[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dentin-hypersensitivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dentin-hypersensitivity":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,45,68,98,119,152,185,219,244,265,290,311,333],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100642929","evaluation-of-different-non-invasive-methods-in-the-treatment-of-dentin-hypersensitivity-associated-with-non-carious-cervical-lesions-a-split-mouth-clinical-study-100642929",false,"NCT07648147","Evaluation of Different Non-Invasive Methods in the Treatment of Dentin Hypersensitivity Associated With Non-Carious Cervical Lesions: A Split-Mouth Clinical Study","EVALUATION OF DIFFERENT NON-INVASIVE METHODS IN THE TREATMENT OF DENTIN HYPERSENSITIVITY ASSOCIATED WITH NON-CARIOUS CERVICAL LESIONS: A SPLIT-MOUTH CLINICAL STUDY","NCCL-DH","Inclusion Criteria:\n\n* Individuals aged between 18 and 65 years. Systemically healthy individuals. Individuals with dentin hypersensitivity. Presence of two permanent teeth with similar severity of dentin hypersensitivity in the same participant.\n\nParticipants who agree to participate in the study and sign the informed consent form\n\nExclusion Criteria:\n\n* Presence of active caries in the study teeth. Presence of cervical restoration in the study teeth. Presence of pulpal pathology. History of desensitizing treatment within the last 3 months. Pregnancy. Presence of systemic disease. Use of analgesics within the last 48 hours.","ALL","18 Years","65 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this split-mouth clinical study is to compare the effectiveness of D Blue diode laser application and ProSylc bioactive glass powder application in reducing dentin hypersensitivity in patients with non-carious cervical lesions (NCCLs). Different treatment modalities will be applied within the same participant, and changes in dentin hypersensitivity will be evaluated following treatment. The primary outcome measure will be the reduction in dentin hypersensitivity after the interventions. The findings of this study are expected to contribute to the identification of effective non-invasive treatment approaches for the management of dentin hypersensitivity associated with non-carious cervical lesions.",[28,29],"Non-Carious Cervical Lesions (NCCLs)","Dentin Hypersensitivity",[31],"Non-Carious Cervical Lesions; Dentin Hypersensitivity; Diode Laser; D Blue Diode Laser; Bioactive Glass; ProSylc; Split-Mouth Study; Non-Invasive Treatment","NOT_YET_RECRUITING","2026-06-10",{"date":35,"type":36},"2026-06-15","ACTUAL",{"date":38,"type":22},"2026-07-20",{"date":40,"type":22},"2027-01-20",{"name":42,"class":43},"Cukurova University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":44},"100638802","effectiveness-of-two-different-desensitizing-dental-varnishes-100638802","NCT07622043","Effectiveness of Two Different Desensitizing Dental Varnishes","Effectiveness of Two Different Desensitizing Dental Varnishes: A Prospective, Randomized Split Mouth Clinical Investigation","Inclusion Criteria:\n\n* Informed Consent signed by the subject\n* Age: 18-65 years\n* Hypersensitivity assessment scale ≥ Grade 2 in\n* two non-neighboring teeth in different quadrants\n* The affected teeth are\u002Fhave: vital, caries-free, received no restorations within the last month\n* No change in medication anticipated over the next 3 months (e.g. due to upcoming surgery etc.)\n\nExclusion Criteria:\n\n* Contraindications and limitations of the MD as described in the instructions for use.\n* Known hypersensitivity or allergy to the device material (especially acrylates, mint flavouring)\n* Pregnant or other vulnerable subjects\n* Participants with severe systemic disease\n* Enrolment of employees of the dental clinic of Ivoclar Vivadent AG\n* Recent change in medication concerning Analgesics, NSAIDs, psychotropic drugs, other medications that may alter pain perception\n* Intake of analgesics prior to appointment\n* Professional desensitizing therapy in the last 3 months\n* Bleaching procedures in the last 4 weeks\n* Confounding dental conditions at test sites: defective or extensive restorations, abutment teeth for prostheses, recent restorations, pulpitis\u002Fperiapical pathology.