[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depressive-symptom\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depressive-symptom":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,51,96,132,159,183],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100643409","music-breathing-in-enhancing-resilience-among-elders-at-risk-of-mental-health-problems-100643409",false,"NCT07631845","Music Breathing in Enhancing Resilience Among Elders at Risk of Mental Health Problems","Effects of a Mindfulness-based Music Breathing Intervention in Enhancing Resilience Among Community-dwelling Elders at Risk of Mental Health Problems: A Pilot Randomised Controlled Trial","Inclusion Criteria:\n\n* Aged 65 years or above\n* Able to read Chinese and communicate in Cantonese\u002FMandarin.\n* Has mild to moderate anxiety and\u002For depressive symptoms, based on the - Hospital Anxiety and Depression Scale (HADS) (i.e., a score of 8 or higher on either the anxiety or depression subscale)\n\nExclusion Criteria:\n\n* Partcipants will be excluded if they have cognitive impairment, hearing loss, severe depression, known mental illness, or chronic illness.",true,"ALL","65 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this pilot randomised controlled trial is to examine the effects of a mindfulness-based music breathing intervention in enhancing resilience (primary outcome), and in reducing anxiety, depressive symptoms, loneliness, and improving health-related quality of life (secondary outcomes) among community-dwelling older adults at risk of mental health problems.\n\nIt is hypothesised that compared with the control group, participants in the intervention group will report enhanced resilience, reduced anxiety, depressive symptoms, and loneliness, and improved health-related quality of life immediately post-intervention.",[27,28,29,30,31],"Resilience","Anxiety","Depressive Symptom","Loneliness","Health-related Quality of Life",[33,34,35,36,27,37],"Mindfulness","Msuic","Breathing","Community-dwelling elders","Mental health","RECRUITING","2026-06-07",{"date":41,"type":42},"2026-06-10","ACTUAL",{"date":44,"type":42},"2026-06-08",{"date":46,"type":21},"2026-08-31",{"name":48,"class":49},"Chinese University of Hong Kong","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":63,"conditions":64,"keywords":81,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":50},"100573936","phase-3-nebulized-ketamine-for-the-treatment-of-major-depressive-disorder-100573936","NCT06752759","Nebulized Ketamine for the Treatment of Major Depressive Disorder","Nebulized Ketamine for the Treatment of Major Depressive Disorder in an Inpatient Setting: A Midazolam-controlled Randomized Controlled Trial","Inclusion Criteria:\n\n* All individuals 18 years and older with a Montgomery-Asberg Depression Rating Scale score (MADRS) ≥ 20\n* Must have a diagnosis of moderate to severe Major Depressive Disorder (MDD)\n* Structured Clinical Interview for DSM-5 (SCID-5) will be performed to confirm MDD diagnosis\n\nExclusion Criteria:\n\n* Adult patients with an allergy to Ketamine\n* Adult patients with an allergy to Midazolam\n* Individuals with a history of mania\u002Fhypomania or diagnosis of bipolar disorder\n* Patients on lithium and\u002For lamotrigine therapy\n* Recent or current homicidal ideation with an intent to act\n* MDD with psychotic features or current or past diagnosis of a psychotic disorder\n* No substance use disorder in the preceding 3 months except nicotine or caffeine or a positive urine screen for substances (except cannabis)\n* Diagnosis of obsessive-compulsive disorder, antisocial personality disorder, borderline personality disorder, posttraumatic stress disorder, intellectual disability, altered mental status, pregnant or breastfeeding patients,\n* Patients on \\> 2 medications for hypertension\n* Patients with uncontrolled hypertension (BP \\>140 mm Hg systolic and\u002For \\>90 mm Hg diastolic on two separate readings at the time of screening)\n* Body weight of \\> 150kg\n* Patients with history of congestive cardiac failure\n* Day of presentation, patients with unstable vital signs (systolic blood pressure \\\u003C90 or\\>160 mm Hg, pulse rate \\\u003C50 or \\>150 beats\u002Fmin, and respiration rate \\\u003C10 or \\>30 breaths\u002Fmin)\n* Consumption of opioids within 24 hours of drug administration\n* Acutely intoxicated patients will also be excluded","18 Years","88 Years",{"count":20,"type":21},[62],"PHASE3","This