[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dentin-desensitizing-agents\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dentin-desensitizing-agents":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,66,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100643160","dentin-hypersensitivity-in-orthodontic-patients-triple-blinded-randomized-trial-of-three-desensitizing-agents-100643160",false,"NCT07641322","Dentin Hypersensitivity in Orthodontic Patients: Triple-Blinded, Randomized Trial of Three Desensitizing Agents.","Dentin Hypersensitivity: Triple-Blinded, Multicenter Randomized Trial of Three Desensitizing Dentifrices vs Non-Desensitizing Control","Inclusion Criteria:\n\n* Orthodontic patients aged 18-40 years.\n* Presence of mild to moderate dentin hypersensitivity (VAS ≥ 4).\n* Willingness to comply with a 12-week follow-up period.\n* No active periodontal disease or untreated caries.\n* Not pregnant or breastfeeding.\n* No history of allergy to desensitizing agents\n\nExclusion Criteria:\n\n* o Patients with systemic conditions affecting oral health (e.g., diabetes, immunocompromised).\n\n  * Patients using medications that affect tooth sensitivity (e.g., anti-inflammatory drugs).",true,"ALL","18 Years","40 Years",{"count":21,"type":22},200,"ESTIMATED","INTERVENTIONAL",[25],"NA","The effect of desensitizing agents will be studied on dentin hypersensitivity in orthodontic patients.it is a randomized controlled trial. three experimental groups and one placebo group.",[28],"Dentin Desensitizing Agents","NOT_YET_RECRUITING","2026-06-07",{"date":32,"type":33},"2026-06-11","ACTUAL",{"date":35,"type":22},"2026-07-15",{"date":37,"type":22},"2026-12-15",{"name":39,"class":40},"Nishtar Medical University","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":23,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":65},"100638802","effectiveness-of-two-different-desensitizing-dental-varnishes-100638802","NCT07622043","Effectiveness of Two Different Desensitizing Dental Varnishes","Effectiveness of Two Different Desensitizing Dental Varnishes: A Prospective, Randomized Split Mouth Clinical Investigation","Inclusion Criteria:\n\n* Informed Consent signed by the subject\n* Age: 18-65 years\n* Hypersensitivity assessment scale ≥ Grade 2 in\n* two non-neighboring teeth in different quadrants\n* The affected teeth are\u002Fhave: vital, caries-free, received no restorations within the last month\n* No change in medication anticipated over the next 3 months (e.g. due to upcoming surgery etc.)\n\nExclusion Criteria:\n\n* Contraindications and limitations of the MD as described in the instructions for use.\n* Known hypersensitivity or allergy to the device material (especially acrylates, mint flavouring)\n* Pregnant or other vulnerable subjects\n* Participants with severe systemic disease\n* Enrolment of employees of the dental clinic of Ivoclar Vivadent AG\n* Recent change in medication concerning Analgesics, NSAIDs, psychotropic drugs, other medications that may alter pain perception\n* Intake of analgesics prior to appointment\n* Professional desensitizing therapy in the last 3 months\n* Bleaching procedures in the last 4 weeks\n* Confounding dental conditions at test sites: defective or extensive restorations, abutment teeth for prostheses, recent restorations, pulpitis\u002Fperiapical pathology.\n* Current or recent use of desensitizing toothpastes or mouthrinses (i.e. products specifically marketed for the treatment of dentin hypersensitivity) within 4 weeks prior to enrolment","65 Years",{"count":50,"type":22},66,[25],"Dental varnishes are commonly used to relieve dentin hypersensitivity by forming a protective film that occludes dentinal tubules and reduces fluid flow. This clinical investigation aims to compare the desensitizing effect of a fluoride containing varnish with a fluoride free placebo varnish. Primary and secondary objectives include evaluating short and long term reductions in dentinal hypersensitivity, assessing patient reported outcomes and daily experiences, and monitoring the varnish's tolerability and safety.",[54,28],"Dentin Hypersensitivity","2026-05-27",{"date":57,"type":33},"2026-06-02",{"date":59,"type":22},"2026-08",{"date":61,"type":22},"2027-08",{"name":63,"class":64},"Ivoclar Vivadent AG","INDUSTRY",1,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":73,"targetDuration":4,"studyType":23,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":65},"100637605","efficacy-of-an-experimental-gel-based-on-libidibia-ferrea-on-post-bleaching-tooth-sensitivity-100637605","NCT07599514","Efficacy of an Experimental Gel Based on Libidibia Ferrea on Post-bleaching Tooth Sensitivity","Efficacy of an Experimental Gel Based on Libidibia Ferrea in Controlling Post-bleaching Tooth Sensitivity: a Randomized Clinical Trial.","Inclusion Criteria:\n\nGood oral hygiene; Absence of active caries lesions; No previous tooth bleaching treatment; Absence of dental hypersensitivity; Not being pregnant; Presence of at least 28 teeth in the oral cavity.