\n* Current or recent use of desensitizing toothpastes or mouthrinses (i.e. products specifically marketed for the treatment of dentin hypersensitivity) within 4 weeks prior to enrolment",{"count":53,"type":22},66,[25],"Dental varnishes are commonly used to relieve dentin hypersensitivity by forming a protective film that occludes dentinal tubules and reduces fluid flow. This clinical investigation aims to compare the desensitizing effect of a fluoride containing varnish with a fluoride free placebo varnish. Primary and secondary objectives include evaluating short and long term reductions in dentinal hypersensitivity, assessing patient reported outcomes and daily experiences, and monitoring the varnish's tolerability and safety.",[29,57],"Dentin Desensitizing Agents","2026-05-27",{"date":60,"type":36},"2026-06-02",{"date":62,"type":22},"2026-08",{"date":64,"type":22},"2027-08",{"name":66,"class":67},"Ivoclar Vivadent AG","INDUSTRY",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":77,"phases":4,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":44},"100607961","multi-site-study-to-look-at-tooth-wear-and-tooth-sensitivity-and-the-risk-factors-associated-100607961","NCT07195357","Multi-site Study to Look at Tooth Wear and Tooth Sensitivity and the Risk Factors Associated.","Erosive Tooth Wear, Dentin Hypersensitivity and Associated Risk Factors: An Observational, Cross-Sectional, Multi-Site, Epidemiological Study in the U.S.\" IU IRB# 28041","Inclusion Criteria:\n\n1. Be aged 18 or over, of either gender.\n2. Be attending a regularly scheduled appointment at the dental school.\n3. Provide voluntary, written informed consent.\n4. Understand and be willing, able and likely to comply with all study procedures and restrictions.\n5. Be in good health (see exclusion criteria below).\n6. Have a minimum of 10 teeth not including implants or teeth with crowns or bridges.\n\nExclusion Criteria:\n\n1. Have any medical condition that could be expected to interfere with the subject's safety during the study period (including temporomandibular disorders).\n2. Be incapable of responding to the questions.\n3. Be an employee or a family relative of an employee of the sponsor.\n4. Be using maxillary or mandibular orthodontic appliances, except lingual bar.\n5. Have used analgesic (pain relieving) drugs or have used a topical analgesic in the preceding 12 h",{"count":76,"type":22},2500,"OBSERVATIONAL","The goal of this observational study is to learn about tooth wear and tooth sensistivity and reasons for these conditions in five locations throughout the United States. The main question it aims to answer is:\n\nThe main objective of this study is to determine tooth wear and tooth sensitivity in adults in the U.S., and to investigate their association with risk factors",[29,80],"Erosive Tooth Wear",[82,83,84,85,86,87],"erosive tooth wear","ETW","Dentin hypersensitivity","DH","Tooth Sensitivity","Dental Erosion","RECRUITING","2026-05-04",{"date":91,"type":36},"2026-05-05",{"date":93,"type":36},"2026-02-19",{"date":95,"type":22},"2027-10",{"name":97,"class":43},"Indiana University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":105,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":77,"phases":4,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":44},"100618860","a-study-evaluating-oral-health-related-quality-of-life-and-treatment-patterns-among-dentin-hypersensitivity-sufferers-100618860","NCT07337109","A Study Evaluating Oral-Health-Related Quality of Life and Treatment Patterns Among Dentin Hypersensitivity Sufferers","A Longitudinal Study Evaluating Oral-Health-Related Quality of Life and Treatment Patterns Among Dentin Hypersensitivity Sufferers in the Real World","Inclusion Criteria:\n\n* Participant who has provided consent indicating they have been informed of all pertinent aspects of the study.\n* All genders who, at the time of screening, are aged more than or equal to (\\>=)18 years.\n* Anyone who has begun to experience dentin hypersensitivity (self-reported) within the past three months.\n* Anyone who has started to use products to treat their tooth sensitivity within the past three months.\n* Participant who is able to independently complete all activities online.\n* Participants residing in the United States.\n\nExclusion Criteria:\n\n* Anyone who has any chronic health conditions that could impact their participation in this study, such as cancer, mental health disorders, history of serious illness in the last three months, history of substance abuse, or planned surgery during the study period.