[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depression-and-suicide-ideation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depression-and-suicide-ideation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100579873","get-active-study-for-at-risk-youth-100579873",false,"NCT06829953","Get ActivE Study for At-risk Youth","Geospatial and Ecological Momentary Assessment Technology and Activity Engagement for At-risk Youth (Get ActivE)","GetActivE","Inclusion Criteria:\n\n* Adolescents age 12-18\n* Current moderate to severe depression (PHQ-9-M \\> 11)\n* Current clinically significant anhedonia, operationalized as PHQ-9-M anhedonia item score \\> 1\n* English language fluency and literacy level sufficient to engage in study protocol\n* Willing to download the app on their smart phones\n\nExclusion Criteria:\n\n* Evidence of mania, psychosis, or developmental disability precluding comprehension of study procedures per electronic health record review and phone screen.","ALL","12 Years","18 Years",{"count":21,"type":22},75,"ESTIMATED","INTERVENTIONAL",[25],"NA","The study will adapt and deploy a digital Behavioral Activation app with mobile sensing, supported by health coaches, that encourages youth to engage in positive activities. The study has the potential to offer a low-cost and scalable behavioral intervention that may decrease risk of suicide among at-risk youth. This research will examine specifically whether an intervention involving an app called Vira, combined with health coaching (GET ActivE) can improve enjoyment for teens coping with depression. Research participants will be randomly assigned to one of two study intervention. One study intervention involves a) downloading an app called Vira and engaging by responding to a daily question, and b) participating in a conversation via text, phone, or messages through an appt with a health coach. The health coach will use the Vira app and principles from evidence-based therapy and behavior change to provide users with insights to sustain well-being and better manage risk factors for suicidal thoughts and behaviors such as depressed mood and behavioral withdrawal. The second study intervention involves downloading an app called EARS and responding to a daily question.",[28,29],"Anhedonia","Depression and Suicide Ideation",[31,32,28,33,34],"Behavioral Activation","Health Coach","Minority Youth","Suicide","RECRUITING","2026-06-02",{"date":38,"type":39},"2026-06-04","ACTUAL",{"date":41,"type":39},"2025-03-27",{"date":43,"type":22},"2026-12-31",{"name":45,"class":46},"University of Pittsburgh","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":68,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100629466","project-hopeful-a-pn-rct-with-implementation-science-100629466","NCT07475039","Project HOPEFUL: A PN-RCT With Implementation Science","Project HOPEFUL (Helping Older PErsons Find Useful Links): Replicating a Partially Nested Randomized Control Trial With Implementation Science","In order to be eligible as a participant in this study, an individual must meet all of the following criteria:\n\n1. Provision of verbal informed consent\n2. Classify as an Older Adult (65+)\n3. Stated willingness and ability to comply with all study procedures\n4. Receive home and community-based services (HCBS) through the Aging Services Network (i.e. HDM (home delivered meals services), CM (congregate meals), etc.)\n5. Be affiliated with the triple As and aging entities we have partnered with\n\nIn order to be eligible to be a trained provider in this study, an individual must meet all of the following criteria:\n\n1. Provision of written informed consent\n2. State willingness to comply with all study procedures\n3. Be a staff or volunteer within the ASN (Aging Services Network), specifically within the triple As and aging entities we have partnered with\n4. Meet Wymann and colleagues (2008) criteria for being a \"natural helpers\"42 (i.e. be warm, empathic, and having ongoing interaction with participants through one's job role)\n5. Be recommended by the aging entity leadership as meeting these qualifications\n\nIn order to be eligible to be a leadership personnel in this study, an individual must meet all of the following criteria:\n\n1. Provision of written informed consent\n2. State willingness to comply with all study procedures\n3. Be a in a leadership position within the aging entity or triple A in which we partnered, and have worked with the study team in helping implement the 8 week program\n\nExclusion criteria for Participants:\n\n1. Had a dementia diagnosis, or another form of cognitive impairment, and\u002For hearing impairment that would preclude phone conversation.