systemic illness (e.g., diabetes, heart disease, hepatitis)\n* Pregnant\u002Flactating females\n* Tobacco use\n* History of allergies to mouthwash\u002Ftoothpaste\n* Use of mouthwash in past 3 months\n* Abnormal oral morphology or parafunctional habits","13 Years","40 Years",{"count":335,"type":23},60,[26],"This randomized clinical trial aims to compare the effectiveness of Listerine and Chlorhexidine mouthwashes in improving periodontal health in patients undergoing fixed orthodontic treatment. Gingival Index and Plaque Index will be assessed at baseline, 2 weeks, and 4 weeks.",[188,30],[340,286,341,200,31,342],"Listerine","Gingival Index","Orthodontic Appliances","2025-11-20",{"date":345,"type":42},"2025-11-26",{"date":347,"type":42},"2025-08-01",{"date":349,"type":23},"2025-12-30",{"name":351,"class":48},"Khyber Medical University Peshawar",{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":57,"enrollmentInfo":359,"targetDuration":4,"studyType":24,"phases":361,"briefSummary":364,"conditions":365,"keywords":368,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":378,"leadSponsor":379,"locationsCount":49},"100504731","phase-1-oral-changes-with-caloric-and-no-caloric-sweeteners-100504731","NCT05852145","Oral Changes With Caloric and no Caloric Sweeteners","Effect of the Consumption of Beverages Added With Stevia Rebaudiana on Oral pH and Dental Biofilm in Adolescents","Inclusion Criteria:\n\n* Habitual consumption of soft drinks\n* Decayed, Missing, and Filled Teeth (DMF) index of at least 3 (considering as caries those lesions that are visible without the tooth needing to be dry)\n* Agree to participate in the study and sign informed consent\n* Parents sign informed consent\n* Any nutritional condition\n\nExclusion Criteria:\n\n* Orthodontic treatment\n* Topical application of fluoride during the last 3 months\n* Having a motor disability that interfered with tooth brushing\n* Xerostomia\n* Antibiotic therapy during the study period\n* Periodontal infections",{"count":360,"type":23},52,[362,363],"PHASE1","PHASE2","The objective of this clinical trial is to compare the effect that the intake of beverages without sweeteners, added with non-caloric sweeteners (stevioside) and caloric sweeteners (sucrose) on oral pH and dental biofilm microbiome in Mexican adolescents.\n\nParticipants will drink on different occasions a beverage without sweetener, a beverage added with stevioside or a beverage added with sucrose. The researchers will compare the changes that each one causes in salivary pH, dental biofilm pH, dental biofilm bacterial proliferation and dental biofilm microbiome.",[366,367,30],"pH","Microbiome",[369,370,366,371,372,373],"artificial sweetener","stevioside","caries","sucrose","dental biofilm","2025-10-07",{"date":376,"type":42},"2025-10-09",{"date":347,"type":42},{"date":169,"type":23},{"name":380,"class":48},"Hospital Infantil de Mexico Federico Gomez",{"id":382,"slug":383,"hasResults":11,"nctId":384,"briefTitle":385,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":387,"enrollmentInfo":388,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":390,"conditions":391,"keywords":394,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":406,"locationsCount":49},"100604653","digital-quantification-of-dental-plaque-based-on-intraoral-scanner-images-100604653","NCT07152314","Digital Quantification of Dental Plaque Based on Intraoral Scanner Images","Inclusion Criteria:\n\n* Presence of at least 20 natural teeth\n* Visible plaque index \\> 20% at initial assessment\n* Age between 18 and 65 years\n* Both sexes eligible\n\nExclusion Criteria:\n\n* Use of fixed orthodontic appliances\n* Presence of extensive restorations or fixed dentures on the anterior teeth\n* Systemic conditions that interfere with the formation of dental biofilm\n* Use of medications that alter salivary flow","65 Years",{"count":389,"type":23},20,"This diagnostic validation study aims to develop and validate a digital method for dental biofilm quantification using three-dimensional images obtained by an intraoral scanner. Twenty participants will undergo intraoral scanning at three time points: before and after plaque disclosure, and after supervised toothbrushing. The digital method's accuracy will be compared with traditional clinical assessment methods (Turesky Plaque Index).",[392,393,30,188,187],"Dental Plaque (Diagnosis)","Dental Plaque Imaging Methods",[395,396,397,398,399],"Dental Biofilm","Intraoral Scanner","Preventive Dentistry","Plaque quantification","Digital Diagnosis","2025-08-28",{"date":402,"type":42},"2025-09-03",{"date":404,"type":23},"2025-09",{"date":100,"type":23},{"name":407,"class":48},"University of