\n* Participant whose sensitivity could be caused by other factors or clinical pathology than DH, as self-reported on the screening questionnaire, which include:\n\n  1. Anyone who suffers from tooth cavities, significant gum disease, cracked or fractured teeth, temporomandibular joint disease (TMD), or who has had tooth extractions or fillings within the last three months.\n  2. Anyone who wears braces (including Invisalign-like appliances) for treatment or dentures (full or partial).\n  3. Participant who has undergone treatment for periodontal or gum disease within 6 months of screening or is currently undergoing treatment for periodontal or gum disease.\n  4. Participant who has been informed by a Dental Health Care Professional (DHCP) that they have active periodontitis.\n  5. Participant who has been informed by a DHCP that they have active caries.\n  6. Participant with any chronic and\u002For severe painful health condition(s) which lead to regular use of pain relief medications (more than 3 days a week).\n* Anyone who has participated in another dentin hypersensitivity study within the last three months.\n* Currently participating in another research study or will be participating in any other research study at any point during this study's duration.",true,{"count":107,"type":22},375,"The primary purpose of this study is to characterize changes in Oral-Health-Related Quality of Life (OHrQoL), as measured by the Dentin Hypersensitivity Experience Questionnaire (DHEQ) over a 12-month period.",[29],"2026-04-27",{"date":112,"type":36},"2026-04-28",{"date":114,"type":36},"2025-12-16",{"date":116,"type":22},"2027-02",{"name":118,"class":67},"HALEON",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":127,"targetDuration":4,"studyType":23,"phases":129,"briefSummary":130,"conditions":131,"keywords":134,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":44},"100598256","hydroxyapatite-based-home-treatment-for-dentin-sensitivity-in-celiac-patients-100598256","NCT07069127","Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac Patients","Reduction of Dentin Hypersensitivity and Enamel Demineralization in Patients With Celiac Disease: A Randomized Controlled Trial","CELIADENT","Inclusion Criteria:\n\n* Adults (≥18 years of age) with a confirmed diagnosis of celiac disease.\n* Presence of enamel defects (hypomineralization or demineralization).\n* Presence of active carious lesions.\n* Self-reported dentin hypersensitivity.\n* Willingness to comply with the study protocol and follow-up schedule.\n* Written informed consent provided.\n\nExclusion Criteria:\n\n* Age below 18 years.\n* Absence of confirmed celiac disease.\n* Poor compliance or low motivation to participate in a 6-month study.\n* Ongoing treatment with products affecting enamel mineralization.\n* Pregnancy or breastfeeding.\n* Participation in another clinical trial within the previous 30 days.",{"count":128,"type":22},40,[25],"This single-center, randomized controlled clinical trial aims to evaluate the effectiveness of a home-based treatment using hydroxyapatite-based oral care products in adult patients with celiac disease who exhibit enamel demineralization and dentin hypersensitivity. Forty patients will be enrolled and randomly allocated into two parallel groups. The control group will perform home oral hygiene using only a hydroxyapatite-based toothpaste (Biorepair® Total Protection) twice daily. The trial group will follow the same regimen with the toothpaste, but will also apply a hydroxyapatite mousse (Biorepair® Plus Intensive Enamel Repair) once every evening before bedtime throughout the study period.\n\nThe primary objective is to assess the reduction in dentin hypersensitivity using the Schiff Air Index. Secondary outcomes include changes in plaque accumulation (Plaque Index), gingival bleeding (Bleeding on Probing), pain perception (Visual Analogue Scale), and caries experience (DMFT and DMFS indices). Enamel demineralization will be analyzed through near-infrared transillumination (DIAGNOcam), laser fluorescence (DIAGNOdent), and digital image analysis (ImageJ software).