[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"deresuscitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:deresuscitation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100614135","timing-and-dose-of-fluid-deresuscitation-in-critically-ill-patients-100614135",false,"NCT07275658","Timing and Dose of Fluid Deresuscitation in Critically Ill Patients","Timing and Dose of Fluid Deresuscitation in Critically Ill Patients: a Prospective Observational Multicenter Study","TIDE","Inclusion Criteria:\n\n* Admission to one of the participating ICUs;\n* Clinical indication for deresuscitation using diuretics or ultrafiltration as set by the treating physician; first attempt during the ICU stay.\n\nExclusion Criteria:\n\n* Age below 18 years old;\n* Major cardiac shunts;\n* Moderate to severe aortic regurgitation;\n* Morbid Obesisty (BMI \\>40);\n* POCUS impossible or unreliable (i.e. pre-existing interstitial lung disease);\n* PLR or modified form of PLR impossible (i.e. ECMO);\n* Transfer from another ICU;\n* Previous inclusion in this study;\n* Patients who are moribund or facing the end of life;\n* Opt out.","ALL","18 Years",{"count":20,"type":21},150,"ESTIMATED","OBSERVATIONAL","Fluid deresuscitation is an important intervention in the Intensive Care Unit (ICU). This study aims to find (1) determinants of successful deresuscitation, (2) the optimal rate (dose) of deresuscitation based on these determinants, and (3) differences in metabolic profiles for a more personalized approach of deresuscitation.\n\nThis study is a multicenter, prospective, observational cohort study in critically ill patients. This study will include ICU patients who have a clinical indication for deresuscitation as set by the treating physician. Clinical, ultrasound and laboratory values will be collected and used for analysis.",[25,26,27],"Fluid Overload","Critical Care, Intensive Care","Deresuscitation",[29],"ultrasound, RRT, furosemide","RECRUITING","2026-01-19",{"date":33,"type":34},"2026-01-21","ACTUAL",{"date":36,"type":34},"2025-10-15",{"date":38,"type":21},"2027-02-28",{"name":40,"class":41},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},"100453711","lung-ultrasound-guided-fluid-deresuscitation-in-icu-patients-100453711","NCT05188092","Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients","Effect of Lung Ultrasound-Guided Fluid Deresuscitation on Duration of Ventilation in Intensive Care Unit Patients (CONFIDENCE)","CONFIDENCE","Inclusion Criteria:\n\n* Admission to one of the participating ICUs;\n* Invasively ventilated for less than 24 hours at randomization;\n* Expected to be under invasive ventilation for longer than 24 hours after randomization.\n\nExclusion Criteria:\n\n* Age below 18 years old;\n* Suspected or confirmed pregnancy;\n* Participation in other interventional trials with similar endpoints;\n* Use of long term home mechanical ventilation;\n* Neurological condition that can prolong duration of mechanical ventilation (i.e.Guillain-Barré syndrome, high spinal cord lesion, amyotrophic lateral sclerosis, multiple sclerosis, or myasthenia gravis);\n* Conditions in which LUS cannot be performed or correctly interpreted (i.e. chest wall abnormalities, morbid obesity, and pre-existing interstitial lung disease);\n* Conditions in which targeting a negative fluid balance is discouraged (i.e. subarachnoid bleeding, severe rhabdomyolysis (CK \\> 20.000);\n* Previous participation in this RCT;\n* Patients transferred from another center and invasively ventilated for longer than 24 hours.",{"count":51,"type":21},1000,"INTERVENTIONAL",[54],"NA","Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients. Lung ultrasound (LUS) is an easy to learn, safe, cheap and noninvasive bedside imaging tool with high accuracy for pulmonary edema and pleural effusions in ICU patients. The aim of this study is to assess the effect of LUS-guided deresuscitation on duration of invasive ventilation in ICU patients. The investigators hypothesize that LUS-guided fluid deresuscitation is superior to routine fluid deresuscitation (not using LUS) with regard to duration of invasive ventilation.\n\nThis study is an international multicenter randomized clinical trial (RCT) in invasively ventilated ICU patients.This study will include 1,000 consecutively admitted invasively ventilated adult ICU patients, who are expected not to be extubated within the next 24 hours after randomization. Patients are randomly assigned to the intervention group, in which fluid deresuscitation is guided by repeated LUS, or the control group, in which fluid deresuscitation is at the discretion of the treating physician (not using LUS).",[57,25,27,58],"Mechanical Ventilation","Ventilator-free Days","2025-11-28",{"date":61,"type":34},"2025-12-05",{"date":63,"type":34},"2021-12-22",{"date":65,"type":21},"2026-06-01",{"name":40,"class":41},3]