[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dentine-hypersensitivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dentine-hypersensitivity":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100637537","dentine-hypersensitivity-using-dentine-adhesive-with-strontium-doped-bioactive-glass-ceramic-100637537",false,"NCT07628712","Dentine Hypersensitivity Using Dentine Adhesive With Strontium-doped Bioactive Glass-Ceramic","Dentine Hypersensitivity Treatment Using Strontium-doped Bioactive Glass-ceramic-filled Dentine Adhesive: a Randomized Double-blind Controlled Clinical Trial","Inclusion Criteria:\n\n* individuals who experienced cervical dentine sensitivity for 1 month or more\n\nExclusion Criteria:\n\n* 1\\) \\\u003C20 teeth; 2) teeth with poor oral hygiene, severe periodontal conditions, with caries, faulty restorations, dentine exposure at the occlusal surface, covered by prosthetics or orthodontic appliances, or undergoing endodontic treatment; 3) currently using or have used any desensitizing agents in the past 3 months; or have undergone restorative treatment on the sensitive tooth; 4) with a severe medical condition or in chronic use of a medication that could have interfered with the perception of pain or any condition\u002Fmedication that causes xerostomia","ALL","18 Years","69 Years",{"count":20,"type":21},142,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to determine whether strontium-doped bioactive glass-ceramic (SBGC)-filled dentine adhesive is effective in relieving dentine hypersensitivity. The main question it aims to answer is:\n\nIs SBGC-filled dentine adhesive more effective in reducing dentine hypersensitivity than non-SBGC-filled dentine adhesive?\n\nResearchers will compare SBGC-filled dentine adhesive to a dentine adhesive to see if SBGC-filled dentine adhesive is more effective at relieving dentine hypersensitivity.\n\nParticipants will receive a single application of either SBGC-filled dentine adhesive (intervention group) or dentine adhesive (control group) on the root surfaces of teeth presenting with pain subject to an air-blast test. The degree of pain will be assessed using a Sensitivity Score at baseline, immediately after application of either the intervention dentine adhesive or control dentine adhesive. The participants will visit the clinic at 1 month, 3 months and 6 months for re-assessment of the severity of dentine hypersensitivity.",[27],"Dentine Hypersensitivity",[29,30,31],"dentine hypersensitivity","bioactive glass","resin bonding system","NOT_YET_RECRUITING","2026-06-02",{"date":35,"type":36},"2026-06-05","ACTUAL",{"date":38,"type":21},"2026-05-18",{"date":40,"type":21},"2027-09-30",{"name":42,"class":43},"The University of Hong Kong","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":4},"100597312","three-different-topically-applied-materials-as-non-invasive-treatment-of-sensitivity-in-permanent-teeth-with-molar-incisor-hypomineralization-100597312","NCT07056855","Three Different Topically Applied Materials as Non-invasive Treatment of Sensitivity in Permanent Teeth With Molar Incisor Hypomineralization","Comparative Evaluation of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel Versus Fluoride Varnish as Non-invasive Treatment of Dentin Hypersensitivity in Permanent Teeth With Molar Incisor Hypo-mineralization: Randomized Clinical Trial","Participants related criteria:\n\n1. Children aged from six to ten years old.\n2. Medically free children according to the history taken from their parents.\n3. Children who are categorized as Class I or II according to the American Society of Anaesthesiologists (ASA).\n4. Children whom their parents accept to comply with the follow-up visits.\n5. Children who accept, and their guardians, to participate in the study by signing the informed consent.\n\nTooth related criteria:\n\n1\\. The diagnosis of MIH will be done as per the Wurzburg concept, 2023 MIH diagnostic criteria: The child will be confirmed to have MIH if any of the following characteristics are apparent:\n\n* affected teeth show a clearly defined opacity at the occlusal and buccal surfaces of a tooth,\n* defects vary in shape, size, and pattern,\n* white, cream-colored, or yellow-brown color deviations are recognizable,\n* defects variably vary in size,\n* teeth with hypersensitivity are present,\n* teeth have an atypical restoration,\n* permanent teeth for (suspected) MIH reasons are missing (extractions),\n* combinations of the above characteristics are present.\n\n  1. MIH-affected permanent teeth, suffering from dentin hypersensitivity, (MIH-TNI 3).\n  2. Positive Schiff Cold Airblasting Sensitivity score (score 1, 2, or 3).