[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-pulp-necrosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-pulp-necrosis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,57,81,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100634983","metagenomic-analysis-and-postoperative-pain-in-infected-root-canals-using-different-irrigation-protocols-100634983",false,"NCT07546773","Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols","Metagenomic Analysis and Post-operative Pain Assessment of Infected Root Canals Using Different Irrigation Protocols: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adult patients aged 18-60 years\n* Requiring root canal treatment for teeth with necrotic pulp\n* Presence of periapical radiolucency confirmed radiographically\n* Good general health with no systemic diseases affecting healing outcomes\n* Willing to provide informed written consent\n* Available for follow-up appointments\n\nExclusion Criteria:\n\n* Patients with open apices\n* Severe periodontal disease\n* Currently taking antibiotics\n* Allergy to study materials (lidocaine, sodium hypochlorite, methylene blue, latex)\n* Pregnant or breastfeeding women\n* Compromised immunity or systemic conditions (e.g., uncontrolled diabetes, HIV, immunosuppressive therapy)\n* Previous root canal treatment on the study tooth\n* Tooth not restorable\n* Presence of vertical root fracture","ALL","18 Years","60 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure irrigation (PulpSucker device), and mechanical activation (Easy Clean device), have shown promise in enhancing bacterial reduction within the root canal system. However, their impact on postoperative pain has not been fully explored.\n\nThis randomized controlled clinical trial aims to compare bacterial reduction and postoperative pain levels in infected root canals using four different irrigation protocols. The study will use metagenomic analysis to evaluate changes in bacterial community composition and the Visual Analogue Scale (VAS) to assess patient-reported pain levels at multiple time points postoperatively.",[27,28],"Dental Pulp Necrosis","Pulpitis",[30,31,32,33,34,35,36,37,38,39,40,41,42,43],"Root canal treatment","Irrigation protocol","Ultrasonic activation","Laser activation","Negative pressure irrigation","Mechanical activation","Metagenomic analysis","Postoperative pain","Visual analogue scale","Bacterial reduction","Endodontics","PulpSucker","Easy clean device","Next generation sequencing","NOT_YET_RECRUITING","2026-04-28",{"date":47,"type":48},"2026-05-04","ACTUAL",{"date":50,"type":21},"2026-04-30",{"date":52,"type":21},"2028-01-15",{"name":54,"class":55},"Suez Canal University","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":22,"phases":68,"briefSummary":69,"conditions":70,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100611374","influence-of-maintaining-apical-patency-on-post-endodontic-pain-in-molars-100611374","NCT07239752","Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars","Influence of Maintaining Apical Patency in Post-Endodontic Pain in Molars With Necrotic Pulp and Apical Periodontitis: A Randomized Controlled Trial","IMAP-Pain","Inclusion Criteria:Adult patients aged 18-65 years.\n\nMedically healthy, classified as American Society of Anesthesiologists (ASA) Physical Status I or II.\n\nPresence of a single permanent molar tooth diagnosed with necrotic pulp and symptomatic apical periodontitis, and indicated for primary root canal treatment.\n\nPatients who provide informed written consent to participate in the study. -\n\nExclusion Criteria:\n\nTeeth with prior endodontic treatment or complex anatomy (e.g., calcified canals, severe curvature).\n\nPatients with significant systemic illness (e.g., uncontrolled diabetes, immunocompromised status) or pregnancy.\n\nHistory of analgesic intake within 72 hours prior to the root canal procedure.\n\nNon-restorable teeth, teeth with severe periodontal disease (pocket depth \\>5mm), or teeth with root fractures.\n\nExclusion Criteria:\n\n\\-","65 Years",{"count":67,"type":21},48,[24],"This randomized controlled trial will investigate if maintaining apical patency-a technique where a small file is gently moved past the root's end during cleaning-affects pain after a root canal. The study will include 48 adult patients needing root canal treatment on a back molar tooth with a dead nerve and infection at the root tip. Participants will be randomly assigned to one of two groups: one where the apical patency technique is used, and one where it is not. All other treatment steps will be identical. Patients will record their pain levels on a standard scale (0-100 mm Visual Analog Scale) at 6, 12, 24, 48, and 72 hours after the procedure. The goal is to determine if this specific technique influences the intensity and duration of post-treatment pain",[71,27],"Periapical Periodontitis","2025-11-16",{"date":74,"type":48},"2025-11-20",{"date":76,"type":21},"2026-02-10",{"date":78,"type":21},"2026-10-10",{"name":80,"class":55},"College of Physicians and Surgeons Pakistan",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":56},"100596635","chitosan-irrigation-in-premolar-root-canal-therapy-randomized-trial-100596635","NCT07048028","Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)","Evaluation of the Antibacterial Efficacy of Chitosan as an Irrigation Solution: A Randomized Controlled Clinical Trial","CHITO-PRE RCT","Inclusion Criteria:\n\n* Patients who agreed to participate in the study\n* Systemically healthy patient\n* Mandibular premolar teeth\n* Teeth that respond negatively to thermal tests and EPT\n* Patients who have not used antibiotics for at least 2 weeks\n\nExclusion Criteria:\n\n* Teeth with previous primary root-canal treatment\n* Pregnant patients\n* Severely curved roots (\\>25° curvature)\n* Canals with instrument separation during preparation\n* Calcified (obliterated) canals",true,{"count":91,"type":21},90,[24],"The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment. The main questions it will answer are:\n\nHow much does a chitosan solution used alone lower the number of bacteria inside the root canal? Do the combinations sodium hypochlorite + chitosan or sodium hypochlorite + EDTA lower bacteria even more than chitosan alone? Researchers will compare the three irrigation methods to see which one achieves the greatest bacterial reduction.