[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depressive-disorder-major-depressive-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depressive-disorder-major-depressive-disorder":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,57],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":35,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100613187","improving-treatment-for-depression-in-general-practice-using-a-step-by-step-care-plan-100613187",false,"NCT07263321","Improving Treatment for Depression in General Practice Using a Step-by-Step Care Plan.","Optimising Treatment for Patients With Depressive Episodes in General Practice Through Algorithm-Based Treatment: A Randomised, Open-label Controlled Trial.","ODEGA","Inclusion Criteria:\n\n1. The participant must be referred to the study with a diagnosis of unipolar depressive disorder, as judge by the GP.\n2. Severity of the depressive episode corresponding to moderate depression, as judged by the GP.\n3. Clinical uncertainty regarding which of the treatments, medication or psychotherapy, would be the better choice in the case concerned.\n4. Age criteria: Participants must be at least 18 years old and no more than 65 years old at the time of randomisation.\n5. The participant must be a patient in general practice.\n6. Participants must be able to participate in virtual meetings (e.g. by phone or computer) and have e-Boks.\n7. The participant must be willing to receive psychotherapy by a psychologist and\u002For medication.\n8. Must have signed the document of informed consent.\n\nExclusion Criteria:\n\n1. Misuse of substances that might influence the study, as judged by the investigator.\n2. Difficulty in understanding the Danish language, as judged by the investigator.\n3. A diagnosis of dementia.\n4. Medical conditions that might interfere with the study outcome or safety, judged so by the investigator.\n5. Pregnancy.\n6. High risk of non-adherence at the investigator's discretion.\n7. Suicidality: according to C-SSRS with a positive response to question 4 or 5 within the last three months or upon investigator's discretion.\n8. No current medical or psychotherapy treatment initiated within the last 4 weeks prior to screening.","ALL","18 Years","65 Years",{"count":21,"type":22},171,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to compare three different treatments for depression in patients with moderate depression in General Practice, aged 18-65 years.\n\nWe wish to investigate the effect of the treatment approaches, and 171 patients will be included in the trial. The participants will be randomised to one of the following three treatments:\n\n1. Standard treatment provided by a general practitioner (i.e. the general practitioner treats the patient as he\u002Fshe would normally do, when treating a patient with depression).\n2. Standard treatment provided by a psychologist in the form behavioural therapy (i.e. the psychologist treats the patient as he\u002Fshe would normally do, when treating a patient with depression).\n3. A step-by-step treatment plan carried out by a general practitioner. The plan includes pre-determined follow-ups and a pre-determined, structured plan for which medications to use and when to increase dose or switch medication.\n\nThe hypothesis is that a structured and step-by-step treatment approach regarding patients with depression, treated in general practice, is more effective than standard treatment provided by a general practitioner and a psychologist.\n\nAll the participants will:\n\n1. Receive one of the three treatments for 12 weeks.\n2. Have meetings with the project staff every 4 weeks (week 0, 4, 8 and 12) were rating scales will be completed, e.g. a rating scale to measure progress or deterioration in the participant's depression.",[28,29,30,31,32,33,34],"Depressive Disorder","Depression - Major Depressive Disorder","Depressive Disorder, Major Depressive Disorder","Depressive Disorders","Depression","Depressive Episodes","Depressive Episode",[36,37,38,39,40,41,42,43],"Treatment for depressive disorder in General Practice","Algorithm-based treatment in General Practice","Algorithm-guided treatment in General Practice","Algorithm-based treatment for depression in General Practice","Algorithm-based treatment for depressive disorder in General Practice","Algorithm-based treatment for depressive episodes in General Practice","Algorithm-guided treatment for depressive episodes in General Practice","Optimising treatment for depressive episodes in general practice","RECRUITING","2025-12-04",{"date":47,"type":48},"2025-12-10","ACTUAL",{"date":50,"type":22},"2025-12",{"date":52,"type":22},"2027-06",{"name":54,"class":55},"Aalborg University Hospital","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":17,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":23,"phases":68,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":56},"100599130","exploring-the-role-of-the-prefrontal-cortex-in-decision-making-100599130","NCT07080489","Exploring the Role of the Prefrontal Cortex in Decision-Making","Inclusion Criteria (Healthy):\n\n* Written Informed Consent\n* Age between 20-40 or 60-75 years\n* Fluent in German\n* Normal or corrected-to-normal vision\n* No color blindness\n* Right-handed\n* Non-smoker\n\nExclusion Criteria (Healthy):\n\n* History of neurological disorders\n* History of psychiatric disorders\n* Use of psychotropic medication\n* Presence of magnetizable implants\n* Alcohol or drug dependence\n\nInclusion Criteria (Patient):\n\n* Written Informed Consent\n* Diagnosed with mild to moderate depression\n* Age between 20-40 or 60-75 years\n* Fluent in German\n* Normal or corrected-to-normal vision\n* No color blindness\n\nExclusion Criteria (Patient):\n\n* Intake of benzodiazepines or antipsychotic medication\n* psychiatric disorders other than depression (e.g., psychosis, mania, personality disorders) or depression with organic cause\n* Presence of magnetizable implants\n* Alcohol or drug dependence",true,"20 Years","75 Years",{"count":67,"type":22},444,[25],"The goal of this study is to examine whether high-definition transcranial direct current stimulation (HD-tDCS) can influence decision-making for emotionally valenced content in younger and older adults, with or without major depression.\n\nThe main questions are:\n\nIn healthy adults, does brain stimulation modulate how people respond to emotionally valenced content during a decision-making task? What happens in the brain during modulation? Do these effects differ between younger and older adults?\n\nIn adults with depression, does brain stimulation help shift attention towards positive content during the task? What happens in the brain? Are these effects moderated by age (younger vs. older adults)?\n\nThe investigators will compare participants who receive real stimulation to those who receive sham (placebo) stimulation.\n\nParticipants will:\n\nReceive high-definition transcranial direct current stimulation (HD-tDCS) of the dorsolateral prefrontal cortex (DLPFC)\n\nPerform a decision-making task involving emotionally valenced words\n\nComplete the task while undergoing a brain scan using ultra-high field 7 Tesla magnetic resonance imaging (MRI) to measure brain activity",[30,71,72],"Healthy Volunteer","Aging",[74,75,76,77,78,79,32,72],"UHF fMRI","DLPFC","fMRI","HD-tDCS","Cognitive Control","Noninvasive Brain Stimulation","2025-07-14",{"date":82,"type":48},"2025-07-23",{"date":84,"type":48},"2025-03-04",{"date":86,"type":22},"2027-10",{"name":88,"class":55},"University of Bern"]