\n2. Participation in another warm calling behavioral treatment or intervention study simultaneously occurring\n\nExclusion criteria for trained natural helpers:\n\n1. Does not have ongoing interactions with potential old adult participants (i.e. is a part of an optimized nutrition service provider in which they do not serve the same older adults consistently over time)\n2. Participation in another warm calling behavioral treatment or intervention study simultaneously occurring\n\nExclusion criteria for aging leaders:\n\n1. Has not worked with the study team directly in implementing the 8-week treatment\n2. Is not familiar with the implementation of the program",true,"55 Years",{"count":58,"type":22},400,[25],"This PN-RCT replicates and evaluates an 8-week warm calling treatment (i.e. caring contacts) delivered to older adults receiving home and community-based services (HCBS; classified as \"homebound\") in 20-30 minute call \"dosages\", across 3 conditions, while adding in implementation science measures at multiple levels. Conditions include 2 treatment (i.e. treatment provided by helpers trained in a standardized and manualized Belongingness and Empathy training grounded in narrative reminiscence and the befriending literature (BE condition), and treatment provided by helpers trained in BE + a standardized, manualized, and evidence based suicide intervention training, the Aging Variant of LivingWorks ASIST (BE + ASIST condition), and 1 control (no treatment during the trial; opportunity to receive treatment after the 8 weeks). At the conclusion of treatment, acceptability, appropriateness, feasibility, useability, and sustainability of the program will be evaluated by interventionists, senior center leadership, and regional leadership.",[62,63,29,64,65,66,67],"Older Adults (50-90 Years)","Mental Health","Social Functioning","Quality of Life","Thwarted Belongingness","Perceived Burdensomeness",[69,70,71,72,73],"Older adults","Intervention trial","Suicidality","Home Bound Meals","warm-calling","2026-03-11",{"date":76,"type":39},"2026-03-16",{"date":78,"type":39},"2025-09-05",{"date":80,"type":22},"2030-08-30",{"name":82,"class":46},"University of Florida",1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":83},"100591439","culturally-adapted-psychological-support-for-conflict-affected-afghans-study-protocol-on-mental-health--violence-100591439","NCT06980441","Culturally Adapted Psychological Support for Conflict-Affected Afghans: Study Protocol on Mental Health & Violence","Feasibility and Acceptability of Culturally Adapted, Evidence-Informed Psychological Support on Mental Health Symptoms and Violence for Conflict-Affected Populations in Afghanistan: A Study Protocol","Inclusion Criteria:\n\n* Psychological Distress, measured at \\>15 on the Kessler Psychological Distress Scale (K10)\n* Afghan nationality\n* Age between 16 and 30\n* Ability to read and write in Dari\n\nExclusion Criteria:\n\n* Imminent suicide risk\n* Experiencing psychosis\n* Neurological or cognitive disabilities","16 Years","30 Years",{"count":94,"type":22},60,[25],"This pilot study examines the feasibility and acceptability of a culturally adapted psychological intervention-Problem Management Plus with Emotional Processing (PM+ EP)-for young Afghans aged 16-30 experiencing high psychological distress. Through a pilot randomized control trial and qualitative interviews, the study explores whether PM+ EP can reduce symptoms of anxiety, depression, PTSD, and aggression, and improve daily functioning. Findings will inform the potential for a larger trial and address critical mental health and violence prevention needs in conflict-affected Afghan communities.",[29,98,99],"Anxiety","PTSD",[101,102,103,104,105,106,107],"Youth mental health","Afghanistan","Implementation science","Culturally adapted psychological support","Evidence informed interventions","Mental health symptoms","Psychological experiences","NOT_YET_RECRUITING","2025-05-11",{"date":111,"type":39},"2025-05-20",{"date":113,"type":22},"2025-06",{"date":115,"type":22},"2026-12",{"name":117,"class":46},"Peace of Mind Association (PoMA)"]