[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depression-not-otherwise-specified\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depression-not-otherwise-specified":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100581880","improving-behavioral-health-for-caregivers-and-children-after-pediatric-injury-100581880",false,"NCT06856057","Improving Behavioral Health for Caregivers and Children After Pediatric Injury","Improving Quality of Life and Behavioral Health Service Access for Caregivers and Young Children After Pediatric Traumatic Injury","Inclusion Criteria:\n\n* Caregivers (≥18 years old) of children hospitalized with pediatric injury\n* Children hospitalized with pediatric injury \\<12 years old\n* Screen positive on the ASC-Kids (aged 8-11 years) or PDI Caregiver measure of acute distress.\n\nExclusion Criteria:\n\n* A caregiver whose primary language is not English\n* A cognitive challenge (caregiver or child) that would impair ability to consent\n* Presence of a self-afflicted injury\n* Presence of injuries resulting from caregiver abuse or neglect (these patients will follow an alternative treatment path).",true,"ALL","18 Years",{"count":20,"type":21},348,"ESTIMATED","INTERVENTIONAL",[24],"NA","Pediatric traumatic injury (PTI) is a public health priority, with more than 125,000 children experiencing injuries that require hospitalization each year. These children, and their caregivers, are affected in many ways that may affect quality of life, emotional and behavioral health, physical recovery, family roles and routines, and academic functioning; yet US trauma centers do not adequately address these outcomes and a scalable national model of care for these families is needed. This proposal builds on prior research from the investigative team to test a technology-assisted, stepped care behavioral health intervention for children (\\<12 years) and their caregivers after PTI, CAARE (Caregivers' Aid to Accelerate Recovery after pediatric Emergencies), via a hybrid type I effectiveness-implementation trial with 348 families randomly assigned to CAARE (n=174) vs. guideline-adherent enhanced usual care (EUC) (n=174).",[27,28,29,30],"Quality of Life","PTSD","Depression Not Otherwise Specified","Child Externalizing Behavior","RECRUITING","2025-07-07",{"date":34,"type":35},"2025-07-10","ACTUAL",{"date":37,"type":35},"2025-05-28",{"date":39,"type":21},"2028-08-31",{"name":41,"class":42},"Medical University of South Carolina","OTHER",4,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100577974","phase-4-vortioxetine-for-depressive-symptoms-and-freezing-of-gait-in-parkinson-disease-100577974","NCT06805266","Vortioxetine for Depressive Symptoms and Freezing of Gait in Parkinson Disease","An Open Study to Evaluate the Efficacy of Vortioxetine on Freezing of Gait in Patients Affected by Parkinson Disease with Depressive Symptoms","Inclusion Criteria:\n\n1. Diagnosis of PD according to published criteria\n2. Occurrence of depression according to Beck Depression Inventory II (score ≥ 15)\n3. A score ≥ 2 on the freezing question #2.13 of part 2 of the MDS-UPDRS (moderate-severe FOG).\n4. FOG not responsive to dopaminergic treatment.\n\nExclusion Criteria:\n\n1. Treatment with IMAO-B (rasagiline, selegiline, safinamide) (to be included, IMAO-B need to be withdrawn for at least 15 days)\n2. Concomitant treatment with other antidepressant drugs\n3. Hepatic and renal insufficiency\n4. Treatment with tramadol or triptans\n5. Psychotic disorder\n6. Dementia according to DSM-V",{"count":52,"type":21},40,[54],"PHASE4","The present study involves patients with Parkinson Disease (PD) suffering from freezing of gait (FOG) and depressive symptoms. The main aim of the study is evaluating the efficacy of vortioxetine in reducing moderate\u002Fsevere FOG not responsive to dopaminergic treatment in patients with PD with depressive symptoms.",[57,58,29],"Parkinson Disease, Idiopathic","Freezing of Gait",[60,61,62],"Parkinson Disease","freezing of gait","depression NOS","NOT_YET_RECRUITING","2025-02-03",{"date":66,"type":35},"2025-02-06",{"date":68,"type":21},"2025-02",{"date":70,"type":21},"2027-02",{"name":72,"class":42},"Marianna Amboni"]