\n\nAll clinical parameters will be evaluated at baseline and after 1 week, 1 month, 3 months, and 6 months. The study seeks to determine whether the addition of a remineralizing mousse to daily oral care provides superior benefits in reducing sensitivity and improving enamel integrity in patients with celiac disease.",[132,29,133],"Celiac Disease","Tooth Demineralization",[132,29,135,136,137,138,139,140,141,142],"Enamel Demineralization","Hydroxyapatite","Remineralizing Agents","Biorepair","Toothpaste","Oral Mousse","Dental Sensitivity","Randomized Controlled Trial","2026-04-22",{"date":145,"type":36},"2026-04-23",{"date":147,"type":36},"2025-07-30",{"date":149,"type":22},"2026-09-10",{"name":151,"class":43},"University of Pavia",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":17,"minAge":159,"maxAge":160,"enrollmentInfo":161,"targetDuration":4,"studyType":23,"phases":163,"briefSummary":164,"conditions":165,"keywords":167,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":4},"100627479","diode-laser-plus-cpp-acpf-vs-cpp-acpf-alone-for-dentin-hypersensitivity-100627479","NCT07449169","Diode Laser Plus CPP-ACPF vs CPP-ACPF Alone for Dentin Hypersensitivity","Comparative Efficacy of Diode Laser Photobiomodulation Combined With CPP-ACPF Varnish Versus CPP-ACPF Varnish Alone in the Management of Dentin Hypersensitivity: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult participants aged from 20 to 50 years of age.\n* Participants with good oral hygiene.\n* Presence of at least one tooth with dentin hypersensitivity confirmed by the air blast and\u002For tactile stimuli (scoring ≥3 on the VAS).\n* Participants willing to cooperate and attend recall appointments\n* Teeth with Non-Carious Cervical Lesions.\n* Patients with dentin hypersensitivity due to GERD and Parafunctional habits e.g., bruxism.\n* Patients with dentin hypersensitivity associated with gingival recession.\n\nExclusion Criteria:\n\n* Participants with poor oral hygiene.\n* History of professional or at-home desensitizing treatment within the previous 3 months.\n* Pregnant or lactating females.\n* Concurrent participation in other research studies.\n* Inability to comply with study procedures.\n* History of allergic reactions to study materials.\n* Medical conditions interfering with pain reporting accuracy (pain disorders, constant use of analgesics, anti-inflammatory, or psychotropic medications).\n* History of periodontal surgeries within the last six months.\n* Periodontitis and pulpitis.","20 Years","50 Years",{"count":162,"type":22},70,[25],"This study aims to compare the effectiveness of diode laser photobiomodulation combined with CPP-ACPF varnish versus CPP-ACPF varnish alone in reducing dentin hypersensitivity. Participants diagnosed with dentin hypersensitivity will receive either the combined treatment or varnish application alone. Pain levels will be evaluated using a standardized visual analog scale before and after treatment sessions. The results of this study may help determine whether adding diode laser therapy enhances the effectiveness of conventional varnish treatment in managing dentin hypersensitivity.",[29,166],"Tooth Hypersensitivity",[168,169,170,171,172,173,174,175],"dentin hypersensitivity","tooth hypersensitivity","diode laser","CPP-ACPF varnish","Dental laser treatment","Non-carious cervical lesions","Desensitizing treatment","photobiomodulation","2026-02-27",{"date":178,"type":36},"2026-03-04",{"date":180,"type":22},"2026-04-01",{"date":182,"type":22},"2027-10-01",{"name":184,"class":43},"Cairo University",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":195,"briefSummary":198,"conditions":199,"keywords":204,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":44},"100607406","phase-2-gluma-compared-with-bonding-agent-for-post-operative-sensitivity-following-composite-restorations-100607406","NCT07188142","Gluma Compared With Bonding Agent for Post-operative Sensitivity Following Composite Restorations","Investigating the Effects of Two Different Desensitizing Agents on Mitigating Post-Operative Sensitivity Following Composite Restorations - a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18-45 years.\n* Good oral hygiene.\n* Active primary class I carious lesions on vital molar teeth with ICDAS score 3\n* Patients complaining of sensitivity to air and osmotic stimulus.\n* Teeth having a positive cold test.\n* No signs of pulp inflammation or spontaneous pain before treatment.