Guarulhos",{"id":409,"slug":410,"hasResults":11,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":4,"eligibilityCriteria":414,"healthyVolunteers":17,"sex":18,"minAge":387,"maxAge":4,"enrollmentInfo":415,"targetDuration":4,"studyType":24,"phases":417,"briefSummary":418,"conditions":419,"keywords":422,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":436,"locationsCount":438},"100560355","antibacterial-photodynamic-therapy-as-an-adjunctive-treatment-on-oral-hygiene-in-elderly-persons-100560355","NCT06576063","Antibacterial Photodynamic Therapy as an Adjunctive Treatment on Oral Hygiene in Elderly Persons","Effects of the Regular Use of Antibacterial Photodynamic Therapy as an Adjunctive Treatment on Oral Hygiene in Elderly Persons Living at Home or at Care Homes","Inclusion Criteria:\n\n* An elderly (age ≥ 65 years) person living at home or at care home, with a possibility to regular dental care appointments\n* Ability to understand and sign the informed consent\n* At least 10 teeth in the mouth, including implants\n* Ability to understand and follow the study protocol, including tooth brushing and following the instructions for the use of Lumoral Treatment, based on the assessment of the investigator\n\nExclusion Criteria:\n\n* Uncontrolled diabetes mellitus (DM)\n* Severe dementia or other similar conditions that may restrict understanding of the study information and protocol\n* Presence of any physical limitation or restriction that might restrict Lumoral use\n* Active smoking and use of other tobacco products\n* Use of antibiotics within 4 weeks week prior study\n* Oral thrush\n* Known sensitivity to near-infrared or antibacterial blue light.",{"count":416,"type":23},100,[26],"On average, the dental condition of elderly people is poor due to various reasons. The importance of oral health maintenance of the ageing population has been recognized by the World Health Organization (WHO), as oral health plays a key role in reaching the global goal of the \"Decade of Healthy Ageing 2021-2030\".\n\nNew measures for maintaining good oral health are welcome. The use of antibacterial photodynamic therapy (aPDT) and antibacterial blue light (aBL) has been studied and found to reduce the amount of plaque in the mouth. The Lumoral device is a CE-marked home medical device combining aPDT and aBL, and it is effective in reducing the development of plaque and harmful bacteria in the plaque. The device has also been shown to be easy and safe to use. In this study, a combination of regular dental appointments with the importance of enhanced dental self-care, will be tested as one regional solution for reaching the global goal set by WHO.",[30,420,421],"Bleeding of Subgingival Space","Oral Complication",[423,424,425,426,427,428],"Lumoral","Preventive oral care","Antibacterial photodynamic therapy (aBPT)","aMMP-8","Plaque control","Oral hygiene","2025-08-05",{"date":431,"type":42},"2025-08-07",{"date":433,"type":42},"2025-01-02",{"date":435,"type":23},"2027-06",{"name":437,"class":103},"Koite Health Oy",3,{"id":440,"slug":441,"hasResults":11,"nctId":442,"briefTitle":443,"officialTitle":444,"acronym":445,"eligibilityCriteria":446,"healthyVolunteers":17,"sex":18,"minAge":447,"maxAge":448,"enrollmentInfo":449,"targetDuration":4,"studyType":24,"phases":451,"briefSummary":452,"conditions":453,"keywords":457,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":459,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":465,"locationsCount":49},"100538105","targeting-of-preventive-treatment-for-adolescents-at-risk-of-oral-diseases-100538105","NCT06286501","Targeting of Preventive Treatment for Adolescents at Risk of Oral Diseases","Identification of Adolescent Patients at Risk of Oral Diseases and Targeting of Preventive Treatment, and the Use of Antibacterial Photodynamic Therapy as an Adjunctive Treatment Method","LumoPrevent","Inclusion Criteria:\n\n* 14-16 years old, and a junior high school 8th-grade pupil from the area of the Wellbeing Services of County Pirkanmaa\n* Agreement to participate in the study and to sign a written consent form, including either consent from caregiver(s) with pupils under 14 years, or information to caregiver(s) with pupils from 15 to 16 years old\n* Able to cooperate with the treatment\n\nExclusion Criteria:\n\n* Presence of any physical limitation or restriction that might restrict Lumoral use\n* Unwilling to participate in the study\n* Periodontal treatment within 3 months prior to study","14 Years","16 Years",{"count":450,"type":23},120,[26],"The aim of the study is to identify adolescent patients that are at risk of developing oral diseases, and to assess if targeted preventive oral treatment