[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dental-restoration-permanent\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dental-restoration-permanent":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,63,93,122,153],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":62},"100589516","clinical-investigation-measuring-the-long-term-clinical-performance-and-safety-of-biodentine-xp-in-patients-treated-for-coronal-restorative-or-endodontic-dental-indications-100589516",false,"NCT06955429","Clinical Investigation Measuring the Long Term Clinical Performance and Safety of Biodentine™ XP in Patients Treated for Coronal Restorative or Endodontic Dental Indications.","Observational, Prospective, International and Multicenter Clinical Investigation Measuring the Longterm Clinical Performance and Safety of Biodentine™ XP in Patients Treated for Coronal Restorative or Endodontic Dental Indications.","BIOD XP","Inclusion Criteria:\n\n1. Temporary tooth, from a child ≥ 2 years old, requiring dental restorative treatment with Biodentine™ XP, and\u002For, Permanent (mature or immature) tooth, from a child or an adult, requiring a dental restorative and\u002For an endodontic treatment with Biodentine™ XP.\n2. Adult patient with a signed informed consent form; For the minor, if in age to understand, an assent is required, and at least one parent or legal representative must consent.\n3. Only in France: Subject affiliated or benefiting from a social\u002Fhealth insurance system.\n\nExclusion Criteria:\n\n1. Patient with one or more documented contraindication to use Biodentine™ XP (Refer to IFU).\n2. Inadequate expected tooth lifetime as estimated by the investigator:\n\n   * For a Temporary tooth: high probability of tooth loss within 2 years after treatment with Biodentine™ XP.\n   * For a permanent tooth: high probability of tooth loss within 10 years after treatment with Biodentine™ XP.\n3. Patient with any systemic disease that may hinder the normal healing process and\u002For the follow-up.\n4. Adult patient under legal protection measures or unable to express his\u002Fher consent, and individual deprived of liberty by judicial or administrative decision, as well as individual receiving psychiatric care.\n5. Periodontitis (stage 3, 4 or stage 2 grade C).\n6. Inability to comply with study procedures.\n7. Participation in another interventional clinical investigation that can induce bias in the study results.","ALL","2 Years",{"count":20,"type":21},275,"ESTIMATED","OBSERVATIONAL","The aim of this present study is to collect additional data for the post-marketing follow-up of Biodentine™ XP and measure long-term (up to 10 years) performance and safety of the biomaterial in all its indications.",[25,26,27],"Dental Restoration, Permanent","Dental Restorations","Endodontic Treatment",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49],"Dentine restoration","Coronal carious lesions","Restoration of cervical lesion","Restoration of radicular lesion","Pulp capping","Pulpotomy","Apexification","Revitalization","Endodontic treatment","Root","Crown","Pulp","Root perforations","Furcation perforations","Perforating internal resorptions","External resorption","Root-end filling","Permanent dentine restoration","Temporary dentine-enamel restoration","Biodentine","Biodentine XP","RECRUITING","2026-04-30",{"date":53,"type":54},"2026-05-06","ACTUAL",{"date":56,"type":54},"2025-10-23",{"date":58,"type":21},"2037-02-28",{"name":60,"class":61},"Septodont","INDUSTRY",8,{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":17,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":92},"100595392","comparison-of-clinical-performance-of-partial-restorations-fabricated-with-three-dimensional-printer-and-cad-cam-100595392","NCT07031856","Comparison of Clinical Performance of Partial Restorations Fabricated With Three-Dimensional Printer and CAD-CAM","Comparison of Clinical Performance of Partial Restorations Fabricated With Three-Dimensional Printer and CAD-CAM: A Split-Mouth Randomized Clinical Trial","İncluiding:\n\n\\-- Patients with periodontally stable and appropriate oral hygiene habits without serious systemic diseases that preclude restoration. - Male and female patients with hard tissue loss in their mouth or with 2 teeth in need of restoration replacement (eligibility for split-mouth design). - People who can comply with the treatment and volunteer for follow-up for 2 years-\n\nExclusion Criteria:\n\nPatients with systemic conditions that may affect the study process (e.g. diabetes, autoimmune diseases).\n\n* Patients with excessive bruxism or parafunctional habits.\n* Pregnant or lactating women.\n* Patients with gum disease or severe bone loss.