[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depth-of-anesthesia-monitoring\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depth-of-anesthesia-monitoring":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100053505","the-effects-of-midazolam-dexmedetomidine-and-esketamine-on-bispectral-index-and-raw-electroencephalogram-in-patients-under-propofol-remifentanil-baseline-anesthesia-100053505",false,"NCT07699523","The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline Anesthesia","Inclusion Criteria:\n\n1. ASA physical status I-II;\n2. BMI 18-28 kg\u002Fm²;\n3. Scheduled for elective laparoscopic cholecystectomy, with an expected surgical duration from skin incision to completion of wound closure of ≥45 min;\n4. Planned to receive propofol-remifentanil total intravenous anesthesia, with routine intraoperative BIS monitoring and simultaneous acquisition of raw EEG signals;\n5. Voluntarily agrees to participate in this study, has signed the informed consent form, and is able to cooperate with the intervention and assessment procedures.\n\nExclusion Criteria:\n\n1. A confirmed history of psychiatric or neurological disorders, or use of antipsychotics, antidepressants, benzodiazepines, or other sedative-hypnotic drugs within 4 weeks before surgery;\n2. Cognitive impairment identified by Mini-Cog screening;\n3. Poorly controlled or untreated hypertension, sinus bradycardia, or severe cardiac conduction block;\n4. Acute angle-closure glaucoma;\n5. Known allergy to any required anesthetic drug;\n6. Difficulty in electrode placement or any condition that may interfere with EEG monitoring.","ALL","18 Years","65 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"NA","This prospective, single-center, randomized interventional study aims to investigate the effects of commonly used adjunct anesthetic drugs on the Bispectral Index (BIS) and electroencephalographic (EEG) activity during total intravenous anesthesia.\n\nBIS monitoring is widely used to estimate the depth of anesthesia. However, previous studies suggest that certain anesthetic drugs, particularly dexmedetomidine and esketamine, may alter BIS values independently of the patient's actual level of consciousness. As a result, BIS readings may not always accurately reflect anesthetic depth when multiple drugs are administered together.\n\nAdult patients undergoing elective laparoscopic cholecystectomy under standardized propofol-remifentanil anesthesia will be randomly assigned to receive one of the following adjunct drugs: midazolam, dexmedetomidine, esketamine, or no additional study drug (control group). Continuous BIS values and raw EEG signals will be recorded throughout the study period.\n\nThe primary objective is to compare changes in BIS values among different adjunct anesthetic drugs under otherwise similar anesthetic conditions. The study will also explore corresponding EEG characteristics associated with these changes. The findings are expected to improve understanding of drug-related differences in processed EEG monitoring and provide data for future development of more accurate anesthesia depth assessment methods.",[26,27],"Depth of Anesthesia Monitoring","BIS-EEG",[29,30,31,32,33,34],"Bispectral Index","Electroencephalography","Midazolam","Dexmedetomidine","Esketamine","Total Intravenous Anesthesia","NOT_YET_RECRUITING","2026-07-08",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":20},"2026-06-30",{"date":43,"type":20},"2027-12-30",{"name":45,"class":46},"China-Japan Friendship Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":47},"100632045","effect-of-hypothermia-on-bis-and-psi-correlation-during-cardiopulmonary-bypass-100632045","NCT07508579","Effect of Hypothermia on BIS and PSI Correlation During Cardiopulmonary Bypass","Effect of Hypothermia on the Correlation Between Bispectral Index (BIS) and Patient State Index (PSI) During Cardiopulmonary Bypass","Inclusion Criteria:\n\n* Age ≥18 years\n* Elective on-pump Coronary Artery Bypass Grafting (CABG) surgery\n* Planned use of general anesthesia\n* Written informed consent\n\nExclusion Criteria:\n\n* Preexisting neurological disease\n* Use of medications affecting Electroencephalography (e.g., antiepileptics)\n* Severe hepatic dysfunction\n* Emergency surgery\n* Inadequate signal quality for anesthesia depth monitoring","80 Years",{"count":57,"type":20},60,"OBSERVATIONAL","The goal of this observational study is to evaluate whether hypothermia affects the relationship between electroencephalography-derived indices during cardiac surgery in adult patients undergoing cardiopulmonary bypass.\n\nThe main questions it aims to answer are:\n\nDoes the correlation between Bispectral Index (BIS) and Patient State Index (PSI) change between normothermic and hypothermic phases during cardiopulmonary bypass? How do BIS and PSI values change in response to decreasing body temperature?\n\nParticipants will:\n\nUndergo standard general anesthesia for elective on-pump coronary artery bypass surgery Be monitored simultaneously with BIS and PSI devices during surgery Have data recorded at predefined temperature-based time points during cardiopulmonary bypass",[61,62,26],"Cardiopulmonary Bypass","Hypothermia; Anesthesia",[29,64,65,66,67,68,69],"Patient State Index","Processed EEG","Cardiac Surgery","Hypothermic CPB","Depth of Anesthesia","Intraoperative Monitoring","RECRUITING","2026-05-05",{"date":73,"type":39},"2026-05-11",{"date":75,"type":39},"2026-05-01",{"date":77,"type":20},"2026-12-31",{"name":79,"class":46},"Sakarya University"]