\n\nWhat participants will do\n\nBe randomly assigned to one of three groups:\n\nGroup 1: Chitosan only Group 2: Sodium hypochlorite followed by chitosan Group 3: Sodium hypochlorite followed by EDTA\n\nAttend two clinic visits:\n\nVisit 1:\n\nReceive standard root-canal treatment under local anesthesia. Provide tiny paper-point samples from inside the canal before and after the assigned rinse (painless; takes seconds).\n\nVisit 2 (about 1 week later):\n\nReturn for a check-up and final filling of the tooth. Record any pain or discomfort for the first three days after treatment in a simple diary (or by phone).\n\nAbout 90 adults will take part. All procedures are routine in dental care, and there is no cost to participate. Participants may withdraw at any time and can ask the study dentist any questions throughout the trial.",[95,27,96],"Apical Periodontitis","Root Canal Infection","RECRUITING","2025-07-01",{"date":100,"type":48},"2025-07-04",{"date":102,"type":48},"2025-05-05",{"date":104,"type":21},"2025-12-12",{"name":106,"class":55},"ESRA DAĞCI",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":121,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":135},"100408974","one-vs-two-visits-root-canal-treatments-in-infected-teeth-100408974","NCT04605445","One Vs Two Visits Root Canal Treatments in Infected Teeth","One Vs Two Visits Endodontics - a Prospective Randomized Multicenter Study in General Dental Practice","Inclusion Criteria:\n\n* Patient older than 17 years.\n* Permanent tooth excluding third molars.\n* Necrotic tooth with\u002Fwithout clinical and\u002For radiological signs of apical (juxta radicular) periodontitis (non-bleeding pulp in the canal orifice. In case of a multi rooted tooth, a non-bleeding pulp in at least one root canal orifice) where orthograde endodontic treatment is planned.\n\nExclusion Criteria:\n\n* Patients with severe general disease and\u002F or where endodontic treatment requires special consideration for health reasons (eg radiation-treated jaw bone in the area or increased susceptibility to infection).\n* Systemic involvement (fever).\n* Swelling (extra- and\u002For intra oral).\n* Previously root canal treated tooth (instrumented and\u002For rotfilled).\n* Confirmed or strong suspicion of transverse or longitudinal root fracture.\n* Trauma to the tooth (\\\u003C6 month).\n* Marginal bone loss \\>1\u002F3 of the root lenght.\n* Root resorption.\n* Non restorable tooth.\n* Endodontic treatment is not considered feasible because rubberdam cannot be used on the tooth.\n* Follow-up at the clinic of the treatment after\\> 1 year is considered not feasible.",{"count":115,"type":21},1000,[24],"The primary aim of the study is to compare the outcome of one vs two visits endodontics (root canal treatments) performed in general dental practice of infected (necrotic) teeth, one and four years after treatment. Secondary aims are to compare the root filling quality and the frequency of complications for both treatment modalities.\n\nA pilot study will identify the shortcomings of the protocol, which will be revised accordingly.\n\nA multi-center study in several clinics from five counties throughout Sweden is planned. Consecutive eligible patients (see inclusion and exclusion criteria) with one tooth each will be included.\n\nThe study sample size calculation was based on a judgement that a minimal worthwhile effect of less than 10% was not clinically relevant. The presumption was that successful outcomes would be of 75% and 65% for the different treatment arms, respectively. Three hundred and fifty six patients per group are thus needed to detect that difference as statistical significant with a power of 80% and an alfa-error of 5%. To compensate for around 30% drop-outs a number of 1000 patients will be recruited.\n\nPatients will be randomly enrolled in two arms: one in which the endodontic treatment (root canal treatment) is performed in one visit, and in the other arm in two visits. The allocation sequences for one vs multiple visit endodontics will be computer generated followed by a dark colored envelope concealed allocation.\n\nThe patients will be contacted by telephone 5-7 days post-operatively, and a control visit at the clinic will be scheduled one month post-operatively to assess complications related to the treatment.\n\nA clinical control will be performed at the clinic one and four years after treatment. Intra-oral radiographs will be taken. The radiographs will be examined by two blinded and independent observers. A successful outcome is defined by clinical and radiographic normalcy.\n\nThe statistical methods selected to analyse the primary outcome will be the Chi square test of 2x2 tables, or Fisher´s exact test when proportions are small and the expected value \\\u003C5. The calculations will be two-tailed. Results will be considered statistically significant at p\\\u003C0.05.",[95,119,120,27],"Pain","Tooth Loss",[40,122,123,124,125],"General Dental Practice","Single Visit","Multiple Visits","Infection Barrier","2024-12-11",{"date":128,"type":48},"2024-12-16",{"date":130,"type":48},"2020-11-18",{"date":132,"type":21},"2031-12",{"name":134,"class":55},"Malmö University",7]