[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depression-in-old-age\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depression-in-old-age":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,67,94,115,142],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100586045","leveraging-adult-protective-service-interaction-to-offer-evidence-based-treatment-for-depression-in-elder-neglectself-neglect-100586045",false,"NCT06910267","Leveraging Adult Protective Service Interaction to Offer Evidence-Based Treatment for Depression in Elder Neglect\u002FSelf Neglect","Inclusion Criteria:\n\n* APS Case in APS Region VI- Must have open case\n* PHQ 9 score- Must have score of nine (9) or more\n\nExclusion Criteria:\n\n* Previous mental health diagnosis of bipolar disorder, psychotic disorders, and moderate to severe dementia\n* Assessment of Consent Proxy- Those who need assessment of consent proxy\n* Suicidal Intent (as indexed by PhQ-9 question 9)- Those scoring 2 or 3\n* Current Alcohol and Drug Dependency- As evidenced by Cut down, Annoyed, Guilty, and Eye-opener (CAGE) score of 3 or more","ALL","65 Years",{"count":18,"type":19},50,"ESTIMATED","INTERVENTIONAL",[22],"NA","The purpose of this study is to test the feasibility and acceptability of an evidence-based treatment for depression delivered over an ipad, computer, or smartphone can help Adult Protective Services (APS) clients with their activities of daily living to evaluate whether reductions on measures of depression and apathy (a) mediate reduced Elder Neglect\u002FSelf Neglect (EN\u002FSN) behaviors; and (b) whether secondary posited mediating mechanisms are also active in impacting depression and apathy",[25],"Depression in Old Age",[27,28],"Elder neglect","Self neglect","RECRUITING","2026-06-26",{"date":32,"type":33},"2026-06-30","ACTUAL",{"date":35,"type":33},"2026-05-15",{"date":37,"type":19},"2027-01-24",{"name":39,"class":40},"The University of Texas Health Science Center, Houston","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":20,"phases":51,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":41},"100535843","improving-adult-protective-services-client-outcomes-a-stepped-care-social-and-mental-health-engagement-program-100535843","NCT06257095","Improving Adult Protective Services Client Outcomes: A Stepped-Care Social and Mental Health Engagement Program","Inclusion Criteria:\n\nOlder Adults\n\n* an APS validated EM\u002FSN case\n* able to provide informed consent\n* able to speaks English or Spanish\n* able to hear sufficiently using the telephone\n* transitioning out of APS intervention (i.e. in the case closure phase of the APS service).\n\nStudent\n\n* college or university student\n* enrolled in a health-related program\n* commit to making 8-weekly consecutive calls\n* complete the required 1-hour training and assessment.\n\nExclusion Criteria:\n\nOlder Adults\n\n* Individuals needing a proxy to consent\n* suspected or confirmed decision-making capacity impairments or uncontrolled psychiatric illnesses such as schizophrenia, paranoia, delusion, or delirium\n\nStudent\n\n-only engaging in the program to fulfill some educational requirement",true,{"count":50,"type":19},400,[22],"The purpose of this study is to ascertain the feasibility and effectiveness of an 8-week social engagement program aimed at reducing depression and increasing social engagement among seniors who are transitioning out of Adult Protective Services (APS) for either elder abuse or self-neglect.",[25],[55,56,57,58],"social engagement","Adult Protective Services (APS)","elder abuse","self neglect","2026-05-29",{"date":61,"type":33},"2026-06-03",{"date":63,"type":33},"2023-08-09",{"date":65,"type":19},"2026-10-31",{"name":39,"class":40},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":20,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":41},"100504712","phase-4-serotonin-norepinephrine-reuptake-inhibitor-in-prophylaxis-of-depression-following-fragility-fractures-100504712","NCT05851898","Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures","The Role of SNRI's in the Prophylaxis of Depression in the First Year Following Lower Extremity Fragility Fractures in Geriatric Patients","SNRI","Inclusion Criteria:\n\n* Geriatric (greater than or equal to 65 years old)\n* Lower extremity fragility fractures managed operatively\n\nExclusion Criteria:\n\n* Polytrauma\n* Pathological fractures\n* Patients