[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"descemet-membrane-endothelial-keratoplasty-dmek\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:descemet-membrane-endothelial-keratoplasty-dmek":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,38,64],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":16,"targetDuration":4,"studyType":19,"phases":4,"briefSummary":20,"conditions":21,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100638417","impact-of-iridotomyiridectomy-size-on-postoperative-pupillary-block-and-dysphotopsia-following-dmek-100638417",false,"NCT07577635","Impact of Iridotomy\u002FIridectomy Size on Postoperative Pupillary Block and Dysphotopsia Following DMEK","Inclusion Criteria:\n\n* Adults aged ≥ 18 years\n* Patients undergoing Descemet membrane endothelial keratoplasty (DMEK) at the Department of Ophthalmology, University Hospital Leipzig\n* Preoperative Nd:YAG laser iridotomy or intraoperative surgical iridectomy performed as part of standard care\n* Ability to provide written informed consent\n* Willingness to complete the postoperative dysphotopsia questionnaire\n\nExclusion Criteria:\n\n* Inability to provide informed consent or refusal to participate\n* Pre-existing surgical iridectomy\n* Missing or incomplete preoperative or postoperative anterior segment OCT data\n* Active anterior uveitis or panuveitis at the time of surgery","ALL",{"count":17,"type":18},100,"ESTIMATED","OBSERVATIONAL","Descemet membrane endothelial keratoplasty (DMEK) is the standard surgical treatment for corneal endothelial disorders. A postoperative pupillary block may occur despite routine preoperative laser iridotomy or intraoperative surgical iridectomy. Insufficient size or incomplete patency of the iridotomy\u002Firidectomy (IT) may contribute to this complication, while excessively large openings may be associated with postoperative dysphotopsia. This prospective observational study investigates the association between IT size measured by anterior segment optical coherence tomography (AS-OCT) and the occurrence of postoperative pupillary block and dysphotopsia after DMEK.",[22,23,24,25],"Pupillary Block After DMEK","Laser Iridotomy \u002F Surgical Iridectomy","Dysphotopsia","Descemet Membrane Endothelial Keratoplasty (DMEK)","NOT_YET_RECRUITING","2026-07-01",{"date":29,"type":30},"2026-07-02","ACTUAL",{"date":32,"type":18},"2026-06-01",{"date":34,"type":18},"2027-07-01",{"name":36,"class":37},"University of Leipzig","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":45,"targetDuration":4,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":63},"100621684","influence-of-supine-positioning-on-the-outcomes-after-descemet-membrane-endothelial-keratoplasty-dmek-100621684","NCT07373821","Influence of Supine Positioning on the Outcomes After Descemet Membrane Endothelial Keratoplasty (DMEK)","SUPINE","Inclusion Criteria:\n\nFuchs Endothelial Corneal Dystrophy Bullous Keratopathy\n\nExclusion Criteria:\n\nComorbidities preventing supine positioning",{"count":46,"type":18},102,"INTERVENTIONAL",[49],"NA","The goal of this clinical trial is to learn if a longer period of lying on the back after corneal transplant surgery (Descemet Membrane Endothelial Keratoplasty, DMEK) helps the transplant stick better in the eye. It will also learn about side effects, such as back pain.\n\nThe main questions it aims to answer are:\n\n* Does lying on the back for 5 days reduce the size of transplant detachment compared to lying on the back for only 1 day?\n* Do participants who lie on their back longer need fewer additional procedures (rebubbling)?\n* What symptoms or problems do participants experience with short vs. long back positioning?\n\nResearchers will compare two groups:\n\n* 1 day of back positioning\n* 5 days of back positioning\n\nParticipants will:\n\n* Be randomly assigned to one of the two positioning groups\n* Wear a movement sensor that records head position\n* Have their eyes checked regularly with vision tests and imaging (AS-OCT)\n* Answer questions about their vision and comfort\n* Keep a diary of any positioning-related complaints, such as back pain",[52,25],"Fuchs Endothelial Corneal Dystrophy","RECRUITING","2026-01-23",{"date":56,"type":30},"2026-01-28",{"date":58,"type":30},"2025-10-02",{"date":60,"type":18},"2027-03",{"name":62,"class":37},"University Hospital Heidelberg",1,{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":15,"minAge":72,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":47,"phases":75,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":63},"100444809","phase-4-dsaekdmek-and-cystoid-macular-edema---the-role-for-topical-nsaids-nepafenac-dmec-100444809","NCT05072262","DSAEK\u002FDMEK and Cystoid Macular Edema - the Role for Topical NSAIDs (Nepafenac) (DMEC)","A Randomized Clinical Two-arm Trial Comparing Inflammation and Cystoid Macular Edema for the Medication Regimens Postoperative Topical NSAIDs and Steroids to Only Postoperative Topical Steroids in Patients Undergoing Corneal Endothelial Transplantations (DMEC)","DMEC","Inclusion Criteria:\n\n* Patients must be 18 years and older at the time of the signing of the informed consent. There is no upper age limit.\n* Scheduled for DSAEK or DMEK\n* Ability to cooperate fairly well during the examinations\n* Willing to participate in the study and capable of giving informed consent, which includes compliance with the requirements and restrictions in the informed consent form (ICF) and in this protocol.\n\nExclusion Criteria:\n\n* Contraindications for use of any medication (as listed in the approved SPC, e.g. allergy, pregnancy, breastfeeding)\n* Pregnancy or possible pregnancy during the study period\n* Preoperative macular edema and\u002For ongoing treatment for macular edema\n* Re-transplantation\n* In-operated glaucoma shunt \u002F valve (e.g. Ahmed glaucoma valve)\n* Aphakic eyes (eyes without a biological or artificial intraocular lens)\n* Loss of central vision (expected visual acuity potential after surgery below 0.1 Snellen)","18 Years",{"count":74,"type":18},300,[76],"PHASE4","The DMEC trial is a randomized clinical two-arm trial comparing inflammation and cystoid macular edema for the medication regimens postoperative topical NSAIDs and steroids to only postoperative topical steroids in patients undergoing corneal endothelial transplantations (DSAEK or DMEK).",[79,25],"Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)","2022-11-26",{"date":82,"type":30},"2022-12-01",{"date":84,"type":30},"2022-11-25",{"date":86,"type":18},"2026-10",{"name":88,"class":37},"Oslo University Hospital"]