is a double-blind active placebo controlled clinical trial for individuals with moderate to severe depression. The purpose of this study is to assess if nebulized ketamine can reduce depressive symptoms.",[65,66,67,68,69,70,71,72,73,74,75,29,76,77,78,79,80],"Severe Depression","Moderate Depression","Ketamine","Midazolam","Peripheral Nervous System Agents","Central Nervous System Agents","Neurotransmitter Agents","Physiologic Effects of Drugs","Sensory System Agents","Analgesics, Non-Narcotic","Anti-Inflammatory Agents, Non-Steroidal","Hypnotics and Sedatives","Anti-anxiety Agents","Tranquilizing Agents","Psychotropic Drugs","Anesthetics Agent",[82,83,67,68,69,73,84,85,86],"Maimonides Medical Center","Psychiatry","Anesthetics, Dissociative","Nebulized Medications for depression","GABA Agents","2026-04-21",{"date":89,"type":42},"2026-04-24",{"date":91,"type":42},"2024-10-16",{"date":93,"type":21},"2027-09-30",{"name":95,"class":49},"Theresa Jacob, PhD, MPH",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":108,"conditions":109,"keywords":113,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":50},"100616423","integrative-therapeutic-programme-to-regulate-expressed-emotions-among-informal-caregivers-of-people-with-dementia-100616423","NCT07305415","Integrative Therapeutic Programme to Regulate Expressed Emotions Among Informal Caregivers of People With Dementia","Integrative Therapeutic Programme to Regulate Expressed Emotions Among Informal Caregivers of People With Dementia: a Pilot Randomized Controlled Trial","COPE","Inclusion Criteria:\n\n* (1) With a high level of EE as indicated by a cut-off score of 35 or above on the Family Attitude Scale (Chinese version; FAS-C)\n* (2) Provides care at least 4 hours per day\n* (3) Consent to participate\n* (4) No acute psychiatric illness\n\nExclusion Criteria:\n\n* (1) With a score below 35 on the Family Attitude Scale (Chinese version; FAS-C)\n* (2) Provides care no more than 4 hours per day\n* (3) Does not consent to participate\n* (4) With acute psychiatric illness.","100 Years",{"count":106,"type":21},56,[24],"The dual-modal (face-to-face and online approaches), client-customized Caregivers Of dementia Processing Emotions (COPE) programme aims to\n\n1. reduce caregivers' Expressed Emotion (EE),\n2. reduce caregivers' depressive symptoms,\n3. reduce the behaviourally interactive social dynamic of maladaptation (i.e., dysfunctional dyadic relationship and quality of care), and\n4. improve caregivers' perceived stress from PwD's Behavioral and Psychological Symptoms of Dementia (BPSD).\n\nResearchers will compare COPE to a control group (standard therapy) to examine how effective the COPE programme is.\n\nParticipants will take part in:\n\nPretest prior to COPE implementation Post-test after COPE completion Follow up test in 3 months after COPE completion",[110,111,29,112],"BPSD (Behavioral and Psycological Symptoms of Dementia)","Expressed Emotion","Caregiving Stress",[114,115,111,116,117,118,119,120,121,122],"BPSD","behavioral and psychological symptoms of dementia","Dementia caregivers","Dementia caregiving","preceived stress","caregiver depression","caregiving stress","caregiving relationship","dyadic care relationship","2026-03-25",{"date":125,"type":42},"2026-03-31",{"date":127,"type":42},"2025-12-20",{"date":129,"type":21},"2027-03-30",{"name":131,"class":49},"The University of Hong Kong",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":17,"minAge":140,"maxAge":58,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":144,"conditions":145,"keywords":146,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":50},"100605476","digital-cognitive-behavioral-therapy-for-chinese-adolescents-with-depressive-symptomscads-d--100605476","NCT07163013","Digital Cognitive Behavioral Therapy for Chinese Adolescents With Depressive Symptoms（CADS-D )","Digital Cognitive Behavioral Therapy for Chinese Adolescents With Depressive Symptoms（CADS-D ): A Randomized Clinical Trial","CADS-D","Inclusion Criteria:\n\n1. Age 12 to 18 years;\n2. Scored 28 or higher on the children's depression rating scale-revised (CDRS-R);\n3. Have the ability to read and write in Chinese;\n4. Participant and at least one of their guardians provided written consent;\n5. Have access to mobile phone and internet.