[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dentinal-hypersensitivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dentinal-hypersensitivity":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100644143","phase-3-comparative-efficacy-of-different-dentin-occluding-toothpaste-technologies-100644143",false,"NCT07664592","Comparative Efficacy of Different Dentin Occluding Toothpaste Technologies","Comparative Efficacy of Different Dentin Occluding Toothpaste Technologies on Instant and Short-term Relief of Dentin Hypersensitivity: a Randomized Clinical Trial","SENSBZ","Inclusion Criteria:\n\n1. Sign an Informed Consent Form;\n2. Male or female 18 to 70 years of age, inclusive;\n3. Be in good general health as determined by the study investigators (absence of any condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study. Examples include heart problems, valve\u002Fhip replacements, etc);\n4. Willingness to provide information related to their medical history;\n5. Available for the two (2) weeks duration of the study;\n6. Minimum of 16 uncrowned permanent natural teeth (excluding third molars and crowns);\n7. Must present at least two (2) sensitive teeth which must meet ALL of the following criteria:\n\n   1. Be anterior to the molars and demonstrating dentin exposure due to cervical erosion\u002Fabrasion and\u002For gingival recession;\n   2. Have a qualifying dentin hypersensitivity response to air blast stimuli applied for one second to the cervical surface (gingivo-facial 1\u002F3) as defined by a score of 2 or 3 on the Schiff Cold Air Sensitivity Scale.\n\nExclusion Criteria:\n\n1. Gross oral pathology, chronic disease, and\u002For history of allergies to any of the test products;\n2. Use of a desensitizing oral care product and\u002For recipient of any dental desensitizing treatment within the past month prior to start of the study;\n3. Advanced periodontal disease and\u002For treatment for periodontal disease (including surgery) within the past twelve months, dental cleaning it's permitted;\n4. Sensitive teeth with a mobility greater than one;\n5. Teeth with extensive\u002Fdefective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures;\n6. Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, daily use of analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study; to be defined by the dental examiner; or other drugs that could affect pain sensation;\n7. Current smokers and subjects with a history of alcohol or drug abuse;\n8. Participation in any other oral clinical study for the duration of this study;\n9. Self-reported pregnancy and\u002For currently breastfeeding;\n10. Allergies to oral care products, personal care consumer products, and\u002For their ingredients;\n11. Medical condition which prohibits not eating\u002Fdrinking for 4 hours.\n12. Extended use of antibiotics or therapeutic mouthwash (eg: Chlorhexidine) any time during the three months prior to entry into the study;\n13. Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine);\n14. Current use of orthodontic appliances (including fixed braces, clear aligners, or permanent retainers)","ALL","18 Years","70 Years",{"count":21,"type":22},132,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","The purpose of this clinical study is to evaluate and compare how well three different types of toothpaste technologies work to relieve tooth sensitivity, also known as dentin hypersensitivity. The study asks the question: How effective are toothpastes containing 8% Arginine, 8% Arginine with Zinc Phosphate, or 5% Calcium Sodium Phosphosilicate (CSPS) at providing immediate and short-term relief for people suffering from sensitive teeth?",[28,29],"Dentinal Sensitivity","Dentinal Hypersensitivity",[31,32,33,34],"Dentin Hypersensitivity","Arginine","Oral Health Quality of Life","Sensitive Teeth","NOT_YET_RECRUITING","2026-06-18",{"date":38,"type":39},"2026-06-24","ACTUAL",{"date":41,"type":22},"2026-06-29",{"date":43,"type":22},"2026-09-30",{"name":45,"class":46},"Colgate Palmolive","INDUSTRY",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":71},"100574451","comparison-of-laser-therapy-and-desensitizing-agents-in-dentinal-hypersensitivity-100574451","NCT06759454","Comparison of LASER Therapy and Desensitizing Agents in Dentinal Hypersensitivity","Comparison of Mean Pain Score Using LASER Therapy and Desensitizing Agents in Patients With Dentinal Hypersensitivity: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Participants aged 18-50 years with a preoperative VAS score of ≥2 for dentinal hypersensitivity.\n* Participants with sensitivity due to gingival recession, cervical abrasion, or enamel erosion.\n* Participants with good systemic health.\n* Minimum of two hypersensitive teeth present in two different quadrants.\n\nExclusion Criteria:\n\n* Teeth with caries, defective restorations, or cervical defects \\> 2 mm (may affect sensitivity measurements).\n* Periodontal surgery or deep periodontal pockets (\\> 6 mm) within the past three months (potential influence on periodontal health and sensitivity).\n* Participants using desensitizing toothpaste within the past three months (could interfere with study outcomes).\n* Presence of gross oral pathology or systemic diseases (e.g., eating disorders, chronic diseases, uncontrolled metabolic conditions) (may alter oral health status).\n* Pregnant or lactating women (hormonal changes can influence oral health).","50 Years",{"count":56,"type":22},172,[58],"NA","This study evaluates the effectiveness of laser therapy versus desensitizing agents in reducing pain among participants with dentinal hypersensitivity conducted in Saidu College of Dentistry. Pain will be measured at baseline, immediately post-treatment, one week, and three months using the Visual Analog Scale (VAS)",[29],"2025-05-07",{"date":63,"type":39},"2025-05-11",{"date":65,"type":22},"2025-06-30",{"date":67,"type":22},"2026-06-30",{"name":69,"class":70},"Kemia Gul","OTHER",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":17,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":71},"100568729","evaluation-of-dental-and-periodontal-health-after-ipr-in-patients-in-orthodontic-treatment-with-clear-aligners-100568729","NCT06685016","Evaluation of Dental and Periodontal Health After IPR in Patients in Orthodontic Treatment With Clear Aligners","Evaluation of Dental and Periodontal Health After Interproximal Enamel Reduction, in Patients in Orthodontic Treatment With Clear Aligners, and Comparison Between Laser Diode and Sodium Fluoride for the Treatment of Dentin Hypersensitivity","Inclusion Criteria:\n\n* to be in orthodontic treatment with clear aligners and this treatment requires interproximal enamel reduction;\n* permanent dentition;\n* good oral and periodontal health.\n\nExclusion Criteria:\n\n* enamel defects;\n* cervical caries;\n* periodontal disease;\n* history of trauma or craniofacial anomalies;\n* pregnancy.",true,"17 Years","100 Years",{"count":83,"type":22},30,[58],"This study aimed to evaluate dental and periodontal health after interproximal enamel reduction and to compare Laser diode (a device used in the Orthodontic Program) and sodium fluoride (often used in the Orthodontic Program and in the Material Dental Program). The hypothesis was that the intervention groups would show a lower dentin hypersensitivity incidence than the control group during orthodontic treatment.",[29,87,88],"Plaque, Dental","Bleeding Gum",[90,91],"Clear Aligners","Interproximal enamel reduction","RECRUITING","2024-11-12",{"date":95,"type":39},"2024-11-14",{"date":97,"type":39},"2023-06-24",{"date":99,"type":22},"2024-12",{"name":101,"class":70},"University of Campania Luigi Vanvitelli"]