\n\nExclusion Criteria:\n\n* Excessive tooth wear due to clenching or abnormal habits.\n* Traumatic occlusion.\n* Periodontal or gingival disease.\n* Patients using analgesics and\u002For anti-inflammatory medicine.","45 Years",{"count":194,"type":22},60,[196,197],"PHASE2","PHASE3","* The aim of this study is to compare the effectiveness of Gluma desensitizer in reducing post-operative sensitivity following composite restorations in posterior teeth. -Patients visiting OPD will be selected after fulfilment of inclusion criteria. Patients aged 18-45 meeting inclusion criteria and presenting with active primary class I carious lesions on vital molar teeth with ICDAS score 3 will be randomly assigned into two groups: -Group A: Patients will be provided with Gluma desensitizer, Universal Bonding agent and Composite restoration and -Group B: Patients will receive Universal bonding agent and Composite restoration. -The progress of treatment will be followed up immediately (baseline) and at regular follow up visits at 1 week, 1 month and 3 months.\n* Post-operative sensitivity will be assessed using an air stimulus and rated on a numeric rating scale for post-operative sensitivity assessment ranging from 0 to 10.",[200,29,201,202,203],"Post-operative Sensitivity","Dental Caries","Tooth Sensitivity After Composite Restorations","Post-operative Sensitivity After Class I Composite Restorations",[205,206,207,208,209],"Post-operative sensitivity","Dentinal hypersensitivity","Class I caries","Gluma desensitizer","Composite restoration","2025-09-19",{"date":212,"type":36},"2025-09-23",{"date":214,"type":22},"2025-12-01",{"date":216,"type":22},"2026-06-01",{"name":218,"class":43},"Beenish Hassan",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":105,"sex":17,"minAge":226,"maxAge":192,"enrollmentInfo":227,"targetDuration":4,"studyType":23,"phases":229,"briefSummary":230,"conditions":231,"keywords":232,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":44},"100602179","clinical-effectiveness-of-episodic-use-of-bioactive-silica-based-versus-in-management-of-dentin-hypersensitivity-a-6m-randomized-clinical-trial-100602179","NCT07120139","Clinical Effectiveness of Episodic Use of Bioactive Silica Based Versus in Management of Dentin Hypersensitivity (A 6m Randomized Clinical Trial)","Clinical Effectiveness of Episodic Use of Bioactive Silica Based Versus Continuous Use of Fluoride Desensitizing Toothpastes in Management of Dentin Hypersensitivity (A 6m Randomized Clinical Trial)","Inclusion Criteria:\n\nPatients with DH, VAS ≥ 3 and Schiff sensitivity score needed to be ≥2, indicating that application of a jet of air makes the patient respond and move or requests discontinuation of the stimuli application.\n\n• Teeth with DH related to Non- carious Cervical lesions (abrasion, abfracture, erosion).\n\n• Teeth with gingival recession and exposed root dentin.\n\n\\-\n\nExclusion Criteria:\n\n* Patients with known allergies or adverse reactions to any ingredient of the tested materials.\n\nSystematic disease and\u002F or physical disabilities that may affect participation. • Patients who did any periodontal surgeries within the previous 3 months.\n\n• Patients with orthodontic appliances, or restorative work that might interfere with evaluation.\n\n• Patient who frequently use analgesics or any drugs that could affect the pain level.\n\n• Home or in-office bleaching and\u002F or in office fluoride application for 6 months before beginning of treatment.\n\n• Pregnant females with frequent vomiting attacks.\n\n• Smokers.\n\n• Systemic conditions that cause or predispose patients to develop dentin hypersensitivity (for example, gastroesophageal reflux disease, GERD).\n\n• Excessive dietary or environmental exposure to acids.","22 Years",{"count":228,"type":22},50,[25],"The aim of the study to compare the clinical effectiveness of Episodic use of Bioactive Silica Based versus continuous use of fluoride based desensitizing toothpastes in management of dentin hypersensitivity (DH) of adult patients over 6m follow up and evaluating patient satisfaction regarding the treatment provided. Episodic use will be tested as it reflects the effectiveness in a clinical scenario regarding patient compliance and adherence to the treatment where some of the Egyptian patients stop the treatment once improvement occurs due to financial