on hospice\n* Patients with previously diagnosed psychiatric disorders\n* Patients with previously diagnosed dementia\n* Patients already taking Selective serotonin reuptake inhibitors (SSRI)s and Serotonin- norepinephrine reuptake inhibitors (SNRI)s\n* Patients already taking mood stabilizing medication\n* Unable to provide informed consent (no use of a legal authorized representative)\n* Patients with pre-existing life limiting diagnoses (cancer, etc.)",{"count":76,"type":19},100,[78],"PHASE4","The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture. The main questions it aims to answer are:\n\n* What are the obstacles to enrolling patients and prescribing anti-depressants among older adults?\n* Is it possible to start prescribing SNRI medication upon discharge?\n* What is the prevalence of depressive symptoms amongst patients with different types of injuries and weightbearing status?\n* What is a transition of care plan for patients who have geriatric depression and require further care?\n\nParticipants will:\n\n* Undergo screening using the Geriatric Depression Scale\n* Start on Duloxetine 30mg daily at time of discharge\n* Report medication compliance and complete re-screening monthly\n* Complete patient reported outcome measures and 3 months, 6 months, and 1 year\n* Receive a referral to behavioral health, primary care, or psychiatrist for evaluation if they screen positive at any timepoint",[25,81],"Fragility Fracture",[83,84],"Geriatrics","Serotonin-norepinephrine","2026-03-11",{"date":87,"type":33},"2026-03-12",{"date":89,"type":33},"2024-04-08",{"date":91,"type":19},"2028-12",{"name":93,"class":40},"Wake Forest University Health Sciences",{"id":95,"slug":4,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":15,"minAge":99,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":20,"phases":102,"briefSummary":103,"conditions":104,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":41},"100543633","NCT06358404","Developing a Peer Support Intervention for Depression in SCD","Inclusion Criteria:\n\n* Older adults aged 60+\n* Endorse subjective cognitive decline\n* Endorse depressive symptoms\n* not currently experiencing suicidal ideation nor active, untreated manic, psychotic, or substance use disorder\n* fluent in English and able to give informed consent\n\nExclusion Criteria:\n\n* Meets diagnostic criteria for mild cognitive impairment or Alzheimer's dementia\n* Meets diagnostic criteria for a current major depressive disorder\n* have a history of neurological and psychiatric comorbidities such as major depressive disorder in the past 12 months","60 Years",{"count":101,"type":19},30,[22],"The purpose of this study is to assess the feasibility, acceptability, and fidelity of an 8-week intervention where peer coaches will deliver depression care to adults 60 years of age or older who have depression and subjective cognitive decline.",[105,25],"Subjective Cognitive Decline","2025-05-09",{"date":108,"type":33},"2025-05-12",{"date":110,"type":33},"2024-05-01",{"date":112,"type":19},"2026-04-30",{"name":114,"class":40},"Massachusetts General Hospital",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":15,"minAge":99,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":20,"phases":124,"briefSummary":125,"conditions":126,"keywords":130,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":41},"100466659","engage-for-late-life-depression-and-comorbid-executive-dysfunction-100466659","NCT05356611","Engage for Late-Life Depression and Comorbid Executive Dysfunction","Engage: A Treatment for Late-Life Depression and Comorbid Executive\u002FCognitive Dysfunction","Inclusion Criteria:\n\n* Age 60 or older\n* Ability to read, write, and speak English\n* Located in Las Vegas or surrounding area\n* Ability to travel to UNLV campus by self or possible caregiver for regular study visits\n* Clinically significant symptoms of depression as evidenced by: 1) Scores \\> 5 on the Geriatric Depression Scale-Short Form (GDS-SF)\n* Mild cognitive impairment as evidenced by: 1) Scores \\> 18 and \\\u003C 25 on the Montreal Cognitive Assessment (MoCA)\n\nExclusion Criteria:\n\n* Active suicidal ideation\n* History of suicide attempt(s)\n* Current symptoms of: 1) Psychosis; 2) Active substance use disorder\n* Reported history of: 1) Bipolar disorder (\"manic depression\"); 2) Intellectual disability\n* Currently in or scheduled to initiate individual psychotherapy