[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depressiveanxiety-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depressiveanxiety-symptoms":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100594648","lifestyle-intervention-for-symptoms-of-depression-with-app-support-in-general-practice-100594648",false,"NCT07022184","Lifestyle Intervention for Symptoms of Depression wIth App Support in General Practice","A Personalized Lifestyle Intervention for Depression Symptomatology in General Practice - a Cluster Randomized Multicenter Trial","LIDIAS","Inclusion Criteria:\n\n* Currently experiencing an episode of symptoms of depression and receiving treatment for this episode from their GP or GP-MHW for less than six months\n* Have a smartphone\n* Be proficient in Dutch\n\nExclusion Criteria:\n\n* Severe mental illness (such as psychosis or bipolar disorder)\n* Severe alcohol or drug addiction requiring specialized secondary care\n* High suicide risk\n* moderate to severe cognitive impairment (as determined by the GP)\n\nPatients who visit their GP for depressive symptoms but with a PHQ-9 of \\\u003C5 at baseline are allowed to use the PLI, but will not be included in the primary analysis.","ALL","18 Years",{"count":20,"type":21},216,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to find out whether a smartphone app can help reduce symptoms of depression by supporting healthy lifestyle changes and encouraging self-monitoring in adults who visit their general practitioner with symptoms of depression.\n\nThe main questions this study aims to answer are:\n\nDoes a personalized lifestyle intervention delivered through the app, in addition to regular care, reduce depression symptoms more effectively than regular care alone? Is this approach more cost-effective than regular care alone?\n\nResearchers will compare patients who use the app alongside their regular care to patients who receive regular care without the app, to see whether the app leads to better outcomes.\n\nParticipants who use the app will:\n\nComplete a lifestyle questionnaire focused on six themes: mental wellbeing, use of harmful substances, social relationships, healthy eating, sleep, and physical activity.\n\nSet personal goals based on their results and receive tailored lifestyle advice.\n\nTrack their depression symptoms regularly within the app to support ongoing care.\n\nHave follow-up conversations with their general practitioner or mental health nurse to discuss their progress.\n\nFill out questionnaires about their symptoms and experiences during the study.",[27,28],"Depressive\u002FAnxiety Symptoms","Depressive Disorder",[30,31,32,33,34,35,36,37,38],"Personalized lifestyle intervention","eHealth","Measurement-based care","Depression symptomatology","Cluster randomized trial","General practice","Lifestyle changes","Mental health support","Primary care","RECRUITING","2025-12-19",{"date":42,"type":43},"2025-12-22","ACTUAL",{"date":45,"type":43},"2025-06-17",{"date":47,"type":21},"2027-02",{"name":49,"class":50},"Radboud University Medical Center","OTHER",3,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":5},"100582573","internet-delivered-cognitive-behaviour-therapy-for-women-with-perimenopausal-anxiety-100582573","NCT06865066","Internet-Delivered Cognitive Behaviour Therapy for Women with Perimenopausal Anxiety","Developing an Internet-Delivered Cognitive Behaviour Therapy Program for Women with Perimenopausal Anxiety: a Feasibility and Acceptability Study","Inclusion Criteria:\n\n* In perimenopausal staging (as defined by the STRAW +10 criteria)\n* Assigned female at birth\n* Diagnosis of GAD according to DSM-5 by attending psychiatrist on research team\n* Competence to consent to participate\n* Ability to speak and read English\n* Consistent and reliable access to the internet\n\nExclusion Criteria:\n\n* Undergone CBT or hormone therapy within the last 6 months will be excluded\n* Active psychosis\n* Acute mania\n* Severe alcohol or substance use disorder\n* Active suicidal or homicidal ideation","FEMALE","40 Years","60 Years",{"count":63,"type":21},25,[24],"The goal of this clinical trial is to design an online Cognitive Behavioural Therapy (CBT) and Acceptance Commitment Therapy (ACT) program and to learn if it can treat anxiety in women transitioning into menopause (perimenopause).\n\nThe main questions it aims to answer are:\n\n* Is our online psychotherapy program a practical and acceptable means of managing anxiety during perimenopause?\n* Does our online psychotherapy program work in improving anxiety levels during perimenopause?\n\nParticipants will participate in weekly e-CBT module sessions tailored to perimenopausal anxiety and will be given weekly feedback on assignments from trained care providers through a secure online platform. Participants will complete questionnaires at the beginning, middle, and at end of the study, as well as at the three and six-month follow-up.",[67,68,27,69],"Menopause","Anxiety","Perimenopause",[67,68,71,72,73,74,75,76,69,77],"Online Psychotherapy","e-CBT","CBT","ACT","Menopause Transition","Digital Therapy","Perimenopausal Anxiety","2025-03-03",{"date":80,"type":43},"2025-03-07",{"date":82,"type":43},"2024-11-11",{"date":84,"type":21},"2025-02-28",{"name":86,"class":50},"Dr. Nazanin Alavi"]