\n* Patients with a history of allergic reactions.",true,"18 Years","65 Years",{"count":74,"type":21},12,"INTERVENTIONAL",[77],"NA","The aim of this clinical study is to compare CAD-CAM and 3D restorations in individuals with two hard tissue losses or restorations in their mouths. The main question it aims to answer is: Is there a difference between CAD-CAM and 3D restorations according to FDI criteria? Researchers will compare participants to see if there is a difference between the two restorations according to FDI criteria. In this split-mouth study, participants will be randomized to receive a CAD-CAM partial restoration on one tooth and a 3D partial restoration on the other tooth.",[80,25,81],"Dental Caries","Tooth Diseases","2026-03-27",{"date":84,"type":54},"2026-04-02",{"date":86,"type":54},"2025-07-01",{"date":88,"type":21},"2026-11",{"name":90,"class":91},"Cukurova University","OTHER",1,{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":71,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":75,"phases":104,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":92},"100622081","3d-printed-ceramic-filled-photopolymer-resin-vs-cadcam-resin-composite-overlays-for-restoration-of-extensively-damaged-endodontically-treated-posterior-teeth-an-18-month-follow-up-100622081","NCT07378982","3D Printed Ceramic-Filled Photopolymer Resin Vs. CAD\u002FCAM Resin Composite Overlays for Restoration of Extensively Damaged Endodontically Treated Posterior Teeth. An 18-month Follow-up","Three Dimensionally Printed Ceramic-Filled Photopolymer Resin Versus CAD\u002FCAM Resin Composite Overlays for Restoration of Extensively Damaged Endodontically Treated Posterior Teeth. An 18-month Follow-up Randomized Controlled Trial","3D CAD\u002FCAM RCT","Inclusion Criteria:\n\nFor Participants:\n\n* Age: 18-60 years.\n* Males or females.\n* Participants with endodontically treated molar teeth. Lower molars indicated for onlay (one or two missing cusps)\n* Patients with at least 20 teeth under occlusion.\n* Good oral hygiene.\n* Co-operative patients approving to participate in the trial.\n* Have sufficient cognitive ability to understand consent procedures.\n\nFor Teeth:\n\nBadly destructed endodontically treated molars teeth indicated for cuspal total cuspal coverage (Overlay restoration)\n\n* No signs or symptoms after endodontic treatment.\n* No signs of clinical mobility.\n* Teeth with healthy periodontium.\n\nExclusion Criteria:\n\nFor Participants:\n\n* Participants with parafunctional habits or bruxism.\n* Participants with systemic diseases or disabilities that may affect participation.\n* Heavy smoking.\n* Pregnancy.\n* Lack of compliance.\n* Severe or active periodontal disease.\n* Cognitive impairment for teeth:\n* Periapical pathosis indicating failure in endodontic treatment.\n* Vital teeth.\n* Signs of pathological wear.\n* Severe periodontal affection or tooth indicated for extraction.\n* Signs of Vertical root fracture.","60 Years",{"count":103,"type":21},32,[77],"II. Introduction:\n\n6\\. Background and rationale: Restoring badly mutilated teeth was and has always been a challenge in restorative dentistry. In order to solve this issue, different approaches have been proposed, including cuspal protection or cuspal coverage. This proved to increase the fracture resistance of remaining tooth structure and overall survivability of endodontically treated teeth. Different materials and techniques have been proposed to attain cuspal coverage, such as using indirect milled or pressed ceramics, indirect milled composite, and direct composite restorations(Abu-Awwad, 2019).\n\nThe integration of 3D printing in dentistry has revolutionized the fabrication of permanent indirect restorations, including inlays, onlays, and overlays. Evaluation of whether the mechanical properties, clinical feasibility, and accuracy of 3D-printed resin restorations are compared to traditional milled and pressed alternatives. Key findings highlight superior marginal fit, cost-efficiency, and adaptability of 3D-printed resins, while addressing limitations such as stain susceptibility and long-term durability\n\nResearch question:\n\nDoes a 3D printed ceramic-filled photopolymer resin show any difference in clinical performance when compared to a CAD\u002FCAM milled composite in restoring badly decayed endodontically treated posterior teeth?