[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"detrusor-overactivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:detrusor-overactivity":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100638308","the-effectiveness-of-transcutaneous-sacral-neuromodulation-techniques-magnetic-stimulation-and-electrical-stimulation-on-detrusor-overactivity-in-patients-with-spinal-cord-injury-100638308",false,"NCT07578532","The Effectiveness of Transcutaneous Sacral Neuromodulation Techniques-Magnetic Stimulation and Electrical Stimulation-on Detrusor Overactivity in Patients With Spinal Cord Injury","Inclusion Criteria:\n\n* 18-65 years old Traumatic and non-traumatic suprasacral SCI; Detrusor overactivity confirmed by urodynamics (spontaneous and\u002For provocative detrusor contraction during the filling phase will be accepted as detrusor overactivity) Patients who have been receiving anticholinergic and\u002For sympathomimetic treatment for the last 3 months and whose pharmacological medical treatment dose has not been changed since the last urodynamic examination will be included in the study.\n\nExclusion Criteria:\n\n* Patients with a cardiac pacemaker,\n* Patients diagnosed with epilepsy,\n* Patients with a metal implant within a 10 cm radius of the area where the treatment will be applied,\n* Patients who have received botox injection to the bladder in the last 6 months,\n* Patients who have received any neuromodulation technique in the last 6 months,\n* Patients who have undergone surgical procedure for neurogenic bladder,\n* Patients with another neurological disease that may affect neurogenic bladder (Parkinson's, polyneuropathy, neurodegenerative disease, cerebrovascular disease, etc.)\n* Patients with acute urinary tract infection,\n* Patients diagnosed with bladder outlet obstruction (urethral stricture, benign prostatic hyperplasia, etc.) will not be included in the study.","ALL","18 Years","65 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this prospective, randomized clinical trial is to compare the efficacy and safety of transcutaneous sacral magnetic stimulation versus sacral electrical stimulation for detrusor overactivity in 40 male and female patients aged 18-65 with suprasacral Spinal Cord Injury (SCI) whose DOA is confirmed by urodynamics and is refractory to anticholinergic medication. The main question(s) aims to answer :\n\nIs there a difference between SMS and SES in their effect on objective urodynamic parameters, such as maximum detrusor pressure during filling and bladder compliance? Is there a difference between SMS and SES in reducing the frequency of incontinence episodes and improving the Neurogenic Bladder Dysfunction Score? Researchers will compare Sacral Magnetic Stimulation and Sacral Electrical Stimulation to see if there are differences in their effects on urodynamic measures, clinical symptoms, and patient satisfaction\u002Fdiscomfort.\n\nParticipants will:\n\nBe randomly assigned to one of two intervention groups: Sacral Magnetic Stimulation or Sacral Electrical Stimulation.\n\nReceive 20 sessions of the assigned transcutaneous sacral stimulation technique (5 times a week for 20 minutes per session).\n\nUndergo a series of evaluations before and after the 20 treatment sessions, including:\n\nUrodynamic assessment (cystometry + EMG). Clinical assessments (3-day bladder diary, Neurogenic Bladder Dysfunction Score, Neurogenic Bowel Dysfunction Score, Spinal Cord Independence Measure - SCIM).\n\nPatient-reported outcomes (Treatment Satisfaction Level - Likert Scale, Treatment Discomfort Level - Visual Analog Scale)",[26,27],"Spinal Cord Injuries (SCI)","Detrusor Overactivity",[29,30,31,32],"spinal cord injury","transcutenous sacral magnetic stimulation","transcutenous sacral electrical stimulation","detrusor overactivity","RECRUITING","2026-05-06",{"date":36,"type":37},"2026-05-11","ACTUAL",{"date":39,"type":37},"2025-03-26",{"date":41,"type":20},"2026-09-26",{"name":43,"class":44},"Ankara City Hospital Bilkent","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":45},"100607111","platelet-rich-plasma-versus-botulinum-toxin-for-refractory-overactive-bladder-a-randomized-trial-100607111","NCT07184307","Platelet-Rich Plasma Versus Botulinum Toxin for Refractory Overactive Bladder: A Randomized Trial","Intra-vesical Injection of Platelet-Rich Plasma Compared With Botox for Management of Patients With Refractory Overactive Bladder: A