constraints",[29],[233,234],"Bioactive Silica Based with calcium booster (Refix technology) toothpaste","Dentin hypersensitivity.","2025-08-12",{"date":237,"type":36},"2025-08-13",{"date":239,"type":22},"2025-08-20",{"date":241,"type":22},"2026-02-28",{"name":243,"class":43},"Rawda Hesham Abd ElAziz",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":105,"sex":17,"minAge":159,"maxAge":251,"enrollmentInfo":252,"targetDuration":4,"studyType":23,"phases":253,"briefSummary":254,"conditions":255,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":4},"100558965","effectiveness-of-calcium-silicate-and-sodium-fluoride-nanoparticles-in-the-management-of-dentin-hypersensitivity-100558965","NCT06557980","Effectiveness of Calcium Silicate and Sodium Fluoride Nanoparticles in The Management of Dentin Hypersensitivity","Effectiveness of Calcium Silicate and Sodium Fluoride Nanoparticles in The Management of Dentin Hypersensitivity (Randomized Controlled Clinical Trial and In-Vitro Study)","Inclusion Criteria:\n\n* Hypersensitive areas on facial surfaces of the teeth (incisors, cuspids, bicuspids, and first molars with exposed cervical dentine)\n* Areas with hard tissue erosion\n* cuneiform defect, pathological abrasion.\n* Gingival recession\n* Good overall physical health\n* Age between 20 to 40 years; and provision of written informed consent\n\nExclusion Criteria:\n\n* chipped teeth\n* Defective restorations\n* fractured un displaced cuspids\n* deep dental caries\n* deep periodontal pockets\n* orthodontic appliances, dentures, or bridgework that would interfere with the evaluation of hypersensitivity.\n* periodontal surgery within the previous 6 months.\n* ongoing treatment with antibiotics and\u002For anti-inflammatory and\u002For analgesic drugs.\n* ongoing treatment for tooth hypersensitivity, pregnancy, or lactation; heavy smoking and alcohol or drug abuse.","40 Years",{"count":194,"type":22},[25],"This study will be performed to assess the effect of inert prepared tooth paste loaded with Calcium Silicate Nanoparticles (CSNPs) and compare it to another one containing Sodium Fluoride Nanoparticles in the management of patients complaining of hypersensitivity and laboratory investigating the efficacy of CSNPs and NaFl Nps containing toothpaste in dentinal tubules occlusion.",[29],"2025-05-06",{"date":258,"type":36},"2025-05-11",{"date":260,"type":22},"2025-05",{"date":262,"type":22},"2025-10",{"name":264,"class":43},"Minia University",{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":105,"sex":17,"minAge":18,"maxAge":272,"enrollmentInfo":273,"targetDuration":4,"studyType":23,"phases":274,"briefSummary":275,"conditions":276,"keywords":277,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":4},"100581727","evaluation-of-the-combined-effect-of-bioactive-toothpastes-desensitizing-agents-and-er-yag-laser-on-dentin-hypersensitivity-an-in-vivo-study-100581727","NCT06854068","Evaluation of the Combined Effect of Bioactive Toothpastes, Desensitizing Agents and Er-YAG Laser on Dentin Hypersensitivity: an In-Vivo Study","In-Vivo Evaluation of the Effect of Bioactive Material-Containing Toothpastes and Combined Use of Er-YAG Laser on Dentin Hypersensitivity","Inclusion Criteria:\n\n1. Individuals over the age of 18,\n2. Individuals with good oral hygiene,\n3. Individuals without systemic contraindications for treatment,\n4. Individuals who are reliable for periodic follow-ups, cooperative, and willing to participate in the study,\n5. Individuals with sensitivity in at least three teeth,\n6. Individuals who have been using a standard toothpaste containing 1100 ppm fluoride for at least one month.\n\nExclusion Criteria:\n\n1. Individuals with a history of alcohol, drug, or medication addiction,\n2. Individuals known to be unable to attend follow-up sessions,\n3. Individuals with allergies to any of the products used in the study,\n4. Individuals with unstable mental or physical conditions,\n5. Pregnant or breastfeeding individuals, as well as those planning pregnancy during the study.","84 Years",{"count":128,"type":22},[25],"Here's the revised version with the corrected treatment and follow-up session schedule:\n\n\\---\n\nThe aim of this clinical trial is to evaluate the effectiveness of bioactive toothpastes, desensitizing agents, and Er-YAG laser treatments in reducing dentin hypersensitivity. This study also aims to assess the safety and comparative efficiency of these treatment methods. The main research questions are:\n\n* Do bioactive toothpastes, desensitizing agents, and laser treatments individually or in combination reduce dentin hypersensitivity?