[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"depth-of-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:depth-of-anesthesia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100629826","phase-4-anesthesia-maintenance-with-target-controlled-infusion-of-propofol-and-remifentanil-at-fixed-ratio-100629826",false,"NCT07479719","Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio","Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio on Neurocognitive Recovery in Older Patients After Surgery: a Randomized Trial","Inclusion Criteria:\n\n1. Aged ≥ 65 years.\n2. Scheduled to undergo noncardiac surgery expected to last ≥ 1 hour under general anesthesia.\n3. Require patient-controlled intravenous analgesia after surgery.\n4. Provide written informed consent.\n\nExclusion Criteria:\n\n1. Inability to communicate in the preoperative period because of coma, profound dementia, language barrier, or other reasons.\n2. Previous history of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis.\n3. Traumatic brain injury or neurosurgery.\n4. Severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m2), or critical illness (preoperative American Society of Anesthesiologists physical status classification ≥IV).\n5. Planned ICU admission with endotracheal intubation after surgery.\n6. Enrolled in the other studies.\n7. Other reasons that are considered unsuitable for study participation by the responsible surgeons or investigators.","ALL","65 Years",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The impact of anesthesia depths on early postoperative neurocognitive complications after total intravenous anesthesia (TIVA) remains controversial. In some studies investigating TIVA, anesthesiologists mainly achieve the target depth of anesthesia by adjusting the dose of propofol, whereas the doses of opioids remains comparable between different anesthetic depth groups, possibly resulting inadequate analgesia. This study is aimed to investigate the impact of different anesthesia depths maintained by target-controlled infusion of propofol and remifentanil at a fixed ratio on the incidence of early postoperative neurocognitive complications in older patients undergoing noncardiac surgery.",[26,27,28,29,30],"Elderly","Surgery","Depth of Anesthesia","Total Intravenous Anesthesia","Delayed Neurocognitive Recovery",[26,27,32,33,34],"Depth of anesthesia","Total intravenous anesthesia","Delayed neurocognitive recovery","NOT_YET_RECRUITING","2026-03-15",{"date":38,"type":39},"2026-03-18","ACTUAL",{"date":41,"type":20},"2026-04",{"date":43,"type":20},"2027-01",{"name":45,"class":46},"Peking University First Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":47},"100562514","anesthesia-induction-scheme-for-painless-gastrointestinal-endoscopy-patients-based-on-nociceptive-stimulation-monitoring-100562514","NCT06604156","Anesthesia Induction Scheme for Painless Gastrointestinal Endoscopy Patients Based on Nociceptive Stimulation Monitoring","The Effect of the Nociception Index (qNOX) in Painless Gastrointestinal Endoscopy :a Clinical Study","Inclusion Criteria:\n\n1. Aged 18-60 years old;\n2. American Society of Anesthesiologists (ASA) Class I-III;\n3. Body mass index (BMI): 18-30 kg\u002Fm\\^2;\n4. Individuals scheduled for elective gastroscopy and colonoscopy examinations;\n5. Willing to comply with the experimental procedures and voluntarily sign the informed consent form\n\nExclusion Criteria:\n\n1. Pregnant or breastfeeding women;\n2. Individuals with allergies to sedatives\u002Fanesthetic drugs or other severe anesthetic risks;\n3. Patients with chronic preoperative pain or a history of substance abuse;\n4. Individuals with severe neurological diseases, such as stroke, hemiplegia, seizures, epilepsy, etc.;\n5. Patients with clearly difficult airways, such as those with limited mouth opening, neck or jaw mobility restrictions, rheumatoid arthritis, or temporomandibular joint disorders;\n6. Individuals with respiratory diseases, such as bronchitis, asthma, chronic obstructive pulmonary disease, or acute respiratory infections, which may lead to increased airway sensitivity;\n7. Patients with chronic pharyngitis, laryngitis, laryngeal edema, or recurrent laryngeal nerve paralysis that may affect normal throat function;\n8. Individuals with esophagitis, esophageal strictures, or esophageal motility disorders that may cause difficulty swallowing or reflux;\n9. Patients with poorly controlled life-threatening cardiovascular diseases, such as uncontrolled severe hypertension, severe arrhythmias, or unstable angina; 10.10.Patients with liver dysfunction (Child-Pugh grade C or above), acute upper gastrointestinal bleeding with shock, severe anemia, or gastrointestinal obstruction with retained gastric contents.","18 Years","60 Years",{"count":58,"type":20},220,"OBSERVATIONAL","Nociception is the encoding and processing of noxious stimulation and is considered an objective indicator for monitoring pain. Currently, a new clinically-applied medical-engineering integrated monitoring device for noxious stimulation response has emerged. Its fundamental principle is based on the monitoring of electroencephalographic (EEG) activity, incorporating two monitoring parameters: the quantitative consciousness (qCON) index and the quantitative nociceptive (qNOX) index. However, in the context of sedation for gastrointestinal endoscopy, how the dynamic changes of the quantitative consciousness index (qCON) and the quantitative nociception index (qNOX) reflect the depth of sedation and nociceptive response remains unclear. Safe and effective sedation monitoring includes both direct visual monitoring and physiological monitoring, that is, monitoring the patient's hemodynamics and depth of sedation. This study utilizes qCON and qNOX monitoring to assess the sedation and analgesic states of patients undergoing painless gastroenterological endoscopy. By combining visual assessment (cough reflex, respiratory depression, and limb movement) with clinical physiological monitoring (vital signs monitoring and pulse oximetry), the aim is to explore the optimal sedation range for gastrointestinal endoscopy under sedation, providing new anesthesia monitoring tools for clinical use.",[28,62,63],"Nociception","Painless Gastrointestinal Endoscopy",[65,66,67],"Painless Gastrointestinal endoscopy","depth of anesthesia","nociception","RECRUITING","2025-03-04",{"date":71,"type":39},"2025-03-06",{"date":73,"type":39},"2024-09-01",{"date":75,"type":20},"2025-10-31",{"name":77,"class":46},"Min Su"]