Comparative Randomized Study","Inclusion Criteria:\n\n* Age 18 years or older\n* History of urgency, frequency, nocturia, with or without urge urinary incontinence, lasting for at least 6 months\n* Failure of standard medical treatment (antimuscarinics, beta-3 adrenergic agonists, or other appropriate therapy) for at least 6 months\n* Willing and able to complete bladder diaries, questionnaires, and urodynamic testing\n* Provides informed consent\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Previous intravesical biological therapy (e.g., platelet-rich plasma or botulinum toxin)\n* Prior pelvic or bladder surgery that may affect bladder function\n* Active urinary tract infection or sexually transmitted infection\n* Vaginitis or chronic bacterial prostatitis\n* Bladder or lower ureteral stones confirmed by imaging\n* Bladder outlet obstruction on urodynamic study\n* Bladder malignancy (mass on imaging or malignant cells on cytology)\n* Use of indwelling urinary catheter\n* Severe uncontrolled medical conditions (e.g., uncontrolled diabetes, advanced renal or hepatic impairment)\n* Known hypersensitivity to botulinum toxin or contraindication to platelet-rich plasma preparation (e.g., coagulopathy, inability to discontinue anticoagulation safely)",{"count":54,"type":20},48,[23],"Overactive bladder is a common condition that causes sudden urges to urinate, frequent urination, night-time urination, and sometimes leakage of urine. Many people with overactive bladder improve with lifestyle changes and medicines. However, some patients do not respond to these standard treatments and continue to suffer from bothersome symptoms. This study is designed to help patients who have not improved with available medical therapy.\n\nTwo treatments will be compared in this research. The first treatment uses platelet-rich plasma. Platelet-rich plasma is made from a patient's own blood and contains growth factors that may help repair the lining of the bladder and improve bladder function. The second treatment uses botulinum toxin. Botulinum toxin is a protein that can reduce unwanted bladder contractions and is already approved for use in patients with overactive bladder who did not respond to other treatments.\n\nThe purpose of this study is to evaluate whether platelet-rich plasma injection into the bladder wall is safe, effective, and durable when compared with botulinum toxin injection into the bladder muscle. We believe that platelet-rich plasma may improve bladder health by encouraging tissue repair and reducing inflammation, while botulinum toxin may reduce bladder overactivity by blocking chemical signals that cause muscle contractions.\n\nThis study will take place at Benha University Hospital in Egypt. About 48 adult participants with overactive bladder that has not improved after at least six months of medical therapy will be enrolled. Participants will be randomly assigned to one of two groups. One group will receive platelet-rich plasma injections into the bladder lining, and the other group will receive botulinum toxin injections into the bladder muscle. The procedures will be performed under anesthesia using a cystoscope, which is a thin instrument inserted into the bladder.\n\nParticipants will be followed for one year. At several time points during follow-up, they will complete bladder symptom questionnaires, keep a voiding diary, and undergo urodynamic studies to measure bladder capacity and function. Researchers will also monitor safety by recording any side effects, such as urinary tract infections or temporary difficulty emptying the bladder.\n\nThe main goal of this study is to determine whether platelet-rich plasma can reduce symptoms of overactive bladder as effectively as botulinum toxin, with fewer side effects and longer-lasting results. If successful, platelet-rich plasma could offer a new treatment option for patients who continue to struggle with overactive bladder despite standard medical therapy.",[58,59,27],"Overactive Bladder Syndrome","Urinary Urge Incontinence",[61,62,63,64,65,66,67,27,68,69],"Platelet-Rich Plasma","Botulinum Toxin Type A","Overactive Bladder","Refractory Overactive Bladder","Urinary Urgency","Urinary Frequency","Urge Urinary Incontinence","Intravesical Injection","Regenerative Therapy","2025-09-13",{"date":72,"type":37},"2025-09-19",{"date":74,"type":37},"2025-04-15",{"date":76,"type":20},"2026-04-15",{"name":78,"class":44},"Benha University"]