[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depression-in-remission\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depression-in-remission":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100527301","mechanisms-of-change-of-positive-interventions-in-reducing-vulnerability-for-depression-100527301",false,"NCT06145984","Mechanisms of Change of Positive Interventions in Reducing Vulnerability for Depression","Understanding Mechanisms of Prevention of Depression: a Mechanistic Cross-over Trial of Mindfulness vs. Fantasizing to Reduce Perseverative Cognition Underlying Vulnerability for Depression","MINDCOG","Inclusion Criteria:\n\nIn order to be eligible to participate in this study, all participants must meet all the following criteria:\n\n* Participants should be between 18 and 60 years old. Participants should not exceed 60 years of age in order to minimize aging-related decline in information processing;\n* Participants should display normal intelligence (IQ\\>85, as assessed with the Dutch Adult Reading Test and\u002For having finished an education on at least vocational level) in order to assure sufficient task comprehension.\n\nParticipants in the remitted Major Depressive Disorder group should meet the following criteria to make sure that participants are at high risk of depressive relapse and currently show no clinically relevant severity of depressive symptoms:\n\n* Remitted participants should have experienced at least two depressive episodes, according to criteria defined by the Diagnostic Statistical Manual, version 5 (DSM-5), experienced in past ten years;\n* Remitted participants should score 21 or lower on the Inventory of Depressive Symptomatology (IDS-SR30), indicative of the absence of clinically relevant depressive symptoms.\n\nExclusion Criteria:\n\nFurthermore, individuals who meet any of the following criteria will be excluded from participation in this study:\n\n* Fulfilling criteria for any current DSM-5 diagnosis as objectified with the Structured Clinical Interview for DSM-5 (SCID-5);\n* Daily use of anti-depressive medication, benzodiazepines, methylphenidate, beta blockers or other medication potentially influencing electrocardiogram currently or in the last four weeks;\n* Recent engagement (defined as in their last episode, or as one year prior to inclusion in case the last episode was more than a year before inclusion) in preventive cognitive therapy including the positive fantasizing technique and\u002For have recent experiences (defined as daily practice in the past two years for at least two weeks) with mindfulness, meditation, or mindful yoga. This criterion prevents underestimation of true effects of mindfulness and\u002For positive fantasizing and maximizes treatment effects;\n* Participation in another clinical intervention study at the moment of inclusion in the study to prevent overlapping intervention effects.\n\nIndividuals for the Never-Depressed control group who additionally meet any of the following criteria will be excluded from participation of this study:\n\n* Presence of symptoms of depression according to the IDS-SR30 (score \\> 13), to make sure participants are not currently experiencing clinically relevant depressive symptoms;\n* Any life-time psychopathology of any disorder as objectified with the SCID-5.",true,"ALL","18 Years","60 Years",{"count":22,"type":23},100,"ESTIMATED","INTERVENTIONAL",[26],"NA","The purpose of this study is to understand the effects of mindfulness and fantasizing in reducing perseverative cognition underlying vulnerability for depression.",[29],"Depression in Remission","RECRUITING","2026-06-15",{"date":33,"type":34},"2026-06-16","ACTUAL",{"date":36,"type":34},"2020-06-19",{"date":38,"type":23},"2026-09-24",{"name":40,"class":41},"University Medical Center Groningen","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":24,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":42},"100484264","mood-and-thought-process-study-100484264","NCT05585775","Mood and Thought Process Study","Affective Executive Functioning as a Mechanism of Treatments for Depression Symptoms","MAT Process","Inclusion Criteria:\n\n1. Adults 18 years or older\n2. English fluency in order to complete study procedures\n3. Normal vision or corrected to normal vision\n4. QIDS score ≥ 5 and ≤ 15 to include individuals with elevated, but not severe symptoms of depression\n5. No presence of psychotic symptoms that interfere with functioning\n6. No current hazardous alcohol or drug use\n7. No previous experience with mindfulness-based treatment (i.e., enrollment in MBSR or MBCT previously)\n8. No current symptoms of mania indicative of a manic episode\n9. No current cognitive impairment\n10. No history of a formally diagnosed learning disability in reading, intellectual disability or other developmental disorder\n11. No history of a neurologic illness affecting cognition\n12. If on psychiatric medications, no change in medications for at least 4 weeks\n13. If in psychotherapy, no change in therapy status for at least 4 weeks\n\nExclusion Criteria:\n\nExclusion criteria include: (a) presence of psychotic symptoms that interfere with one's ability to function as determined by the SCID-5 Psychotic Screening Module; (b) current hazardous alcohol or drug use as indicated by a score of \\>10 for men and women on the AUDIT and the DUDIT for cannabis use, and \\>6 for men and women on the DUDIT for all other drugs (everything but cannabis), (c) change in psychiatric drug prescription within 4 weeks; (d) started psychotherapy or other psychiatric treatment within the past 4 weeks; (e) current suicide ideation or behavior which requires urgent intervention due to safety concerns; (f) Previous enrollment in MBCT or MBSR; (g) symptoms of mild cognitive impairment as indicated by a score of \\\u003C26 on the MoCA; (h) formally diagnosed learning disability, intellectual disability, or other developmental disorder; (i) history of neurologic illness affecting cognition; (j) current symptoms indicative of a manic episode per the SCID-5 Mood Disorders Module.",{"count":52,"type":23},76,[26],"The primary objective for this project is to test whether affective executive functioning is a mechanism of action of mindfulness-based cognitive therapy and Wellness for Wellbeing. The main questions it aims to answer are:\n\n1. Test the effect of MBCT vs. Wellness for Wellbeing on affective inhibition (i.e., emotionally valenced inhibition as measured via the affective Go\u002FNo Go task) using an RCT.\n2. Test the effect of MBCT vs. Wellness for Wellbeing on (a) affective updating and (b) affective shifting. Outcomes will be measured with the affective n-Back and the affective Internal Switching Task, respectively.\n\n3a) The investigators will examine whether depression symptom severity co-varies with change in affective executive functioning (i.e., affecting inhibition, shifting, and updating) over time. 3b) The investigators will examine whether compliance with treatment protocol (e.g., number of classes attended, amount of home practice) predicts endpoint executive functioning.\n\nParticipants will complete surveys, interviews, and computer tasks, and will be randomized to either Mindfulness-Based Cognitive Therapy or Wellness for Wellbeing.",[29,56,57],"Depressive Symptoms","Depression","2025-11-04",{"date":60,"type":34},"2025-11-05",{"date":62,"type":34},"2023-04-06",{"date":64,"type":23},"2026-12-31",{"name":66,"class":41},"Butler Hospital"]