\n\nStatement of the problem:\n\nThe problems of indirect milled composites include the initial cost of the milling machine, running cost of machine repairs, bur changes, and the cost of discs and blocks, not to mention that the concept of milling as a manufacturing process has an unavoidable loss of material. (Josic et al., 2023)\n\nRationale for conducting the research:\n\nIndirect restorations, such as inlays (without cusp coverage), onlays (partial cusp coverage), and overlays (full cusp coverage), aim to preserve tooth structure while restoring function and esthetics. Historically, these restorations were fabricated using ceramics or composite resins via subtractive milling or heat-pressing techniques. However, 3D printing has emerged as a transformative technology, enabling additive manufacturing of resin-based restorations with enhanced precision and reduced material waste. (Tribst et al., 2024)\n\nReview of literature:\n\nExtensively destructed endodontically treated molars may represent a high-risk restorative scenario due to loss of internal dentin support and undermined cusps leading to increased flexure, stress concentration and analysis, making failure more likely to occur due to cuspal fracture, bulk fracture, tooth splitting or adhesive debonding rather than simple marginal defects. Contemporary restorative concepts therefore emphasize preserving remaining tooth structure while providing cuspal coverage through adhesively bonded partial-coverage restorations like onlays, overlays and endocrowns, aiming to redistribute occlusal loads and reduce catastrophic tooth fracture. Clinical reviews of root-filled teeth consistently highlight that prognosis depends less on \"endodontic status\" itself and more on the quantity and quality of remaining coronal tissue, presence of ferrule, and the capacity of the definitive restoration to protect the tooth under function.\n\nAmong current treatment options, direct resin composite restorations remain attractive for being conservative, repairable, and cost-efficient. However, the effectiveness of this treatment modality decreases as cavity size leading to increased polymerization shrinkage stresses, reduced cuspal stiffness as a result of increased cavity depth, difficulty in achieving durable proximal anatomy in very large defects, and technique sensitivity under moisture compromised isolation, which can translate into higher risk of fracture or marginal breakdown over time. Indirect restorations including full crowns, partial-coverage ceramic restorations, and resin-based CAD\u002FCAM restorations can provide better anatomic control and cuspal coverage, but has some drawbacks like added steps, cost, and may require more tooth reduction depending on design and material used.\n\nSystematic review and meta-analysis evidence focusing specifically on endodontically treated posterior teeth suggests that outcomes between direct composite and indirect approaches can be broadly comparable in some settings, but there is a tendency for indirect restorations to be favored as defect severity increases and remaining walls decrease, while direct restorations may be more appropriate for smaller defects; importantly, the available evidence is heterogeneous and often limited by variation in preparation design, materials, and follow-up.",[107,25],"Endodontically Treated Molar",[109,110,111],"3D printing","CAD\u002FCAM milling","Overlay restoration","NOT_YET_RECRUITING","2026-02-02",{"date":115,"type":54},"2026-02-04",{"date":117,"type":21},"2026-02-01",{"date":119,"type":21},"2027-10-01",{"name":121,"class":91},"Cairo University",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":70,"sex":17,"minAge":129,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":133,"conditions":134,"keywords":136,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":92},"100616749","colour-match-stability-and-patients-satisfaction-of-single-shade-composites-in-anterior-teeth-100616749","NCT07309653","Colour Match, Stability, and Patient's Satisfaction of Single-Shade Composites in Anterior Teeth","Colour Matching, Stability, and Patient's Satisfaction in Maxillary Anterior Restorations Using Single-Shade Composite and Silicone-Guided Index: A 12-Month Clinical Evaluation","Inclusion Criteria:\n\n* Children who exhibit cooperative dental behaviours (rating 3 and 4) according to Frankl's behaviour rating scale (Frankl et al. 1962)\n* Presence of at least one maxillary anterior permanent tooth with one-third of crown structure loss from dental trauma\n* The affected tooth must be vital or have undergone vital pulp therapy (e.g., pulpotomy with Calcium hydroxide, white-MTA, or Biodentine)\n\nExclusion Criteria:\n\n* Known allergy to methacrylate-based materials\n* Presence of parafunctional habits, such as bruxism\n* Presence of rampant caries\n* Presence of signs of hypomineralisation, such as post-eruptive breakdown, hypersensitivity, changes in enamel texture and hardness, and abnormal translucency on radiographs.\n* The affected tooth is classified as having moderate or severe discolouration according to Dean's fluorosis index (Dean, 1942)\n* The affected tooth has lost less than one-third of its coronal crown structure\n* The affected tooth has a fracture located at the subgingival margin\n* The affected tooth requires splinting due to the severity of the trauma\n* Presence of severe malocclusion that could compromise the integrity of the restoration","6 Years","15 Years",{"count":132,"type":21},23,"The goal of this observational study is to evaluate the clinical performance of a single-shade composite resin, used with an injection moulding technique, in restoring maxillary incisors affected by traumatic dental injury in patients aged 6-15 years.