\n\nExclusion Criteria:\n\n1. The researchers assessed that the adolescent's depressive symptoms were too severe to participate to CADS-D;\n2. Scored 5 or higher on item 13 (suicidal ideation) on CDRS-R;\n3. Participants who met diagnosis of other mental disorder except depression;\n4. Severe physical illnesses or other physical disabilities that prevented the use of DCBT;\n5. Within the past three months or currently undergoing any antidepressant treatment, including medication therapy, psychotherapy, and physical therapy;\n6. Unavailability to follow up months after intervention.","12 Years",{"count":142,"type":21},200,[24],"CADS-D aimes to evaluate the effectiveness and feasibility of a newly DCBT program for Chinese adolescents with depressive symptoms.",[29],[147,148,149],"Depressive symptoms","Digital cognitive behavioral therapy","Adolescent","2026-01-25",{"date":152,"type":42},"2026-01-27",{"date":154,"type":42},"2025-05-12",{"date":156,"type":21},"2026-09",{"name":158,"class":49},"First Affiliated Hospital of Chongqing Medical University",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":17,"minAge":166,"maxAge":140,"enrollmentInfo":167,"targetDuration":4,"studyType":22,"phases":169,"briefSummary":170,"conditions":171,"keywords":172,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":182,"locationsCount":50},"100605700","musical-training-to-enhance-resilience-of-underprivileged-school-aged-children-100605700","NCT07165925","Musical Training to Enhance Resilience of Underprivileged School-aged Children","A Gamified Instrumental Musical Training to Enhance Resilience of Underprivileged School-aged Children at Risk of Mental Health Problems: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Hong Kong Chinese children aged 8-12 years.\n* Able to read Chinese and communicate in Cantonese\u002FMandarin.\n* From low-income families.\n* Have a risk of mental health problems, specifically depression and\u002For anxiety (determined through screening during the recruitment process using the Center for Epidemiological Studies Depression Scale for Children, with a cut-off score of ≥16 indicating a high risk of depression, and\u002For the State Anxiety Scale for Children, with scores between 36 and 60 indicating a significant level of anxiety)\n\nExclusion Criteria:\n\n* Have chronic health conditions, cognitive and learning difficulties\n* if they or their siblings are currently receiving or have received any music-based interventions before the study.","8 Years",{"count":168,"type":21},174,[24],"This is a multi-centre randomised controlled trial aims to examine the effects of a group-based gamified instrumental musical training in enhancing resilience (primary outcome), reducing psychological distress (depressive symptoms and anxiety), enhancing self-esteem, and improving HRQoL (secondary outcomes) among underprivileged school-aged children at risk of mental health problems (depression and anxiety) during a 12-month follow-up.",[27,29,28],[173,27,174,175],"Musical training","underprivileged children","mental health","2025-12-17",{"date":178,"type":42},"2025-12-18",{"date":180,"type":42},"2025-09-08",{"date":93,"type":21},{"name":48,"class":49},{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":4,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":190,"minAge":191,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":22,"phases":195,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":200,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":4},"100573062","breathing-exercises-on-depression-in-postmenopausal-women-100573062","NCT06741384","Breathing Exercises on Depression in Postmenopausal Women","Effect of Breathing Exercises on Depression and Sexual Function in Postmenopausal Women","Inclusion Criteria:\n\n* Minimum of 3 years after menopause.\n* Mild to moderate depression.\n* Mild to moderate sexual dysfunction.\n* Their ages will be ranged from 45 to 60 years old.\n* Their BMI will be less than 30 kg\u002Fm2.\n\nExclusion Criteria:\n\n* Prolapse of the pelvic organs.\n* Pelvic tumors.\n* Vaginal infections.\n* Musculoskeletal\u002F neurological limitations to exercise.\n* Psychiatric disorders.\n* Unstable cardiovascular conditions.\n* Diabetes.","FEMALE","45 Years","60 Years",{"count":194,"type":21},60,[24],"Evaluate the effect of breathing exercises on depression and sexual function in postmenopausal women",[198,29,199],"Postmenopausal","Breathing Exercises","NOT_YET_RECRUITING","2024-12-18",{"date":203,"type":42},"2024-12-20",{"date":205,"type":21},"2024-12-26",{"date":207,"type":21},"2025-03-25",{"name":209,"class":49},"Middle East University"]