\n* Are there any adverse effects associated with these treatments?\n\nParticipants will:\n\n* Be randomly assigned to one of four treatment groups, each using a specific toothpaste (Pro-Argin, Nano-Hydroxyapatite, NovaMin, or CPP-ACP), alongside desensitizing agents, laser treatments, or a placebo.\n* Receive two treatment sessions: the first at baseline and the second one week later.\n* Attend follow-up evaluations at the 2nd week, 1st month, and 3rd month to assess dentin hypersensitivity using the Visual Analog Scale (VAS) and dental unit air-water sprays.\n\nResearchers will compare the outcomes across groups using statistical analyses (Kolmogorov-Smirnov, Kruskal-Wallis, and Pearson\u002FSpearman tests) to determine the most effective approach for managing dentin hypersensitivity.",[29],[168,278,279,280],"laser","desensitization agent","toothpaste","2025-02-25",{"date":283,"type":36},"2025-03-03",{"date":285,"type":22},"2025-05-01",{"date":287,"type":22},"2026-09-01",{"name":289,"class":43},"Ege University",{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":105,"sex":17,"minAge":18,"maxAge":297,"enrollmentInfo":298,"targetDuration":4,"studyType":23,"phases":299,"briefSummary":300,"conditions":301,"keywords":302,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":308,"leadSponsor":309,"locationsCount":44},"100564331","phase-3-efficacy-of-a-potassium-nitrate-containing-herbal-mouthwash-to-a-potassium-oxalate-mouthwash-in-dentinal-hypersensitivity-100564331","NCT06627790","Efficacy of a Potassium Nitrate Containing Herbal Mouthwash to a Potassium Oxalate Mouthwash in Dentinal Hypersensitivity","Comparative Evaluation of Efficacy of a Potassium Nitrate Containing Herbal Mouthwash to a Potassium Oxalate Mouthwash in Dentinal Hypersensitivity - a Randomised Clinical Trial","Inclusion Criteria:\n\n* Participants with at least two DH sites with VAS score ≥4\n* Participants with teeth showing cervical abrasion, erosion, gingival recession\n* Participants \\>18 years in general good health\n* Participants self-reporting with history of dentinal hypersensitivity to various stimuli.\n* Participants with minimum 20 natural teeth\n\nExclusion Criteria:\n\n* Teeth with severe caries, faulty restoration, prosthetic crown, chipping, fracture, symptoms of pulpal damage\n* Participants who has taken long term analgesic therapy within 30 days before the start of the study\n* Participants who have undergone any treatment for dentinal hypersensitivity in past 3 months\n* Participants with ongoing orthodontic therapy\n* Participants with history or presence kidney disorder, kidney stones, eating disorders, uncontrolled gastro-oesophageal reflux disease, excessive exposure to acids or any other systemic condition that predisposes to dentinal hypersensitivity\n* Severe Periodontal disease characterized by extensive tooth mobility and or extensive alveolar bone loss involving 10 or more teeth\n* Women who are pregnant or lactating","60 Years",{"count":128,"type":22},[197],"The goal of this clinical trial is to compare the efficacy of potassium nitrate containing herbal mouthwash to potassium oxalate mouthwash in management of dentinal hypersensitivity.\n\n* Participants will be divided into two groups by computer generated randomization. The participants will be divided into two groups, Group 'A' and Group 'B' by Simple Random Allocation as both groups, each group will involve 20 participants with at least two sites showing dentinal hypersensitivity\n* The assessment of Dentinal Hypersensitivity will be done after scaling and\u002For root planing (if required) by subjecting affected sites with Air Blast Test (ABT), Cold Water Test (CWT) and Tactile Response assessment will be recorded using Visual Analogue Scale (VAS). All sensitivity tests will be executed by a single examiner who will be blinded to the randomization and will record DH at baseline and at 4, 8 and 12 weeks",[29],[303],"dentinal hypersensitivity","2025-02-11",{"date":306,"type":36},"2025-02-13",{"date":281,"type":22},{"date":260,"type":22},{"name":310,"class":43},"Dr. D. Y. Patil