to avoid treatment interference\n* Psychotropic medication permitted if dose was stable over the past 2 weeks\n* Currently living in an institutional setting (e.g., assisted living, inpatient, skilled nursing)\n* Presence of notable memory-specific cognitive deficits as evidenced by: scores \\\u003C 9 on the MoCA memory subscale (rendering it difficult to participate in and track\u002Frecall events for weekly psychotherapy)",{"count":123,"type":19},20,[22],"Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations. Cognitive decline is one such factor that places significant burden on older adults and can interfere with traditional mental health therapies. Engage is a behavioral treatment approach that has shown to be effective in treating late life depression. The investigators are testing the feasibility of Engage as a treatment method for late life depression in older adults with cognitive decline. The objective is to corroborate Engage as an alternative late life depression treatment method for a sub-population of older adults with cognitive decline. Cognitive decline poses a unique mental health treatment barrier that is often over looked in younger populations. With a relatively higher prevalence of cognitive decline in older adulthood, it is imperative that a feasible mental health treatment program that can be effective in the presence of cognitive decline.",[25,127,128,129],"Psychotherapy","Mild Cognitive Impairment","Executive Dysfunction",[131,132],"Older Adults","Late-Life Depression","2024-08-04",{"date":135,"type":33},"2024-08-06",{"date":137,"type":33},"2023-09-24",{"date":139,"type":19},"2025-05",{"name":141,"class":40},"University of Nevada, Las Vegas",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":48,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":20,"phases":151,"briefSummary":152,"conditions":153,"keywords":156,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":41},"100536845","development-of-a-healthcare-service-platform-for-successful-aging-100536845","NCT06270121","Development of a Healthcare Service Platform for Successful Aging","Development of an Integrated Contactless Healthcare Service Platform Based on Intelligent IoT for the Successful Aging of the Elderly","Inclusion Criteria:\n\n* Community dwelling older adults who are 65 years old and older\n\nExclusion Criteria:\n\n* Older adults with cognitive, sensory, and functional problems that may hinder them from participating surveys.\n* Older adults with iOS mobile device that would not allow them to use the developed mobile application.\n* Older adults in nursing home or who are hospitalized because this platform is designed to support independent living of an older adults in their home.",{"count":150,"type":19},84,[22],"The goal of this living-lab clinical trial is to test the effectiveness of digital health monitoring and feedback platform for community dwelling older adults. The main questions it aims to answer are:\n\n* Identify digital sensing variables that are predictive of mental and physical health declines and health emergencies of older adults\n* Develop digital health monitoring service to inform individualized daily health status of older adults users\n* Develop ICT network to share the daily health status and emergency signals with community based healthcare service providers and family caregivers if an older adult user approves of them to receive their health information.\n\nParticipants will be asked to participate in a living lab using a wearable sensor, motion sensor, and smartphone applications for 6 weeks and also take part in pre-mid-post surveys to evaluate the usability, accuracy, and effectiveness of the digital healthcare service platform to improve health managements and connections with community and family caregivers.\n\nIf there is a comparison group: Researchers will compare age and gender matched control group to see if health status of the living-lab group is better than the control group.",[25,154,155],"Chronic Pain","Sleep Disorder Insomnia Chronic",[157,158,159,160,161,162],"geriatric depression","digital mental health phenotyping","community based hybrid digital senior care service","digital healthcare monitoring platform for elderly","chronic pain","sleep disorders","2024-02-13",{"date":165,"type":33},"2024-02-21",{"date":167,"type":33},"2020-10-21",{"date":169,"type":19},"2030-11-30",{"name":171,"class":40},"Sunmi Song"]