\n\nExclusion Criteria:\n\nVolunteers undergoing orthodontic treatment; Presence of periodontal disease; Dental cracks or fractures; Restorations or prostheses on anterior teeth; Extensive restorations in molars; Gastroesophageal disorders; Severe intrinsic tooth discoloration; Presence of dentin exposure in anterior and\u002For posterior teeth.",{"count":74,"type":22},75,[25],"This randomized, parallel, single-blind, placebo-controlled clinical trial aims to investigate the effects of an experimental 0.5% Libidibia ferrea gel on the control of post-bleaching tooth sensitivity and its influence on bleaching efficacy. Seventy-five selected volunteers will be randomly allocated into three groups: CT (placebo gel), KF2 (5% potassium nitrate and 2% sodium fluoride), and JUC (experimental Libidibia ferrea gel). Each group will receive the corresponding desensitizing treatment, and the assigned product will be actively applied to the labial surfaces of the anterior teeth and the buccal surfaces of the first premolars for 10 minutes. Subsequently, all groups will undergo an in-office tooth bleaching protocol with 35% hydrogen peroxide, consisting of two sessions with three 15-minute applications each, with a 7-day interval between sessions. Postoperative sensitivity will be recorded daily by the patients for 14 days using a visual analog scale (VAS), while tooth color will be measured using a spectrophotometer at baseline and one week after the end of treatment. Data will be subjected to statistical analysis according to sample distribution, with a statistical power of 80% and a significance level of 5%.",[78,79,28],"Tooth Bleaching","Pain","2026-05-19",{"date":82,"type":33},"2026-05-22",{"date":84,"type":22},"2026-06-13",{"date":86,"type":22},"2027-03-30",{"name":88,"class":40},"Universidade Federal do Para",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":96,"targetDuration":4,"studyType":23,"phases":97,"briefSummary":98,"conditions":99,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":104,"leadSponsor":105,"locationsCount":65},"100636714","effects-of-an-experimental-propolis-gel-on-tooth-sensitivity-control-and-post-bleaching-color-change-a-randomized-clinical-trial-100636714","NCT07569276","Effects of an Experimental Propolis Gel on Tooth Sensitivity Control and Post-bleaching Color Change: a Randomized Clinical Trial","Effects of a 0.5% Experimental Propolis Gel on Tooth Sensitivity Control and Post-bleaching Color Change: a Randomized Clinical Trial","Inclusion Criteria:\n\n* good oral hygiene\n* absence of active caries lesions\n* never having previous whitening therapy\n* not present dental hypersensitivity\n* don't be a smoker\n* not be pregnant\n* present at least 28 teeth in the oral cavity.\n\nExclusion Criteria:\n\n* volunteers who were under orthodontic treatment,\n* presence of periodontal disease\n* dental cracks or fractures\n* restorations and prostheses on anterior teeth\n* extensive molar restorations\n* gastroesophageal disorders\n* severe internal dental darkening\n* presence of dentinal exposure in anterior and\u002For posterior teeth.",{"count":50,"type":22},[25],"This randomized, parallel, double-blind, placebo-controlled clinical study aims to investigate the effects of an experimental 0.5% propolis gel on controlling tooth sensitivity and discoloration after in-office dental bleaching. Sixty-six volunteers will be selected according to inclusion and exclusion criteria and will be randomly assigned to three experimental groups: Placebo - received application of a gel without active ingredient (K-Y Original), KF2 - received application of 5% potassium nitrate and 2% sodium fluoride (Desensitize KF 2%), and Propolis 0.5% - application of the experimental 0.5% propolis gel. All participants will undergo two in-office bleaching sessions with 35% hydrogen peroxide, with seven-day intervals between them. The bleaching agent will be applied for 30 minutes. The desensitizing agents will be applied prior to bleaching and kept in contact with the vestibular dental surface for ten minutes. Sensitivity will be monitored daily using the Visual Analogue Scale for fourteen days, while color change will be determined by spectrophotometry, using the parameters of the CIELab\\* system and calculation of ΔE00, measured before bleaching (T0) and 7 days after the second bleaching session (T1). The data will be subjected to statistical analysis according to sample distribution, adopting a power of 80% and a significance level of 5%.",[78,79,28],"2026-04-29",{"date":102,"type":33},"2026-05-06",{"date":100,"type":22},{"date":86,"type":22},{"name":88,"class":40}]