\n* Exclusion criteria:\n\nParticipants related criteria:\n\n1. Children with severe behavioral or emotional disabilities.\n2. Children who received analgesics within the last 24 hours before the procedure.\n3. Patients who are using chlorhexidine-based gels or mouthwashes.\n\nTooth related criteria:\n\n1. A tooth with signs and symptoms of irreversible pulpitis.\n2. A tooth with signs and symptoms of necrotic pulp.\n3. Sealing therapy or application of desensitizing agent on the MIH teeth within one month before participation in the study.\n4. Presence of dental caries on the MIH-affected permanent tooth.\n5. Presence of restoration(s) on MIH-affected permanent tooth.",true,"6 Years","10 Years",{"count":55,"type":21},48,[24],"This clinical study main goal is to investigate the effectiveness of nano hydroxy apatite crystal varnish and potassium nitrate gel as a non invasive approach in managing Dentin Hypersensitivity in MIH-affected teeth.",[27],"2025-06-29",{"date":61,"type":36},"2025-07-09",{"date":63,"type":21},"2025-07-10",{"date":65,"type":21},"2025-07-20",{"name":67,"class":43},"Cairo University",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":77,"phases":4,"briefSummary":78,"conditions":79,"keywords":80,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":92},"100564780","neurological-responses-in-patients-with-dentine-hypersensitivity-100564780","NCT06633627","Neurological Responses in Patients with Dentine Hypersensitivity","Identification and Quantification of Neurological Responses in Patients with Dentine Hypersensitivity","Inclusion Criteria:\n\n1. Adults 18 years and older;\n2. Understands and is willing, able and likely to comply with all study procedures and restrictions;\n3. Accepts the form of the study and signs a declaration of informed consent;\n4. In good health (in the opinion of the clinical dental professional);\n5. A minimum of 10 teeth not including teeth with crowns or bridges from upper right 4 to upper left 4 and lower right 4 to lower left 4;\n\nFor patients with dentine sensitivity only (experimental group): self-reported sensitivity in at least 1 tooth; confirmed by response to air puff.\n\nExclusion Criteria:\n\n1. Adults currently using maxillary or mandibular orthodontic appliances;\n2. Obvious signs of untreated caries, which in the opinion of the clinical dental professional, will affect the scientific validity of the study;\n3. Periodontal pocket depth ≥4mm in the anterior upper or lower sextants;\n4. Evidence of periodontitis.\n5. Have a history of seizures;\n6. Taking medications that affect brain responses;\n7. Experience damaged skin on the scalp due to cuts, psoriasis, eczema, or other conditions;\n8. Any participant who in the investigator's judgment will not comply with the study protocol;\n9. Any participant who has difficulties in adequate understanding of English.",{"count":76,"type":21},60,"OBSERVATIONAL","Dentine hypersensitivity (also known as sensitive teeth) is a common dental condition in which the dentine, a layer of sensitive hard tissue under the enamel of the teeth, becomes exposed making the teeth sensitive to stimuli, such as hot and cold. It poses a significant challenge for clinicians and affects patients' quality of life.\n\nThe overall aim of the study is to understand if a way of measuring brain activity (electroencephalography \\[EEG\\]) shows a response to tooth stimulation, and see how these responses may be different in patients with dentine sensitivity.\n\nEEG records brain signals and can provide information about how the brain processes painful stimuli. EEG recording is a non-evasive and painless procedure. It involves using a cap with small sensors called electrodes to pick up brain signals. During the EEG assessment appointment, brain signals will be recorded throughout the duration when cold temperatures and short bursts of air are applied to the tooth. Brain signals recorded during tooth stimulation from participants with and without dentine sensitivity will then be compared to explore if there are any differences.\n\nThe investigators hope that EEG responses could be helpful to objectively assess dentine sensitivity, further the understanding of brain processing of dental pain, and allow the comparison of the effectiveness of different treatment options in the future.\n\nThis information may help to improve treatments and the quality of life for patients with dentine sensitivity and potentially other types of dental pain.",[27],[81,27],"Electroencephalography","RECRUITING","2024-10-08",{"date":85,"type":36},"2024-10-09",{"date":87,"type":21},"2024-10-11",{"date":89,"type":21},"2025-09-30",{"name":91,"class":43},"Sheffield Teaching Hospitals NHS Foundation Trust",1]