Dental College & Hospital",{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":105,"sex":17,"minAge":18,"maxAge":318,"enrollmentInfo":319,"targetDuration":4,"studyType":23,"phases":321,"briefSummary":322,"conditions":323,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":4},"100557528","dentin-hypersensitivity---varnish-or-laser-100557528","NCT06539286","Dentin Hypersensitivity - Varnish or Laser?","Dentin Hypersensitivity - Varnish or Laser? A Randomized Clinical Study Comparing Three Wavelengths (2940 nm, 1064 nm and 970 nm) and the Desensitizer Gluma","Inclusion Criteria:\n\n* all genders\n* 18-70 years\n* good general health\n* at least two hypersensitive teeth in either jaw\n* initial VAS-score \\>3\n\nExclusion Criteria:\n\n* Active carious lesions, insufficient restorations, enamel cracks, reversible pulpitis\n* Active periodontal disease, periodontal surgery (in the last 6 months)\n* Bleaching procedure in the last 3 months\n* Analgetic use in the last 72 hours\n* Pregnant\u002Flactating women","70 Years",{"count":320,"type":22},80,[25],"Dentin hypersensitivity is a common condition described as a short and sharp pain caused by thermal, evaporative, tactile, osmotic, or chemical stimuli to exposed dentin that cannot be related to another defect or dental pathology. The variety of treatment options and products on the market might seem overwhelming. This study aims to show that laser treatments are efficient in reducing pain scores compared to a desensitizing agent (Gluma). 80 patients with at least two hypersensitive teeth will be enrolled in this study. Patients will be divided randomly into four groups (control group (Gluma), laser group 1 (2.94 µm wavelength), laser group 2 (1064 nm wavelength), laser group 3 (970 nm wavelength)). Visual Analog Scale will be measured before treatment, right after treatment, one week after treatment, one month after treatment, three months after treatment. Mixed Anova's and descriptive analysis will be used for statistical evaluation.",[29],"2024-08-01",{"date":326,"type":36},"2024-08-06",{"date":328,"type":22},"2024-09-02",{"date":330,"type":22},"2024-12-14",{"name":332,"class":43},"Sigmund Freud PrivatUniversitat",{"id":334,"slug":335,"hasResults":11,"nctId":336,"briefTitle":337,"officialTitle":338,"acronym":4,"eligibilityCriteria":339,"healthyVolunteers":105,"sex":17,"minAge":18,"maxAge":297,"enrollmentInfo":340,"targetDuration":4,"studyType":23,"phases":342,"briefSummary":344,"conditions":345,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":4},"100554008","phase-1-efficacy-of-formulated-eggshell-derived-nano-hydroxyapatite-containing-toothpaste-with-and-without-addition-of-fluoride-vs-conventional-desensitizing-fluoride-containing-toothpaste-in-management-of-dentin-hypersensitivity-100554008","NCT06493500","Efficacy of Formulated Eggshell Derived Nano-hydroxyapatite Containing Toothpaste With and Without Addition of Fluoride vs. Conventional Desensitizing Fluoride Containing Toothpaste in Management of Dentin Hypersensitivity","Efficacy of Nano-hydroxyapatite Containing Tooth Paste on Dentin Hypersensitivity of Adult Patient","Inclusion Criteria:\n\n* Adult Patients Aged 18-60\n* Males or females.\n* Good oral hygiene\n* Absence of abnormal occlusion habits (e.g. bruxism, nail biting, tooth clenching and mouth breathing).\n* Teeth with hypersensitivity, VAS ≥5\n* Co-operative patients who show interest to participate in the study.\n\nExclusion Criteria:\n\n* Patients with known allergic or adverse reaction to the tested materials.\n* Systematic disease that may affect participation.\n* Xerostomic patients.\n* Patients with bad oral hygiene\n* Patients with orthodontic appliances, or bridge work that might interfere with evaluation\n* Patients who did any periodontal surgeries within the previous 6 months.\n* Patients with physical disabilities",{"count":341,"type":22},39,[343],"PHASE1","compare the effectiveness of Eggshell derived nano-Hydroxyapatite with and without fluoride and conventional fluoride containing tooth paste versus conventional desensitizing fluoride containing tooth paste on dentinal tubule occlusion and dentin mineral deposition.",[29,346,347],"Fluoride","Nano-hydroxy Apatite","2024-07-06",{"date":350,"type":36},"2024-07-10",{"date":352,"type":22},"2024-07",{"date":354,"type":22},"2025-03",{"name":184,"class":43}]