with antibacterial dual-light therapy as an adjunctive treatment method can have a positive impact in preventing oral diseases from emerging.",[454,30,455,456],"Dental Caries in Children","Tooth Decay","Periodontitis",[458,424,423],"Antibacterial",{"date":460,"type":42},"2025-08-06",{"date":462,"type":42},"2024-04-18",{"date":464,"type":23},"2025-12-31",{"name":466,"class":48},"Wellbeing Services County of Pirkanmaa",{"id":468,"slug":469,"hasResults":11,"nctId":470,"briefTitle":471,"officialTitle":471,"acronym":4,"eligibilityCriteria":472,"healthyVolunteers":11,"sex":18,"minAge":57,"maxAge":473,"enrollmentInfo":474,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":475,"conditions":476,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":479,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":49},"100600675","bacteria-in-dental-plaque-and-atheroma-plaque-100600675","NCT07100574","Bacteria in Dental Plaque and Atheroma Plaque","Inclusion Criteria:\n\n* Diagnosed with endarterectomy\n* Not receiving chemotherapy\n* Not having received this treatment before\n\nExclusion Criteria:\n\n* Having systemic infection\n* Patients with severe heart disease","85 Years",{"count":335,"type":23},"Periodontitis is considered a focus of infection where oral bacteria, bacterial by-products or inflammatory mediators can interact with other parts of the organism via the blood. Periodontal pathogen components such as DNA, RNA or specific antigens of P. gingivalis, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Treponema denticola (T. denticola), Fusobacterium nucleatum (F. nucleatum) or Campylobacter rectus have been isolated from different tissues such as atheroma plaques, placenta, amniotic sac and respiratory tract. It has been reported that periodontitis may contribute to endothelial dysfunction leading to the formation of atherosclerosis.",[92,30,477,478],"Atheroma Plaque","Oral Bacteria",{"date":480,"type":42},"2025-08-03",{"date":482,"type":42},"2024-12-10",{"date":484,"type":23},"2026-03-30",{"name":486,"class":48},"Istanbul Saglik Bilimleri University",{"id":488,"slug":489,"hasResults":11,"nctId":490,"briefTitle":491,"officialTitle":492,"acronym":4,"eligibilityCriteria":493,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":494,"targetDuration":4,"studyType":24,"phases":496,"briefSummary":497,"conditions":498,"keywords":501,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":508,"lastUpdatePostDateStruct":509,"startDateStruct":511,"completionDateStruct":513,"leadSponsor":514,"locationsCount":49},"100448702","investigation-of-biofilm-formation-on-temporary-push-on-rings-of-implant-crowns-100448702","NCT05122897","Investigation of Biofilm Formation on Temporary push-on Rings of Implant Crowns","Temporary push-on Rings of Antimicrobial Alloys for Transmucosal Implant Abutment Systems: a Randomized Clinical Study on Early and Mature Biofilm Formation","Inclusion Criteria:\n\n* Informed Consent signed by the subject\n* Presence of one or more bone level titanium implant prior to insertion of the final restoration\n* No systemic illness\n* No heavy smoking (smoking \\\u003C10 cigarettes\u002Fday)\n* No pregnancy\n* No active periodontitis (probing pocket depth ≤4 mm)\n* No pharmacological treatment or antibiotic therapy during or up to three months before the study\n\nExclusion Criteria:\n\n* Systemic illness (e.g. Diabetes)\n* Heavy smoking (smoking \\>10 cigarettes\u002Fday)\n* Known or suspected non-compliance, drug or alcohol abuse\n* Pregnancy\n* Active periodontitis (probing pocket depth \\>4 mm)\n* Pharmacological treatment or antibiotic therapy during or up to three months before the study",{"count":495,"type":23},33,[26],"This in-vivo study investigates early (48h), mature (2 weeks) and long-term (3 months) biofilm formation and composition on temporary push-on cones (exchangeable conical rings) made of noble-alloy-based materials (Pagalinor, PA) in comparison to Titanium-6Aluminum-7Niobium alloy (TAN) presently used in the transmucosal portion of dental implant abutments.",[30,499,500],"Oral Biofilm","Peri-implantitis",[502,503,504,505,506,507],"Titanium-6Aluminum-7Niobium alloy","Pagalinor","transmucosal implant abutment","implant crowns","temporary push-on rings","Variobase abutments","2025-07-21",{"date":510,"type":42},"2025-07-25",{"date":512,"type":42},"2022-01-11",{"date":301,"type":23},{"name":515,"class":48},"University Hospital, Basel, Switzerland",{"id":517,"slug":518,"hasResults":11,"nctId":519,"briefTitle":520,"officialTitle":521,"acronym":4,"eligibilityCriteria":522,"healthyVolunteers":17,"sex":18,"minAge":523,"maxAge":333,"enrollmentInfo":524,"targetDuration":4,"studyType":24,"phases":525,"briefSummary":526,"conditions":527,"keywords":530,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":533,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":538,"locationsCount":4},"100585028","ai-generated-whatsapp-reminders-vs-no-reminders-impact-on-oral-health-in-young-adults-100585028","NCT06897033","AI-Generated WhatsApp Reminders vs. No Reminders: Impact on Oral Health in Young Adults","Effect of Artificial Intelligence-Generated WhatsApp Reminders Compared to No Reminders on Oral Health Among Young Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Received a non-surgical periodontal treatment and oral hygiene instructions.