[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depigmentation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depigmentation":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100645064","effect-of-co-enzyme-q10-and-vitamin-c-alone-or-in-combination-after-a-surgical-gingival-depigmentation-100645064",false,"NCT07677826","Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation","Ffect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation a Randomized Clinical Study","Effect of Coe","Inclusion Criteria:\n\n* Systemically healthy patient of both genders aged from 18-45 years.\n* Presence of bilateral physiologic gingival pigmentation in the anterior maxillary or mandibular region DOPI grades III-IV only.\n* Good oral hygiene.\n* Thick gingival phenotype.\n\nExclusion Criteria:\n\n* Patient clinically diagnosed with periodontitis.\n* Pregnant or lactating females.\n* Patient with previous treatment of gingival hyperpigmentation.\n* History of hypersensitivity to any study material.\n* Patients who are active or previous smokers.",true,"ALL","18 Years","45 Years",{"count":22,"type":23},20,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation.",[29,30],"Depigmentation Treatment","Depigmentation","RECRUITING","2026-06-29",{"date":34,"type":35},"2026-07-01","ACTUAL",{"date":37,"type":35},"2026-03-02",{"date":39,"type":23},"2026-12-20",{"name":41,"class":42},"Al-Azhar University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":24,"phases":53,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":43},"100637285","phase-2-gingival-hyperpigmentation-treatment-100637285","NCT07595705","Gingival Hyperpigmentation Treatment","Gingival Hyperpigmentation Treatment With Injectable Vitamin C in Conjunction With Glutathione Versus The Conventional Surgical Depigmentation: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\nThe selection criteria were done according to Gingival pigmentation index is as follows (Dummett and Bolden)10:\n\n1. Score0:absence of pigmentation\n2. Score1:spotsofbrowntoblackcolororpigments\n3. Score2:browntoblackpatchesbutnotdiffusepigmentation\n4. Score3:diffuse brown to black pigmentation,marginal,and attached.\n\nPatients who have Dummett and Bolden index score 1, 2, or 3 will be included in addition to the following criteria:\n\n1. above 18yrs\n2. systemically free\n3. physiologic gingival hyperpigmentation related to esthetic region\n4. well maintained oral hygiene and willing to undergo minor surgical procedures\n\nExclusion Criteria:\n\n1. systemic diseases associated with pathological hyperpigmentation or improper delayed wound healing (uncontrolled diabetes, autoimmune diseases, etc.)\n2. pregnant and lactating mothers\n3. usage of chlorhexidine or povidone iodine\n4. Local causes (smoking)\n5. periodontal diseases (plaque and non-plaque induced gingivitis or periodontitis)\n6. non compliant patients",{"count":52,"type":23},30,[54],"PHASE2","It is a clinical study conducted to evaluate the effect of vitamin C and Glucathonine injection of pigmented gingival tissue versus surgical removal by scalpel",[57,30,58,59],"Gingival Pigmentation","Vitamin C","Glutathione",[61,62,63,64],"depigmentation","vit c","glutathione","gingival depigmentation","2026-05-15",{"date":67,"type":35},"2026-05-19",{"date":69,"type":35},"2025-08-01",{"date":71,"type":23},"2027-10",{"name":73,"class":42},"Cairo University"]