\n\nThe main questions it aims to answer are:\n\n* How well does a single composite resin colour match the natural tooth?\n* How stable is the colour over a 6- and 12-month follow-up?\n* How satisfied are the children and parents with the restoration?",[135,25],"Tooth Injuries",[137,138,139,140,141,142,143],"Patient satisfaction","Color stability","Color matching","Single shade composter resins","Injection moulding technique","Flowable composite resins","Dental trauma","2025-12-29",{"date":146,"type":54},"2026-01-02",{"date":148,"type":54},"2025-12-16",{"date":150,"type":21},"2027-10-28",{"name":152,"class":91},"Mahidol University",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":70,"sex":17,"minAge":71,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":75,"phases":163,"briefSummary":164,"conditions":165,"keywords":168,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":92},"100592316","effect-of-phosphoric-acid-etching-duration-on-direct-resin-based-composite-restorations-in-permanent-anterior-teeth-100592316","NCT06991842","Effect of Phosphoric Acid Etching Duration on Direct Resin-Based Composite Restorations in Permanent Anterior Teeth","Effect of Phosphoric Acid Etching Duration on the Performance of Direct Resin-Based Composite Restorations in Permanent Anterior Teeth: A Randomized Controlled Single-Center Trial","ETCH-PRO","Inclusion Criteria:\n\nSigned informed consent by the participant\n\nAge 18 years or older\n\nIndication for a Class III or Class IV resin-based composite (RBC) restoration on an anterior permanent tooth due to one or more of the following conditions:\n\nProximal carious lesion with cavitation\n\nDefective restoration requiring replacement\n\nNecessary proximal reshaping due to developmental anomalies (e.g., peg teeth, proximal gaps from Bolton discrepancies, orthodontic tooth position, or esthetic concerns like black triangles caused by periodontal tissue recession)\n\nVital teeth with regular sensitivity\n\nSufficient language skills to understand and comply with study procedures\n\nPreoperative Visual Analog Scale (VAS) scores \\\u003C 3 for tooth sensitivity and biting discomfort\n\nGood oral hygiene, including the ability to maintain effective oral hygiene\n\nClinical periodontal health (intact periodontium or a reduced periodontium due to non-periodontal causes or after periodontal treatment)\n\nExclusion Criteria:\n\nInability to achieve sufficient isolation and contamination control during restorative procedures\n\nClass IV restoration required due to crown fracture, crown-root fracture, extensive tooth wear, or carious lesion affecting the incisal edge\n\nMissing antagonist tooth without prosthodontic replacement\n\nIntent to undergo professional tooth bleaching within five years following the Class III or IV restoration (Note: Professional tooth bleaching must be completed at least two weeks prior to study enrollment)\n\nKnown or suspected allergy to any constituents of the materials used (e.g., methacrylates or local anesthetics)\n\nPregnancy or lactation\n\nAcute or chronic health conditions that may impair study participation (e.g., systemic diseases, oral conditions, or treatments that interfere with study procedures)",{"count":162,"type":21},66,[77],"The goal of this clinical trial is to learn if reducing the phosphoric acid etching (PAE) time affects the performance of direct resin-based composite (RBC) restorations in permanent anterior teeth. It will also learn about the safety of using a shortened PAE protocol. The main questions it aims to answer are:\n\nDoes a shorter PAE time lead to more or less marginal staining in restored teeth?\n\nWhat sensitivity or other clinical issues do participants experience after restoration using different PAE times?\n\nResearchers will compare a reduced PAE protocol to a standard PAE protocol to see how each affects the outcome of Class III and IV anterior restorations.\n\nParticipants will:\n\nReceive one or two direct RBC restorations using either a shortened or standard PAE protocol\n\nVisit the clinic for follow-ups at baseline, and at 1, 2, 3, and 5 years after restoration\n\nHave sensitivity and restoration quality evaluated using clinical exams, photographs, and questionnaires",[25,166,167],"Dental Caries (Disorder)","Dental Restoration Failure",[169,170,171,172,173,174,175,176,177,178,179],"Resin-based composite","Universal adhesive","Class III restoration","Class IV restoration","Phosphoric acid etching","Adhesive dentistry","Anterior tooth restoration","Permanent dental restoration","Dental bonding","Etch-and-rinse technique","Restorative dentistry","2025-08-04",{"date":182,"type":54},"2025-08-05",{"date":184,"type":54},"2025-06-01",{"date":186,"type":21},"2031-12-31",{"name":188,"class":91},"Florin Eggmann"]