\n* Own a smartphone with WhatsApp installed.\n* Willing and able to provide informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Individuals with pre-existing oral health conditions requiring specialized care.\n* Patients who received surgical periodontal interventions.\n* Participation in another oral health or diet-related study.\n* Individuals who do not use WhatsApp or are unwilling to receive messages through the platform.","20 Years",{"count":335,"type":23},[26],"This randomized controlled trial aims to evaluate the effectiveness of artificial intelligence-generated WhatsApp reminders on improving oral hygiene practices among individuals aged 20-40 years visiting the periodontal clinic at El-Qasr El-Ainy Dental Hospital. Participants will be randomly assigned to either receive health education followed by AI-generated WhatsApp reminders over a 3-month period or to a control group receiving health education only. The primary outcome is the presence of white spot lesions, assessed using the modified Gorelick White Spot Lesion (WSL) index. Secondary outcomes include the presence of dental plaque, measured by the Plaque Index (PI). This study seeks to determine whether AI-generated reminders can enhance oral hygiene adherence compared to standard health education alone.",[528,30,529],"White Spot Lesions","Oral Hygiene, Oral Health",[428,531],"Reminders","2025-03-27",{"date":534,"type":42},"2025-04-02",{"date":536,"type":23},"2025-05",{"date":404,"type":23},{"name":539,"class":48},"Cairo University",{"id":541,"slug":542,"hasResults":11,"nctId":543,"briefTitle":544,"officialTitle":545,"acronym":4,"eligibilityCriteria":546,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":547,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":549,"conditions":550,"keywords":4,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":551,"lastUpdatePostDateStruct":552,"startDateStruct":554,"completionDateStruct":556,"leadSponsor":557,"locationsCount":49},"100574501","comparative-accuracy-of-ai-models-and-clinical-assessment-for-dental-plaque-detection-in-children-100574501","NCT06760104","Comparative Accuracy of AI Models and Clinical Assessment for Dental Plaque Detection in Children","Accuracy of Dental Plaque Detection From Intraoral Images Using Different Artificial Intelligence Models Versus Clinical Assessment Among a Group of Children: A Diagnostic Accuracy Study.","Inclusion Criteria:\n\n.Study participants: Children within age range (7-12) years old. .Teeth without metal crowns or amalgam restoration.\n\nExclusion Criteria:\n\n* Children with developmental enamel defects\n* Children who are unwilling to cooperate or who has mental retardation and are prohibited from having their images taken. .Children who's their legal guardians will not approve to participate in the study.",{"count":548,"type":23},323,"This diagnostic accuracy study aims to evaluate the effectiveness of various artificial intelligence models in detecting dental plaque from intraoral images compared to clinical assessments performed by dentists among children. The study seeks to determine the accuracy, sensitivity, specificity, and overall performance of AI technologies in identifying dental plaque. study study Design: Observational study",[30],"2025-01-03",{"date":553,"type":42},"2025-01-06",{"date":555,"type":23},"2025-01-01",{"date":349,"type":23},{"name":558,"class":48},"Naema Ahmed",{"id":560,"slug":561,"hasResults":11,"nctId":562,"briefTitle":563,"officialTitle":564,"acronym":4,"eligibilityCriteria":565,"healthyVolunteers":17,"sex":18,"minAge":566,"maxAge":4,"enrollmentInfo":567,"targetDuration":4,"studyType":24,"phases":568,"briefSummary":569,"conditions":570,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":572,"startDateStruct":574,"completionDateStruct":576,"leadSponsor":578,"locationsCount":49},"100573876","probiotic-treatment-of-orthodontic-patients-100573876","NCT06751979","Probiotic Treatment of Orthodontic Patients","Effect of the Probiotic Strain Streptococcus Salivarius M18 on de Novo Formation and Composition of Dental Biofilm in Orthodontic Patients: A Randomized Double-blind Placebo-controlled Clinical Trial.","Inclusion Criteria:\n\n1. Generally healthy males and females ≥ 10 years of age.\n2. Able to read and receive a copy of the signed informed consent form.\n3. Have at least 20 natural teeth.\n4. Have been undergoing orthodontic treatment with fixed orthodontic appliances in the upper and\u002For lower jaw \\> 6 months.\n5. An average plaque score of \\> 2 according to the Modified Orthodontic Plaque Index (MOPI) at the screening appointment.\n\nExclusion Criteria:\n\n1. Significant oral soft tissue pathology based on a visual examination.\n2. History of allergy or significant adverse events following use of oral hygiene products such as toothpastes, mouth rinses, breath mints, lozenges, or chewing gum or their ingredients.\n3. History of allergies to milk proteins.\n4. History of allergies towards probiotics.\n5. Self-reported as pregnant or nursing.\n6. Self-reported serious medical conditions.\n7. Antibiotic or anti-inflammatory medication within 30 days of screening visit.\n8. Acute sinusitis or severe oral-pharyngeal infections.\n9. Smoker.","10 Years",{"count":335,"type":23},[26],"The purpose of this study is to examine the effect of treatment with a lozenge containing the probiotic strain S. salivarius M18 on the formation, composition and virulence of dental plaque and in healthy orthodontic patients, compared to placebo control.",[30,117],"2024-12-27",{"date":573,"type":42},"2024-12-30",{"date":575,"type":42},"2024-10-02",{"date":577,"type":23},"2025-03",{"name":579,"class":48},"University of Aarhus",{"id":581,"slug":582,"hasResults":11,"nctId":583,"briefTitle":584,"officialTitle":585,"acronym":4,"eligibilityCriteria":586,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":333,"enrollmentInfo":587,"targetDuration":4,"studyType":24,"phases":589,"briefSummary":590,"conditions":591,"keywords":4,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":592,"lastUpdatePostDateStruct":593,"startDateStruct":595,"completionDateStruct":597,"leadSponsor":598,"locationsCount":49},"100543479","an-investigation-of-the-efficacy-of-ohem-for-improving-oral-hygiene-in-children-100543479","NCT06356402","An Investigation of the Efficacy of OHEM for Improving Oral Hygiene in Children","A Feasibility Study of the Investigation on the Efficacy of Oral Health Education for Mothers (OHEM) Module for Improving Oral Hygiene in Children.","The inclusion criteria of the study are based on mothers and children.\n\nInclusion criteria for Mothers:\n\n1. Mothers with children aged 12 to 15 years old, who are residing in Gulshan-e-Sikandarabad with no plan to move within the next 12 months.\n2. Mothers with the ability to understand and read the Urdu language.\n3. Only biological mothers with good physical and psychological health.\n\nExclusion criteria for mothers:\n\n1. Mothers with new-born\n2. Mothers with a history of receiving formal oral health promotion or preventive programs.\n\nInclusion criteria for Children:\n\n1. Aged 12,13,14, and 15 years old (studying in classes 6,7,8, and 9 respectively) residing in union council Gulshan-e-Sikandrabad,\n2. Live with biological mothers at home,\n3. Present with moderate to severe plaque accumulation and gingivitis during oral screening.\n\nExclusion criteria for Children:\n\n1. Have genetic or medical conditions, such as physical and psychological disabilities that can affect the comprehension of instruction and tooth brushing activities, such as learning disabilities or auditory or visual disorders.\n2. Have genetic dental anomalies such as anodontia, amelogenesis imperfecta, and supernumerary teeth.\n3. Have been previously exposed to any form of oral health education.",{"count":588,"type":23},540,[26],"This pilot study evaluates the feasibility of conducting a larger Randomized Controlled Trial to compare three oral health education delivery methods to a control group. Except for the control group, mothers in the three intervention groups will receive the same oral health education based on the OHEM module but differ in the delivery methods, namely lecture, exhibition, and demonstration. All groups will receive a booklet and oral hygiene kits and be instructed to educate their children at home. Pre- and post-intervention assessments include the satisfaction of participants, the researchers' evaluation and cost of the trial, oral hygiene status, and the knowledge of the parents and children.",[30,188],"2024-07-23",{"date":594,"type":42},"2024-07-24",{"date":596,"type":23},"2024-10",{"date":536,"type":23},{"name":599,"class":48},"Ziauddin University"]